Agap3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3) - Rat Genome Database

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Gene: Agap3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3) Rattus norvegicus
Analyze
Symbol: Agap3
Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
RGD ID: 1310751
Description: Predicted to enable GTPase activator activity; GTPase activity; and polyubiquitin modification-dependent protein binding activity. Predicted to act upstream of or within cellular response to reactive oxygen species; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein import into nucleus. Predicted to be located in cell periphery and cytoplasm. Predicted to be active in nucleus. Orthologous to human AGAP3 (ArfGAP with GTPase domain, ankyrin repeat and PH domain 3); PARTICIPATES IN endocytosis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3; centaurin, gamma 3; Centg3; LOC362300
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,567,191 - 11,617,610 (-)NCBIGRCr8
mRatBN7.2410,674,746 - 10,724,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,674,064 - 10,725,244 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,820,842 - 15,871,089 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,641,034 - 11,691,279 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.049,992,816 - 10,043,063 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,202,330 - 7,253,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,202,330 - 7,253,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,213,697 - 7,264,499 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,038,279 - 6,064,813 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,039,389 - 6,093,727 (-)NCBI
Celera46,288,813 - 6,315,118 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. AGAP3 and Arf6 regulate trafficking of AMPA receptors and synaptic plasticity. Oku Y and Huganir RL, J Neurosci. 2013 Jul 31;33(31):12586-98. doi: 10.1523/JNEUROSCI.0341-13.2013.
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16461359   PMID:37749596  


Genomics

Comparative Map Data
Agap3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,567,191 - 11,617,610 (-)NCBIGRCr8
mRatBN7.2410,674,746 - 10,724,848 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,674,064 - 10,725,244 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,820,842 - 15,871,089 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,641,034 - 11,691,279 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.049,992,816 - 10,043,063 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,202,330 - 7,253,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,202,330 - 7,253,072 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,213,697 - 7,264,499 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,038,279 - 6,064,813 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,039,389 - 6,093,727 (-)NCBI
Celera46,288,813 - 6,315,118 (-)NCBICelera
Cytogenetic Map4q11NCBI
AGAP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387151,085,867 - 151,144,434 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7151,085,831 - 151,144,436 (+)EnsemblGRCh38hg38GRCh38
GRCh377150,782,954 - 150,841,521 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,414,759 - 150,472,456 (+)NCBINCBI36Build 36hg18NCBI36
Build 347150,221,473 - 150,279,171NCBI
Celera7145,341,154 - 145,398,859 (+)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,594,965 - 144,653,057 (+)NCBIHuRef
CHM1_17150,791,315 - 150,849,895 (+)NCBICHM1_1
T2T-CHM13v2.07152,258,976 - 152,317,511 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27150,112,452 - 150,171,043 (+)NCBI
Agap3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,657,175 - 24,707,045 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl524,657,175 - 24,707,045 (+)EnsemblGRCm39 Ensembl
GRCm38524,452,177 - 24,502,047 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,452,177 - 24,502,047 (+)EnsemblGRCm38mm10GRCm38
MGSCv37523,957,995 - 24,007,865 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36523,962,242 - 24,012,112 (+)NCBIMGSCv36mm8
Celera521,394,522 - 21,452,021 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map511.81NCBI
Agap3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,523,969 - 5,573,387 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,546,097 - 5,573,866 (+)NCBIChiLan1.0ChiLan1.0
AGAP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,507,834 - 187,566,328 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,518,132 - 39,576,595 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,672,773 - 142,731,261 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,825,594 - 154,884,340 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,822,312 - 154,884,339 (+)Ensemblpanpan1.1panPan2
AGAP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,163,705 - 15,193,053 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,137,024 - 15,193,538 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,744,734 - 15,801,147 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,858,855 - 16,915,349 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1616,858,468 - 16,915,324 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,231,701 - 15,287,508 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,813,103 - 15,868,934 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,863,297 - 15,919,795 (+)NCBIUU_Cfam_GSD_1.0
Agap3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,339,801 - 6,393,200 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,510,223 - 6,563,154 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,510,223 - 6,563,656 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AGAP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,081,681 - 6,145,522 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,081,680 - 6,145,115 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,445,525 - 6,502,093 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AGAP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,268,918 - 119,327,623 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607215,239,703 - 15,298,444 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Agap3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,487,200 - 5,535,707 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248005,486,728 - 5,535,691 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Agap3
242 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:200
Count of miRNA genes:131
Interacting mature miRNAs:155
Transcripts:ENSRNOT00000064386
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat

Markers in Region
D4Got15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,675,789 - 10,675,932 (+)MAPPERmRatBN7.2
Rnor_6.047,204,056 - 7,204,196NCBIRnor6.0
Rnor_5.047,215,423 - 7,215,563UniSTSRnor5.0
RGSC_v3.446,040,004 - 6,040,145RGDRGSC3.4
RGSC_v3.446,040,005 - 6,040,145UniSTSRGSC3.4
RGSC_v3.146,040,004 - 6,040,145RGD
Celera46,290,539 - 6,290,683UniSTS
RH 2.0 Map40.0RGD
Cytogenetic Map4q11UniSTS
AV028425  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,694,144 - 10,694,229 (+)MAPPERmRatBN7.2
Rnor_6.047,222,405 - 7,222,489NCBIRnor6.0
Rnor_5.047,233,769 - 7,233,853UniSTSRnor5.0
RGSC_v3.446,058,355 - 6,058,439UniSTSRGSC3.4
Celera46,308,860 - 6,308,944UniSTS
Cytogenetic Map4q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 34 18 16 3 16 2 74 22 33 11
Low 1 9 39 25 16 25 8 9 13 8 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001398853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF447874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000064386   ⟹   ENSRNOP00000063846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,674,064 - 10,725,138 (-)Ensembl
Rnor_6.0 Ensembl47,202,330 - 7,228,675 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084777   ⟹   ENSRNOP00000072199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,674,064 - 10,725,244 (-)Ensembl
Rnor_6.0 Ensembl47,203,003 - 7,252,950 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087120   ⟹   ENSRNOP00000070947
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,674,746 - 10,725,244 (-)Ensembl
Rnor_6.0 Ensembl47,203,441 - 7,253,072 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097225   ⟹   ENSRNOP00000077364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,674,064 - 10,725,138 (-)Ensembl
RefSeq Acc Id: NM_001398853   ⟹   NP_001385782
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,567,191 - 11,617,285 (-)NCBI
mRatBN7.2410,674,746 - 10,724,848 (-)NCBI
RefSeq Acc Id: XM_006235938   ⟹   XP_006236000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,567,197 - 11,595,811 (-)NCBI
mRatBN7.2410,674,750 - 10,707,703 (-)NCBI
Rnor_6.047,203,016 - 7,231,453 (-)NCBI
Rnor_5.047,213,697 - 7,264,499 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235939   ⟹   XP_006236001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,567,197 - 11,595,748 (-)NCBI
mRatBN7.2410,674,755 - 10,707,699 (-)NCBI
Rnor_6.047,203,016 - 7,231,452 (-)NCBI
Rnor_5.047,213,697 - 7,264,499 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235940   ⟹   XP_006236002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,567,197 - 11,595,754 (-)NCBI
mRatBN7.2410,674,755 - 10,707,687 (-)NCBI
Rnor_6.047,203,016 - 7,231,450 (-)NCBI
Rnor_5.047,213,697 - 7,264,499 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235941   ⟹   XP_006236003
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,567,197 - 11,617,610 (-)NCBI
mRatBN7.2410,674,750 - 10,724,848 (-)NCBI
Rnor_6.047,203,016 - 7,253,386 (-)NCBI
Rnor_5.047,213,697 - 7,264,499 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006235943   ⟹   XP_006236005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,586,515 - 11,617,605 (-)NCBI
mRatBN7.2410,694,076 - 10,724,848 (-)NCBI
Rnor_6.047,222,336 - 7,253,385 (-)NCBI
Rnor_5.047,213,697 - 7,264,499 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008762650   ⟹   XP_008760872
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,567,197 - 11,617,609 (-)NCBI
mRatBN7.2410,674,750 - 10,724,848 (-)NCBI
Rnor_6.047,203,016 - 7,253,385 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592682   ⟹   XP_017448171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,586,515 - 11,595,730 (-)NCBI
mRatBN7.2410,694,076 - 10,707,711 (-)NCBI
Rnor_6.047,222,336 - 7,231,456 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107748   ⟹   XP_038963676
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,567,197 - 11,589,452 (-)NCBI
mRatBN7.2410,674,750 - 10,697,013 (-)NCBI
RefSeq Acc Id: XM_039107749   ⟹   XP_038963677
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,567,197 - 11,576,550 (-)NCBI
mRatBN7.2410,674,755 - 10,684,415 (-)NCBI
RefSeq Acc Id: XM_039107750   ⟹   XP_038963678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,567,197 - 11,589,452 (-)NCBI
mRatBN7.2410,674,755 - 10,696,880 (-)NCBI
RefSeq Acc Id: XM_063286226   ⟹   XP_063142296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,576,103 - 11,595,730 (-)NCBI
RefSeq Acc Id: XM_063286227   ⟹   XP_063142297
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,589,252 - 11,595,730 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_006236003   ⟸   XM_006235941
- Peptide Label: isoform X4
- UniProtKB: A0A0G2K2D4 (UniProtKB/TrEMBL),   U6A022 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236002   ⟸   XM_006235940
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y9H3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236001   ⟸   XM_006235939
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006236000   ⟸   XM_006235938
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006236005   ⟸   XM_006235943
- Peptide Label: isoform X11
- UniProtKB: A0A0G2JZ83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760872   ⟸   XM_008762650
- Peptide Label: isoform X12
- UniProtKB: U6A022 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448171   ⟸   XM_017592682
- Peptide Label: isoform X7
- UniProtKB: G3V9Z5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072199   ⟸   ENSRNOT00000084777
RefSeq Acc Id: ENSRNOP00000070947   ⟸   ENSRNOT00000087120
RefSeq Acc Id: ENSRNOP00000063846   ⟸   ENSRNOT00000064386
RefSeq Acc Id: XP_038963676   ⟸   XM_039107748
- Peptide Label: isoform X8
- UniProtKB: A6K545 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963678   ⟸   XM_039107750
- Peptide Label: isoform X10
- UniProtKB: A6K545 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963677   ⟸   XM_039107749
- Peptide Label: isoform X9
- UniProtKB: A6K545 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077364   ⟸   ENSRNOT00000097225
RefSeq Acc Id: NP_001385782   ⟸   NM_001398853
RefSeq Acc Id: XP_063142296   ⟸   XM_063286226
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063142297   ⟸   XM_063286227
- Peptide Label: isoform X6
Protein Domains
Arf-GAP   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2D4-F1-model_v2 AlphaFold A0A0G2K2D4 1-812 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310751 AgrOrtholog
BioCyc Gene G2FUF-46046 BioCyc
Ensembl Genes ENSRNOG00000012764 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064386.3 UniProtKB/TrEMBL
  ENSRNOT00000084777.2 UniProtKB/TrEMBL
  ENSRNOT00000087120.2 UniProtKB/TrEMBL
  ENSRNOT00000097225.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.220.150 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9088856 IMAGE-MGC_LOAD
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  ArfGAP UniProtKB/TrEMBL
  ARFGAP/RecO UniProtKB/TrEMBL
  ArfGAP_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
KEGG Report rno:362300 UniProtKB/TrEMBL
MGC_CLONE MGC:187854 IMAGE-MGC_LOAD
NCBI Gene 362300 ENTREZGENE
PANTHER ARF-GAP WITH GTPASE, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 3 UniProtKB/TrEMBL
  CENTAURIN-GAMMA-1A UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  ArfGap UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  Ras UniProtKB/TrEMBL
PhenoGen Agap3 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
  REVINTRACTNG UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  ARFGAP UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012764 RatGTEx
SMART ArfGap UniProtKB/TrEMBL
  RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP ANK UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
  SSF57863 UniProtKB/TrEMBL
UniProt A0A0G2JZ83 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K2D4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5Y9H3 ENTREZGENE, UniProtKB/TrEMBL
  A6K545 ENTREZGENE, UniProtKB/TrEMBL
  B0BN79_RAT UniProtKB/TrEMBL
  G3V9Z5 ENTREZGENE, UniProtKB/TrEMBL
  U6A022 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-15 Agap3  ArfGAP with GTPase domain, ankyrin repeat and PH domain 3  Centg3  centaurin, gamma 3   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Centg3  centaurin, gamma 3   Centg3_predicted  centaurin, gamma 3 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Centg3_predicted  centaurin, gamma 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED