Ints8 (integrator complex subunit 8) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Ints8 (integrator complex subunit 8) Rattus norvegicus
Analyze
Symbol: Ints8
Name: integrator complex subunit 8
RGD ID: 1310592
Description: Predicted to be involved in snRNA 3'-end processing. Predicted to be part of integrator complex. Orthologous to human INTS8 (integrator complex subunit 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC297823; RGD1310592; similar to RIKEN cDNA 2810013E07
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8529,094,475 - 29,141,874 (-)NCBIGRCr8
mRatBN7.2524,295,542 - 24,344,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl524,297,191 - 24,344,740 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0524,446,002 - 24,493,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl524,445,886 - 24,493,670 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0529,171,591 - 29,219,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4525,043,872 - 25,091,357 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1525,043,876 - 25,091,436 (-)NCBI
Celera523,515,547 - 23,563,020 (-)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
integrator complex  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16239144  


Genomics

Comparative Map Data
Ints8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8529,094,475 - 29,141,874 (-)NCBIGRCr8
mRatBN7.2524,295,542 - 24,344,642 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl524,297,191 - 24,344,740 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0524,446,002 - 24,493,819 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl524,445,886 - 24,493,670 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0529,171,591 - 29,219,259 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4525,043,872 - 25,091,357 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1525,043,876 - 25,091,436 (-)NCBI
Celera523,515,547 - 23,563,020 (-)NCBICelera
Cytogenetic Map5q13NCBI
INTS8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38894,823,287 - 94,881,746 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl894,813,311 - 94,881,746 (+)EnsemblGRCh38hg38GRCh38
GRCh37895,835,515 - 95,893,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36895,904,710 - 95,961,897 (+)NCBINCBI36Build 36hg18NCBI36
Celera892,020,737 - 92,077,921 (+)NCBICelera
Cytogenetic Map8q22.1NCBI
HuRef891,043,438 - 91,100,696 (+)NCBIHuRef
CHM1_1895,875,841 - 95,933,067 (+)NCBICHM1_1
T2T-CHM13v2.0895,948,260 - 96,006,732 (+)NCBIT2T-CHM13v2.0
Ints8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39411,199,158 - 11,254,264 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl411,199,158 - 11,254,258 (-)EnsemblGRCm39 Ensembl
GRCm38411,199,158 - 11,254,265 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl411,199,158 - 11,254,258 (-)EnsemblGRCm38mm10GRCm38
MGSCv37411,126,305 - 11,181,406 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36411,126,305 - 11,181,376 (-)NCBIMGSCv36mm8
MGSCv36410,682,764 - 10,738,665 (-)NCBIMGSCv36mm8
Celera411,009,643 - 11,064,963 (-)NCBICelera
Cytogenetic Map4A1NCBI
cM Map45.08NCBI
Ints8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541710,975,103 - 11,027,697 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541710,975,716 - 11,027,697 (+)NCBIChiLan1.0ChiLan1.0
INTS8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27112,151,701 - 112,208,934 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1887,688,740 - 87,745,976 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0891,442,560 - 91,499,916 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1893,645,053 - 93,702,373 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl893,645,053 - 93,702,373 (+)Ensemblpanpan1.1panPan2
INTS8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12939,482,834 - 39,533,761 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2939,474,640 - 39,533,719 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2939,644,306 - 39,695,236 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02939,687,365 - 39,737,725 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2939,687,359 - 39,737,725 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12939,699,399 - 39,749,982 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02939,695,597 - 39,745,833 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02940,136,118 - 40,187,065 (+)NCBIUU_Cfam_GSD_1.0
Ints8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530339,925,605 - 40,008,627 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365447,784,242 - 7,839,565 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365447,784,093 - 7,839,646 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
INTS8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl441,821,768 - 41,878,690 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1441,820,718 - 41,878,857 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2445,138,933 - 45,206,626 (-)NCBISscrofa10.2Sscrofa10.2susScr3
INTS8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1889,790,758 - 89,846,764 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl889,790,758 - 89,850,755 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603950,986,134 - 51,042,368 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ints8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247632,186,027 - 2,242,393 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247632,185,841 - 2,242,469 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ints8
169 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:69
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000010789
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat

Markers in Region
RH143047  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2524,312,140 - 24,312,261 (+)MAPPERmRatBN7.2
Rnor_6.0524,461,024 - 24,461,144NCBIRnor6.0
Rnor_5.0529,186,613 - 29,186,733UniSTSRnor5.0
RGSC_v3.4525,059,003 - 25,059,123UniSTSRGSC3.4
Celera523,530,442 - 23,530,562UniSTS
RH 3.4 Map5148.0UniSTS
Cytogenetic Map5q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 41 52 36 19 36 7 7 74 34 39 11 7
Low 2 5 5 5 1 4 1 2 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010789   ⟹   ENSRNOP00000010789
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl524,297,191 - 24,344,626 (-)Ensembl
Rnor_6.0 Ensembl524,446,085 - 24,493,670 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081395   ⟹   ENSRNOP00000071592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl524,297,191 - 24,344,740 (-)Ensembl
Rnor_6.0 Ensembl524,445,886 - 24,489,468 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105805   ⟹   ENSRNOP00000081175
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl524,297,280 - 24,344,740 (-)Ensembl
RefSeq Acc Id: NM_001427841   ⟹   NP_001414770
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,094,475 - 29,141,855 (-)NCBI
RefSeq Acc Id: XM_063287282   ⟹   XP_063143352
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,094,475 - 29,141,873 (-)NCBI
RefSeq Acc Id: XR_010066348
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8529,111,254 - 29,141,874 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414770 (Get FASTA)   NCBI Sequence Viewer  
  XP_063143352 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11674 (Get FASTA)   NCBI Sequence Viewer  
  EDM11675 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010789.8
  ENSRNOP00000071592.2
  ENSRNOP00000081175.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000071592   ⟸   ENSRNOT00000081395
RefSeq Acc Id: ENSRNOP00000010789   ⟸   ENSRNOT00000010789
RefSeq Acc Id: ENSRNOP00000081175   ⟸   ENSRNOT00000105805
RefSeq Acc Id: XP_063143352   ⟸   XM_063287282
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001414770   ⟸   NM_001427841

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLQ6-F1-model_v2 AlphaFold D3ZLQ6 1-994 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310592 AgrOrtholog
BioCyc Gene G2FUF-41957 BioCyc
Ensembl Genes ENSRNOG00000008124 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010789.8 UniProtKB/TrEMBL
  ENSRNOT00000081395.2 UniProtKB/TrEMBL
  ENSRNOT00000105805.1 UniProtKB/TrEMBL
InterPro Int8 UniProtKB/TrEMBL
NCBI Gene 297823 ENTREZGENE
PANTHER INTEGRATOR COMPLEX SUBUNIT 8 UniProtKB/TrEMBL
  PTHR13350 UniProtKB/TrEMBL
PhenoGen Ints8 PhenoGen
RatGTEx ENSRNOG00000008124 RatGTEx
UniProt A0A0G2K0V1_RAT UniProtKB/TrEMBL
  A0A8I5ZR25_RAT UniProtKB/TrEMBL
  D3ZLQ6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-22 Ints8  integrator complex subunit 8  RGD1310592  similar to RIKEN cDNA 2810013E07  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1310592  similar to RIKEN cDNA 2810013E07   RGD1310592_predicted  similar to RIKEN cDNA 2810013E07 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1310592_predicted  similar to RIKEN cDNA 2810013E07 (predicted)  LOC297823_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC297823_predicted  similar to RIKEN cDNA 2810013E07 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL