Mixl1 (Mix paired-like homeobox 1)

Gene: Mixl1 (Mix paired-like homeobox 1) Rattus norvegicus

Analyze

Symbol:

Mixl1

Name:

Mix paired-like homeobox 1

RGD ID:

1310011

Description:

Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including endodermal cell differentiation; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including cell migration involved in gastrulation; endoderm development; and positive regulation of mesoderm development. Predicted to be located in nucleoplasm. Predicted to be part of chromatin. Orthologous to human MIXL1 (Mix paired-like homeobox); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

homeobox protein MIXL1; LOC289311; Mix paired-like homeobox; Mix1 homeobox-like 1; Mix1 homeobox-like 1 (Xenopus laevis); NEWGENE_1310011

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MIXL1 (Mix paired-like homeobox)	HGNC	EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Mixl1 (Mix paired-like homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Mixl1 (Mix paired-like homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MIXL1 (Mix paired-like homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MIXL1 (Mix paired-like homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Mixl1 (Mix paired-like homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MIXL1 (Mix paired-like homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MIXL1 (Mix paired-like homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Mixl1 (Mix paired-like homeobox)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MIXL1 (Mix paired-like homeobox)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Mixl1 (Mix paired-like homeobox)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	mixl1 (Mix paired-like homeobox)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	94,953,907 - 94,957,938 (-)	NCBI		GRCr8
mRatBN7.2	13	92,422,031 - 92,426,065 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	92,422,031 - 92,426,065 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	94,927,431 - 94,931,466 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	96,327,378 - 96,331,405 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	93,502,070 - 93,506,101 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	97,278,258 - 97,282,299 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	98,973,041 - 98,975,426 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	13	97,278,258 - 97,282,299 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	103,973,473 - 103,977,504 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	96,427,597 - 96,431,628 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	96,618,156 - 96,620,542 (-)	NCBI
Celera	13	91,967,784 - 91,971,815 (-)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

parathyroid carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-sulfonyldiphenol (EXP)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

bictegravir (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

butylated hydroxyanisole (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dicrotophos (ISO)

disodium selenite (ISO)

dolutegravir (ISO)

fluoxetine (ISO)

fonofos (ISO)

hydrogen peroxide (ISO)

lead(0) (ISO)

leflunomide (ISO)

lithium chloride (ISO)

menadione (ISO)

methimazole (EXP)

methoxyacetic acid (ISO)

mono(2-ethylhexyl) phthalate (ISO)

Monobutylphthalate (ISO)

parathion (ISO)

perfluorohexanesulfonic acid (ISO)

pyrazinecarboxamide (EXP)

quercetin (ISO)

quinolin-8-ol (ISO)

sunitinib (ISO)

terbufos (ISO)

tert-butyl hydroperoxide (ISO)

thalidomide (ISO)

triclosan (ISO)

tris(2-butoxyethyl) phosphate (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell migration involved in gastrulation (ISO)

digestive tract development (ISO)

endoderm development (ISO)

endoderm formation (IBA,ISO)

endodermal cell differentiation (ISO)

gastrulation (ISO)

heart development (ISO)

hematopoietic progenitor cell differentiation (ISO)

hemopoiesis (ISO)

negative regulation of hematopoietic progenitor cell differentiation (ISO)

positive regulation of mesoderm development (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

chromatin (ISO)

nucleoplasm (IEA,ISO)

nucleus (ISO)

Molecular Function

cis-regulatory region sequence-specific DNA binding (ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (ISO)

DNA-binding transcription factor activity, RNA polymerase II-specific (IBA)

identical protein binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,ISO)

RNA polymerase II-specific DNA-binding transcription factor binding (ISO)

sequence-specific double-stranded DNA binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12117810	PMID:12619131	PMID:16403910	PMID:17151016	PMID:19038793	PMID:19711456	PMID:22164283	PMID:22265737

Genomics

Comparative Map Data

Mixl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	94,953,907 - 94,957,938 (-)	NCBI		GRCr8
mRatBN7.2	13	92,422,031 - 92,426,065 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	92,422,031 - 92,426,065 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	94,927,431 - 94,931,466 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	96,327,378 - 96,331,405 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	93,502,070 - 93,506,101 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	97,278,258 - 97,282,299 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	98,973,041 - 98,975,426 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0 Ensembl	13	97,278,258 - 97,282,299 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	103,973,473 - 103,977,504 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	96,427,597 - 96,431,628 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	96,618,156 - 96,620,542 (-)	NCBI
Celera	13	91,967,784 - 91,971,815 (-)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

MIXL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	226,223,664 - 226,227,060 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	226,223,618 - 226,227,060 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	226,411,365 - 226,414,761 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	224,478,006 - 224,480,136 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	222,718,117 - 222,720,248	NCBI
Celera	1	199,602,144 - 199,604,274 (+)	NCBI		Celera
Cytogenetic Map	1	q42.12	NCBI
HuRef	1	196,928,386 - 196,930,516 (+)	NCBI		HuRef
CHM1_1	1	227,684,126 - 227,686,256 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	225,411,532 - 225,414,928 (+)	NCBI		T2T-CHM13v2.0

Mixl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	180,520,608 - 180,524,599 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	180,520,608 - 180,524,599 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	180,693,043 - 180,697,034 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	180,693,043 - 180,697,034 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	182,623,174 - 182,627,165 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	182,529,718 - 182,533,709 (-)	NCBI		MGSCv36	mm8
Celera	1	187,754,505 - 187,758,493 (-)	NCBI		Celera
Cytogenetic Map	1	H4	NCBI
cM Map	1	84.46	NCBI

Mixl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955489	418,650 - 422,428 (+)	NCBI	ChiLan1.0	ChiLan1.0

MIXL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	23,312,503 - 23,316,315 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	23,260,972 - 23,264,778 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	201,682,488 - 201,686,358 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	206,671,344 - 206,679,904 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

MIXL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	38,651,481 - 38,652,560 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	38,132,918 - 38,135,788 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	38,485,283 - 38,487,650 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	7	38,323,946 - 38,326,305 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	38,330,845 - 38,333,218 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	38,602,254 - 38,605,581 (-)	NCBI		UU_Cfam_GSD_1.0

Mixl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	51,756,331 - 51,762,377 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936526	2,984,907 - 2,987,893 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936526	2,984,900 - 2,989,494 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MIXL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	14,102,290 - 14,105,983 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	14,102,273 - 14,105,544 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	15,667,360 - 15,670,704 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MIXL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	3,542,923 - 3,546,561 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	3,544,169 - 3,546,305 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	3,543,098 - 3,548,489 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mixl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624807	322,723 - 326,149 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624807	322,723 - 325,089 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Mixl1
13 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	243
Count of miRNA genes:	161
Interacting mature miRNAs:	187
Transcripts:	ENSRNOT00000004244, ENSRNOT00000074370
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	1	101056920	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	31241331	93395974	Rat
70181	BpQTLcluster11	Blood pressure QTL cluster 11	6.922		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	13	31241331	93395974	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	52362171	97362171	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	56056920	101056920	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	74023918	97213863	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	74862117	101339893	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	80753256	106807694	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium
Low	3	4	26	10	18	10	8	9	11	10	10	10	8
Below cutoff		19	15	15	1	15		1	47	21	29	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105979	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769810	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272166	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000004244 ⟹ ENSRNOP00000004244

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	92,422,031 - 92,426,065 (-)	Ensembl
Rnor_6.0 Ensembl	13	97,278,258 - 97,282,299 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000074370 ⟹ ENSRNOP00000064882

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	13	98,973,041 - 98,975,426 (-)	Ensembl

RefSeq Acc Id:

NM_001105979 ⟹ NP_001099449

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,953,907 - 94,957,938 (-)	NCBI
mRatBN7.2	13	92,422,031 - 92,426,065 (-)	NCBI
Rnor_6.0	13	97,278,258 - 97,282,299 (-)	NCBI
Rnor_5.0	13	103,973,473 - 103,977,504 (-)	NCBI
RGSC_v3.4	13	96,427,597 - 96,431,628 (-)	RGD
Celera	13	91,967,784 - 91,971,815 (-)	RGD

Sequence:

show sequence

TCCCGGGAAACGTCCCGGAGTGATGGCCGCAGCAGGGTCCCAGCAGCTTCAGTTCGCAGAGGGC
GCCGCTTTCCCCACCTTCCCGGCCGCGCACCCCGGAGGACAGCTGCTCCCGGCCGCGCGCCCAG
CCACTGGGCTACCCCCGGCGCCCCCGGACTCTCGCGCCCCAGCGGCCACGCCATGCTTTCCAAG
CCGGGGCCCCAGGCCCGCAGCGCAGACTCCCACCGGCCTGGATCCGCCCGGACCCTCCAAAGGC
TCGGCCGCCCCGTCTGCGCCGCAGCGCCGCAAGCGCACGTCGTTCAGCTCCGAGCAGCTGCAGT
TGCTGGAGCTCGTCTTCCGACAGACCATGTACCCCGACATCCACTTGCGGGAGCGTCTGGCTGC
GCTCACGCTGCTACCCGAGTCAAGGATCCAGGTGTGGTTCCAGAACAGACGGGCCAAGTCCCGG
CGTCAGAGCGGGAAGTCGTTTCAGCCCTTATCCTCAAGGCGGGAAGATTTCCTCCATCGTCCTG
CTCCGGGGACTGAAGCAAGGTGTCTGAAGCCTCAGTTGCCTCTAGAGGCGGATGTGAACCACGT
TCTGGATTCCAGTATGGCTGGAGGAGGCGTCTGTACATCTGGTTCTCAGGGTTTTGAAACTTAC
TCCTCTCTCTCTGAAGATATTGGCTCAAAGTTGGACTCATGGGAGGAGCACATCTTTTCTGCCT
TGGGTAGCTTCTGAGGATTCTGGGAGAGTTCAAGATGTACTCAGGGAGATCTGGGAGATTCGAA
CCAGACCCTGTCTGATCTCCTGACTGGCCAGGTCTTGGTTCTGGATCACCTCTCATATTTAGGT
TTCCCTTCTCCGACACAGCCTTTACTGCTGGCTTGTTCTTGGTAGCCACCCGCCCTCCCACCCG
CAAGTCACTGTGAATCTCCAAGACTGCACATTATCATCGGTCTACATCCCCTGGGCCTTCTCAC
TAGGGTTATTCTCGTTTTCCAGACTGATTATTCAAAATTTGCTTTCCTCATAGGAACCTCCAGC
TGGATTCAATTTCTCCCCTTTCTCGGCAGCTGCCTACAACGTGGGTTCACTCTCTCTCACCCAA
ATCCTTATCACCAAGACTTAGTACTTTTTATTGAATCTTTTTGTTTTGTTTTTGACCTTGCTGT
GTAAGTAAGGATGGCATGAACTCCTGTCCTCCCACCTCTATTTGCCATCGTGACTGACTGGATG
TTGCTATTTTTGCTTAAAATTGTGTATGATATTAAGATATATATCCAAATCAAGCTTAACACAT
GCATGAGATCAGTCACCTTCCTTTTTTCTGCGATGATACAATCTATTAGCAATTTCAAGTATAT
GAAATATCGATACTAACTCTAGCCATTACCATTGAGTTCTTCAGCTTCTCTCTCCTAGCTGACT
GAGTATCCTAGCCACCTCCCCTGCCCTCACTTGACTGGTTTCTCGTCTGGCCTGTCAACTTTAC
ACTCCATCAGTAAAGATGCTACTTTCAACCTCTTTCAAGAACCCCATGCCTCTTGTTCCCCACT
TTCTTTCTTTCTTTTTCTTTTTTTTTTTTGGTTCTTTTTTTTTTTCGGAGCTGGGGACTGAACC
CAGGGCCTTGCGCTTCCTAGGTAAGCGCTCTACCACTGAGCTAAATCCCCAGCCCCTCTTTCTT
TCTTTTTTAAATTACTCTATTTGGAAATCTGTGGCAGCATCCAGTTACCAAACCATAAGACCCT
GTCAAGCACGCTCCTAGTCAATGACATCATCTTTAGCTTATGCAAACTTTAAGATCATTTACCC
ACAATGTGCTTCTCTGTCTGTCTCTGTCTGTCATTCCTTTCTAGTTGGGACTCAGTGAGAAAGC
TTCTCTTTCAAAACAGCTCAAGCACACCGCTTTCTGAAGCCTGAACTTTTCTTAACTAATCCTG
TTTTTCGTACCTGTTACTTTGATGACCATTTTTCTTAGCACTTGTTCTTATTATGTTTCCTGTA
CAACATTAGTGGATTACTAAATGCTCCTCACTGCCGTTTTTTACATGAATCCCATTGAAATGAG
CCCTGTTTTCCCAGACCTCAGCACTGGGAAAGTTGGGGAATACATAATGAATGACAGAAAACAT
TCTGAAGGGAACTTTCTGCACACACAGTACATCGAGAATTTATTTGAGCACGCTTATCTGCTGG
GCTGCTGAGATAGCTCAGTGGAGGTAAACATGTTGTCACCAAGCATGACAATCTGAGTTTGATC
CCCAAGACCCACATGGTGAGAAGGAGAATGGATTTGTCTTTTAGACTTCCACATGTGTGCTATG
GTGTATACCCACATACATACACACATACAAAATAAATA

hide sequence

RefSeq Acc Id:

XM_063272166 ⟹ XP_063128236

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	94,954,741 - 94,957,916 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099449	(Get FASTA)	NCBI Sequence Viewer
	XP_063128236	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL94829	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004244
	ENSRNOP00000004244.2

RefSeq Acc Id:

NP_001099449 ⟸ NM_001105979

- UniProtKB:

D4A558 (UniProtKB/TrEMBL), A6JGH3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAAGSQQLQFAEGAAFPTFPAAHPGGQLLPAARPATGLPPAPPDSRAPAATPCFPSRGPRPAA
QTPTGLDPPGPSKGSAAPSAPQRRKRTSFSSEQLQLLELVFRQTMYPDIHLRERLAALTLLPES
RIQVWFQNRRAKSRRQSGKSFQPLSSRREDFLHRPAPGTEARCLKPQLPLEADVNHVLDSSMAG
GGVCTSGSQGFETYSSLSEDIGSKLDSWEEHIFSALGSF

hide sequence

RefSeq Acc Id:

ENSRNOP00000064882 ⟸ ENSRNOT00000074370

RefSeq Acc Id:

ENSRNOP00000004244 ⟸ ENSRNOT00000004244

RefSeq Acc Id:	XP_063128236 ⟸ XM_063272166
- Peptide Label:	isoform X1

Protein Domains

Homeobox

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A558-F1-model_v2	AlphaFold	D4A558	1-231	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310011	AgrOrtholog
BioCyc Gene	G2FUF-17116	BioCyc
Ensembl Genes	ENSRNOG00000003176	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000048085	Ensembl
Ensembl Transcript	ENSRNOT00000004244	ENTREZGENE
	ENSRNOT00000004244.4	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeodomain-like	UniProtKB/TrEMBL
	MIXL1	UniProtKB/TrEMBL
KEGG Report	rno:289311	UniProtKB/TrEMBL
NCBI Gene	289311	ENTREZGENE
PANTHER	HOMEOBOX PROTEIN MIXL1	UniProtKB/TrEMBL
	PTHR47656	UniProtKB/TrEMBL
Pfam	Homeobox	UniProtKB/TrEMBL
PhenoGen	Mixl1	PhenoGen
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003176	RatGTEx
	ENSRNOG00000048085	RatGTEx
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	Homeodomain_like	UniProtKB/TrEMBL
UniProt	A6JGH3	ENTREZGENE, UniProtKB/TrEMBL
	D4A558	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Mixl1	Mix paired-like homeobox 1	NEWGENE_1310011	Mix paired-like homeobox	Data merged from RGD:11496769	737654	PROVISIONAL
2016-08-02	NEWGENE_1310011	Mix paired-like homeobox			Symbol and Name status set to provisional	70820	PROVISIONAL
2011-08-02	Mixl1	Mix paired-like homeobox 1	Mixl1	Mix1 homeobox-like 1 (Xenopus laevis)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Mixl1	Mix1 homeobox-like 1 (Xenopus laevis)	Mixl1_predicted	Mix1 homeobox-like 1 (Xenopus laevis) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Mixl1_predicted	Mix1 homeobox-like 1 (Xenopus laevis) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar