Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be involved in several processes, including bone mineralization; calcium ion homeostasis; and endochondral bone morphogenesis. Predicted to act upstream of or within cell maturation and chondrocyte differentiation. Predicted to be located in cytosol and extracellular region. Predicted to be active in cytoplasm; extracellular space; and vesicle. Orthologous to several human genes including CST5 (cystatin D); INTERACTS WITH bisphenol A; fenvalerate; 17beta-estradiol (ortholog).
[Estradiol binds to ESR2 protein] promotes the reaction [NCOA2 protein binds to CST5 promoter] and Estradiol promotes the reaction [ESR2 protein affects the expression of CST5 mRNA]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CST5 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CST5 mRNA
[bisphenol A co-treated with Fulvestrant] results in decreased methylation of CST5 gene and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CST5 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CST5 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CST5 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CST5 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CST5 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CST5 mRNA