Klhl30 (kelch-like family member 30) - Rat Genome Database

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Gene: Klhl30 (kelch-like family member 30) Rattus norvegicus
Analyze
Symbol: Klhl30
Name: kelch-like family member 30
RGD ID: 1309644
Description: Orthologous to human KLHL30 (kelch like family member 30); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: kelch-like 30; kelch-like 30 (Drosophila); kelch-like protein 30; LOC316624; RGD1309644; similar to Hypothetical protein KIAA0469
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,389,982 - 99,400,295 (+)NCBIGRCr8
mRatBN7.2991,942,475 - 91,952,756 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,942,504 - 91,952,730 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,369,239 - 100,379,520 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,504,995 - 105,515,278 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,868,592 - 103,878,877 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,490,583 - 98,500,880 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,490,608 - 98,500,867 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0998,167,151 - 98,177,317 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,580,293 - 90,588,134 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1990,781,311 - 90,792,168 (+)NCBI
Celera989,483,479 - 89,493,780 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635  


Genomics

Comparative Map Data
Klhl30
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,389,982 - 99,400,295 (+)NCBIGRCr8
mRatBN7.2991,942,475 - 91,952,756 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl991,942,504 - 91,952,730 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,369,239 - 100,379,520 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,504,995 - 105,515,278 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09103,868,592 - 103,878,877 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,490,583 - 98,500,880 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,490,608 - 98,500,867 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0998,167,151 - 98,177,317 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4990,580,293 - 90,588,134 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1990,781,311 - 90,792,168 (+)NCBI
Celera989,483,479 - 89,493,780 (+)NCBICelera
Cytogenetic Map9q36NCBI
KLHL30
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,138,668 - 238,152,947 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,138,668 - 238,152,947 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,047,309 - 239,061,588 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,714,156 - 238,726,286 (+)NCBINCBI36Build 36hg18NCBI36
Celera2232,759,906 - 232,774,089 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2230,838,490 - 230,852,667 (+)NCBIHuRef
CHM1_12239,052,469 - 239,066,653 (+)NCBICHM1_1
T2T-CHM13v2.02238,628,419 - 238,642,688 (+)NCBIT2T-CHM13v2.0
Klhl30
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,278,795 - 91,290,126 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,278,738 - 91,290,138 (+)EnsemblGRCm39 Ensembl
GRCm38191,351,073 - 91,362,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,351,016 - 91,362,416 (+)EnsemblGRCm38mm10GRCm38
MGSCv37193,247,650 - 93,258,981 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,181,479 - 93,192,810 (+)NCBIMGSCv36mm8
Celera194,288,207 - 94,299,554 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.09NCBI
Klhl30
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555422,418,324 - 2,428,062 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555422,418,399 - 2,427,571 (-)NCBIChiLan1.0ChiLan1.0
KLHL30
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213140,770,218 - 140,786,608 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B140,787,147 - 140,801,575 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B125,370,477 - 125,386,866 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B244,220,949 - 244,234,879 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B244,220,949 - 244,234,879 (+)Ensemblpanpan1.1panPan2
KLHL30
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12548,638,889 - 48,650,050 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2548,640,753 - 48,648,830 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2549,134,407 - 49,146,021 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02549,024,541 - 49,036,145 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2549,025,018 - 49,035,264 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12548,899,709 - 48,911,318 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02548,688,321 - 48,699,927 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02548,920,320 - 48,931,941 (+)NCBIUU_Cfam_GSD_1.0
Klhl30
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303190,591,813 - 190,602,225 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936525337,308 - 347,906 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936525337,473 - 347,860 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL30
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15137,709,322 - 137,721,800 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115137,709,315 - 137,721,806 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215152,121,459 - 152,132,837 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL30
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110124,157,815 - 124,174,204 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10124,161,796 - 124,175,409 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604075,243,014 - 75,258,472 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl30
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248473,302,135 - 3,310,696 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248473,302,124 - 3,310,701 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Klhl30
31 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:124
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000027232
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
631656Bp108Blood pressure QTL 1085.970.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94859825193598251Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
4889943Bss90Bone structure and strength QTL 904.1tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)98636963192058970Rat

Markers in Region
RH141808  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2991,952,367 - 91,952,581 (+)MAPPERmRatBN7.2
Rnor_6.0998,500,495 - 98,500,708NCBIRnor6.0
Rnor_5.0998,177,044 - 98,177,257UniSTSRnor5.0
RGSC_v3.4990,587,837 - 90,588,050UniSTSRGSC3.4
Celera989,493,392 - 89,493,605UniSTS
RH 3.4 Map9785.39UniSTS
Cytogenetic Map9q36UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 34 8 11 2 8
Low 3 9 21 14 8 14 28 35 32 11
Below cutoff 28 19 11 19 46 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027232   ⟹   ENSRNOP00000027232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl991,942,504 - 91,952,730 (+)Ensembl
Rnor_6.0 Ensembl998,490,608 - 98,500,867 (+)Ensembl
RefSeq Acc Id: NM_001399332   ⟹   NP_001386261
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,390,014 - 99,400,295 (+)NCBI
mRatBN7.2991,942,475 - 91,952,756 (+)NCBI
RefSeq Acc Id: XM_039084734   ⟹   XP_038940662
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,391,717 - 99,400,295 (+)NCBI
mRatBN7.2991,944,176 - 91,952,756 (+)NCBI
RefSeq Acc Id: XM_063267317   ⟹   XP_063123387
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8999,389,982 - 99,398,058 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001386261 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940662 (Get FASTA)   NCBI Sequence Viewer  
  XP_063123387 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92029 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000027232
  ENSRNOP00000027232.4
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000027232   ⟸   ENSRNOT00000027232
RefSeq Acc Id: XP_038940662   ⟸   XM_039084734
- Peptide Label: isoform X1
- UniProtKB: D3ZHA2 (UniProtKB/TrEMBL),   A6JQQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386261   ⟸   NM_001399332
- UniProtKB: D3ZHA2 (UniProtKB/TrEMBL),   A6JQQ8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123387   ⟸   XM_063267317
- Peptide Label: isoform X2
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHA2-F1-model_v2 AlphaFold D3ZHA2 1-581 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696863
Promoter ID:EPDNEW_R7382
Type:initiation region
Name:Klhl30_1
Description:kelch-like family member 30
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0998,490,632 - 98,490,692EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309644 AgrOrtholog
BioCyc Gene G2FUF-26719 BioCyc
Ensembl Genes ENSRNOG00000020105 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027232 ENTREZGENE
  ENSRNOT00000027232.7 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  Kelch-like_gigaxonin UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
  KLHL30 UniProtKB/TrEMBL
KEGG Report rno:316624 UniProtKB/TrEMBL
NCBI Gene 316624 ENTREZGENE
PANTHER KELCH PROTEIN UniProtKB/TrEMBL
  PTHR24412:SF398 UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PhenoGen Klhl30 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/TrEMBL
PROSITE BTB UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020105 RatGTEx
SMART BACK UniProtKB/TrEMBL
  BTB UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
  SSF117281 UniProtKB/TrEMBL
UniProt A6JQQ8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZHA2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-27 Klhl30  kelch-like family member 30  Klhl30  kelch-like 30 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Klhl30  kelch-like 30 (Drosophila)  RGD1309644_predicted  similar to Hypothetical protein KIAA0469 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1309644_predicted  similar to Hypothetical protein KIAA0469 (predicted)  LOC316624_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC316624_predicted  similar to Hypothetical protein KIAA0469 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL