Dock7 (dedicator of cytokinesis 7) - Rat Genome Database

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Gene: Dock7 (dedicator of cytokinesis 7) Rattus norvegicus
Analyze
Symbol: Dock7
Name: dedicator of cytokinesis 7
RGD ID: 1309790
Description: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in several processes, including negative regulation of cold-induced thermogenesis; nervous system development; and positive regulation of vascular associated smooth muscle cell migration. Predicted to act upstream of or within hematopoietic progenitor cell differentiation and pigmentation. Predicted to be part of COP9 signalosome. Predicted to be active in neuromuscular junction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 23. Orthologous to human DOCK7 (dedicator of cytokinesis 7); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dedicator of cytokinesis protein 7; LOC313388; MGC189434
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85118,714,863 - 118,898,362 (-)NCBIGRCr8
mRatBN7.25113,599,371 - 113,782,871 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5113,600,198 - 113,782,813 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5116,173,874 - 116,331,721 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05117,899,210 - 118,057,047 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05117,961,741 - 118,119,584 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05117,595,194 - 117,780,844 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5117,596,136 - 117,780,777 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05121,536,701 - 121,718,634 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45119,377,149 - 119,535,973 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5112,163,983 - 112,318,639 (-)NCBICelera
Cytogenetic Map5q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
CGP 52608  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
flutamide  (EXP)
FR900359  (ISO)
gallic acid  (ISO)
hexadecanoic acid  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
lovastatin  (ISO)
mercury dibromide  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
thapsigargin  (ISO)
thioacetamide  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
warfarin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Altered thermogenesis and impaired bone remodeling in Misty mice. Motyl KJ, etal., J Bone Miner Res. 2013 Sep;28(9):1885-97. doi: 10.1002/jbmr.1943.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:2379821   PMID:12477932   PMID:16982419   PMID:18426980   PMID:18850735   PMID:21423176   PMID:22158624   PMID:22475431   PMID:22842144   PMID:24029230   PMID:27018747   PMID:31505169  


Genomics

Comparative Map Data
Dock7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85118,714,863 - 118,898,362 (-)NCBIGRCr8
mRatBN7.25113,599,371 - 113,782,871 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5113,600,198 - 113,782,813 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5116,173,874 - 116,331,721 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05117,899,210 - 118,057,047 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05117,961,741 - 118,119,584 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05117,595,194 - 117,780,844 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5117,596,136 - 117,780,777 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05121,536,701 - 121,718,634 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45119,377,149 - 119,535,973 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera5112,163,983 - 112,318,639 (-)NCBICelera
Cytogenetic Map5q33NCBI
DOCK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38162,454,726 - 62,688,386 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl162,454,298 - 62,688,386 (-)EnsemblGRCh38hg38GRCh38
GRCh37162,920,397 - 63,154,057 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36162,692,985 - 62,926,557 (-)NCBINCBI36Build 36hg18NCBI36
Build 34162,632,417 - 62,865,990NCBI
Celera161,209,606 - 61,442,836 (-)NCBICelera
Cytogenetic Map1p31.3NCBI
HuRef161,032,437 - 61,265,993 (-)NCBIHuRef
CHM1_1163,035,730 - 63,269,026 (-)NCBICHM1_1
T2T-CHM13v2.0162,333,313 - 62,566,591 (-)NCBIT2T-CHM13v2.0
Dock7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39498,824,669 - 99,019,190 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl498,824,908 - 99,009,152 (-)EnsemblGRCm39 Ensembl
GRCm38498,936,659 - 99,130,953 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl498,936,671 - 99,120,915 (-)EnsemblGRCm38mm10GRCm38
MGSCv37498,603,356 - 98,787,606 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36498,428,693 - 98,612,878 (-)NCBIMGSCv36mm8
Celera497,303,728 - 97,492,465 (-)NCBICelera
Cytogenetic Map4C6NCBI
cM Map445.6NCBI
Dock7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542327,044,341 - 27,233,710 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542327,043,621 - 27,233,710 (+)NCBIChiLan1.0ChiLan1.0
DOCK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21164,163,998 - 164,396,907 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11163,313,398 - 163,546,558 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,713,217 - 61,946,371 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1163,528,826 - 63,760,513 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl163,529,227 - 63,740,970 (-)Ensemblpanpan1.1panPan2
DOCK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1547,435,209 - 47,653,312 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl547,462,224 - 47,653,163 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha547,495,341 - 47,714,450 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0547,618,819 - 47,837,750 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl547,618,797 - 47,837,603 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1547,574,121 - 47,792,708 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0547,519,806 - 47,739,083 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0547,782,016 - 48,001,146 (+)NCBIUU_Cfam_GSD_1.0
Dock7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505875,846,153 - 76,038,630 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936692162,390 - 353,721 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936692161,979 - 354,028 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOCK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6149,748,036 - 149,972,168 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16149,745,375 - 149,971,853 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26138,013,920 - 138,172,803 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DOCK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12070,371,775 - 70,599,311 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2070,372,534 - 70,598,614 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603346,854,700 - 47,083,061 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dock7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474231,189,852 - 31,390,478 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474231,189,890 - 31,390,284 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dock7
876 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:366
Count of miRNA genes:190
Interacting mature miRNAs:227
Transcripts:ENSRNOT00000011405, ENSRNOT00000065112
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
2290448Scl54Serum cholesterol level QTL 542.93blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)531663789131345958Rat
1641912Alcrsp18Alcohol response QTL 18response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)535189153141643988Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1576312Emca8Estrogen-induced mammary cancer QTL 84.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)550328551141643988Rat
70189Mcs5Mammary carcinoma susceptibility QTL 510.51mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)555805606132207589Rat
1358895Bp254Blood pressure QTL 2543.60.0003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)558829236128034027Rat
61426Scl2Serum cholesterol level QTL 27.30.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)559793399143070159Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
2306971Anxrr21Anxiety related response QTL 219.47fear/anxiety-related behavior trait (VT:1000241)number of entries into a discrete space in an experimental apparatus (CMO:0000960)566174080124160948Rat
1354598Srn6Serum renin concentration QTL 63.8blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)569540295151018848Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
1598846Bp293Blood pressure QTL 2933.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)579584860124584860Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1298086Bp156Blood pressure QTL 156arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)584132602129132602Rat
7411601Foco12Food consumption QTL 1219.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
7411564Bw135Body weight QTL 1350.001body mass (VT:0001259)body weight gain (CMO:0000420)587468046132468046Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
6903316Bw113Body weight QTL 11320.0103body mass (VT:0001259)body weight (CMO:0000012)587765973132765973Rat
1358889Bp261Blood pressure QTL 2612.86arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)590067849128034027Rat
1358909Kidm25Kidney mass QTL 251.87kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)590067849128034027Rat
631527Tls1T-lymphoma susceptibility QTL 100.001thymus integrity trait (VT:0010555)post-insult time to onset of T-cell lymphoma (CMO:0001907)590450144135450144Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
2317753Glom24Glomerulus QTL 243.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)597570330136479578Rat
1582212Livw2Liver weight QTL 23.50.0004liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)599016066119085810Rat
1358187Emca1Estrogen-induced mammary cancer QTL 14.4mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)599216724148607142Rat
1578673Bmd13Bone mineral density QTL 134.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)5103689353148689353Rat
2317056Wbc3White blood cell count QTL 32.510.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)5105999803150999803Rat
7207488Bss110Bone structure and strength QTL 18.4femur strength trait (VT:0010010)femur stiffness (CMO:0001674)5106906205151906205Rat
7207491Bss112Bone structure and strength QTL 1127femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)5106906205151906205Rat
7207481Bss106Bone structure and strength QTL 1067.9femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)5106906205151906205Rat
7207486Bss109Bone structure and strength QTL 109femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)5106906205151906205Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat
1298089Scl14Serum cholesterol level QTL 145.80.0004blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)5108845856153845856Rat
1598847Cm62Cardiac mass QTL 623.4heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5108845856153845856Rat
8657050Bw146Body weight QTL 14619.840.001body mass (VT:0001259)body weight gain (CMO:0000420)5108938288153938288Rat
8694441Bw169Body weight QTL 16917.610.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)5111416838156416838Rat
8694198Abfw3Abdominal fat weight QTL 316.130.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)5111416838156416838Rat
8694389Bw160Body weight QTL 1606.170.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)5111416838156416838Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
7794743Bp373Blood pressure QTL 3730.0058arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5112175546116047089Rat

Markers in Region
RH131293  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25113,710,616 - 113,710,834 (+)MAPPERmRatBN7.2
Rnor_6.05117,706,380 - 117,706,597NCBIRnor6.0
Rnor_5.05121,647,177 - 121,647,394UniSTSRnor5.0
RGSC_v3.45119,487,264 - 119,487,481UniSTSRGSC3.4
Celera5112,271,625 - 112,271,842UniSTS
RH 3.4 Map5789.9UniSTS
Cytogenetic Map5q33UniSTS
RH129449  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25113,703,534 - 113,704,516 (+)MAPPERmRatBN7.2
Rnor_6.05117,699,298 - 117,700,279NCBIRnor6.0
Rnor_5.05121,640,095 - 121,641,076UniSTSRnor5.0
RGSC_v3.45119,480,182 - 119,481,163UniSTSRGSC3.4
Celera5112,264,404 - 112,265,524UniSTS
RH 3.4 Map5793.0UniSTS
Cytogenetic Map5q33UniSTS
BF386383  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25113,615,563 - 113,615,761 (+)MAPPERmRatBN7.2
Rnor_6.05117,611,502 - 117,611,699NCBIRnor6.0
Rnor_5.05121,553,009 - 121,553,206UniSTSRnor5.0
RGSC_v3.45119,392,515 - 119,392,712UniSTSRGSC3.4
Celera5112,179,347 - 112,179,544UniSTS
RH 3.4 Map5793.0UniSTS
Cytogenetic Map5q33UniSTS
RH135495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25113,703,231 - 113,703,328 (+)MAPPERmRatBN7.2
Rnor_6.05117,698,995 - 117,699,091NCBIRnor6.0
Rnor_5.05121,639,792 - 121,639,888UniSTSRnor5.0
RGSC_v3.45119,479,879 - 119,479,975UniSTSRGSC3.4
Celera5112,264,101 - 112,264,197UniSTS
Cytogenetic Map5q33UniSTS
AL009364  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25113,751,250 - 113,751,399 (+)MAPPERmRatBN7.2
Rnor_6.05117,746,911 - 117,747,059NCBIRnor6.0
Rnor_5.05121,687,790 - 121,687,938UniSTSRnor5.0
Celera5112,312,261 - 112,312,409UniSTS
Cytogenetic Map5q33UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 36 26 10 16 10 1 1 74 30 40 11 1
Low 3 7 31 31 3 31 7 10 5 1 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001415885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287648 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063287651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC167079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ124295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000011405   ⟹   ENSRNOP00000011405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5113,602,535 - 113,757,622 (-)Ensembl
Rnor_6.0 Ensembl5117,596,136 - 117,754,571 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000065112   ⟹   ENSRNOP00000063286
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5113,600,198 - 113,757,927 (-)Ensembl
Rnor_6.0 Ensembl5117,596,138 - 117,612,123 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000081971   ⟹   ENSRNOP00000072637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5113,600,198 - 113,782,813 (-)Ensembl
Rnor_6.0 Ensembl5117,596,341 - 117,780,777 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100273   ⟹   ENSRNOP00000089895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5113,602,535 - 113,757,716 (-)Ensembl
RefSeq Acc Id: NM_001415885   ⟹   NP_001402814
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,714,863 - 118,898,335 (-)NCBI
mRatBN7.25113,599,371 - 113,782,841 (-)NCBI
RefSeq Acc Id: NM_001415886   ⟹   NP_001402815
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,714,863 - 118,898,335 (-)NCBI
mRatBN7.25113,599,371 - 113,782,841 (-)NCBI
RefSeq Acc Id: XM_063287643   ⟹   XP_063143713
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,715,690 - 118,898,337 (-)NCBI
RefSeq Acc Id: XM_063287644   ⟹   XP_063143714
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,715,690 - 118,898,337 (-)NCBI
RefSeq Acc Id: XM_063287645   ⟹   XP_063143715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,715,690 - 118,898,337 (-)NCBI
RefSeq Acc Id: XM_063287646   ⟹   XP_063143716
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,715,690 - 118,898,337 (-)NCBI
RefSeq Acc Id: XM_063287647   ⟹   XP_063143717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,715,690 - 118,898,362 (-)NCBI
RefSeq Acc Id: XM_063287648   ⟹   XP_063143718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,755,192 - 118,898,337 (-)NCBI
RefSeq Acc Id: XM_063287649   ⟹   XP_063143719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,715,690 - 118,781,368 (-)NCBI
RefSeq Acc Id: XM_063287650   ⟹   XP_063143720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,801,786 - 118,898,337 (-)NCBI
RefSeq Acc Id: XM_063287651   ⟹   XP_063143721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85118,715,690 - 118,898,337 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000063286   ⟸   ENSRNOT00000065112
RefSeq Acc Id: ENSRNOP00000072637   ⟸   ENSRNOT00000081971
RefSeq Acc Id: ENSRNOP00000011405   ⟸   ENSRNOT00000011405
RefSeq Acc Id: ENSRNOP00000089895   ⟸   ENSRNOT00000100273
RefSeq Acc Id: NP_001402815   ⟸   NM_001415886
- Peptide Label: isoform 2
- UniProtKB: F6PUC8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402814   ⟸   NM_001415885
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K3H2 (UniProtKB/TrEMBL),   A0A8I6ACL2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143717   ⟸   XM_063287647
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063143721   ⟸   XM_063287651
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063143716   ⟸   XM_063287646
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063143714   ⟸   XM_063287644
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063143715   ⟸   XM_063287645
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063143713   ⟸   XM_063287643
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063143719   ⟸   XM_063287649
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063143718   ⟸   XM_063287648
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063143720   ⟸   XM_063287650
- Peptide Label: isoform X8
Protein Domains
C2 DOCK-type   DOCKER

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K3H2-F1-model_v2 AlphaFold A0A0G2K3H2 1-2129 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693860
Promoter ID:EPDNEW_R4379
Type:initiation region
Name:Dock7_1
Description:dedicator of cytokinesis 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05117,780,792 - 117,780,852EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309790 AgrOrtholog
BioCyc Gene G2FUF-40581 BioCyc
Ensembl Genes ENSRNOG00000008298 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011405.9 UniProtKB/TrEMBL
  ENSRNOT00000065112 ENTREZGENE
  ENSRNOT00000065112.3 UniProtKB/TrEMBL
  ENSRNOT00000081971 ENTREZGENE
  ENSRNOT00000081971.2 UniProtKB/TrEMBL
  ENSRNOT00000100273.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.740 UniProtKB/TrEMBL
  1.25.40.410 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7317229 IMAGE-MGC_LOAD
InterPro C2_Dock-C UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  DHR-2 UniProtKB/TrEMBL
  DOCK UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DOCK_C/D_N UniProtKB/TrEMBL
  DOCK_C_lobe_A UniProtKB/TrEMBL
  DOCK_C_lobe_C UniProtKB/TrEMBL
  DOCKER_Lobe_A UniProtKB/TrEMBL
  DOCKER_Lobe_B UniProtKB/TrEMBL
  DOCKER_Lobe_C UniProtKB/TrEMBL
MGC_CLONE MGC:189434 IMAGE-MGC_LOAD
NCBI Gene 313388 ENTREZGENE
PANTHER DEDICATOR OF CYTOKINESIS PROTEIN 7 UniProtKB/TrEMBL
  PTHR23317 UniProtKB/TrEMBL
Pfam Ded_cyto UniProtKB/TrEMBL
  DHR-2_Lobe_B UniProtKB/TrEMBL
  DHR-2_Lobe_C UniProtKB/TrEMBL
  DOCK-C2 UniProtKB/TrEMBL
  DUF3398 UniProtKB/TrEMBL
PhenoGen Dock7 PhenoGen
PROSITE DHR_1 UniProtKB/TrEMBL
  DHR_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008298 RatGTEx
UniProt A0A0G2K3H2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ACL2 ENTREZGENE, UniProtKB/TrEMBL
  B2RZA1_RAT UniProtKB/TrEMBL
  F1LRS2_RAT UniProtKB/TrEMBL
  F6PUC8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Dock7  dedicator of cytokinesis 7  Dock7_predicted  dedicator of cytokinesis 7 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Dock7_predicted  dedicator of cytokinesis 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED