Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 1,2-dimethylhydrazine | decreases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of ZC3H6 mRNA | CTD | PMID:22206623 | 17beta-estradiol | decreases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Estradiol results in decreased expression of ZC3H6 mRNA | CTD | PMID:31614463 | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:19095052 | 2,3',4,4',5-Pentachlorobiphenyl | increases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:31388691 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of ZC3H6 mRNA | CTD | PMID:22298810 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ZC3H6 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Zc3h6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of ZC3H6 mRNA | CTD | PMID:26377647 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of ZC3H6 mRNA | CTD | PMID:20188158 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of ZC3H6 mRNA | CTD | PMID:26251327 | 4,4'-sulfonyldiphenol | decreases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | bisphenol S results in decreased expression of ZC3H6 mRNA | CTD | PMID:37611474 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of ZC3H6 mRNA | CTD | PMID:30047161 | aflatoxin B1 | decreases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of ZC3H6 mRNA | CTD | PMID:22100608 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of ZC3H6 mRNA | CTD | PMID:30047161 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of ZC3H6 mRNA | CTD | PMID:30779732 | antirheumatic drug | increases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of ZC3H6 mRNA | CTD | PMID:24449571 | aristolochic acid A | decreases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of ZC3H6 mRNA | CTD | PMID:33212167 | arsane | affects methylation | ISO | ZC3H6 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ZC3H6 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | ZC3H6 (Homo sapiens) | 6480464 | Arsenic affects the methylation of ZC3H6 gene | CTD | PMID:25304211 | benzo[a]pyrene | increases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of ZC3H6 mRNA | CTD | PMID:22228805 | bisphenol A | increases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of ZC3H6 mRNA | CTD | PMID:29275510 | bisphenol A | increases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | bisphenol A results in increased expression of ZC3H6 mRNA | CTD | PMID:35598803 and PMID:37611474 | bisphenol A | decreases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of ZC3H6 mRNA | CTD | PMID:33221593 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ZC3H6 mRNA | CTD | PMID:30816183 more ... | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of ZC3H6 mRNA | CTD | PMID:25181051 and PMID:33296240 | butanal | decreases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of ZC3H6 mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | ISO | Zc3h6 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ZC3H6 mRNA | CTD | PMID:37325564 | cadmium dichloride | multiple interactions | ISO | Zc3h6 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ZC3H6 mRNA | CTD | PMID:37325564 | carbon nanotube | decreases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | ZC3H6 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to ZC3H6 gene] | CTD | PMID:28238834 | chlorpyrifos | decreases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of ZC3H6 mRNA | CTD | PMID:37019170 | copper atom | multiple interactions | ISO | ZC3H6 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of ZC3H6 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | ZC3H6 (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of ZC3H6 mRNA | CTD | PMID:20971185 | dimethylarsinic acid | multiple interactions | ISO | Zc3h6 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of ZC3H6 mRNA | CTD | PMID:34876320 | dinophysistoxin 1 | decreases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | dinophysistoxin 1 results in decreased expression of ZC3H6 mRNA | CTD | PMID:28939011 | dioxygen | increases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Oxygen deficiency results in increased expression of ZC3H6 mRNA | CTD | PMID:26516004 | dorsomorphin | multiple interactions | ISO | ZC3H6 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of ZC3H6 mRNA | CTD | PMID:29803840 | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of ZC3H6 mRNA | CTD | PMID:29391264 | entinostat | decreases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | entinostat results in decreased expression of ZC3H6 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | ZC3H6 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZC3H6 mRNA | CTD | PMID:27188386 | ethanol | affects expression | ISO | Zc3h6 (Mus musculus) | 6480464 | Ethanol affects the expression of ZC3H6 mRNA | CTD | PMID:30319688 | ethyl methanesulfonate | increases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of ZC3H6 mRNA | CTD | PMID:23649840 | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of ZC3H6 mRNA | CTD | PMID:24793618 | FR900359 | increases phosphorylation | ISO | ZC3H6 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of ZC3H6 protein | CTD | PMID:37730182 | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of ZC3H6 gene | CTD | PMID:22079235 | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of ZC3H6 mRNA | CTD | PMID:33387578 | lead(0) | affects expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Lead affects the expression of ZC3H6 mRNA | CTD | PMID:28903495 | leflunomide | increases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | leflunomide results in increased expression of ZC3H6 mRNA | CTD | PMID:28988120 | methamphetamine | decreases expression | EXP | | 6480464 | Methamphetamine results in decreased expression of ZC3H6 mRNA | CTD | PMID:19564919 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of ZC3H6 mRNA | CTD | PMID:30047161 | methyl methanesulfonate | increases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of ZC3H6 mRNA | CTD | PMID:23649840 | methylarsonic acid | multiple interactions | ISO | Zc3h6 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of ZC3H6 mRNA | CTD | PMID:34876320 | methylmercury chloride | decreases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of ZC3H6 mRNA | CTD | PMID:28001369 | nickel atom | decreases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Nickel results in decreased expression of ZC3H6 mRNA | CTD | PMID:24768652 and PMID:25583101 | panobinostat | multiple interactions | ISO | ZC3H6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZC3H6 mRNA | CTD | PMID:27188386 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of ZC3H6 mRNA | CTD | PMID:33387578 | pentanal | decreases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | pentanal results in decreased expression of ZC3H6 mRNA | CTD | PMID:26079696 | phenethyl isothiocyanate | increases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | phenethyl isothiocyanate results in increased expression of ZC3H6 mRNA | CTD | PMID:26678675 | phenylmercury acetate | decreases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of ZC3H6 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | ZC3H6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZC3H6 mRNA | CTD | PMID:27188386 | potassium dichromate | decreases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of ZC3H6 mRNA | CTD | PMID:23608068 | quercetin | increases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Quercetin results in increased expression of ZC3H6 mRNA | CTD | PMID:21632981 | quercetin | affects expression | EXP | | 6480464 | Quercetin affects the expression of ZC3H6 mRNA | CTD | PMID:18178720 | SB 431542 | multiple interactions | ISO | ZC3H6 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silicon dioxide | decreases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of ZC3H6 mRNA | CTD | PMID:25895662 | sodium arsenate | multiple interactions | ISO | Zc3h6 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of ZC3H6 mRNA | CTD | PMID:34876320 | sodium arsenite | multiple interactions | ISO | Zc3h6 (Mus musculus) | 6480464 | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in increased expression of ZC3H6 mRNA | CTD | PMID:34876320 | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of ZC3H6 mRNA | CTD | PMID:19281266 | sotorasib | multiple interactions | ISO | ZC3H6 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ZC3H6 mRNA | CTD | PMID:36139627 | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of ZC3H6 mRNA | CTD | PMID:30047161 | sunitinib | increases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of ZC3H6 mRNA | CTD | PMID:31533062 | testosterone | increases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | Testosterone deficiency results in increased expression of ZC3H6 mRNA | CTD | PMID:33848595 | testosterone | multiple interactions | ISO | Zc3h6 (Mus musculus) | 6480464 | 1 more ... | CTD | PMID:33848595 | tetraphene | increases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | benz(a)anthracene results in increased expression of ZC3H6 mRNA | CTD | PMID:26377693 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of ZC3H6 mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of ZC3H6 mRNA | CTD | PMID:23409001 | trametinib | multiple interactions | ISO | ZC3H6 (Homo sapiens) | 6480464 | [sotorasib co-treated with trametinib co-treated with NVP-BKM120] results in decreased expression of ZC3H6 mRNA | CTD | PMID:36139627 | trichloroethene | increases expression | EXP | | 6480464 | Trichloroethylene results in increased expression of ZC3H6 mRNA | CTD | PMID:33387578 | triphenyl phosphate | increases expression | EXP | | 6480464 | triphenyl phosphate results in increased expression of ZC3H6 mRNA | CTD | PMID:30589522 | trovafloxacin | decreases expression | ISO | Zc3h6 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of ZC3H6 mRNA | CTD | PMID:35537566 | valproic acid | affects expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of ZC3H6 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | ZC3H6 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of ZC3H6 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | ZC3H6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ZC3H6 mRNA | CTD | PMID:27188386 | |