Herc4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4) - Rat Genome Database

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Gene: Herc4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4) Rattus norvegicus
Analyze
Symbol: Herc4
Name: HECT and RLD domain containing E3 ubiquitin protein ligase 4
RGD ID: 1310971
Description: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including negative regulation of smoothened signaling pathway; protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and fibrillar center. Predicted to be active in cytoplasm. Orthologous to human HERC4 (HECT and RLD domain containing E3 ubiquitin protein ligase 4); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: HECT domain and RCC1-like domain-containing protein 4; hect domain and RLD 4; HECT-type E3 ubiquitin transferase HERC4; LOC309758; probable E3 ubiquitin-protein ligase HERC4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82025,329,005 - 25,403,443 (-)NCBIGRCr8
mRatBN7.22025,329,972 - 25,404,657 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,330,280 - 25,404,657 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2026,023,208 - 26,097,568 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02025,376,231 - 25,450,593 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02025,962,772 - 26,037,143 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02026,755,948 - 26,831,267 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2026,755,911 - 26,830,931 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,063,820 - 8,139,150 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,591,774 - 25,665,597 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12025,605,573 - 25,679,395 (+)NCBI
Celera2026,628,361 - 26,702,717 (-)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IEA,ISO)
fibrillar center  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Disruption of the ubiquitin ligase HERC4 causes defects in spermatozoon maturation and impaired fertility. Rodriguez CI and Stewart CL, Dev Biol. 2007 Dec 15;312(2):501-8. Epub 2007 Oct 4.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:31010679  


Genomics

Comparative Map Data
Herc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82025,329,005 - 25,403,443 (-)NCBIGRCr8
mRatBN7.22025,329,972 - 25,404,657 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2025,330,280 - 25,404,657 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2026,023,208 - 26,097,568 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02025,376,231 - 25,450,593 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02025,962,772 - 26,037,143 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02026,755,948 - 26,831,267 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2026,755,911 - 26,830,931 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,063,820 - 8,139,150 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42025,591,774 - 25,665,597 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12025,605,573 - 25,679,395 (+)NCBI
Celera2026,628,361 - 26,702,717 (-)NCBICelera
Cytogenetic Map20p11NCBI
HERC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381067,921,905 - 68,075,283 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1067,921,899 - 68,075,301 (-)EnsemblGRCh38hg38GRCh38
GRCh371069,681,662 - 69,835,040 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361069,351,662 - 69,505,109 (-)NCBINCBI36Build 36hg18NCBI36
Build 341069,352,252 - 69,505,019NCBI
Celera1062,956,525 - 63,109,715 (-)NCBICelera
Cytogenetic Map10q21.3NCBI
HuRef1063,681,241 - 63,834,644 (-)NCBIHuRef
CHM1_11069,963,663 - 70,116,856 (-)NCBICHM1_1
T2T-CHM13v2.01068,790,646 - 68,944,156 (-)NCBIT2T-CHM13v2.0
Herc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391063,079,122 - 63,153,660 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1063,079,589 - 63,153,657 (+)EnsemblGRCm39 Ensembl
GRCm381063,243,751 - 63,317,881 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1063,243,810 - 63,317,878 (+)EnsemblGRCm38mm10GRCm38
MGSCv371062,706,733 - 62,780,625 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361062,639,342 - 62,713,234 (+)NCBIMGSCv36mm8
Celera1064,344,505 - 64,417,884 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.56NCBI
Herc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542520,309,449 - 20,418,338 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542520,310,264 - 20,418,154 (-)NCBIChiLan1.0ChiLan1.0
HERC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2880,084,224 - 80,238,793 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11080,090,126 - 80,244,093 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01064,405,164 - 64,559,651 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11066,717,537 - 66,870,774 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1066,716,761 - 66,870,774 (-)Ensemblpanpan1.1panPan2
HERC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1419,223,525 - 19,352,490 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl419,210,166 - 19,351,709 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha419,352,188 - 19,484,809 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0419,489,565 - 19,622,141 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl419,489,565 - 19,622,026 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1419,372,156 - 19,504,936 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0419,594,124 - 19,726,917 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0419,937,349 - 20,070,205 (-)NCBIUU_Cfam_GSD_1.0
Herc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721361,683,669 - 61,800,939 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493652110,176,132 - 10,292,845 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493652110,176,191 - 10,294,761 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HERC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1471,122,792 - 71,269,424 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11471,126,100 - 71,269,517 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21477,237,996 - 77,279,396 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HERC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1963,311,619 - 63,460,621 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl963,311,651 - 63,461,536 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604824,079,840 - 24,229,746 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Herc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247542,336,163 - 2,466,862 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247542,335,585 - 2,466,955 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Herc4
206 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:25
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000051367
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat

Markers in Region
AW553563  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22025,330,546 - 25,330,648 (-)MAPPERmRatBN7.2
Rnor_6.02026,830,584 - 26,830,685NCBIRnor6.0
Rnor_5.0208,138,467 - 8,138,568UniSTSRnor5.0
RGSC_v3.42025,665,227 - 25,665,328UniSTSRGSC3.4
Celera2026,628,630 - 26,628,731UniSTS
Cytogenetic Map20p11UniSTS
RH130359  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22025,330,161 - 25,330,347 (-)MAPPERmRatBN7.2
Rnor_6.02026,830,885 - 26,831,070NCBIRnor6.0
Rnor_5.0208,138,768 - 8,138,953UniSTSRnor5.0
RGSC_v3.42025,665,528 - 25,665,713UniSTSRGSC3.4
Celera2026,628,245 - 26,628,430UniSTS
Cytogenetic Map20p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 57 41 19 41 8 8 74 35 41 11 8
Low 5 3
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001012074 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256136 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039098759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497262 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC087104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000083017   ⟹   ENSRNOP00000072219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,330,280 - 25,404,657 (-)Ensembl
Rnor_6.0 Ensembl2026,755,911 - 26,830,931 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107240   ⟹   ENSRNOP00000082108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2025,330,287 - 25,404,566 (-)Ensembl
RefSeq Acc Id: NM_001012074   ⟹   NP_001012074
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,372 (-)NCBI
mRatBN7.22025,330,278 - 25,404,657 (-)NCBI
Rnor_6.02026,755,948 - 26,830,954 (+)NCBI
Rnor_5.0208,063,820 - 8,139,150 (+)NCBI
RGSC_v3.42025,591,774 - 25,665,597 (+)RGD
Celera2026,628,361 - 26,702,717 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256134   ⟹   XP_006256196
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,423 (-)NCBI
mRatBN7.22025,330,100 - 25,404,480 (-)NCBI
Rnor_6.02026,756,176 - 26,831,267 (+)NCBI
Rnor_5.0208,063,820 - 8,139,150 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256135   ⟹   XP_006256197
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,433 (-)NCBI
mRatBN7.22025,330,100 - 25,404,544 (-)NCBI
Rnor_6.02026,756,175 - 26,831,267 (+)NCBI
Rnor_5.0208,063,820 - 8,139,150 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006256136   ⟹   XP_006256198
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,401,079 (-)NCBI
mRatBN7.22025,329,972 - 25,402,364 (-)NCBI
Rnor_6.02026,763,006 - 26,831,267 (+)NCBI
Rnor_5.0208,063,820 - 8,139,150 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601656   ⟹   XP_017457145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,026 (-)NCBI
mRatBN7.22025,330,100 - 25,403,369 (-)NCBI
Rnor_6.02026,756,278 - 26,831,267 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098756   ⟹   XP_038954684
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,424 (-)NCBI
mRatBN7.22025,330,100 - 25,404,544 (-)NCBI
RefSeq Acc Id: XM_039098757   ⟹   XP_038954685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,424 (-)NCBI
mRatBN7.22025,330,100 - 25,404,544 (-)NCBI
RefSeq Acc Id: XM_039098758   ⟹   XP_038954686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,376,943 (-)NCBI
mRatBN7.22025,329,972 - 25,378,237 (-)NCBI
RefSeq Acc Id: XM_039098759   ⟹   XP_038954687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,366,384 (-)NCBI
mRatBN7.22025,329,972 - 25,367,659 (-)NCBI
RefSeq Acc Id: XM_063279170   ⟹   XP_063135240
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,026 (-)NCBI
RefSeq Acc Id: XM_063279171   ⟹   XP_063135241
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,443 (-)NCBI
RefSeq Acc Id: XM_063279172   ⟹   XP_063135242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,329,005 - 25,403,423 (-)NCBI
RefSeq Acc Id: XR_005497262
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82025,348,722 - 25,403,425 (-)NCBI
mRatBN7.22025,349,995 - 25,404,544 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001012074   ⟸   NM_001012074
- UniProtKB: Q5PQN1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006256197   ⟸   XM_006256135
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWE9 (UniProtKB/TrEMBL),   A6JKY7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256196   ⟸   XM_006256134
- Peptide Label: isoform X1
- UniProtKB: Q5PQN1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006256198   ⟸   XM_006256136
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017457145   ⟸   XM_017601656
- Peptide Label: isoform X1
- UniProtKB: Q5PQN1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072219   ⟸   ENSRNOT00000083017
RefSeq Acc Id: XP_038954686   ⟸   XM_039098758
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038954687   ⟸   XM_039098759
- Peptide Label: isoform X8
RefSeq Acc Id: XP_038954685   ⟸   XM_039098757
- Peptide Label: isoform X5
- UniProtKB: A6JKY6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954684   ⟸   XM_039098756
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000082108   ⟸   ENSRNOT00000107240
RefSeq Acc Id: XP_063135241   ⟸   XM_063279171
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWE9 (UniProtKB/TrEMBL),   A6JKY7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135242   ⟸   XM_063279172
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063135240   ⟸   XM_063279170
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZWE9 (UniProtKB/TrEMBL),   A6JKY7 (UniProtKB/TrEMBL)
Protein Domains
HECT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PQN1-F1-model_v2 AlphaFold Q5PQN1 1-1057 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701566
Promoter ID:EPDNEW_R12090
Type:initiation region
Name:Herc4_1
Description:HECT and RLD domain containing E3 ubiquitin protein ligase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02026,756,026 - 26,756,086EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310971 AgrOrtholog
BioCyc Gene G2FUF-3819 BioCyc
Ensembl Genes ENSRNOG00000061040 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055009895 UniProtKB/Swiss-Prot
  ENSRNOG00060002900 UniProtKB/Swiss-Prot
  ENSRNOG00065023020 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000083017 ENTREZGENE
  ENSRNOT00000083017.2 UniProtKB/Swiss-Prot
  ENSRNOT00000107240.1 UniProtKB/TrEMBL
  ENSRNOT00055016754 UniProtKB/Swiss-Prot
  ENSRNOT00060004693 UniProtKB/Swiss-Prot
  ENSRNOT00065039348 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/Swiss-Prot
  Hect, E3 ligase catalytic domain UniProtKB/Swiss-Prot
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7192894 IMAGE-MGC_LOAD
InterPro HECT_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RCC1/BLIP-II UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Reg_chr_condens UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:309758 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94698 IMAGE-MGC_LOAD
NCBI Gene 309758 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE HERC4-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN-PROTEIN LIGASE E3A-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RCC1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Herc4 PhenoGen
PRINTS RCCNDNSATION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RCC1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RCC1_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000061040 RatGTEx
  ENSRNOG00055009895 RatGTEx
  ENSRNOG00060002900 RatGTEx
  ENSRNOG00065023020 RatGTEx
SMART HECTc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50985 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56204 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZWE9 ENTREZGENE, UniProtKB/TrEMBL
  A6JKY6 ENTREZGENE, UniProtKB/TrEMBL
  A6JKY7 ENTREZGENE, UniProtKB/TrEMBL
  HERC4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-07-17 Herc4  HECT and RLD domain containing E3 ubiquitin protein ligase 4  Herc4  hect domain and RLD 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Herc4  hect domain and RLD 4  Herc4_predicted  hect domain and RLD 4 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Herc4_predicted  hect domain and RLD 4 (predicted)      Symbol and Name status set to approved 70820 APPROVED