Fbxo48 (F-box protein 48) - Rat Genome Database

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Gene: Fbxo48 (F-box protein 48) Rattus norvegicus
Analyze
Symbol: Fbxo48
Name: F-box protein 48
RGD ID: 1309073
Description: Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be located in cytoplasm. Predicted to be part of SCF ubiquitin ligase complex. Orthologous to human FBXO48 (F-box protein 48); INTERACTS WITH acetamide; bisphenol A; flutamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: F-box only protein 48; LOC364205; RGD1309073; similar to RIKEN cDNA A630050E13 gene
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,582,493 - 95,583,950 (+)NCBIGRCr8
mRatBN7.21491,380,857 - 91,382,314 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,380,857 - 91,382,314 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,694,828 - 95,696,285 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01496,939,153 - 96,940,610 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,404,222 - 93,405,679 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,129,835 - 100,140,400 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,135,271 - 100,136,728 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,397,383 - 100,412,297 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,825,562 - 97,827,019 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11497,844,792 - 97,854,902 (+)NCBI
Celera1490,429,587 - 90,431,044 (+)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Fbxo48
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,582,493 - 95,583,950 (+)NCBIGRCr8
mRatBN7.21491,380,857 - 91,382,314 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1491,380,857 - 91,382,314 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,694,828 - 95,696,285 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01496,939,153 - 96,940,610 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01493,404,222 - 93,405,679 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.014100,129,835 - 100,140,400 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl14100,135,271 - 100,136,728 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.014100,397,383 - 100,412,297 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,825,562 - 97,827,019 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11497,844,792 - 97,854,902 (+)NCBI
Celera1490,429,587 - 90,431,044 (+)NCBICelera
Cytogenetic Map14q22NCBI
FBXO48
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38268,459,422 - 68,467,294 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl268,459,422 - 68,467,294 (-)EnsemblGRCh38hg38GRCh38
GRCh37268,686,554 - 68,694,426 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36268,543,002 - 68,547,894 (-)NCBINCBI36Build 36hg18NCBI36
Celera268,539,478 - 68,544,370 (-)NCBICelera
Cytogenetic Map2p13.3NCBI
HuRef268,426,348 - 68,431,240 (-)NCBIHuRef
CHM1_1268,618,820 - 68,623,712 (-)NCBICHM1_1
T2T-CHM13v2.0268,471,784 - 68,479,683 (-)NCBIT2T-CHM13v2.0
Fbxo48
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391116,901,225 - 16,908,516 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1116,901,375 - 16,904,772 (+)EnsemblGRCm39 Ensembl
GRCm381116,951,224 - 16,954,777 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1116,951,375 - 16,954,772 (+)EnsemblGRCm38mm10GRCm38
MGSCv371116,851,413 - 16,854,775 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361116,851,413 - 16,854,775 (+)NCBIMGSCv36mm8
Celera1117,325,170 - 17,328,533 (+)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.41NCBI
Fbxo48
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542416,451,521 - 16,455,415 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542416,449,166 - 16,455,034 (+)NCBIChiLan1.0ChiLan1.0
FBXO48
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21257,947,630 - 57,955,220 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A57,951,578 - 57,959,168 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A68,504,304 - 68,509,113 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A69,627,257 - 69,632,218 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A69,627,187 - 69,632,218 (-)Ensemblpanpan1.1panPan2
FBXO48
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11067,449,168 - 67,453,540 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1067,450,934 - 67,451,855 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1067,339,076 - 67,344,119 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01068,468,500 - 68,473,590 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1068,470,273 - 68,471,194 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11068,151,424 - 68,156,440 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01068,449,759 - 68,454,838 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01068,745,092 - 68,750,201 (-)NCBIUU_Cfam_GSD_1.0
Fbxo48
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629215,713,590 - 15,720,120 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649112,851,539 - 12,857,692 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649112,854,829 - 12,857,682 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO48
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl373,831,336 - 73,838,553 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1373,831,299 - 73,838,552 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2377,362,273 - 77,363,255 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO48
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11438,636,899 - 38,640,875 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1438,638,522 - 38,640,190 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604573,335,611 - 73,339,879 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo48
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247624,848,676 - 4,850,962 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247624,847,757 - 4,850,962 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbxo48
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:343
Count of miRNA genes:204
Interacting mature miRNAs:232
Transcripts:ENSRNOT00000032965
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 22 31 20 19 20 71 26 38 10
Below cutoff 1 19 24 19 19 7 8 3 8 3 1 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000032965   ⟹   ENSRNOP00000034586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1491,380,857 - 91,382,314 (+)Ensembl
Rnor_6.0 Ensembl14100,135,271 - 100,136,728 (+)Ensembl
RefSeq Acc Id: NM_001108863   ⟹   NP_001102333
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81495,582,493 - 95,583,950 (+)NCBI
mRatBN7.21491,380,857 - 91,382,314 (+)NCBI
Rnor_6.014100,135,271 - 100,136,728 (+)NCBI
Rnor_5.014100,397,383 - 100,412,297 (-)NCBI
RGSC_v3.41497,825,562 - 97,827,019 (+)RGD
Celera1490,429,587 - 90,431,044 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102333 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97899 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000034586
  ENSRNOP00000034586.2
Reference Protein Sequences
RefSeq Acc Id: NP_001102333   ⟸   NM_001108863
- UniProtKB: D3ZKN5 (UniProtKB/TrEMBL),   A6JPY2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000034586   ⟸   ENSRNOT00000032965
Protein Domains
F-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKN5-F1-model_v2 AlphaFold D3ZKN5 1-160 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309073 AgrOrtholog
BioCyc Gene G2FUF-14940 BioCyc
Ensembl Genes ENSRNOG00000023026 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032965 ENTREZGENE
  ENSRNOT00000032965.3 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
  FBXO9/FBXO48 UniProtKB/TrEMBL
KEGG Report rno:364205 UniProtKB/TrEMBL
NCBI Gene 364205 ENTREZGENE
PANTHER F-BOX ONLY PROTEIN 48 UniProtKB/TrEMBL
  PTHR12874 UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
PhenoGen Fbxo48 PhenoGen
PROSITE FBOX UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023026 RatGTEx
SMART FBOX UniProtKB/TrEMBL
Superfamily-SCOP F-box_dom_Skp2-like UniProtKB/TrEMBL
UniProt A6JPY2 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKN5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-27 Fbxo48  F-box protein 48  RGD1309073  similar to RIKEN cDNA A630050E13 gene   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1309073  similar to RIKEN cDNA A630050E13 gene   RGD1309073_predicted  similar to RIKEN cDNA A630050E13 gene (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1309073_predicted  similar to RIKEN cDNA A630050E13 gene (predicted)  LOC364205_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC364205_predicted  similar to RIKEN cDNA A630050E13 gene (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL