Iscu (iron-sulfur cluster assembly enzyme) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Iscu (iron-sulfur cluster assembly enzyme) Rattus norvegicus
Analyze
Symbol: Iscu
Name: iron-sulfur cluster assembly enzyme
RGD ID: 1309562
Description: Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; protein homodimerization activity; and transition metal ion binding activity. Predicted to be involved in several processes, including [2Fe-2S] cluster assembly; negative regulation of iron ion import across plasma membrane; and positive regulation of mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in cytosol and mitochondrion. Predicted to be part of mitochondrial iron-sulfur cluster assembly complex. Predicted to be active in mitochondrial matrix. Orthologous to human ISCU (iron-sulfur cluster assembly enzyme); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: iron-sulfur cluster assembly enzyme ISCU; iron-sulfur cluster assembly enzyme ISCU, mitochondrial; iron-sulfur cluster scaffold homolog; iron-sulfur cluster scaffold homolog (E. coli); IscU iron-sulfur cluster scaffold homolog; IscU iron-sulfur cluster scaffold homolog (E. coli); LOC288740; RGD1309562; similar to nitrogen fixation cluster-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81248,512,852 - 48,518,696 (-)NCBIGRCr8
mRatBN7.21242,852,305 - 42,858,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,852,305 - 42,858,150 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,018,678 - 44,024,102 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01244,632,273 - 44,637,697 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,692,805 - 43,698,229 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,621,454 - 48,627,297 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,621,454 - 48,627,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,403,338 - 50,409,181 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,886,419 - 43,892,329 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11243,749,819 - 43,755,677 (-)NCBI
Celera1244,453,913 - 44,459,757 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N and Rouault TA, Biochim Biophys Acta. 2015 Jun;1853(6):1493-512. doi: 10.1016/j.bbamcr.2014.09.009. Epub 2014 Sep 19.
3. miR-210 is a target of hypoxia-inducible factors 1 and 2 in renal cancer, regulates ISCU and correlates with good prognosis. McCormick RI, etal., Br J Cancer. 2013 Mar 19;108(5):1133-42. doi: 10.1038/bjc.2013.56. Epub 2013 Feb 28.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. MIR-210 modulates mitochondrial respiration in placenta with preeclampsia. Muralimanoharan S, etal., Placenta. 2012 Oct;33(10):816-23. doi: 10.1016/j.placenta.2012.07.002. Epub 2012 Jul 26.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11060020   PMID:12477932   PMID:14651853   PMID:16527810   PMID:17597094   PMID:18614015   PMID:20436681   PMID:26702583   PMID:30656514   PMID:32388695  


Genomics

Comparative Map Data
Iscu
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81248,512,852 - 48,518,696 (-)NCBIGRCr8
mRatBN7.21242,852,305 - 42,858,150 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1242,852,305 - 42,858,150 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1244,018,678 - 44,024,102 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01244,632,273 - 44,637,697 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01243,692,805 - 43,698,229 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01248,621,454 - 48,627,297 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1248,621,454 - 48,627,297 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,403,338 - 50,409,181 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,886,419 - 43,892,329 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11243,749,819 - 43,755,677 (-)NCBI
Celera1244,453,913 - 44,459,757 (-)NCBICelera
Cytogenetic Map12q16NCBI
ISCU
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812108,561,463 - 108,569,384 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12108,562,582 - 108,569,368 (+)EnsemblGRCh38hg38GRCh38
GRCh3712108,955,239 - 108,963,160 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612107,480,512 - 107,487,273 (+)NCBINCBI36Build 36hg18NCBI36
Celera12108,625,685 - 108,632,553 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12106,020,849 - 106,027,716 (+)NCBIHuRef
CHM1_112108,922,512 - 108,929,380 (+)NCBICHM1_1
T2T-CHM13v2.012108,530,831 - 108,538,753 (+)NCBIT2T-CHM13v2.0
Iscu
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395113,910,479 - 113,916,349 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5113,910,809 - 113,916,349 (+)EnsemblGRCm39 Ensembl
GRCm385113,772,418 - 113,778,288 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5113,772,748 - 113,778,288 (+)EnsemblGRCm38mm10GRCm38
MGSCv375114,222,821 - 114,228,291 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365114,033,811 - 114,039,281 (+)NCBIMGSCv36mm8
Celera5110,873,936 - 110,879,406 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.55NCBI
Iscu
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554559,833,924 - 9,841,619 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554559,833,924 - 9,840,547 (+)NCBIChiLan1.0ChiLan1.0
ISCU
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210116,622,727 - 116,629,492 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112116,619,125 - 116,625,859 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012106,132,987 - 106,140,879 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112109,529,162 - 109,537,053 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12109,529,162 - 109,537,053 (+)Ensemblpanpan1.1panPan2
ISCU
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12618,300,800 - 18,307,668 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2618,300,803 - 18,307,652 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2617,492,198 - 17,499,090 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02618,647,123 - 18,654,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2618,647,126 - 18,653,991 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12617,701,195 - 17,708,096 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02618,638,137 - 18,645,016 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02618,656,527 - 18,663,400 (-)NCBIUU_Cfam_GSD_1.0
Iscu
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118144,977,307 - 144,983,670 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936769491,530 - 498,692 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936769492,024 - 498,587 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISCU
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1442,216,111 - 42,222,711 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11442,216,103 - 42,222,570 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21444,761,391 - 44,767,990 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ISCU
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111103,753,175 - 103,760,168 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11103,753,189 - 103,760,364 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037141,335,350 - 141,342,158 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iscu
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474711,808,640 - 11,816,400 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474711,808,789 - 11,815,269 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Iscu
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:65
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000000890
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
RH128101  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,852,372 - 42,852,554 (+)MAPPERmRatBN7.2
Rnor_6.01248,621,522 - 48,621,703NCBIRnor6.0
Rnor_5.01250,403,406 - 50,403,587UniSTSRnor5.0
RGSC_v3.41243,886,487 - 43,886,668UniSTSRGSC3.4
Celera1244,453,981 - 44,454,162UniSTS
Cytogenetic Map12q16UniSTS
RH129226  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,852,369 - 42,852,551 (+)MAPPERmRatBN7.2
Rnor_6.01248,621,519 - 48,621,700NCBIRnor6.0
Rnor_5.01250,403,403 - 50,403,584UniSTSRnor5.0
RGSC_v3.41243,886,484 - 43,886,665UniSTSRGSC3.4
Celera1244,453,978 - 44,454,159UniSTS
Cytogenetic Map12q16UniSTS
RH129298  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21242,852,347 - 42,852,515 (+)MAPPERmRatBN7.2
Rnor_6.01248,621,497 - 48,621,664NCBIRnor6.0
Rnor_5.01250,403,381 - 50,403,548UniSTSRnor5.0
RGSC_v3.41243,886,462 - 43,886,629UniSTSRGSC3.4
Celera1244,453,956 - 44,454,123UniSTS
RH 3.4 Map8428.0UniSTS
Cytogenetic Map12q16UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000890   ⟹   ENSRNOP00000000890
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1242,852,305 - 42,858,150 (-)Ensembl
Rnor_6.0 Ensembl1248,621,454 - 48,627,297 (-)Ensembl
RefSeq Acc Id: NM_001105936   ⟹   NP_001099406
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81248,512,852 - 48,518,696 (-)NCBI
mRatBN7.21242,852,305 - 42,858,150 (-)NCBI
Rnor_6.01248,621,454 - 48,627,297 (-)NCBI
Rnor_5.01250,403,338 - 50,409,181 (-)NCBI
RGSC_v3.41243,886,419 - 43,892,329 (-)RGD
Celera1244,453,913 - 44,459,757 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099406 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI67056 (Get FASTA)   NCBI Sequence Viewer  
  EDM13962 (Get FASTA)   NCBI Sequence Viewer  
  EDM13963 (Get FASTA)   NCBI Sequence Viewer  
  EDM13964 (Get FASTA)   NCBI Sequence Viewer  
  EDM13965 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000890
  ENSRNOP00000000890.4
Reference Protein Sequences
RefSeq Acc Id: NP_001099406   ⟸   NM_001105936
- UniProtKB: B2RZ79 (UniProtKB/TrEMBL),   F6T7V8 (UniProtKB/TrEMBL),   A6J225 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000890   ⟸   ENSRNOT00000000890
Protein Domains
NIF system FeS cluster assembly NifU N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RZ79-F1-model_v2 AlphaFold B2RZ79 1-167 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698720
Promoter ID:EPDNEW_R9244
Type:multiple initiation site
Name:Iscu_1
Description:iron-sulfur cluster assembly enzyme
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01248,627,287 - 48,627,347EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309562 AgrOrtholog
BioCyc Gene G2FUF-18927 BioCyc
Ensembl Genes ENSRNOG00000000701 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000890 ENTREZGENE
  ENSRNOT00000000890.6 UniProtKB/TrEMBL
Gene3D-CATH 3.90.1010.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7369214 IMAGE-MGC_LOAD
InterPro ISC_FeS_clus_asmbl_IscU UniProtKB/TrEMBL
  NIF_FeS_clus_asmbl_NifU_N UniProtKB/TrEMBL
KEGG Report rno:288740 UniProtKB/TrEMBL
MGC_CLONE MGC:189356 IMAGE-MGC_LOAD
NCBI Gene 288740 ENTREZGENE
PANTHER NIFU_N DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PTHR10093 UniProtKB/TrEMBL
Pfam NifU_N UniProtKB/TrEMBL
PhenoGen Iscu PhenoGen
RatGTEx ENSRNOG00000000701 RatGTEx
Superfamily-SCOP SufE/NifU UniProtKB/TrEMBL
UniProt A6J225 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ79 ENTREZGENE, UniProtKB/TrEMBL
  F6T7V8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-16 Iscu  iron-sulfur cluster assembly enzyme  Iscu  iron-sulfur cluster scaffold homolog (E. coli)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-16 Iscu  iron-sulfur cluster scaffold homolog (E. coli)  Iscu  IscU iron-sulfur cluster scaffold homolog (E. coli)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Iscu  IscU iron-sulfur cluster scaffold homolog (E. coli)  RGD1309562_predicted  similar to nitrogen fixation cluster-like (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1309562_predicted  similar to nitrogen fixation cluster-like (predicted)  LOC288740_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC288740_predicted  similar to nitrogen fixation cluster-like (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL