Aggf1 (angiogenic factor with G patch and FHA domains 1) - Rat Genome Database

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Gene: Aggf1 (angiogenic factor with G patch and FHA domains 1) Rattus norvegicus
Analyze
Symbol: Aggf1
Name: angiogenic factor with G patch and FHA domains 1
RGD ID: 1310888
Description: Predicted to enable nucleic acid binding activity. Predicted to be involved in cell adhesion; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Predicted to be located in extracellular region and perinuclear region of cytoplasm. Orthologous to human AGGF1 (angiogenic factor with G-patch and FHA domains 1); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC310005; RGD1310888; similar to RIKEN cDNA 2010009L17
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,354,073 - 28,380,794 (-)NCBIGRCr8
mRatBN7.2226,619,336 - 26,646,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,619,339 - 26,645,952 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0225,068,804 - 25,095,429 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl225,069,620 - 25,095,106 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0244,227,286 - 44,253,899 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,723,668 - 25,749,359 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,644,037 - 25,679,865 (-)NCBI
Celera222,684,509 - 22,711,225 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:14961121   PMID:26850475   PMID:28153879  


Genomics

Comparative Map Data
Aggf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8228,354,073 - 28,380,794 (-)NCBIGRCr8
mRatBN7.2226,619,336 - 26,646,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl226,619,339 - 26,645,952 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0225,068,804 - 25,095,429 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl225,069,620 - 25,095,106 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0244,227,286 - 44,253,899 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4225,723,668 - 25,749,359 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1225,644,037 - 25,679,865 (-)NCBI
Celera222,684,509 - 22,711,225 (-)NCBICelera
Cytogenetic Map2q12NCBI
AGGF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38577,030,404 - 77,065,234 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl577,029,251 - 77,065,234 (+)EnsemblGRCh38hg38GRCh38
GRCh37576,326,229 - 76,361,059 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,361,988 - 76,396,794 (+)NCBINCBI36Build 36hg18NCBI36
Build 34576,361,987 - 76,396,791NCBI
Celera572,220,718 - 72,255,361 (+)NCBICelera
Cytogenetic Map5q13.3NCBI
HuRef571,532,859 - 71,567,837 (+)NCBIHuRef
CHM1_1575,759,108 - 75,794,521 (+)NCBICHM1_1
T2T-CHM13v2.0577,512,128 - 77,546,904 (+)NCBIT2T-CHM13v2.0
Aggf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391395,487,191 - 95,511,865 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1395,487,191 - 95,511,860 (-)EnsemblGRCm39 Ensembl
GRCm381395,350,683 - 95,375,357 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1395,350,683 - 95,375,352 (-)EnsemblGRCm38mm10GRCm38
MGSCv371396,120,671 - 96,145,289 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361396,451,415 - 96,476,033 (-)NCBIMGSCv36mm8
Celera1398,972,068 - 98,996,687 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1349.41NCBI
Aggf1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542523,847,673 - 23,874,404 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542523,847,502 - 23,873,964 (-)NCBIChiLan1.0ChiLan1.0
AGGF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2438,232,858 - 38,265,220 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1536,386,503 - 36,418,418 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0538,236,209 - 38,268,530 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1538,762,317 - 38,794,606 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl538,762,317 - 38,794,594 (-)Ensemblpanpan1.1panPan2
AGGF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1329,578,050 - 29,682,265 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl329,647,592 - 29,682,776 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha330,804,004 - 30,921,635 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0329,486,014 - 29,601,272 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl329,566,220 - 29,601,792 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1329,420,293 - 29,538,033 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0329,400,940 - 29,518,896 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,770,262 - 29,888,021 (-)NCBIUU_Cfam_GSD_1.0
Aggf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213185,749,025 - 185,789,458 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365495,068,656 - 5,111,406 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365495,069,164 - 5,109,299 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGGF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl285,890,481 - 85,934,358 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1285,890,423 - 85,941,314 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2287,506,911 - 87,552,643 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AGGF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1471,277,293 - 71,309,973 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl471,277,315 - 71,310,159 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604920,115,923 - 20,148,633 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aggf1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248691,538,833 - 1,580,471 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248691,538,603 - 1,577,119 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aggf1
164 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:73
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000051653
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat

Markers in Region
RH131861  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,619,459 - 26,619,671 (+)MAPPERmRatBN7.2
Rnor_6.0225,068,928 - 25,069,139NCBIRnor6.0
Rnor_5.0244,227,410 - 44,227,621UniSTSRnor5.0
RGSC_v3.4225,723,006 - 25,723,217UniSTSRGSC3.4
Celera222,684,633 - 22,684,844UniSTS
RH 3.4 Map213.3UniSTS
Cytogenetic Map2q12UniSTS
BE119372  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2226,644,919 - 26,645,087 (+)MAPPERmRatBN7.2
Rnor_6.0225,094,294 - 25,094,461NCBIRnor6.0
Rnor_5.0244,252,776 - 44,252,943UniSTSRnor5.0
RGSC_v3.4225,748,332 - 25,748,499UniSTSRGSC3.4
Celera222,710,091 - 22,710,258UniSTS
RH 3.4 Map213.3UniSTS
Cytogenetic Map2q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 33 18 19 18 2 74 35 36 11
Low 16 24 23 23 8 9 5 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000051653   ⟹   ENSRNOP00000047981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl225,069,620 - 25,095,106 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085857   ⟹   ENSRNOP00000072154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl226,619,339 - 26,645,952 (-)Ensembl
Rnor_6.0 Ensembl225,072,877 - 25,095,106 (-)Ensembl
RefSeq Acc Id: NM_001427779   ⟹   NP_001414708
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,354,073 - 28,380,759 (-)NCBI
RefSeq Acc Id: XM_063281715   ⟹   XP_063137785
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8228,360,692 - 28,380,794 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414708 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137785 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99754 (Get FASTA)   NCBI Sequence Viewer  
  EDM10097 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072154.2
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000047981   ⟸   ENSRNOT00000051653
RefSeq Acc Id: ENSRNOP00000072154   ⟸   ENSRNOT00000085857
RefSeq Acc Id: NP_001414708   ⟸   NM_001427779
RefSeq Acc Id: XP_063137785   ⟸   XM_063281715
- Peptide Label: isoform X1
Protein Domains
FHA   G-patch   OCRE

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAK0-F1-model_v2 AlphaFold F1MAK0 1-704 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310888 AgrOrtholog
BioCyc Gene G2FUF-54810 BioCyc
Ensembl Genes ENSRNOG00000029304 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000085857.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.20 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623942 IMAGE-MGC_LOAD
InterPro AGGF1_OCRE UniProtKB/TrEMBL
  FHA_dom UniProtKB/TrEMBL
  G_patch_dom UniProtKB/TrEMBL
  OCRE UniProtKB/TrEMBL
  SMAD_FHA_domain UniProtKB/TrEMBL
MGC_CLONE MGC:124664 IMAGE-MGC_LOAD
NCBI Gene 310005 ENTREZGENE
PANTHER ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1 UniProtKB/TrEMBL
  ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1 UniProtKB/TrEMBL
Pfam FHA UniProtKB/TrEMBL
  G-patch UniProtKB/TrEMBL
  OCRE UniProtKB/TrEMBL
PhenoGen Aggf1 PhenoGen
PROSITE FHA_DOMAIN UniProtKB/TrEMBL
  G_PATCH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029304 RatGTEx
SMART FHA UniProtKB/TrEMBL
  G_patch UniProtKB/TrEMBL
Superfamily-SCOP SSF49879 UniProtKB/TrEMBL
UniProt A0A0G2K295_RAT UniProtKB/TrEMBL
  A6I4Y9_RAT UniProtKB/TrEMBL
  Q499U9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Aggf1  angiogenic factor with G patch and FHA domains 1  RGD1310888  similar to RIKEN cDNA 2010009L17  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1310888  similar to RIKEN cDNA 2010009L17  RGD1310888_predicted  similar to RIKEN cDNA 2010009L17 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310888_predicted  similar to RIKEN cDNA 2010009L17 (predicted)  LOC310005_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC310005_predicted  similar to RIKEN cDNA 2010009L17 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL