Dclk3 (doublecortin-like kinase 3)

Gene: Dclk3 (doublecortin-like kinase 3) Rattus norvegicus

Analyze

Symbol:

Dclk3

Name:

doublecortin-like kinase 3

RGD ID:

1309232

Description:

Predicted to enable protein kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within negative regulation of protein localization to nucleus. Predicted to be active in cytoplasm and nucleus. Orthologous to human DCLK3 (doublecortin like kinase 3); INTERACTS WITH 6-propyl-2-thiouracil; acrylamide; amitrole.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Dcamkl3; doublecortin and CaM kinase-like 3; LOC316023; RGD1309232; serine/threonine-protein kinase DCLK3; similar to hypothetical protein C730036H08

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DCLK3 (doublecortin like kinase 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dclk3 (doublecortin-like kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dclk3 (doublecortin like kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DCLK3 (doublecortin like kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DCLK3 (doublecortin like kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dclk3 (doublecortin like kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DCLK3 (doublecortin like kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DCLK3 (doublecortin like kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dclk3 (doublecortin like kinase 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DCLK3 (doublecortin like kinase 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dclk3 (doublecortin-like kinase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	dclk3 (doublecortin-like kinase 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dclk3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	120,279,916 - 120,332,362 (+)	NCBI		GRCr8
mRatBN7.2	8	111,401,544 - 111,453,999 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	111,401,358 - 111,453,999 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	117,017,621 - 117,069,994 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	115,216,862 - 115,269,245 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	113,059,687 - 113,112,073 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	119,691,567 - 119,744,484 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	119,691,388 - 119,744,506 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	119,040,830 - 119,093,605 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	115,830,472 - 115,883,560 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	115,849,754 - 115,902,190 (+)	NCBI
Celera	8	110,683,369 - 110,735,326 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

amitrole (EXP)

benzo[a]pyrene (EXP,ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP)

Butylbenzyl phthalate (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

Cuprizon (EXP)

dibutyl phthalate (EXP)

diethyl phthalate (EXP)

diisobutyl phthalate (EXP)

diisononyl phthalate (EXP)

dimethylarsinic acid (ISO)

epoxiconazole (ISO)

ethanol (ISO)

ethylparaben (ISO)

formaldehyde (ISO)

furan (ISO)

genistein (ISO)

gentamycin (EXP)

glycidol (EXP)

methimazole (EXP)

methoxychlor (EXP)

methylarsonic acid (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodiethylamine (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

propiconazole (EXP)

rotenone (EXP,ISO)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

tetrachloromethane (ISO)

thioacetamide (EXP)

tributylstannane (ISO)

triclosan (ISO)

Triptolide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

intracellular signal transduction (IEA)

negative regulation of protein localization to nucleus (ISO)

protein localization to nucleus (ISO)

Cellular Component

cytoplasm (IBA,ISO)

nucleus (IBA,ISO)

Molecular Function

ATP binding (IEA)

protein binding (ISO)

protein kinase activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:16684769	PMID:16869982	PMID:19103603	PMID:20236041

Genomics

Comparative Map Data

Dclk3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	120,279,916 - 120,332,362 (+)	NCBI		GRCr8
mRatBN7.2	8	111,401,544 - 111,453,999 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	111,401,358 - 111,453,999 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	8	117,017,621 - 117,069,994 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	8	115,216,862 - 115,269,245 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	8	113,059,687 - 113,112,073 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	8	119,691,567 - 119,744,484 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	119,691,388 - 119,744,506 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	119,040,830 - 119,093,605 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	8	115,830,472 - 115,883,560 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	8	115,849,754 - 115,902,190 (+)	NCBI
Celera	8	110,683,369 - 110,735,326 (+)	NCBI		Celera
Cytogenetic Map	8	q32	NCBI

DCLK3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	36,712,421 - 36,764,553 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	36,712,421 - 36,764,553 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	36,753,912 - 36,806,044 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	36,728,917 - 36,756,356 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	36,696,656 - 36,724,088 (-)	NCBI		Celera
Cytogenetic Map	3	p22.2	NCBI
HuRef	3	36,694,656 - 36,722,087 (-)	NCBI		HuRef
CHM1_1	3	36,704,133 - 36,731,552 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	36,713,774 - 36,765,897 (-)	NCBI		T2T-CHM13v2.0

Dclk3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	111,268,149 - 111,318,679 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	111,268,149 - 111,318,186 (+)	Ensembl		GRCm39 Ensembl
GRCm38	9	111,439,081 - 111,489,611 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	111,439,081 - 111,489,118 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	111,341,585 - 111,392,115 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	111,283,929 - 111,333,929 (+)	NCBI		MGSCv36	mm8
Celera	9	111,166,896 - 111,211,288 (+)	NCBI		Celera
Cytogenetic Map	9	F3	NCBI
cM Map	9	61.33	NCBI

Dclk3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955421	3,590,455 - 3,636,801 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955421	3,593,328 - 3,618,427 (-)	NCBI	ChiLan1.0	ChiLan1.0

DCLK3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	36,673,826 - 36,726,054 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	36,678,590 - 36,730,815 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	36,620,793 - 36,670,506 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	36,911,427 - 36,936,326 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	36,911,427 - 36,936,326 (-)	Ensembl	panpan1.1		panPan2

DCLK3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	23	6,631,052 - 6,662,949 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	23	6,670,192 - 6,703,255 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	23	6,915,927 - 6,948,984 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	23	6,735,483 - 6,768,548 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	23	6,878,025 - 6,910,766 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	23	6,868,873 - 6,901,240 (-)	NCBI		UU_Cfam_GSD_1.0

Dclk3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	193,161,622 - 193,203,351 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	26,299,761 - 26,341,884 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936473	26,300,195 - 26,320,953 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DCLK3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	22,040,510 - 22,095,473 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	22,040,518 - 22,095,477 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	23,860,743 - 23,989,814 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DCLK3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	15	2,641,036 - 2,690,573 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	15	2,666,575 - 2,693,611 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666063	11,378,325 - 11,429,770 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dclk3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624788	14,753,483 - 14,787,715 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624788	14,753,550 - 14,787,721 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dclk3
550 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	317
Count of miRNA genes:	211
Interacting mature miRNAs:	238
Transcripts:	ENSRNOT00000044742
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631650	Stl6	Serum triglyceride level QTL 6	4	0.0019	blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	8	10378157	112202585	Rat
1554321	Bmd3	Bone mineral density QTL 3	7.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	40952565	123900184	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	8	46531639	119088626	Rat
70197	BpQTLcluster8	Blood pressure QTL cluster 8	3.482		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	46531639	119088626	Rat
2303171	Bp331	Blood pressure QTL 331	5.57	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	8	61290298	119084929	Rat
631210	Bw3	Body weight QTL3	5.9		mesenteric fat pad mass (VT:0010427)	mesenteric fat pad weight to body weight ratio (CMO:0000654)	8	69349194	112783834	Rat
1300171	Bp184	Blood pressure QTL 184	3.66		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	8	70513503	118219066	Rat
8694446	Bw170	Body weight QTL 170	12.07	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	8	71888757	116888757	Rat
9590292	Uminl3	Urine mineral level QTL 3	3.62	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	8	71888757	116888757	Rat
8694200	Abfw4	Abdominal fat weight QTL 4	9.07	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	8	71888757	116888757	Rat
8694392	Bw161	Body weight QTL 161	8.06	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	8	71888757	116888757	Rat
1549909	Stresp11	Stress response QTL 11	6.83	0.0019	stress-related behavior trait (VT:0010451)	number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)	8	73473045	118473045	Rat
2300181	Bmd55	Bone mineral density QTL 55	5.7	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	76468691	121468691	Rat
61437	Cia6	Collagen induced arthritis QTL 6			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	8	82460758	122812818	Rat
2313400	Anxrr25	Anxiety related response QTL 25			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	8	89265192	114019816	Rat
738011	Anxrr9	Anxiety related response QTL 9	6.1		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	8	93535351	123900184	Rat
1358893	Bp263	Blood pressure QTL 263	5.01		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
1358903	Bp252	Blood pressure QTL 252	7	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	8	93965141	123900184	Rat
738014	Anxrr15	Anxiety related response QTL 15	3.6	0.005	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	8	95718998	123900184	Rat
2300182	Bmd56	Bone mineral density QTL 56	5.4		femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	8	95718998	123900184	Rat
724539	Cm19	Cardiac mass QTL 19	2.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	8	100149864	120994388	Rat

Markers in Region

AW529479

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	111,453,853 - 111,454,003 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	119,744,339 - 119,744,488	NCBI	Rnor6.0
Rnor_5.0	8	119,093,460 - 119,093,609	UniSTS	Rnor5.0
RGSC_v3.4	8	115,883,415 - 115,883,564	UniSTS	RGSC3.4
Celera	8	110,735,181 - 110,735,330	UniSTS
RH 3.4 Map	8	1192.0	UniSTS
Cytogenetic Map	8	q32	UniSTS

RH137832

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	8	111,453,393 - 111,453,525 (+)	MAPPER	mRatBN7.2
Rnor_6.0	8	119,743,879 - 119,744,010	NCBI	Rnor6.0
Rnor_5.0	8	119,093,000 - 119,093,131	UniSTS	Rnor5.0
RGSC_v3.4	8	115,882,955 - 115,883,086	UniSTS	RGSC3.4
Celera	8	110,734,721 - 110,734,852	UniSTS
RH 3.4 Map	8	1191.5	UniSTS
Cytogenetic Map	8	q32	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									21	25
Low	1	17	29	19	3	19	8	11	51	10	34	11	8
Below cutoff	2	24	11	5	15	5			2		7

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001191800	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CK481225	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM063554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000044742 ⟹ ENSRNOP00000046063

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	8	111,401,358 - 111,453,999 (+)	Ensembl
Rnor_6.0 Ensembl	8	119,691,388 - 119,744,506 (+)	Ensembl

RefSeq Acc Id:

NM_001191800 ⟹ NP_001178729

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	8	120,279,916 - 120,332,362 (+)	NCBI
mRatBN7.2	8	111,401,544 - 111,453,999 (+)	NCBI
Rnor_6.0	8	119,691,567 - 119,744,484 (+)	NCBI
Rnor_5.0	8	119,040,830 - 119,093,605 (+)	NCBI
Celera	8	110,683,369 - 110,735,326 (+)	NCBI

Sequence:

show sequence

ATGCCAGCCGCGCCGGTCCTGCGCCCTCCGCCGCCACCGGCGACCCCTGCCCCGCCGGCACCCA
GCCGCCCTGCGCCTGCTATCTCGGGCCATCGGGGTCCGTGTGACCATTCTCTAAAATGCTTAAG
CTCGAAGATCTCTGAGAGAAAGTTGCCAGGCTCCTGGCTGCCTTCGGGACGAGGACCTCTGGAG
AAGCCAGTCCTGGGGCCACGTGGTGCCGTCATGCCGATGTTCAGCCCTCAGAGTAGCCTCCACT
CAGTCCGCGCAGAGCACAGCCCACTGAAGCCCAGGGTGGTTACGGTGGTGAAGCTGGGCGTGCA
GCCCCTCCGCAAGGCCACCCTGCTCCTCAACAGGCGGTCAGTGCAGACCTTTGAGCAGCTCCTG
TCGGACATCTCTGAAGCCTTGGGCTTCCCGCGATGGAAGAATGACCGTGTGCGGAAGCTGTTCA
CCCTCAAGGGCAGGGAGGTCAAGAGTGTGTCTGACTTCTTCCGGGAGGGCGATGCTTTCATAGC
CATGGGCAAAGAGCCACTGACATTGAAGAGTATCCAGTTGGCTATGGAGGAACTGTATCCTAAG
AACCGCGCCCTTGCCCTGGCCCCTCATAGTAGAGTCCCCTCCCCAAGGCTAAGAAGCAGGCTTC
CCAGCAAGCTTCTGAAAGGAAGTCACCGCTGTGGGGAGGCAGGAAGCTATGGTGAGGTAATGGG
GAACAAGGCAGTCATTAGGCACCAGGGCAAGACTTCCACAGAGCTGGCCCCAGAAGACAAGGCA
AGGGCCCAGAAGAAGTGGGTAGGAGGGAAACAGGAATCAGAAAATGGTGGCCTGCCGTCACCTA
GAGAAGCCACTCAGGAGGAGACGCATGCAAGTGGGGAGAAGCACCTCGGGGTGGAGATTGAAAA
GACCTCGGGGGAGATTGTCAGGTGTGAGAAGTGTAAGAGAGAAACAGAGCTGCAGTTGGGCCTA
CAGAGGGGGCAGTGCCCTCCGGGAACCAGTGAGCTGGACCTGGGGAGGGGCCAGAAGAGGGATT
CCGAGAAGTTGGTCAGGACCAAGAGCTGCAGGAGGGCTTCTGAGGCAAAGTCTACAGATGGAGA
GGAAGGGTGGAAGGGTGACAGCCACCGGGGCAGCCCCAGGGATCCCCCTCAGGAACTGAGGAGG
CCCAACAACAACTCAGACAAGAAAGAGAGCAGAGGCTCAGAAGCTCAGGAAAGTCACCCTCAGG
GCGTGGCCAAGGCCCAGAAGGACCTCATGGAAGGTCTGCCAGCTGTAGAGGAGGGGGCGGTGGA
CGCGAGGAGAGATTCCAGGCACACATGCAGGATTAAGCATGCTGCCTGGCTCCGGAGAGAGCAG
CAGGCTGAACCCCCACAGCTCCCCAGAACCCGAGGGGAGGAGAAGGAAGCAGAGCATGAGAAGA
AGTCAGGTGGTCTGGGAGGGAGGAGGATGCTAGAAAAGGAGTCTAAGACGAAGCCGGAAGAGAA
CCGGCCGGAACGACCCAGTGGCCGGAAGCTGAGGCCCACGGGCATCATCTCAGCGGATGTGGAG
AAGCACTATGACATAGGTCGGGTCATTGGGGATGGGAATTTTGCCATCGTGAAGGAATGCAAGC
ACCGAGAGACCAGGCAGGCTTACGCCATGAAGATTATTGACAAATCCCAGCTGAAGGGTAAGGA
GGACATTGTGGACAGTGAGATTTTAATTATCCAGAGTCTCTCTCACCCCAACATAGTGAAACTG
CATGAGGTCTACGAAACAGAGGCAGAGATCTACCTGATCATGGAGTACGTGCAGGGAGGGGACC
TTTTCGATGCCATCATCGAAAGTGTGAAGTTTCCAGAGCCTGACGCTGCAGTTATGATCACAGA
CTTGTGTAAGGCCCTCGTCCACATGCATGACAAGAAGATCGTCCACCGGGACCTGAAGCCGGAA
AACCTCCTGGTTCAGCGAAATGAAGACAAGTCTACCACCTTGAAGCTGGCTGACTTTGGCCTGG
CCAAACATGTGGTGAGGCCTATATTTACTGTGTGTGGGACGCCAACATATGTAGCTCCTGAGAT
TCTTTCTGAGAAAGGTTACGGCCTGGAGGTGGACATGTGGGCCGCAGGTGTGATCCTATACATC
CTCTTGTGTGGCTTCCCTCCTTTCCGAAGTCCTGAGAGGGACCAAGACGAGCTCTTCAACATCA
TCCAGCTGGGCCAGTTTGAGTTCCTCTCTCCTTACTGGGACAACATTTCTGATGCTGCCAAAGA
TCTGGTGAGAAATTTGCTGGTAGTGGACCCCAAGAAGCGGTACACGGCCCACCAGGTCCTACAT
CATCCCTGGATTGGGATGGTGGGGCACCCCAGCACAGTGAACCCACAGAAGGAGGAGTCCCCCA
GCAGCGAGGGTCGCTTCCAGAGCCAGCACAAGAAGGTTGCAGAGCACGTGTCGTAACCTGCCTG
GGACATCTGTCCAGTTTGGTCTCCTTGAGGACAGAGAAGAGAGGGGACGTCTGCGAGCAAGATC
ATGCAAGACACTTCTCCACAGATCTAGGGAAAGAGAAGAGCCACCTGTCATAGTCTAAAGAGTG
TTTAGAAAGCAACAACCTAATGTTGAATGATGTATGATATTTTTAGATTTGTATATCTGAAGTC
TTTAATACTTTTTTTTGGGTAAGAATTGCCACGAATGAGGAGTTTTGATAATAACGATGAATTC
TGTTTTCTTCTTGAAGTCGAGTTCATGGTGGGCTACATGAGTGTGTTTCACATCTCTCAAGCTC
CCCCACACAGTGAATGAGGTGATTCTTGGCTTTTCTATCACAATAAAACACGATGAATAACAGA
GAAAGATCTGCCTTGTTCAATGGTGGGGAGAGCTGGGAAAGTAGTTCGACACAGCTGTATTTTA
ACCTTTGACAAAGAGACCAATACATGTGGTTCTACAAACTGAAATTCCGTGAAAAAACAAAAAA
CAACCCAACACTTTTTTTTTTTTTATGAATCTGCGGGCTGACTGATTAGAATTTCACGATTTTG
GAGAACTGGAATGTACAGATTGAGAGCCAAAATTTACTTTGGGTTATCTCCCATCCCATTAATA
GTCATGTATCACCCAACTGTATGTATGACCTGACAGACAGAGCTGTTGGAACGTAGTAACTCAG
CTGGGCACTGGCTCCTACTAACCCAAAGCTAAGACTGAGAGCATTCAAAGCCGGCCGAAGAGAT
TTCCCCACTTCGCTGTCAGCCGCCTGCCTGATCACGCCACCAGTATGAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001178729	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000046063
	ENSRNOP00000046063.4

RefSeq Acc Id:

NP_001178729 ⟸ NM_001191800

- UniProtKB:

F1LWF2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPAAPVLRPPPPPATPAPPAPSRPAPAISGHRGPCDHSLKCLSSKISERKLPGSWLPSGRGPLE
KPVLGPRGAVMPMFSPQSSLHSVRAEHSPLKPRVVTVVKLGVQPLRKATLLLNRRSVQTFEQLL
SDISEALGFPRWKNDRVRKLFTLKGREVKSVSDFFREGDAFIAMGKEPLTLKSIQLAMEELYPK
NRALALAPHSRVPSPRLRSRLPSKLLKGSHRCGEAGSYGEVMGNKAVIRHQGKTSTELAPEDKA
RAQKKWVGGKQESENGGLPSPREATQEETHASGEKHLGVEIEKTSGEIVRCEKCKRETELQLGL
QRGQCPPGTSELDLGRGQKRDSEKLVRTKSCRRASEAKSTDGEEGWKGDSHRGSPRDPPQELRR
PNNNSDKKESRGSEAQESHPQGVAKAQKDLMEGLPAVEEGAVDARRDSRHTCRIKHAAWLRREQ
QAEPPQLPRTRGEEKEAEHEKKSGGLGGRRMLEKESKTKPEENRPERPSGRKLRPTGIISADVE
KHYDIGRVIGDGNFAIVKECKHRETRQAYAMKIIDKSQLKGKEDIVDSEILIIQSLSHPNIVKL
HEVYETEAEIYLIMEYVQGGDLFDAIIESVKFPEPDAAVMITDLCKALVHMHDKKIVHRDLKPE
NLLVQRNEDKSTTLKLADFGLAKHVVRPIFTVCGTPTYVAPEILSEKGYGLEVDMWAAGVILYI
LLCGFPPFRSPERDQDELFNIIQLGQFEFLSPYWDNISDAAKDLVRNLLVVDPKKRYTAHQVLH
HPWIGMVGHPSTVNPQKEESPSSEGRFQSQHKKVAEHVS

hide sequence

RefSeq Acc Id:

ENSRNOP00000046063 ⟸ ENSRNOT00000044742

Protein Domains

Doublecortin Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LWF2-F1-model_v2	AlphaFold	F1LWF2	1-807	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13696347

Promoter ID:

EPDNEW_R6871

Type:

single initiation site

Name:

Dclk3_1

Description:

doublecortin-like kinase 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	8	119,691,406 - 119,691,466	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309232	AgrOrtholog
BioCyc Gene	G2FUF-29019	BioCyc
Ensembl Genes	ENSRNOG00000033026	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000044742	ENTREZGENE
	ENSRNOT00000044742.6	UniProtKB/TrEMBL
Gene3D-CATH	3.10.20.230	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Doublecortin_dom	UniProtKB/TrEMBL
	Doublecortin_dom_sf	UniProtKB/TrEMBL
	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_kinase_AS	UniProtKB/TrEMBL
KEGG Report	rno:316023	UniProtKB/TrEMBL
NCBI Gene	316023	ENTREZGENE
PANTHER	SERINE/THREONINE-PROTEIN KINASE	UniProtKB/TrEMBL
	SERINE/THREONINE-PROTEIN KINASE DCLK3	UniProtKB/TrEMBL
Pfam	DCX	UniProtKB/TrEMBL
	Pkinase	UniProtKB/TrEMBL
PhenoGen	Dclk3	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
	PS50309	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000033026	RatGTEx
SMART	DCX	UniProtKB/TrEMBL
	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
	SSF89837	UniProtKB/TrEMBL
UniProt	F1LWF2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Dclk3	doublecortin-like kinase 3	Dclk3_predicted	doublecortin-like kinase 3 (predicted)	'predicted' is removed	2292626	APPROVED
2007-04-03	Dclk3_predicted	doublecortin-like kinase 3 (predicted)	Dcamkl3_predicted	doublecortin and CaM kinase-like 3 (predicted)	Symbol and Name updated to reflect Human and Mouse nomenclature	1299863	APPROVED
2006-03-30	Dcamkl3_predicted	doublecortin and CaM kinase-like 3 (predicted)	RGD1309232_predicted	similar to hypothetical protein C730036H08 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1309232_predicted	similar to hypothetical protein C730036H08 (predicted)	LOC316023_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC316023_predicted	similar to hypothetical protein C730036H08 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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