Dcdc2 (doublecortin domain containing 2) - Rat Genome Database

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Gene: Dcdc2 (doublecortin domain containing 2) Rattus norvegicus
Analyze
Symbol: Dcdc2
Name: doublecortin domain containing 2
RGD ID: 1310227
Description: Enables kinesin binding activity. Involved in neuron migration. Located in kinocilium. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autosomal recessive nonsyndromic deafness 66; dyslexia; nephronophthisis 19; and sclerosing cholangitis. Orthologous to human DCDC2 (doublecortin domain containing 2); INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: doublecortin domain-containing protein 2; LOC291130
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,274,009 - 40,459,757 (-)NCBIGRCr8
mRatBN7.21739,845,952 - 40,031,781 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1739,845,952 - 40,030,743 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1739,927,688 - 40,098,839 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,531,733 - 41,702,890 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01739,813,149 - 39,984,339 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01741,838,201 - 42,031,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1741,838,201 - 42,031,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01743,711,172 - 43,899,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41746,899,656 - 47,090,283 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11746,907,816 - 47,107,277 (-)NCBI
Celera1739,500,732 - 39,668,377 (-)NCBICelera
Cytogenetic Map17p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axoneme  (IBA,IEA,ISO,ISS)
centriolar satellite  (IEA,ISO)
cilium  (ISO)
cytoplasm  (ISO,ISS)
cytosol  (IEA,ISO)
kinocilium  (IBA,IDA,IEA)
microtubule  (IBA,IEA)
microtubule cytoskeleton  (ISO)
microtubule organizing center  (IBA,IEA)
mitotic spindle  (IEA,ISO)
synapse  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Postnatal analysis of the effect of embryonic knockdown and overexpression of candidate dyslexia susceptibility gene homolog Dcdc2 in the rat. Burbridge TJ, etal., Neuroscience. 2008 Mar 27;152(3):723-33. doi: 10.1016/j.neuroscience.2008.01.020. Epub 2008 Jan 19.
2. Variants in the DYX2 locus are associated with altered brain activation in reading-related brain regions in subjects with reading disability. Cope N, etal., Neuroimage. 2012 Oct 15;63(1):148-56. doi: 10.1016/j.neuroimage.2012.06.037. Epub 2012 Jun 27.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. DCDC2 Mutations Cause Neonatal Sclerosing Cholangitis. Girard M, etal., Hum Mutat. 2016 Oct;37(10):1025-9. doi: 10.1002/humu.23031. Epub 2016 Aug 24.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation. Grati M, etal., Hum Mol Genet. 2015 May 1;24(9):2482-91. doi: 10.1093/hmg/ddv009. Epub 2015 Jan 18.
7. Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample. Lind PA, etal., Eur J Hum Genet. 2010 Jun;18(6):668-73. doi: 10.1038/ejhg.2009.237. Epub 2010 Jan 13.
8. Complex effects of dyslexia risk factors account for ADHD traits: evidence from two independent samples. Mascheretti S, etal., J Child Psychol Psychiatry. 2017 Jan;58(1):75-82. doi: 10.1111/jcpp.12612. Epub 2016 Aug 8.
9. Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. Massinen S, etal., PLoS One. 2011;6(6):e20580. doi: 10.1371/journal.pone.0020580. Epub 2011 Jun 16.
10. DCDC2 is associated with reading disability and modulates neuronal development in the brain. Meng H, etal., Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):17053-8. Epub 2005 Nov 8.
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability. Truong DT, etal., Genes Brain Behav. 2014 Nov;13(8):802-11. doi: 10.1111/gbb.12170. Epub 2014 Sep 3.
16. The role of gene DCDC2 in German dyslexics. Wilcke A, etal., Ann Dyslexia. 2009 Jun;59(1):1-11. doi: 10.1007/s11881-008-0020-7. Epub 2009 Feb 24.
17. Association of DCDC2 Polymorphisms with Normal Variations in Reading Abilities in a Chinese Population. Zhang Y, etal., PLoS One. 2016 Apr 21;11(4):e0153603. doi: 10.1371/journal.pone.0153603. eCollection 2016.
Additional References at PubMed
PMID:16869982   PMID:16989952   PMID:20236041   PMID:21689730   PMID:21883923   PMID:24094509   PMID:25557784   PMID:26250775  


Genomics

Comparative Map Data
Dcdc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81740,274,009 - 40,459,757 (-)NCBIGRCr8
mRatBN7.21739,845,952 - 40,031,781 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1739,845,952 - 40,030,743 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1739,927,688 - 40,098,839 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01741,531,733 - 41,702,890 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01739,813,149 - 39,984,339 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01741,838,201 - 42,031,265 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1741,838,201 - 42,031,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01743,711,172 - 43,899,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41746,899,656 - 47,090,283 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11746,907,816 - 47,107,277 (-)NCBI
Celera1739,500,732 - 39,668,377 (-)NCBICelera
Cytogenetic Map17p11NCBI
DCDC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38624,171,755 - 24,383,292 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl624,171,755 - 24,358,059 (-)EnsemblGRCh38hg38GRCh38
GRCh37624,171,983 - 24,383,520 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36624,279,962 - 24,466,259 (-)NCBINCBI36Build 36hg18NCBI36
Build 34624,282,502 - 24,466,259NCBI
Celera625,405,284 - 25,591,655 (-)NCBICelera
Cytogenetic Map6p22.3NCBI
HuRef624,122,011 - 24,332,773 (-)NCBIHuRef
CHM1_1624,174,677 - 24,387,757 (-)NCBICHM1_1
T2T-CHM13v2.0624,043,591 - 24,253,315 (-)NCBIT2T-CHM13v2.0
Dcdc2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391325,239,126 - 25,394,689 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1325,239,987 - 25,394,689 (+)EnsemblGRCm39 Ensembl
GRCm381325,055,273 - 25,210,706 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1325,056,004 - 25,210,706 (+)EnsemblGRCm38mm10GRCm38
MGSCv371325,147,873 - 25,302,575 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361325,063,469 - 25,128,988 (+)NCBIMGSCv36mm8
Celera1325,282,677 - 25,437,377 (+)NCBICelera
Cytogenetic Map13A3.1NCBI
cM Map1310.89NCBI
Dcdc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554832,607,925 - 2,778,799 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554832,608,063 - 2,783,872 (+)NCBIChiLan1.0ChiLan1.0
DCDC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2538,810,522 - 38,999,931 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1634,812,140 - 34,999,414 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0624,001,971 - 24,186,530 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1624,337,188 - 24,520,082 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl624,337,188 - 24,520,082 (-)Ensemblpanpan1.1panPan2
DCDC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13522,264,484 - 22,422,769 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3522,266,282 - 22,422,776 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3522,230,688 - 22,391,502 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03522,383,951 - 22,544,907 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3522,386,481 - 22,544,780 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13522,189,453 - 22,350,407 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03522,237,980 - 22,398,987 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03523,667,022 - 23,834,441 (-)NCBIUU_Cfam_GSD_1.0
Dcdc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049462,885,162 - 3,021,294 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936671605,084 - 736,674 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936671605,114 - 736,217 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DCDC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl719,048,088 - 19,219,075 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1719,044,229 - 19,219,055 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2720,197,245 - 20,368,857 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DCDC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11747,880,282 - 48,065,686 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1747,881,346 - 48,066,436 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604424,107,394 - 24,298,206 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dcdc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247562,644,248 - 2,809,787 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247562,644,287 - 2,813,908 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dcdc2
692 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:827
Count of miRNA genes:319
Interacting mature miRNAs:447
Transcripts:ENSRNOT00000068021
Prediction methods:Microtar, Miranda, Pita, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat

Markers in Region
RH138880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21739,846,023 - 39,846,251 (+)MAPPERmRatBN7.2
Rnor_6.01741,838,273 - 41,838,500NCBIRnor6.0
Rnor_5.01743,711,244 - 43,711,471UniSTSRnor5.0
RGSC_v3.41746,899,728 - 46,899,955UniSTSRGSC3.4
Celera1739,500,804 - 39,501,031UniSTS
Cytogenetic Map17p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 15
Low 3 19 17 2 17 74 12 26 8
Below cutoff 33 38 24 16 24 7 8 3 7

Sequence


RefSeq Acc Id: ENSRNOT00000068021   ⟹   ENSRNOP00000060289
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1739,845,952 - 40,030,743 (-)Ensembl
Rnor_6.0 Ensembl1741,838,201 - 42,031,265 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097082   ⟹   ENSRNOP00000077657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1739,845,952 - 40,030,743 (-)Ensembl
RefSeq Acc Id: NM_001106110   ⟹   NP_001099580
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,274,009 - 40,458,790 (-)NCBI
mRatBN7.21739,845,952 - 40,030,743 (-)NCBI
Rnor_6.01741,838,201 - 42,031,265 (-)NCBI
Rnor_5.01743,711,172 - 43,899,961 (-)NCBI
RGSC_v3.41746,899,656 - 47,090,283 (-)RGD
Celera1739,500,732 - 39,668,377 (-)RGD
Sequence:
RefSeq Acc Id: XM_039095509   ⟹   XP_038951437
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,274,009 - 40,459,756 (-)NCBI
mRatBN7.21739,845,952 - 40,031,781 (-)NCBI
RefSeq Acc Id: XM_039095510   ⟹   XP_038951438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,274,009 - 40,459,757 (-)NCBI
mRatBN7.21739,845,952 - 40,031,781 (-)NCBI
RefSeq Acc Id: XM_039095511   ⟹   XP_038951439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81740,274,009 - 40,449,110 (-)NCBI
mRatBN7.21739,845,952 - 40,021,067 (-)NCBI
RefSeq Acc Id: NP_001099580   ⟸   NM_001106110
- UniProtKB: D3ZR10 (UniProtKB/Swiss-Prot),   A0A8I5YBZ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060289   ⟸   ENSRNOT00000068021
RefSeq Acc Id: XP_038951437   ⟸   XM_039095509
- Peptide Label: isoform X1
- UniProtKB: D3ZR10 (UniProtKB/Swiss-Prot),   A0A8I5YBZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951438   ⟸   XM_039095510
- Peptide Label: isoform X1
- UniProtKB: D3ZR10 (UniProtKB/Swiss-Prot),   A0A8I5YBZ0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951439   ⟸   XM_039095511
- Peptide Label: isoform X2
- UniProtKB: A6KLE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077657   ⟸   ENSRNOT00000097082
Protein Domains
Doublecortin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZR10-F1-model_v2 AlphaFold D3ZR10 1-475 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310227 AgrOrtholog
BioCyc Gene G2FUF-9430 BioCyc
Ensembl Genes ENSRNOG00000017511 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055005274 UniProtKB/Swiss-Prot
  ENSRNOG00060023911 UniProtKB/Swiss-Prot
  ENSRNOG00065023551 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000068021 ENTREZGENE
  ENSRNOT00000068021.2 UniProtKB/Swiss-Prot
  ENSRNOT00000097082.1 UniProtKB/TrEMBL
  ENSRNOT00055008462 UniProtKB/Swiss-Prot
  ENSRNOT00060041459 UniProtKB/Swiss-Prot
  ENSRNOT00065040301 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.20.230 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DCDC2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Doublecortin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Doublecortin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:291130 UniProtKB/Swiss-Prot
NCBI Gene 291130 ENTREZGENE
PANTHER DOUBLECORTIN DOMAIN CONTAINING 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23004:SF5 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DCX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Dcdc2 PhenoGen
PROSITE PS50309 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017511 RatGTEx
  ENSRNOG00055005274 RatGTEx
  ENSRNOG00060023911 RatGTEx
  ENSRNOG00065023551 RatGTEx
SMART DCX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF89837 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5YBZ0 ENTREZGENE, UniProtKB/TrEMBL
  A6KLE2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZR10 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-03 Dcdc2  doublecortin domain containing 2  Dcdc2_predicted  doublecortin domain containing 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Dcdc2_predicted  doublecortin domain containing 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED