Cip2a (cellular inhibitor of PP2A) - Rat Genome Database

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Gene: Cip2a (cellular inhibitor of PP2A) Rattus norvegicus
Analyze
Symbol: Cip2a
Name: cellular inhibitor of PP2A
RGD ID: 1310335
Description: Predicted to enable protein homodimerization activity and protein phosphatase inhibitor activity. Predicted to be involved in DNA damage response and chromosome organization. Predicted to act upstream of or within positive regulation of neuroblast proliferation and spermatogenesis. Predicted to be located in cytosol and plasma membrane. Predicted to be active in chromosome. Orthologous to human CIP2A (cellular inhibitor of PP2A); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cell proliferation regulating inhibitor of protein phosphatase 2A; LOC360711; RGD1310335; similar to RIKEN cDNA C330027C09
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,255,123 - 65,285,914 (-)NCBIGRCr8
mRatBN7.21151,792,143 - 51,823,016 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,795,024 - 51,822,938 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01154,373,794 - 54,404,704 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,377,374 - 54,404,612 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,535,086 - 57,565,999 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41153,036,752 - 53,065,176 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11153,094,980 - 53,123,481 (-)NCBI
Celera1151,399,119 - 51,429,954 (-)NCBICelera
Cytogenetic Map11q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (ISO)
cytoplasm  (ISO)
cytosol  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOA pipeline RGD automated data pipeline
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20447748   PMID:22461891   PMID:25468996   PMID:28174209  


Genomics

Comparative Map Data
Cip2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81165,255,123 - 65,285,914 (-)NCBIGRCr8
mRatBN7.21151,792,143 - 51,823,016 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,795,024 - 51,822,938 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01154,373,794 - 54,404,704 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1154,377,374 - 54,404,612 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,535,086 - 57,565,999 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41153,036,752 - 53,065,176 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11153,094,980 - 53,123,481 (-)NCBI
Celera1151,399,119 - 51,429,954 (-)NCBICelera
Cytogenetic Map11q21NCBI
CIP2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383108,549,864 - 108,589,438 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3108,549,864 - 108,589,644 (-)EnsemblGRCh38hg38GRCh38
GRCh373108,268,711 - 108,308,285 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363109,752,094 - 109,790,980 (-)NCBINCBI36Build 36hg18NCBI36
Build 343109,752,094 - 109,790,980NCBI
Celera3106,665,331 - 106,705,415 (-)NCBICelera
Cytogenetic Map3q13.13NCBI
HuRef3105,641,938 - 105,682,017 (-)NCBIHuRef
CHM1_13108,232,834 - 108,272,603 (-)NCBICHM1_1
T2T-CHM13v2.03111,258,902 - 111,309,711 (-)NCBIT2T-CHM13v2.0
Cip2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391648,814,524 - 48,840,079 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1648,814,548 - 48,840,072 (+)EnsemblGRCm39 Ensembl
GRCm381648,994,157 - 49,019,716 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1648,994,185 - 49,019,709 (+)EnsemblGRCm38mm10GRCm38
MGSCv371648,994,301 - 49,019,818 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361648,913,814 - 48,939,328 (+)NCBIMGSCv36mm8
Celera1649,344,570 - 49,370,085 (+)NCBICelera
Cytogenetic Map16B5NCBI
cM Map1630.75NCBI
Cip2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554279,448,102 - 9,480,729 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554279,448,102 - 9,480,729 (-)NCBIChiLan1.0ChiLan1.0
CIP2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22106,510,500 - 106,565,273 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13106,519,913 - 106,570,052 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03105,668,385 - 105,714,487 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13112,606,927 - 112,646,345 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3112,606,933 - 112,646,345 (-)Ensemblpanpan1.1panPan2
CIP2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13313,807,985 - 13,843,296 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3313,808,738 - 13,843,195 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3313,914,424 - 13,949,183 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03313,974,460 - 14,009,049 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3313,974,469 - 14,008,815 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13313,843,821 - 13,878,326 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03313,909,984 - 13,944,741 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03314,322,610 - 14,357,176 (-)NCBIUU_Cfam_GSD_1.0
Cip2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602140,583,645 - 140,621,079 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366452,224,587 - 2,261,881 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366452,224,034 - 2,261,970 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIP2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13150,934,106 - 150,966,424 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113150,934,065 - 150,966,326 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CIP2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12272,192,788 - 72,234,020 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2272,193,060 - 72,231,673 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604194,238,791 - 94,281,856 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cip2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473140,541,869 - 40,572,565 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cip2a
60 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:104
Count of miRNA genes:85
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000033837
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
1641927Alcrsp10Alcohol response QTL 10alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)11843667453436674Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)112328045668280456Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)112952841860324829Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22 24 18 12 18 30 12 33
Low 3 12 25 15 7 15 4 4 44 17 8 11 4
Below cutoff 9 8 8 8 4 6 5 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000033837   ⟹   ENSRNOP00000031394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1151,795,024 - 51,822,938 (-)Ensembl
Rnor_6.0 Ensembl1154,377,374 - 54,404,612 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101749   ⟹   ENSRNOP00000084633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1151,795,024 - 51,822,938 (-)Ensembl
RefSeq Acc Id: NM_001427687   ⟹   NP_001414616
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,255,123 - 65,285,914 (-)NCBI
RefSeq Acc Id: XM_039088875   ⟹   XP_038944803
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81165,258,005 - 65,278,332 (-)NCBI
mRatBN7.21151,792,143 - 51,815,342 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414616 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944803 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11105 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031394.4
  ENSRNOP00000084633.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000031394   ⟸   ENSRNOT00000033837
RefSeq Acc Id: XP_038944803   ⟸   XM_039088875
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000084633   ⟸   ENSRNOT00000101749
RefSeq Acc Id: NP_001414616   ⟸   NM_001427687
Protein Domains
CIP2A N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZF50-F1-model_v2 AlphaFold D3ZF50 1-909 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698127
Promoter ID:EPDNEW_R8649
Type:multiple initiation site
Name:Cip2a_1
Description:cell proliferation regulating inhibitor of protein phosphatase2A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01154,404,658 - 54,404,718EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310335 AgrOrtholog
BioCyc Gene G2FUF-21425 BioCyc
Ensembl Genes ENSRNOG00000039183 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033837.5 UniProtKB/TrEMBL
  ENSRNOT00000101749.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  CIP2A UniProtKB/TrEMBL
  CIP2A_N UniProtKB/TrEMBL
KEGG Report rno:360711 UniProtKB/TrEMBL
NCBI Gene 360711 ENTREZGENE
PANTHER PROTEIN CIP2A UniProtKB/TrEMBL
  PTHR23161 UniProtKB/TrEMBL
Pfam CIP2A_N UniProtKB/TrEMBL
PhenoGen Cip2a PhenoGen
RatGTEx ENSRNOG00000039183 RatGTEx
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
UniProt A0A8I5ZXN3_RAT UniProtKB/TrEMBL
  D3ZF50_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-11 Cip2a  cellular inhibitor of PP2A  Cip2a  cell proliferation regulating inhibitor of protein phosphatase 2A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-07-18 Cip2a  cell proliferation regulating inhibitor of protein phosphatase 2A  RGD1310335  similar to RIKEN cDNA C330027C09  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1310335  similar to RIKEN cDNA C330027C09   RGD1310335_predicted  similar to RIKEN cDNA C330027C09 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1310335_predicted  similar to RIKEN cDNA C330027C09 (predicted)  LOC360711_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360711_predicted  similar to RIKEN cDNA C330027C09 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL