Zfp488 (zinc finger protein 488) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Zfp488 (zinc finger protein 488) Rattus norvegicus
Analyze
Symbol: Zfp488
Name: zinc finger protein 488
RGD ID: 1309835
Description: Predicted to be involved in oligodendrocyte development; positive regulation of myelination; and regulation of DNA-templated transcription. Predicted to act upstream of or within negative regulation of DNA-templated transcription and positive regulation of oligodendrocyte differentiation. Predicted to be active in nucleus. Orthologous to human ZNF488 (zinc finger protein 488); INTERACTS WITH bisphenol A; Cuprizon; fenvalerate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC290571; Znf488
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,289,286 - 9,299,928 (-)NCBIGRCr8
mRatBN7.2169,283,039 - 9,293,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,283,043 - 9,293,671 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx169,302,496 - 9,313,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,447,207 - 10,457,866 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,297,567 - 9,308,224 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,292,964 - 10,304,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,294,931 - 10,296,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,613,607 - 8,625,063 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,599,510 - 9,600,526 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1169,599,507 - 9,614,045 (-)NCBI
Celera165,916,539 - 5,928,369 (+)NCBICelera
Cytogenetic Map16p16-p15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16908628   PMID:22355521  


Genomics

Comparative Map Data
Zfp488
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8169,289,286 - 9,299,928 (-)NCBIGRCr8
mRatBN7.2169,283,039 - 9,293,681 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,283,043 - 9,293,671 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx169,302,496 - 9,313,151 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01610,447,207 - 10,457,866 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0169,297,567 - 9,308,224 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01610,292,964 - 10,304,794 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1610,294,931 - 10,296,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0168,613,607 - 8,625,063 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4169,599,510 - 9,600,526 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1169,599,507 - 9,614,045 (-)NCBI
Celera165,916,539 - 5,928,369 (+)NCBICelera
Cytogenetic Map16p16-p15NCBI
ZNF488
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381047,365,496 - 47,384,293 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1047,365,496 - 47,384,293 (-)EnsemblGRCh38hg38GRCh38
GRCh371048,355,069 - 48,373,866 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361047,975,095 - 47,993,872 (+)NCBINCBI36Build 36hg18NCBI36
Build 341047,975,094 - 47,993,870NCBI
Celera1044,779,013 - 44,797,770 (+)NCBICelera
Cytogenetic Map10q11.22NCBI
HuRef1043,107,591 - 43,126,347 (+)NCBIHuRef
CHM1_11048,520,142 - 48,538,914 (+)NCBICHM1_1
T2T-CHM13v2.01048,256,793 - 48,275,590 (-)NCBIT2T-CHM13v2.0
Zfp488
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391433,689,023 - 33,700,986 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1433,689,027 - 33,700,721 (-)EnsemblGRCm39 Ensembl
GRCm381433,967,070 - 33,979,034 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1433,967,070 - 33,978,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv371434,780,256 - 34,791,950 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361432,796,162 - 32,807,856 (-)NCBIMGSCv36mm8
Celera1430,233,294 - 30,246,477 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.8NCBI
Znf488
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555562,227,805 - 2,237,874 (-)NCBIChiLan1.0ChiLan1.0
ZNF488
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2859,929,326 - 59,944,336 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11059,934,638 - 59,947,631 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01046,565,330 - 46,584,964 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ZNF488
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1434,916,782 - 34,966,706 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl434,899,635 - 34,966,452 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha434,917,453 - 34,930,808 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0435,313,639 - 35,326,951 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl435,275,570 - 35,326,953 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1435,145,417 - 35,158,712 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0435,326,560 - 35,339,844 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0435,834,149 - 35,847,468 (+)NCBIUU_Cfam_GSD_1.0
Znf488
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721381,337,938 - 81,350,135 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365547,350,351 - 7,351,360 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365547,347,632 - 7,362,025 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF488
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1488,474,122 - 88,487,203 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11488,474,122 - 88,526,333 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21496,135,789 - 96,151,008 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF488
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1944,131,989 - 44,149,905 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660483,903,989 - 3,922,244 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Zfp488
95 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:87
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000031496
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6
Low 46 5
Below cutoff 2 31 10 8 8 2 2 22 8 25 4 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000083990   ⟹   ENSRNOP00000075699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl169,283,043 - 9,293,671 (-)Ensembl
Rnor_6.0 Ensembl1610,294,931 - 10,296,341 (-)Ensembl
RefSeq Acc Id: NM_001399139   ⟹   NP_001386068
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8169,289,286 - 9,299,928 (-)NCBI
mRatBN7.2169,283,039 - 9,293,681 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001386068 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075699
  ENSRNOP00000075699.1
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000075699   ⟸   ENSRNOT00000083990
RefSeq Acc Id: NP_001386068   ⟸   NM_001399139
- UniProtKB: D4AAF0 (UniProtKB/TrEMBL)
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AAF0-F1-model_v2 AlphaFold D4AAF0 1-338 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309835 AgrOrtholog
BioCyc Gene G2FUF-12081 BioCyc
Ensembl Genes ENSRNOG00000057542 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000083990 ENTREZGENE
  ENSRNOT00000083990.2 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report rno:290571 UniProtKB/TrEMBL
NCBI Gene 290571 ENTREZGENE
PANTHER AGAP007109-PA UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 488 UniProtKB/TrEMBL
PhenoGen Zfp488 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057542 RatGTEx
SMART ZnF_C2H2 UniProtKB/TrEMBL
UniProt D4AAF0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-19 Zfp488  zinc finger protein 488  Znf488  zinc finger protein 488  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Znf488  zinc finger protein 488  Zfp488  zinc finger protein 488   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Zfp488  zinc finger protein 488   Zfp488_predicted  zinc finger protein 488 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Zfp488_predicted  zinc finger protein 488 (predicted)  Znf488_predicted    Symbol updated 1299863 APPROVED
2005-01-12 Znf488_predicted  zinc finger protein 488 (predicted)      Symbol and Name status set to approved 70820 APPROVED