Wdr77 (WD repeat domain 77) - Rat Genome Database

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Gene: Wdr77 (WD repeat domain 77) Rattus norvegicus
Analyze
Symbol: Wdr77
Name: WD repeat domain 77
RGD ID: 1310479
Description: Predicted to enable methyl-CpG binding activity; nuclear receptor coactivator activity; and ubiquitin ligase-substrate adaptor activity. Predicted to be involved in oocyte axis specification; protein polyubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within several processes, including negative regulation of epithelial cell proliferation involved in prostate gland development; regulation of transcription by RNA polymerase II; and secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be part of Cul4B-RING E3 ubiquitin ligase complex and methylosome. Orthologous to human WDR77 (WD repeat domain 77); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ac2-269; LOC100911453; LOC310769; MEP-50; methylosome protein 50; methylosome protein 50-like; methylosome protein WDR77; RGD1310479; similar to Ac2-269; WD repeat-containing protein 77
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82196,123,882 - 196,133,853 (+)NCBIGRCr8
mRatBN7.22193,435,465 - 193,445,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,435,468 - 193,445,520 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2201,030,033 - 201,040,004 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02198,925,620 - 198,935,589 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02193,742,587 - 193,752,556 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02208,577,292 - 208,587,263 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,420,309 - 208,587,260 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,420,206 - 208,586,356 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02227,998,508 - 228,008,479 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42201,206,860 - 201,216,573 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12201,169,461 - 201,178,632 (+)NCBI
Celera2186,138,007 - 186,147,978 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP)
bisphenol F  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
gedunin  (ISO)
ivermectin  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (ISO)
ozone  (ISO)
paraquat  (EXP)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
trimellitic anhydride  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:12972618   PMID:17032745   PMID:18356297   PMID:18984161   PMID:19188445   PMID:21081503   PMID:25284789   PMID:35352799  


Genomics

Comparative Map Data
Wdr77
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82196,123,882 - 196,133,853 (+)NCBIGRCr8
mRatBN7.22193,435,465 - 193,445,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2193,435,468 - 193,445,520 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2201,030,033 - 201,040,004 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02198,925,620 - 198,935,589 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02193,742,587 - 193,752,556 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02208,577,292 - 208,587,263 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,420,309 - 208,587,260 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl2208,420,206 - 208,586,356 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02227,998,508 - 228,008,479 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42201,206,860 - 201,216,573 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12201,169,461 - 201,178,632 (+)NCBI
Celera2186,138,007 - 186,147,978 (+)NCBICelera
Cytogenetic Map2q34NCBI
WDR77
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381111,439,890 - 111,449,256 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1111,439,890 - 111,449,256 (-)EnsemblGRCh38hg38GRCh38
GRCh371111,982,512 - 111,991,878 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361111,784,035 - 111,793,353 (-)NCBINCBI36Build 36hg18NCBI36
Celera1110,229,435 - 110,238,753 (-)NCBICelera
Cytogenetic Map1p13.2NCBI
HuRef1109,853,961 - 109,863,279 (-)NCBIHuRef
CHM1_11112,097,521 - 112,106,839 (-)NCBICHM1_1
T2T-CHM13v2.01111,454,574 - 111,463,940 (-)NCBIT2T-CHM13v2.0
Wdr77
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393105,866,814 - 105,877,076 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3105,866,685 - 105,877,353 (+)EnsemblGRCm39 Ensembl
GRCm383105,959,498 - 105,969,760 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3105,959,369 - 105,970,037 (+)EnsemblGRCm38mm10GRCm38
MGSCv373105,762,416 - 105,772,678 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363106,087,554 - 106,097,816 (+)NCBIMGSCv36mm8
Celera3108,149,918 - 108,160,180 (+)NCBICelera
Cytogenetic Map3F2.2NCBI
cM Map346.46NCBI
Wdr77
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543514,933,243 - 14,940,438 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543514,929,202 - 14,940,439 (-)NCBIChiLan1.0ChiLan1.0
WDR77
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21115,578,345 - 115,587,572 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11114,727,466 - 114,745,648 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01114,101,570 - 114,110,634 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11126,236,409 - 126,245,444 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1126,236,409 - 126,249,996 (+)Ensemblpanpan1.1panPan2
LOC479902
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1640,626,219 - 40,634,521 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl640,624,886 - 40,635,200 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1763,468,522 - 63,484,623 (+)NCBIDog10K_Boxer_Tasha
Wdr77
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505817,357,155 - 17,368,364 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936690109,359 - 121,125 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936690112,337 - 120,478 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR77
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4108,907,200 - 108,922,144 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14108,907,192 - 108,915,594 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24119,090,107 - 119,098,520 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDR77
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12022,162,605 - 22,171,495 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2022,162,692 - 22,172,171 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603836,307,661 - 36,316,687 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdr77
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247727,158,530 - 7,167,042 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247727,158,530 - 7,167,034 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wdr77
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:148
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000022571
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1331745Bp203Blood pressure QTL 2034.377arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2189599258218414891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1298083Bp158Blood pressure QTL 1582.62arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
2293084Iddm26Insulin dependent diabetes mellitus QTL 262.9blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2174930955213594495Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
4889834Pur24Proteinuria QTL 245.80.014urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)2184114274202447032Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat

Markers in Region
RH128703  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,445,239 - 193,445,438 (+)MAPPERmRatBN7.2
Rnor_6.02208,586,969 - 208,587,167NCBIRnor6.0
Rnor_6.02208,429,989 - 208,430,187NCBIRnor6.0
Rnor_5.02227,851,479 - 227,851,677UniSTSRnor5.0
Rnor_5.02228,008,185 - 228,008,383UniSTSRnor5.0
RGSC_v3.42201,216,488 - 201,216,686UniSTSRGSC3.4
Celera2186,147,684 - 186,147,882UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

nervous system reproductive system respiratory system
High
Medium
Low
Below cutoff 3 5 1

Sequence


RefSeq Acc Id: ENSRNOT00000022571   ⟹   ENSRNOP00000022571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2208,577,388 - 208,586,356 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000073644   ⟹   ENSRNOP00000064692
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2208,420,405 - 208,429,376 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076065   ⟹   ENSRNOP00000068002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2208,420,214 - 208,430,270 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000076654   ⟹   ENSRNOP00000068445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2193,435,468 - 193,445,520 (+)Ensembl
Rnor_6.0 Ensembl2208,577,197 - 208,587,250 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086279   ⟹   ENSRNOP00000075656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2208,420,309 - 208,587,260 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090500   ⟹   ENSRNOP00000074936
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2208,420,206 - 208,586,356 (+)Ensembl
RefSeq Acc Id: NM_001008771   ⟹   NP_001008771
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82196,123,882 - 196,133,853 (+)NCBI
mRatBN7.22193,435,563 - 193,445,534 (+)NCBI
Rnor_6.02208,577,292 - 208,587,263 (+)NCBI
Rnor_5.02227,998,508 - 228,008,479 (+)NCBI
RGSC_v3.42201,206,860 - 201,216,573 (+)RGD
Celera2186,138,007 - 186,147,978 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001008771 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97367 (Get FASTA)   NCBI Sequence Viewer  
  AAP86280 (Get FASTA)   NCBI Sequence Viewer  
  EDL81829 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068445
  ENSRNOP00000068445.1
GenBank Protein Q4QR85 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001008771   ⟸   NM_001008771
- UniProtKB: Q4QR85 (UniProtKB/Swiss-Prot),   A6HUP3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022571   ⟸   ENSRNOT00000022571
RefSeq Acc Id: ENSRNOP00000064692   ⟸   ENSRNOT00000073644
RefSeq Acc Id: ENSRNOP00000074936   ⟸   ENSRNOT00000090500
RefSeq Acc Id: ENSRNOP00000068002   ⟸   ENSRNOT00000076065
RefSeq Acc Id: ENSRNOP00000075656   ⟸   ENSRNOT00000086279
RefSeq Acc Id: ENSRNOP00000068445   ⟸   ENSRNOT00000076654

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4QR85-F1-model_v2 AlphaFold Q4QR85 1-342 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691650
Promoter ID:EPDNEW_R2173
Type:initiation region
Name:LOC100911453_1
Description:methylosome protein 50-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02208,577,316 - 208,577,376EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310479 AgrOrtholog
BioCyc Gene G2FUF-51716 BioCyc
Ensembl Genes ENSRNOG00000016394 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000046022 Ensembl
Ensembl Transcript ENSRNOT00000076654 ENTREZGENE
  ENSRNOT00000076654.3 UniProtKB/Swiss-Prot
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7443204 IMAGE-MGC_LOAD
InterPro WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:310769 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114400 IMAGE-MGC_LOAD
NCBI Gene 310769 ENTREZGENE
PANTHER METHYLOSOME PROTEIN 50 UniProtKB/Swiss-Prot
  METHYLOSOME PROTEIN 50 UniProtKB/Swiss-Prot
  METHYLOSOME PROTEIN 50 UniProtKB/TrEMBL
  METHYLOSOME PROTEIN 50 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wdr77 PhenoGen
PROSITE WD_REPEATS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016394 RatGTEx
  ENSRNOG00000046022 RatGTEx
SMART WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6HUP3 ENTREZGENE, UniProtKB/TrEMBL
  MEP50_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TPI7_RAT UniProtKB/TrEMBL
UniProt Secondary M0R5M2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Wdr77  WD repeat domain 77  LOC100911453  methylosome protein 50-like  Data merged from RGD:6492663 737654 PROVISIONAL
2012-07-05 LOC100911453  methylosome protein 50-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-30 Wdr77  WD repeat domain 77  RGD1310479  similar to Ac2-269  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1310479  similar to Ac2-269  RGD1310479_predicted  similar to Ac2-269 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1310479_predicted  similar to Ac2-269 (predicted)  LOC310769_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC310769_predicted  similar to Ac2-269 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL