Smurf2 (SMAD specific E3 ubiquitin protein ligase 2) - Rat Genome Database

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Gene: Smurf2 (SMAD specific E3 ubiquitin protein ligase 2) Rattus norvegicus
Analyze
Symbol: Smurf2
Name: SMAD specific E3 ubiquitin protein ligase 2
RGD ID: 1310067
Description: Enables SMAD binding activity and transforming growth factor beta receptor binding activity. Predicted to be involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of trophoblast cell migration; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in nuclear speck. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human SMURF2 (SMAD specific E3 ubiquitin protein ligase 2); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta Smad dependent signaling pathway; endocytosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; carbofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: E3 ubiquitin-protein ligase SMURF2; LOC303614; RGD1310067; similar to E3 ubiquitin ligase SMURF2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81092,261,516 - 92,362,185 (-)NCBIGRCr8
mRatBN7.21091,761,798 - 91,862,485 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,761,807 - 91,862,488 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,817,627 - 96,919,359 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01096,280,802 - 96,382,539 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,683,776 - 91,784,593 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01095,018,050 - 95,118,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1095,018,059 - 95,062,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,763,750 - 94,863,160 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41096,170,590 - 96,269,365 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11096,187,581 - 96,283,629 (-)NCBI
Celera1090,428,224 - 90,528,224 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
caffeine  (ISO)
cannabidiol  (ISO)
carbofuran  (EXP)
carbon nanotube  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzyme inhibitor  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
hydralazine  (ISO)
isoprenaline  (ISO)
L-methionine  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mifepristone  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
oxaliplatin  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
selenium atom  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The Nedd4-like family of E3 ubiquitin ligases and cancer. Chen C and Matesic LE, Cancer Metastasis Rev. 2007 Dec;26(3-4):587-604.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Arkadia-Smad7-mediated positive regulation of TGF-beta signaling in a rat model of tubulointerstitial fibrosis. Liu FY, etal., Am J Nephrol. 2007;27(2):176-83. Epub 2007 Mar 7.
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Shi Y and Massague J, Cell. 2003 Jun 13;113(6):685-700.
Additional References at PubMed
PMID:14755250   PMID:15231748   PMID:17054587   PMID:17719543   PMID:18307974   PMID:18842593   PMID:19028597   PMID:19122240   PMID:19255252   PMID:20386537   PMID:22623726   PMID:22624557  
PMID:28447757   PMID:30649914   PMID:32004504   PMID:32538751   PMID:35090322   PMID:36717388  


Genomics

Comparative Map Data
Smurf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81092,261,516 - 92,362,185 (-)NCBIGRCr8
mRatBN7.21091,761,798 - 91,862,485 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1091,761,807 - 91,862,488 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1096,817,627 - 96,919,359 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01096,280,802 - 96,382,539 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01091,683,776 - 91,784,593 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01095,018,050 - 95,118,107 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1095,018,059 - 95,062,987 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01094,763,750 - 94,863,160 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41096,170,590 - 96,269,365 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11096,187,581 - 96,283,629 (-)NCBI
Celera1090,428,224 - 90,528,224 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
SMURF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381764,542,282 - 64,662,307 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1764,542,282 - 64,662,307 (-)EnsemblGRCh38hg38GRCh38
GRCh371762,538,400 - 62,658,425 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,971,197 - 60,088,848 (-)NCBINCBI36Build 36hg18NCBI36
Build 341759,971,196 - 60,088,848NCBI
Celera1757,011,021 - 57,128,748 (-)NCBICelera
Cytogenetic Map17q23.3-q24.1NCBI
HuRef1757,990,112 - 58,108,347 (-)NCBIHuRef
CHM1_11762,604,658 - 62,722,343 (-)NCBICHM1_1
T2T-CHM13v2.01765,412,034 - 65,532,065 (-)NCBIT2T-CHM13v2.0
Smurf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,710,887 - 106,811,544 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11106,710,892 - 106,811,541 (-)EnsemblGRCm39 Ensembl
GRCm3811106,820,061 - 106,920,747 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,820,066 - 106,920,715 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711106,681,378 - 106,782,029 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611106,638,665 - 106,736,485 (-)NCBIMGSCv36mm8
Celera11118,551,475 - 118,651,709 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1170.03NCBI
Smurf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,270,055 - 7,336,390 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554787,205,266 - 7,336,390 (+)NCBIChiLan1.0ChiLan1.0
SMURF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21980,731,000 - 80,851,449 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11785,548,615 - 85,668,777 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01758,638,995 - 58,759,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11763,731,380 - 63,809,298 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,731,386 - 63,809,298 (-)Ensemblpanpan1.1panPan2
SMURF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1912,348,777 - 12,472,636 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl912,351,627 - 12,471,467 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha913,244,612 - 13,367,350 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0914,011,102 - 14,133,799 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl914,013,877 - 14,133,748 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1912,957,178 - 13,079,854 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0914,453,063 - 14,575,662 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0914,454,025 - 14,576,817 (+)NCBIUU_Cfam_GSD_1.0
Smurf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,054,524 - 14,151,300 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365415,046,148 - 5,106,008 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365415,046,147 - 5,147,416 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SMURF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1214,368,701 - 14,492,108 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11214,368,683 - 14,492,129 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SMURF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11656,615,171 - 56,728,239 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607727,219,705 - 27,338,787 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Smurf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624870246,260 - 366,033 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624870243,381 - 365,543 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Smurf2
506 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:335
Count of miRNA genes:199
Interacting mature miRNAs:248
Transcripts:ENSRNOT00000019781
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat

Markers in Region
AW535161  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,783,833 - 91,784,015 (+)MAPPERmRatBN7.2
Rnor_6.01095,039,285 - 95,039,466NCBIRnor6.0
Rnor_5.01094,784,880 - 94,785,061UniSTSRnor5.0
RGSC_v3.41096,193,326 - 96,193,507UniSTSRGSC3.4
Celera1090,449,546 - 90,449,727UniSTS
RH 3.4 Map10990.7UniSTS
Cytogenetic Map10q32.1UniSTS
RH129397  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,871,639 - 91,871,827 (+)MAPPERmRatBN7.2
mRatBN7.21252,390,321 - 252,390,509 (+)MAPPERmRatBN7.2
Rnor_6.01095,119,736 - 95,119,923NCBIRnor6.0
Rnor_6.01274,096,711 - 274,096,898NCBIRnor6.0
Rnor_5.01094,863,620 - 94,863,807UniSTSRnor5.0
Rnor_5.01281,510,369 - 281,510,556UniSTSRnor5.0
Celera1248,112,659 - 248,112,846UniSTS
Celera1090,537,749 - 90,537,936UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic Map1q55UniSTS
RH129636  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,871,617 - 91,871,846 (+)MAPPERmRatBN7.2
Rnor_6.01095,119,714 - 95,119,942NCBIRnor6.0
Rnor_5.01094,863,598 - 94,863,826UniSTSRnor5.0
RGSC_v3.41096,278,955 - 96,279,183UniSTSRGSC3.4
Cytogenetic Map10q32.1UniSTS
RH137820  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,765,189 - 91,765,348 (+)MAPPERmRatBN7.2
Rnor_6.01095,021,441 - 95,021,599NCBIRnor6.0
Rnor_5.01094,767,141 - 94,767,299UniSTSRnor5.0
RGSC_v3.41096,173,981 - 96,174,139UniSTSRGSC3.4
Celera1090,431,615 - 90,431,773UniSTS
RH 3.4 Map10992.6UniSTS
Cytogenetic Map10q32.1UniSTS
RH137833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,840,156 - 91,840,286 (+)MAPPERmRatBN7.2
Rnor_6.01095,096,193 - 95,096,322NCBIRnor6.0
Rnor_5.01094,841,241 - 94,841,370UniSTSRnor5.0
RGSC_v3.41096,247,446 - 96,247,575UniSTSRGSC3.4
Celera1090,505,757 - 90,505,886UniSTS
RH 3.4 Map10992.5UniSTS
Cytogenetic Map10q32.1UniSTS
RH140093  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21091,763,405 - 91,763,589 (+)MAPPERmRatBN7.2
Rnor_6.01095,019,657 - 95,019,840NCBIRnor6.0
Rnor_5.01094,765,357 - 94,765,540UniSTSRnor5.0
RGSC_v3.41096,172,197 - 96,172,380UniSTSRGSC3.4
Celera1090,429,831 - 90,430,014UniSTS
RH 3.4 Map10992.09UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 8 8 74 35 41 11 8
Low 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019781   ⟹   ENSRNOP00000019781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,761,807 - 91,862,074 (-)Ensembl
Rnor_6.0 Ensembl1095,018,059 - 95,062,987 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097173   ⟹   ENSRNOP00000082062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,764,230 - 91,862,074 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107027   ⟹   ENSRNOP00000077079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,761,807 - 91,818,829 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109772   ⟹   ENSRNOP00000082927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,761,807 - 91,862,074 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117200   ⟹   ENSRNOP00000085060
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1091,761,807 - 91,862,488 (-)Ensembl
RefSeq Acc Id: NM_001107061   ⟹   NP_001100531
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,261,516 - 92,361,780 (-)NCBI
mRatBN7.21091,761,798 - 91,862,074 (-)NCBI
Rnor_6.01095,018,050 - 95,118,107 (-)NCBI
Rnor_5.01094,763,750 - 94,863,160 (-)NCBI
RGSC_v3.41096,170,590 - 96,269,365 (-)RGD
Celera1090,428,224 - 90,528,224 (-)RGD
Sequence:
RefSeq Acc Id: XM_039086171   ⟹   XP_038942099
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,261,520 - 92,362,185 (-)NCBI
mRatBN7.21091,761,802 - 91,862,485 (-)NCBI
RefSeq Acc Id: XM_063269213   ⟹   XP_063125283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,261,520 - 92,362,184 (-)NCBI
RefSeq Acc Id: XM_063269215   ⟹   XP_063125285
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81092,261,520 - 92,311,514 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001100531   ⟸   NM_001107061
- UniProtKB: F1M3F2 (UniProtKB/TrEMBL),   A6HK62 (UniProtKB/TrEMBL),   A0A8I5Y0P5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019781   ⟸   ENSRNOT00000019781
RefSeq Acc Id: XP_038942099   ⟸   XM_039086171
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZUV2 (UniProtKB/TrEMBL),   A0A8I5Y0P5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000085060   ⟸   ENSRNOT00000117200
RefSeq Acc Id: ENSRNOP00000082927   ⟸   ENSRNOT00000109772
RefSeq Acc Id: ENSRNOP00000082062   ⟸   ENSRNOT00000097173
RefSeq Acc Id: ENSRNOP00000077079   ⟸   ENSRNOT00000107027
RefSeq Acc Id: XP_063125283   ⟸   XM_063269213
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A1F1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125285   ⟸   XM_063269215
- Peptide Label: isoform X3
Protein Domains
C2   HECT   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M3F2-F1-model_v2 AlphaFold F1M3F2 1-637 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310067 AgrOrtholog
BioCyc Gene G2FUF-22922 BioCyc
Ensembl Genes ENSRNOG00000014623 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019781 ENTREZGENE
  ENSRNOT00000019781.7 UniProtKB/TrEMBL
  ENSRNOT00000097173.1 UniProtKB/TrEMBL
  ENSRNOT00000107027.1 UniProtKB/TrEMBL
  ENSRNOT00000109772.1 UniProtKB/TrEMBL
  ENSRNOT00000117200.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domain UniProtKB/TrEMBL
  Hect, E3 ligase catalytic domains UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
  HECT UniProtKB/TrEMBL
  Hect_E3_ubiquitin_ligase UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
KEGG Report rno:303614 UniProtKB/TrEMBL
NCBI Gene 303614 ENTREZGENE
PANTHER C2 DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE SMURF2 UniProtKB/TrEMBL
  HECT DOMAIN UBIQUITIN-PROTEIN LIGASE UniProtKB/TrEMBL
Pfam HECT UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
  PF00397 UniProtKB/TrEMBL
PhenoGen Smurf2 PhenoGen
PIRSF E3_ub_ligase_SMURF1 UniProtKB/TrEMBL
PROSITE HECT UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014623 RatGTEx
SMART HECTc UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP HECT UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt A0A8I5Y0P5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZTH9_RAT UniProtKB/TrEMBL
  A0A8I5ZUV2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A1F1 ENTREZGENE, UniProtKB/TrEMBL
  A6HK62 ENTREZGENE, UniProtKB/TrEMBL
  F1M3F2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Smurf2  SMAD specific E3 ubiquitin protein ligase 2   Smurf2_predicted  SMAD specific E3 ubiquitin protein ligase 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Smurf2_predicted  SMAD specific E3 ubiquitin protein ligase 2 (predicted)  RGD1310067_predicted  similar to E3 ubiquitin ligase SMURF2 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1310067_predicted  similar to E3 ubiquitin ligase SMURF2 (predicted)  LOC303614_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC303614_predicted  similar to E3 ubiquitin ligase SMURF2 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL