Gene: Fscn2 (fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus))
Rattus norvegicus
Symbol:
Fscn2
Name:
fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
Description:
ENCODES a protein that exhibits actin filament binding (inferred); protein binding, bridging (inferred); INVOLVED IN eye photoreceptor cell development (ortholog); ASSOCIATED WITH Retinitis Pigmentosa (ortholog); Retinitis Pigmentosa 30 (ortholog); FOUND IN actin cytoskeleton (ortholog); stereocilium (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine (ortholog)
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
fascin homolog 2, actin-bundling protein, retinal; fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) (predicted); fascin-2; Fscn2_predicted; LOC303741
Orthologs:
Homo sapiens : FSCN2
(fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus))
HGNC
Fscn2
(fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus))
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 10 q32.3 NCBI RGSC Genome Assembly v5.0 10 109,128,055 - 109,134,594 + NCBI RGSC Genome Assembly v3.4 10 109,789,092 - 109,795,631 + NCBI Rat Celera Assembly 10 104,180,130 - 104,186,669 + NCBI Genome Assembly 3.1 10 109,803,763 - 109,810,072 + NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1319003 6480464 Tetrachlorodibenzodioxin affects the expression of FSCN2 mRNA CTD PMID:22574217
Biological Process biological_process ND 1598407 1/2007: no relevant rat data RGD eye photoreceptor cell development ISO RGD:1319004 1624291 MGI:MGI:3612338 RGD MGI:MGI:3610644 PMID:16043865 eye photoreceptor cell development IEA Ensembl:ENSMUSP00000026445 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Cellular Component actin cytoskeleton ISO RGD:1319004 1624291 MGI:MGI:4820459|PMID:20660251 RGD MGI:MGI:4820459 PMID:20660251 actin cytoskeleton IEA Ensembl:ENSMUSP00000026445 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 cellular_component ND 1598407 1/2007: no relevant rat data RGD cytoplasm IEA UniProtKB-KW:KW-0963 1600115 GO_REF:0000038 UniProtKB GO_REF:0000038 stereocilium ISO RGD:1319004 1624291 MGI:MGI:4820459|PMID:20660251 RGD MGI:MGI:4820459 PMID:20660251 stereocilium IEA Ensembl:ENSMUSP00000026445 1600115 GO_REF:0000019 ENSEMBL GO_REF:0000019 Molecular Function actin filament binding IEA InterPro:IPR010431|InterPro:IPR022768|InterPro:IPR024703 1600115 GO_REF:0000002 InterPro GO_REF:0000002 molecular_function ND 1598407 1/2007: no relevant rat data RGD protein binding, bridging IEA InterPro:IPR010431|InterPro:IPR022768|InterPro:IPR024703 1600115 GO_REF:0000002 InterPro GO_REF:0000002
2316949 Gluco60 Glucose level QTL 60 3.7 Glucose level postprandial 10 14721135 154166503 Rat 631268 Cia21 Collagen induced arthritis QTL 21 3.1 Joint/bone inflammation arthritis severity 10 14721135 159833317 Rat 61354 Pia10 Pristane induced arthritis QTL 10 .01 Joint/bone inflammation pristane induced 10 24006429 160657542 Rat 631267 Cia20 Collagen induced arthritis QTL 20 3.2 Joint/bone inflammation arthritis severity 10 24006429 160657542 Rat 61325 Aia5 Adjuvant induced arthritis QTL 5 .01 Joint/bone inflammation arthritis severity 10 24006429 160657542 Rat 631270 Cia23 Collagen induced arthritis QTL 23 3.9 Joint/bone inflammation arthritis severity 10 41339689 152260081 Rat 631269 Cia22 Collagen induced arthritis QTL 22 8.9 Joint/bone inflammation arthritis severity 10 41339689 152260081 Rat 2298548 Neuinf7 Neuroinflammation QTL 7 2.2 Neuroinflammation 10 65668446 132729388 Rat 1358915 Stresp7 Stress response QTL 7 3.52 Hormone level norepinephrine 10 68955627 113955627 Rat 2317029 Aia19 Adjuvant induced arthritis QTL 19 2.98 Joint/bone inflammation adjuvant induced 10 70229781 115229781 Rat 2317039 Aia6 Adjuvant induced arthritis QTL 6 4.31 Joint/bone inflammation adjuvant induced 10 70229781 115229781 Rat 61396 Bp9 Blood pressure QTL 9 4.8 .0001 Blood pressure salt-loaded systolic 10 72871396 117871396 Rat 2293646 Bss25 Bone structure and strength QTL 25 10.96 .0001 Bone structure 10 74167134 119167134 Rat 2293663 Bss33 Bone structure and strength QTL 33 9.34 .0001 Bone structure 10 74167134 119167134 Rat 2300172 Bmd57 Bone mineral density QTL 57 9.8 .0001 Bone mineral density 10 74167134 119167134 Rat 6893366 Bw106 Body weight QTL 106 .3 .47 Body weight 10 74652410 119652410 Rat 70193 Mcs7 Mammary carcinoma susceptibility QTL 7 2.38 Mammary tumor susceptibility 10 76698917 121698917 Rat 1354641 Bvd2 Brain ventricular dilatation QTL 2 6.36 .001 Head/brain development brain ventricular dilatation 10 79981838 124981838 Rat 4889492 Pancm2 Pancreatic morphology QTL 2 3.2 Pancreatic morphology 10 81350126 126350126 Rat 2303589 Bw87 Body weight QTL 87 2 Body weight 10 86057484 131057484 Rat 2317754 Glom25 Glomerulus QTL 25 3.5 Renal pathology urine protein level 10 86810917 131810917 Rat 631538 Oia5 Oil induced arthritis QTL 5 Joint/bone inflammation arthritis susceptibility 10 91168332 136168332 Rat 61363 Oia3 Oil induced arthritis QTL 3 .001 Joint/bone inflammation oil induced 10 91455572 136455572 Rat 1300137 Bp186 Blood pressure QTL 186 3.57 Blood pressure salt-loaded time series calculation 10 95066219 140066219 Rat 1558652 Bw57 Body weight QTL 57 4.2 .0008 Body weight 10 95361338 140361338 Rat 61436 Cia5 Collagen induced arthritis QTL 5 4.9 Joint/bone inflammation type II collagen induced 10 95692240 140692240 Rat 1302404 Cia27 Collagen induced arthritis QTL 27 Joint/bone inflammation type II collagen induced 10 95695048 111406914 Rat 1576307 Cia28 Collagen induced arthritis QTL 28 Joint/bone inflammation type II collagen-induced 10 100633512 145633512 Rat 1576313 Pia25 Pristane induced arthritis QTL 25 Joint/bone inflammation pristane induced 10 100633512 145633512 Rat 1578663 Bss18 Bone structure and strength QTL 18 3.6 Bone structure femoral neck width 10 101222719 146222719 Rat 1578672 Bmd16 Bone mineral density QTL 16 6.2 Bone mineral density femoral neck cortical vBMD 10 101222719 146222719 Rat 1357340 Bp250 Blood pressure QTL 250 .0001 Blood pressure 10 101848470 146848470 Rat
Gene-Chemical Interaction Annotations
