Tmem45a2 (transmembrane protein 45A2) - Rat Genome Database

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Gene: Tmem45a2 (transmembrane protein 45A2) Rattus norvegicus
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Symbol: Tmem45a2
Name: transmembrane protein 45A2
RGD ID: 1310935
Description: Predicted to be located in membrane; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC360707; RGD1310935; similar to Dermal papilla derived protein 7; transmembrane protein 45A; uncharacterized protein LOC360707
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81156,952,176 - 56,996,145 (+)NCBIGRCr8
mRatBN7.21143,483,509 - 43,527,025 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,483,519 - 43,526,916 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01145,713,345 - 45,763,174 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1145,751,812 - 45,761,371 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01148,896,748 - 48,946,612 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41144,408,766 - 44,452,628 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11144,466,354 - 44,510,125 (+)NCBI
Celera1143,266,696 - 43,311,560 (+)NCBICelera
Cytogenetic Map11q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Tmem45a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81156,952,176 - 56,996,145 (+)NCBIGRCr8
mRatBN7.21143,483,509 - 43,527,025 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1143,483,519 - 43,526,916 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01145,713,345 - 45,763,174 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1145,751,812 - 45,761,371 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01148,896,748 - 48,946,612 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41144,408,766 - 44,452,628 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11144,466,354 - 44,510,125 (+)NCBI
Celera1143,266,696 - 43,311,560 (+)NCBICelera
Cytogenetic Map11q12NCBI
Tmem45a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391656,857,330 - 56,892,486 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1656,857,330 - 56,891,735 (-)EnsemblGRCm39 Ensembl
GRCm381657,036,967 - 57,071,346 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1657,036,967 - 57,071,372 (-)EnsemblGRCm38mm10GRCm38
MGSCv371657,037,080 - 57,071,459 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361656,963,586 - 56,996,297 (-)NCBIMGSCv36mm8
Celera1657,370,975 - 57,405,456 (-)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1634.22NCBI

Variants

.
Variants in Tmem45a2
344 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 7
Low 3 5 4 4 1 17 2
Below cutoff 2 34 23 10 23 5 5 32 8 15 2 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001408930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008776579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008776580 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008776581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000079336   ⟹   ENSRNOP00000070636
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1143,483,519 - 43,526,916 (+)Ensembl
Rnor_6.0 Ensembl1145,751,812 - 45,761,371 (+)Ensembl
RefSeq Acc Id: NM_001408930   ⟹   NP_001395859
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81156,952,622 - 56,996,037 (+)NCBI
mRatBN7.21143,483,509 - 43,526,919 (+)NCBI
RefSeq Acc Id: XM_008768661   ⟹   XP_008766883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81156,952,176 - 56,996,145 (+)NCBI
mRatBN7.21143,515,539 - 43,527,025 (+)NCBI
Rnor_6.01145,718,421 - 45,763,174 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063270631   ⟹   XP_063126701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81156,952,176 - 56,996,145 (+)NCBI
RefSeq Acc Id: XM_063270632   ⟹   XP_063126702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81156,952,176 - 56,996,145 (+)NCBI
RefSeq Acc Id: XM_063270633   ⟹   XP_063126703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81156,952,176 - 56,996,145 (+)NCBI
RefSeq Acc Id: XM_063270635   ⟹   XP_063126705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81156,952,176 - 56,996,145 (+)NCBI
RefSeq Acc Id: XM_063270636   ⟹   XP_063126706
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81156,952,176 - 56,996,145 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008766883   ⟸   XM_008768661
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000070636   ⟸   ENSRNOT00000079336
RefSeq Acc Id: NP_001395859   ⟸   NM_001408930
- UniProtKB: A0A0G2JYF6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063126702   ⟸   XM_063270632
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063126705   ⟸   XM_063270635
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063126703   ⟸   XM_063270633
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063126706   ⟸   XM_063270636
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063126701   ⟸   XM_063270631
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JYF6-F1-model_v2 AlphaFold A0A0G2JYF6 1-245 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310935 AgrOrtholog
BioCyc Gene G2FUF-21534 BioCyc
Ensembl Genes ENSRNOG00000051418 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000079336 ENTREZGENE
  ENSRNOT00000079336.2 UniProtKB/TrEMBL
InterPro DUF716_TMEM45 UniProtKB/TrEMBL
  TMEM45 UniProtKB/TrEMBL
KEGG Report rno:360707 UniProtKB/TrEMBL
NCBI Gene 360707 ENTREZGENE
PANTHER 2310005G13RIK PROTEIN UniProtKB/TrEMBL
  PTHR16007 UniProtKB/TrEMBL
Pfam DUF716 UniProtKB/TrEMBL
PhenoGen Tmem45a2 PhenoGen
RatGTEx ENSRNOG00000051418 RatGTEx
UniProt A0A0G2JYF6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-07-05 Tmem45a2  transmembrane protein 45A2  RGD1310935  similar to Dermal papilla derived protein 7  Name and Symbol changed 629549 APPROVED
2008-04-30 RGD1310935  similar to Dermal papilla derived protein 7   RGD1310935_predicted  similar to Dermal papilla derived protein 7 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1310935_predicted  similar to Dermal papilla derived protein 7 (predicted)  LOC360707_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360707_predicted  similar to Dermal papilla derived protein 7 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL