Ppm1h (protein phosphatase, Mg2+/Mn2+ dependent, 1H)

Gene: Ppm1h (protein phosphatase, Mg2+/Mn2+ dependent, 1H) Rattus norvegicus

Analyze

Symbol:

Ppm1h

Name:

protein phosphatase, Mg2+/Mn2+ dependent, 1H

RGD ID:

1309528

Description:

Predicted to enable [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity and identical protein binding activity. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in glutamatergic synapse and mitochondrion. Orthologous to human PPM1H (protein phosphatase, Mg2+/Mn2+ dependent 1H); INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC314897; protein phosphatase 1H; protein phosphatase 1H (PP2C domain containing)

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	60,224,087 - 60,484,947 (+)	NCBI		GRCr8
mRatBN7.2	7	58,338,661 - 58,599,547 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	58,338,661 - 58,599,547 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	60,210,942 - 60,471,785 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	62,413,758 - 62,674,422 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	62,191,633 - 62,451,550 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	66,845,692 - 67,116,979 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	66,843,865 - 67,116,980 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	67,039,424 - 67,310,772 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	62,448,527 - 62,711,587 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	62,668,699 - 62,732,316 (+)	NCBI
Celera	7	55,512,891 - 55,771,406 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,3-dinitrobenzene (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (EXP,ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenite(3-) (ISO)

atrazine (EXP)

azathioprine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

butanal (ISO)

caffeine (ISO)

calcitriol (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dicrotophos (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

entinostat (ISO)

enzyme inhibitor (ISO)

ethanol (ISO)

flusilazole (EXP)

FR900359 (ISO)

gentamycin (EXP)

lead(0) (ISO)

lithium chloride (ISO)

melphalan (ISO)

mercury dibromide (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N,N-diethyl-m-toluamide (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

progesterone (ISO)

quercetin (ISO)

rotenone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

thioacetamide (EXP)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytoplasm (IEA,ISO,ISS)

glutamatergic synapse (ISO)

mitochondrion (IBA)

nucleoplasm (IEA,ISO)

nucleus (IEA,ISO,ISS)

synapse (ISO)

Molecular Function

[pyruvate dehydrogenase (acetyl-transferring)]-phosphatase activity (IBA)

identical protein binding (ISO)

myosin phosphatase activity (IEA)

phosphoprotein phosphatase activity (ISO,ISS)

protein binding (ISO)

protein serine/threonine phosphatase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:22586611	PMID:24413018

Genomics

Comparative Map Data

Ppm1h
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	60,224,087 - 60,484,947 (+)	NCBI		GRCr8
mRatBN7.2	7	58,338,661 - 58,599,547 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	58,338,661 - 58,599,547 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	60,210,942 - 60,471,785 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	62,413,758 - 62,674,422 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	62,191,633 - 62,451,550 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	66,845,692 - 67,116,979 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	66,843,865 - 67,116,980 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	67,039,424 - 67,310,772 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	62,448,527 - 62,711,587 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	62,668,699 - 62,732,316 (+)	NCBI
Celera	7	55,512,891 - 55,771,406 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

PPM1H
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	62,643,994 - 62,935,150 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	62,643,994 - 62,935,150 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	63,037,774 - 63,328,930 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	61,324,029 - 61,614,932 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	12	62,706,254 - 62,997,164 (-)	NCBI		Celera
Cytogenetic Map	12	q14.1-q14.2	NCBI
HuRef	12	60,087,765 - 60,379,948 (-)	NCBI		HuRef
CHM1_1	12	63,005,564 - 63,296,508 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	62,622,756 - 62,913,942 (-)	NCBI		T2T-CHM13v2.0

Ppm1h
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	122,512,720 - 122,781,700 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	122,514,667 - 122,781,700 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	122,677,428 - 122,945,795 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	122,678,762 - 122,945,795 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	122,115,818 - 122,382,851 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	122,082,079 - 122,324,989 (+)	NCBI		MGSCv36	mm8
Celera	10	125,060,400 - 125,324,712 (+)	NCBI		Celera
Cytogenetic Map	10	D2	NCBI
cM Map	10	70.44	NCBI

Ppm1h
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955458	9,742,629 - 9,899,167 (-)	NCBI	ChiLan1.0	ChiLan1.0

PPM1H
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	31,417,010 - 31,706,699 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	31,413,782 - 31,703,472 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	26,009,094 - 26,299,159 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	26,281,960 - 26,571,046 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	26,281,957 - 26,566,551 (+)	Ensembl	panpan1.1		panPan2

PPM1H
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	5,818,660 - 6,072,182 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	5,818,588 - 6,072,251 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	5,748,686 - 6,001,877 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	5,855,584 - 6,109,395 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	5,857,527 - 6,109,594 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	5,796,507 - 6,050,145 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	6,047,496 - 6,300,693 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	6,185,277 - 6,439,155 (-)	NCBI		UU_Cfam_GSD_1.0

Ppm1h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	52,560,471 - 52,821,554 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936545	1,289,483 - 1,550,059 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936545	1,293,216 - 1,549,976 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PPM1H
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	27,299,778 - 27,572,618 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	27,299,777 - 27,572,303 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	30,314,442 - 30,339,676 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PPM1H
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	58,534,621 - 58,820,709 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	58,534,472 - 58,820,387 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	186,990,066 - 187,274,493 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ppm1h
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	5,100,035 - 5,387,998 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	5,099,669 - 5,402,185 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ppm1h
1772 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	656
Count of miRNA genes:	263
Interacting mature miRNAs:	340
Transcripts:	ENSRNOT00000005798, ENSRNOT00000066381
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	9462246	98011544	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	9866467	60460686	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	15573889	60573889	Rat
2317059	Aia15	Adjuvant induced arthritis QTL 15	2.46		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	7	17004598	62004598	Rat
10755451	Coatc11	Coat color QTL 11		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	17944357	62944357	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	19654317	84928080	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	21921195	66921195	Rat
1641885	Alcrsp9	Alcohol response QTL 9			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	7	24099606	69099606	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	24751841	69751841	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	26737401	63902784	Rat
10402855	Bp379	Blood pressure QTL 379		0.21	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	29409683	74409683	Rat
1300127	Srn1	Serum renin concentration QTL 1	3.87		blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	7	29409683	84928080	Rat
10755453	Coatc12	Coat color QTL 12		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	31112832	76112832	Rat
7411605	Foco14	Food consumption QTL 14	24.1	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	34293282	79293282	Rat
631534	Lnnr1	Liver neoplastic nodule remodeling QTL 1	3.85	0.001	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	7	34293282	79293282	Rat
631513	Scl7	Serum cholesterol level QTL 7	4.1		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	37960569	82960569	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
634326	Hc3	Hypercalciuria QTL 3	2.1		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	7	42787314	87787314	Rat
10053722	Scort27	Serum corticosterone level QTL 27	2.41	0.0083	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	43228750	88228750	Rat
1358361	Sradr5	Stress Responsive Adrenal Weight QTL 5	5.55		adrenal gland mass (VT:0010420)	both adrenal glands wet weight (CMO:0000164)	7	43747012	108555253	Rat
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1300149	Cm6	Cardiac mass QTL 6	4.09		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	7	43747099	102228765	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
61428	Scl3	Serum cholesterol level QTL 3	3.2		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	7	44867533	89867533	Rat
738030	Anxrr8	Anxiety related response QTL 8	4.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	46590070	91590070	Rat
10059605	Kidm47	Kidney mass QTL 47	2.91	0.05	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	47251783	65728867	Rat
2293696	Bmd32	Bone mineral density QTL 32	5.1	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	7	47651439	92651439	Rat
2293707	Bss32	Bone structure and strength QTL 32	7.64	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	47651439	92651439	Rat
2300178	Bmd54	Bone mineral density QTL 54	5.3	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	7	47651439	92651439	Rat
2293644	Bmd29	Bone mineral density QTL 29	5.4	0.0001	femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	7	47651439	92651439	Rat
2293667	Bss42	Bone structure and strength QTL 42	7.25	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	7	47651439	92651439	Rat
2293678	Bss24	Bone structure and strength QTL 24	6.71	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	7	47651439	92651439	Rat
2293685	Bmd21	Bone mineral density QTL 21	4.2	0.0003	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	7	47651439	92651439	Rat
1300151	Bp181	Blood pressure QTL 181	3.36		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	7	53612714	103945643	Rat
61435	Cia4	Collagen induced arthritis QTL 4	5.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	7	58113224	62004598	Rat

Markers in Region

D7Rat220

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	58,532,055 - 58,532,298 (-)	MAPPER	mRatBN7.2
Rnor_6.0	7	66,913,198 - 66,913,440	NCBI	Rnor6.0
Rnor_5.0	7	67,109,037 - 67,109,279	UniSTS	Rnor5.0
RGSC_v3.4	7	62,643,999 - 62,644,242	RGD	RGSC3.4
RGSC_v3.4	7	62,644,000 - 62,644,242	UniSTS	RGSC3.4
RGSC_v3.1	7	62,664,729 - 62,664,972	RGD
Celera	7	55,704,429 - 55,704,671	UniSTS
FHH x ACI Map	7	33.38	RGD
FHH x ACI Map	7	33.38	UniSTS
Cytogenetic Map	7	q22	UniSTS

D7Got44

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	58,528,097 - 58,528,354 (-)	MAPPER	mRatBN7.2
Rnor_6.0	7	66,917,142 - 66,917,398	NCBI	Rnor6.0
Rnor_5.0	7	67,112,981 - 67,113,237	UniSTS	Rnor5.0
RGSC_v3.4	7	62,640,041 - 62,640,298	RGD	RGSC3.4
RGSC_v3.4	7	62,640,042 - 62,640,298	UniSTS	RGSC3.4
RGSC_v3.1	7	62,660,772 - 62,661,028	RGD
Celera	7	55,700,477 - 55,700,727	UniSTS
RH 3.4 Map	7	503.0	UniSTS
RH 3.4 Map	7	503.0	RGD
RH 2.0 Map	7	420.6	RGD
Cytogenetic Map	7	q22	UniSTS

D7Got42

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	66,911,805 - 66,912,033	NCBI	Rnor6.0
Rnor_5.0	7	67,107,644 - 67,107,872	UniSTS	Rnor5.0
RGSC_v3.4	7	62,645,406 - 62,645,635	RGD	RGSC3.4
RGSC_v3.4	7	62,645,407 - 62,645,635	UniSTS	RGSC3.4
RGSC_v3.1	7	62,666,136 - 62,666,365	RGD
Celera	7	55,705,836 - 55,706,052	UniSTS
Cytogenetic Map	7	q22	UniSTS

BI301844

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	58,529,085 - 58,529,282 (-)	MAPPER	mRatBN7.2
Rnor_6.0	7	66,916,214 - 66,916,410	NCBI	Rnor6.0
Rnor_5.0	7	67,112,053 - 67,112,249	UniSTS	Rnor5.0
RGSC_v3.4	7	62,641,030 - 62,641,226	UniSTS	RGSC3.4
Celera	7	55,701,459 - 55,701,655	UniSTS
RH 3.4 Map	7	503.3	UniSTS
Cytogenetic Map	7	q22	UniSTS

RH132891

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	58,599,304 - 58,599,504 (-)	MAPPER	mRatBN7.2
Rnor_6.0	7	66,845,735 - 66,845,934	NCBI	Rnor6.0
Rnor_5.0	7	67,042,665 - 67,042,864	UniSTS	Rnor5.0
RGSC_v3.4	7	62,711,345 - 62,711,544	UniSTS	RGSC3.4
Celera	7	55,771,164 - 55,771,363	UniSTS
RH 3.4 Map	7	502.8	UniSTS
Cytogenetic Map	7	q22	UniSTS

BF403398

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	58,445,044 - 58,445,147 (-)	MAPPER	mRatBN7.2
Rnor_6.0	7	67,010,657 - 67,010,759	NCBI	Rnor6.0
Rnor_5.0	7	67,204,112 - 67,204,214	UniSTS	Rnor5.0
RGSC_v3.4	7	62,556,117 - 62,556,219	UniSTS	RGSC3.4
Celera	7	55,617,467 - 55,617,569	UniSTS
RH 3.4 Map	7	503.5	UniSTS
Cytogenetic Map	7	q22	UniSTS

AU046503

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_5.0	7	67,211,145 - 67,212,612	UniSTS	Rnor5.0
Rnor_5.0	19	10,269,521 - 10,269,692	UniSTS	Rnor5.0
Cytogenetic Map	7	q22	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			1		6				50	35	9	11
Low	3	43	56	41	13	41	8	11	24		32		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001271079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039079145	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC088307	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ228208	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000005798 ⟹ ENSRNOP00000005798

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	58,338,661 - 58,599,547 (+)	Ensembl
Rnor_6.0 Ensembl	7	66,843,865 - 67,116,980 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000066381 ⟹ ENSRNOP00000061506

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	58,536,036 - 58,599,546 (+)	Ensembl
Rnor_6.0 Ensembl	7	66,845,693 - 66,909,470 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108058 ⟹ ENSRNOP00000084629

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	58,560,578 - 58,599,547 (+)	Ensembl

RefSeq Acc Id:

NM_001271079 ⟹ NP_001258008

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	60,224,087 - 60,484,947 (+)	NCBI
mRatBN7.2	7	58,338,661 - 58,599,547 (+)	NCBI
Rnor_6.0	7	66,845,692 - 67,116,979 (-)	NCBI
Rnor_5.0	7	67,039,424 - 67,310,772 (-)	NCBI
Celera	7	55,512,891 - 55,771,406 (+)	NCBI

Sequence:

show sequence

CCCCGCGCTGCACCTCGGCCGGCCGCCGCCTCCTGCTCGCTCAGCGGCTGCCCGGCGCCGGAGT
AATATGCTCACTCGGGTGAAATCTGCCGTGGCCAATTTCATGGGCGGCATCATGGCTGGCAGCT
CCGGCTCCGAGCACGGCGGCAGCGGCTGCGGAGGCTCGGACCTGCCCCTGCGCTTCCCGTACGG
GCGGCCAGAGTTCCTCGGGCTGTCTCAGGATGAGGTGGAGTGCAGCGCAGACCACATCGCCCGC
CCCATCCTCATCCTCAAGGAGACCCGGCGGCTGCCCTGGGCCACGGGCTACGCAGAGGTTATTA
ATGCTGGAAAGAGCACACACAATGAGGACCAAGCCAGCTGCGAGGTGCTCACAGTGAAGAAGAA
AGTTGGGACCATTACTTCCACCCCGAACAGAAATTCCAAGCGAAGGTCATCCCTTCCCAACGGG
GAAGGCCTGCAGTTAAAGGAGAACTCTGAGTCTGAGGGCATCTCCTGCCACTACTGGTCCCTGT
TTGATGGCCACGCAGGCTCAGGTGCTGCTGTGGTGGCATCGCGCCTGCTGCAGCACCACATCAC
ACAACAGCTGCAGGACATCGTGGAGATCCTGAAGAACTCCGCCATCCTTCCCCCGACCTGCCTA
GGGGAGGAGCCAGAGAGCACGCCGGCCCATGGCAGGACCCTAACCCGCGCAGCCTCACTGCGTG
GAGGGGTGGGTGCCCCCGGCTCCCCCAGCACACCACCCACGCGCTTCTTCACGGAGAAGAAGAT
TCCTCATGAGTGTTTGGTCATCGGGGCCCTGGAGAGCGCCTTCAAGGAAATGGACCTTCAAATT
GAACGGGAGAGGAGTGCATATAATATATCCGGTGGCTGCACGGCCCTCATCGTGGTTTGCCTTC
TGGGGAAGCTCTACGTGGCAAATGCAGGTGACAGCAGGGCCATAATCATCCGAAATGGAGAAAT
CATCCCCATGTCTTCCGAATTCACCCCTGAGACTGAGCGTCAGAGACTTCAGTACCTGGCGTTC
ATGCAGCCTCACTTGCTGGGAAATGAGTTCACACACTTGGAGTTTCCAAGGAGAGTACAGAGGA
AAGAACTCGGGAAGAAGATGCTGTACCGGGACTTTAACATGACAGGCTGGGCATACAAAACCAT
TGAGGATGATGACTTGAAGTTTCCCCTTATATATGGAGAAGGCAAGAAGGCCCGGGTAATGGCA
ACTATTGGAGTGACAAGGGGACTTGGGGACCATGACCTGAAGGTTCATGACTCCAACATCTACA
TAAAACCATTCCTGTCTTCAGCTCCAGAGGTCAGAGTCTACGATCTCTCCAAATACGAGCACGG
AGCGGATGACGTGCTGATCCTGGCTACTGATGGACTCTGGGATGTCTTATCAAATGAAGAAGTA
GCGGAAGCAATCACTCAGTTTCTTCCTAACTGTGATCCAGATGACCCTCACAGGTACACACTGG
CAGCTCAGGACCTGGTGATGCGTGCCCGAGGCGTCCTGAAGGACCGAGGATGGCGGATATCAAA
TGACCGACTGGGCTCAGGAGATGACATTTCTGTATACGTCATTCCTTTAATACACGGAAACAAA
CTGTCATGAAAGTGACCCAGGGGACTAGGAAGACAGAAGAAGGGAAGAAAACTGGGGTGCCTCC
AAGCAGGGCGGGACTGGGGAGTAAGTACCTGGGCTGGATTCCAGGTGACGCACATTTTCCCCAG
CCCAGGTGGGGAATTTGCTGCCAAAAGGCCTCTGGCTTTGCTTCAAGGAGACCCTTGGGTTTCC
GTTTCTTCTTTGGTAACAGGTCTGGACACTGAATAAGAGCAAAACGCACAGCCTGCTACTGAGG
GTTACATCTCTCTTGGTTTCTACAGTAGGGCTCCTAGGCGGCAGCAGCCTATTTGGGGCGCAGG
CACACGTTTATTTATTTTACCTAGAATAGCAGGGACAGCCATTCCGGGTGTAACTGGTAAAAGA
CTTCTCAGCCTGTCAAGCTGCCAGCATCTCTCCAGGAGAAGAGCCACATTGAAAAGTTGGGGGA
CCATACCTCAGAAAGTACGAGCAGTCATCTCATTGTGTGTTCCAGTTATTTCAGGGATCCTTCC
TGCCCCCCATTTCCTGCCCCCTCCGTTTCTCTATATTCTTTTGTGGTGATGGTGGGGTGAGGCA
GAGTTTTTTTGGGTTTTTTTTTGTTTTGTTTTTGTTTTTTTGACATTTCTCCCATCTTTCCCAT
TTCCCTCCACCGGGACTTTCCAAATTGTCACTGGACAGTTTCCAGATCAGAAACCAGCCCATTC
TGACTAGTCCCATGTTCTGTGCCCCATAGTTTTGTCCAGAGCAATGTCTAAGGTGACGGTCTGT
CTTTGTTGTGTAACATTTACCCCGGGGTTCTGTTTTTCTCCCCAAATAGATATGTTTGCTTCAA
AACATGGGTGTTTCATTGGACCAGTGGTTCCTGGGTTATCTTTAAGGCCCCTCTGTGTGTCTGG
AGGCTCTGCCACGAGAGGCTGGGTTTGCGGTTCTGGATTGGCGATACTCCCCGCCTTCTGTGTC
CTGGAGAGGCATAGGAAGCAGCGTCCAGCACCACGGCTAAGCAGGCTCTTGTATCCAGCACTTG
ACCATGTTTCCTTAGGGAAGGGGGTGTGGGATTCAGGCTCCTTGGTCGCTGACTGTTCTCCAGG
CACAGGAGGATCGAGTGTCACAGCTCAGCTAAGCAGCAGCTCTTCCTGACACCTTTGTGCAAGG
ATAACTAGGATGACACTTGAATAAAAGTGAATTTGAATTGCA

hide sequence

RefSeq Acc Id:

XM_039079145 ⟹ XP_038935073

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	60,224,154 - 60,372,897 (+)	NCBI
mRatBN7.2	7	58,338,667 - 58,476,565 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001258008	(Get FASTA)	NCBI Sequence Viewer
	XP_038935073	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88307	(Get FASTA)	NCBI Sequence Viewer
	EDM16538	(Get FASTA)	NCBI Sequence Viewer
	EDM16539	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005798
	ENSRNOP00000005798.4
	ENSRNOP00000061506
	ENSRNOP00000061506.3
	ENSRNOP00000084629.1
GenBank Protein	Q5M821	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001258008 ⟸ NM_001271079

- UniProtKB:

Q5M821 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MLTRVKSAVANFMGGIMAGSSGSEHGGSGCGGSDLPLRFPYGRPEFLGLSQDEVECSADHIARP
ILILKETRRLPWATGYAEVINAGKSTHNEDQASCEVLTVKKKVGTITSTPNRNSKRRSSLPNGE
GLQLKENSESEGISCHYWSLFDGHAGSGAAVVASRLLQHHITQQLQDIVEILKNSAILPPTCLG
EEPESTPAHGRTLTRAASLRGGVGAPGSPSTPPTRFFTEKKIPHECLVIGALESAFKEMDLQIE
RERSAYNISGGCTALIVVCLLGKLYVANAGDSRAIIIRNGEIIPMSSEFTPETERQRLQYLAFM
QPHLLGNEFTHLEFPRRVQRKELGKKMLYRDFNMTGWAYKTIEDDDLKFPLIYGEGKKARVMAT
IGVTRGLGDHDLKVHDSNIYIKPFLSSAPEVRVYDLSKYEHGADDVLILATDGLWDVLSNEEVA
EAITQFLPNCDPDDPHRYTLAAQDLVMRARGVLKDRGWRISNDRLGSGDDISVYVIPLIHGNKL
S

hide sequence

RefSeq Acc Id:

ENSRNOP00000061506 ⟸ ENSRNOT00000066381

RefSeq Acc Id:

ENSRNOP00000005798 ⟸ ENSRNOT00000005798

RefSeq Acc Id:	XP_038935073 ⟸ XM_039079145
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSRNOP00000084629 ⟸ ENSRNOT00000108058

Protein Domains

PPM-type phosphatase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5M821-F1-model_v2	AlphaFold	Q5M821	1-513	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309528	AgrOrtholog
BioCyc Gene	G2FUF-33854	BioCyc
Ensembl Genes	ENSRNOG00000004314	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005798	ENTREZGENE
	ENSRNOT00000005798.8	UniProtKB/Swiss-Prot
	ENSRNOT00000066381	UniProtKB/TrEMBL
	ENSRNOT00000066381.2	UniProtKB/Swiss-Prot
	ENSRNOT00000108058.1	UniProtKB/TrEMBL
Gene3D-CATH	3.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7324259	IMAGE-MGC_LOAD
InterPro	PP2C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PPM-type_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PPM-type_phosphatase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:314897	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:109521	IMAGE-MGC_LOAD
NCBI Gene	314897	ENTREZGENE
PANTHER	PROTEIN PHOSPHATASE 1H	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR13832	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PP2C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ppm1h	PhenoGen
PROSITE	PPM_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000004314	RatGTEx
SMART	PP2Cc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF81606	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0H2UI17_RAT	UniProtKB/TrEMBL
	A0A8I6A011_RAT	UniProtKB/TrEMBL
	A6HQN3_RAT	UniProtKB/TrEMBL
	A6HQN4_RAT	UniProtKB/TrEMBL
	PPM1H_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-10-10	Ppm1h	protein phosphatase, Mg2+/Mn2+ dependent, 1H	Ppm1h	protein phosphatase 1H (PP2C domain containing)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Ppm1h	protein phosphatase 1H (PP2C domain containing)	Ppm1h_predicted	protein phosphatase 1H (PP2C domain containing) (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Ppm1h_predicted	protein phosphatase 1H (PP2C domain containing) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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