Fkbp6 (FKBP prolyl isomerase family member 6)

Gene: Fkbp6 (FKBP prolyl isomerase family member 6) Rattus norvegicus

Analyze

Symbol:

Fkbp6

Name:

FKBP prolyl isomerase family member 6

RGD ID:

1308926

Description:

Predicted to enable Hsp90 protein binding activity and identical protein binding activity. Involved in spermatogenesis. Predicted to be located in cytosol and synaptonemal complex. Predicted to be active in cytoplasm. Used to study male infertility. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and spermatogenic failure. Orthologous to human FKBP6 (FKBP prolyl isomerase family member 6 (inactive)); INTERACTS WITH bisphenol A; 17alpha-ethynylestradiol (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

36 kDa FK506 binding protein; FK506 binding protein 6; FK506 binding protein 6, 36kDa; FK506-binding protein 6; FKBP prolyl isomerase 6; FKBP-36; immunophilin FKBP36; inactive peptidyl-prolyl cis-trans isomerase FKBP6; inactive PPIase FKBP6; peptidyl-prolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase FKBP6; PPiase; rotamase

RGD Orthologs

Alliance Genes

More Info

more info ...

Is Marker For:

Strains: TT/Sgn

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	26,947,443 - 27,026,913 (+)	NCBI		GRCr8
mRatBN7.2	12	21,318,251 - 21,390,350 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	21,319,568 - 21,390,350 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	22,461,416 - 22,532,119 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	23,073,748 - 23,144,453 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	22,140,220 - 22,210,927 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	24,365,941 - 24,438,088 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	24,367,199 - 24,438,019 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	26,363,264 - 26,435,311 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	22,474,002 - 22,544,784 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	22,464,474 - 22,476,654 (+)	NCBI
Celera	12	23,082,103 - 23,152,967 (+)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autistic disorder (ISO)

genetic disease (ISO)

intestinal volvulus (ISO)

male infertility (IAGP,ISO)

Neurodevelopmental Disorders (ISO)

pleomorphic xanthoastrocytoma (ISO)

schizophrenia (ISO)

Spermatogenic Failure 77 (ISO)

Volvulus Of Midgut (ISO)

Williams-Beuren syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

benzo[a]pyrene (ISO)

Benzo[ghi]perylene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

crocidolite asbestos (ISO)

folic acid (ISO)

fulvestrant (ISO)

levonorgestrel (ISO)

paracetamol (ISO)

sodium arsenite (ISO)

testosterone undecanoate (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

meiotic cell cycle (IEA,ISO,ISS)

piRNA processing (IBA,IEA,ISO,ISS)

positive regulation of viral genome replication (IEA,ISO)

protein folding (IEA,ISO,ISS)

regulatory ncRNA-mediated gene silencing (ISO,ISS)

siRNA-mediated retrotransposon silencing by heterochromatin formation (IEA,ISO,ISS)

spermatogenesis (IBA,IEA,IMP,ISO)

Cellular Component

cytoplasm (IBA,IEA,ISO,ISS)

cytosol (IEA,ISO,ISS)

synaptonemal complex (IEA,ISO,ISS)

Molecular Function

Hsp90 protein binding (IBA,IEA,ISO,ISS)

identical protein binding (IEA,ISO)

peptidyl-prolyl cis-trans isomerase activity (IEA,ISO,ISS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Testicular disruption in the As (aspermia) mutant rat, with special reference to the aggregate of ribosomes.	Atagi Y, etal., J Vet Med Sci. 1993 Apr;55(2):301-6.
2.	Essential role of Fkbp6 in male fertility and homologous chromosome pairing in meiosis.	Crackower MA, etal., Science. 2003 May 23;300(5623):1291-5.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	A novel human gene FKBP6 is deleted in Williams syndrome.	Meng X, etal., Genomics. 1998 Sep 1;52(2):130-7.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7493967	PMID:18408354	PMID:22902560	PMID:26567527

Genomics

Comparative Map Data

Fkbp6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	26,947,443 - 27,026,913 (+)	NCBI		GRCr8
mRatBN7.2	12	21,318,251 - 21,390,350 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	21,319,568 - 21,390,350 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	22,461,416 - 22,532,119 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	23,073,748 - 23,144,453 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	22,140,220 - 22,210,927 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	24,365,941 - 24,438,088 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	24,367,199 - 24,438,019 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	26,363,264 - 26,435,311 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	22,474,002 - 22,544,784 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	22,464,474 - 22,476,654 (+)	NCBI
Celera	12	23,082,103 - 23,152,967 (+)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

FKBP6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	73,328,161 - 73,358,625 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	73,328,161 - 73,358,637 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	72,742,164 - 72,772,634 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	72,380,236 - 72,410,577 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	71,884,933 - 72,217,283	NCBI
Celera	7	68,220,437 - 68,250,915 (+)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	68,623,892 - 68,654,372 (+)	NCBI		HuRef
CHM1_1	7	72,888,174 - 72,918,659 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	74,528,332 - 74,558,802 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	72,075,227 - 72,105,718 (+)	NCBI

Fkbp6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	135,320,558 - 135,380,662 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	135,320,558 - 135,378,898 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	135,291,704 - 135,351,809 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	135,291,704 - 135,350,044 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	135,767,574 - 135,825,861 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	135,576,331 - 135,634,618 (-)	NCBI		MGSCv36	mm8
Celera	5	132,303,410 - 132,361,697 (-)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	75.11	NCBI

Fkbp6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	14,291,260 - 14,318,310 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955456	14,291,445 - 14,318,310 (-)	NCBI	ChiLan1.0	ChiLan1.0

FKBP6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	91,543,547 - 91,573,368 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	139,808,180 - 139,838,025 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	7	80,481,443 - 80,511,813 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	80,481,443 - 80,511,813 (+)	Ensembl	panpan1.1		panPan2

FKBP6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	6,836,043 - 6,868,268 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	6,836,086 - 6,868,818 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	8,533,363 - 8,565,559 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	6,656,533 - 6,688,674 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	6,656,576 - 6,688,946 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	6,626,768 - 6,658,955 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	6,589,432 - 6,621,560 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	6,752,768 - 6,784,970 (-)	NCBI		UU_Cfam_GSD_1.0

Fkbp6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	131,367,109 - 131,398,573 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	2,638,016 - 2,646,589 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	2,638,189 - 2,646,589 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FKBP6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	10,669,664 - 10,682,618 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	10,659,456 - 10,716,210 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	10,365,246 - 10,407,830 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FKBP6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	9,688,493 - 9,718,633 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666070	6,744,849 - 6,774,903 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fkbp6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	14,369,164 - 14,400,480 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	14,369,214 - 14,400,560 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Fkbp6
190 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	57
Count of miRNA genes:	47
Interacting mature miRNAs:	48
Transcripts:	ENSRNOT00000001971
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
10755457	Coatc14	Coat color QTL 14		0.01759	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	12	1	22591684	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	23297788	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	1	29333307	Rat
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	8449490	28302290	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	8525423	28064601	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	9318216	32103380	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	11073825	24234895	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	28064557	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	13635523	30827399	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	13635523	35682913	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	15550826	38478808	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	15872653	32974238	Rat
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	19144362	46669029	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	19610870	24139202	Rat
737822	Alc10	Alcohol consumption QTL 10	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	19610870	40218516	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610870	42828880	Rat
61324	Eae5	Experimental allergic encephalomyelitis QTL 5	14		nervous system integrity trait (VT:0010566)	percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)	12	19610870	46669029	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610889	35682913	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	19835789	38193007	Rat
631521	Pia12	Pristane induced arthritis QTL 12	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	20259417	23672083	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	20328819	46669029	Rat

Markers in Region

Fkbp6

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	21,329,204 - 21,329,685 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	24,376,848 - 24,377,328	NCBI	Rnor6.0
Rnor_5.0	12	26,374,151 - 26,374,631	UniSTS	Rnor5.0
RGSC_v3.4	12	22,483,639 - 22,484,119	UniSTS	RGSC3.4
Celera	12	23,091,638 - 23,092,118	UniSTS
Cytogenetic Map	12	q12	UniSTS

D5S503

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	21,381,405 - 21,382,889 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	24,429,050 - 24,430,532	NCBI	Rnor6.0
Rnor_5.0	12	26,426,353 - 26,427,835	UniSTS	Rnor5.0
RGSC_v3.4	12	22,535,841 - 22,537,323	UniSTS	RGSC3.4
Celera	12	23,143,832 - 23,145,506	UniSTS
Cytogenetic Map	12	q12	UniSTS

Related Rat Strains

The following Strains have been annotated to Fkbp6

TT/Sgn

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium										26
Low	4					1	1	5		8		1
Below cutoff	31	4	1	4	1	3	4	17	2	3	1	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001105922	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006249131	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769130	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063271157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC087262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC090529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000001971 ⟹ ENSRNOP00000001971

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	21,319,568 - 21,390,350 (+)	Ensembl
Rnor_6.0 Ensembl	12	24,367,199 - 24,438,019 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000094090 ⟹ ENSRNOP00000086905

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	21,319,568 - 21,390,350 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000098264 ⟹ ENSRNOP00000083089

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	21,319,682 - 21,390,350 (+)	Ensembl

RefSeq Acc Id:

NM_001105922 ⟹ NP_001099392

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,956,131 - 27,026,913 (+)	NCBI
mRatBN7.2	12	21,319,568 - 21,390,350 (+)	NCBI
Rnor_6.0	12	24,367,211 - 24,437,993 (+)	NCBI
Rnor_5.0	12	26,363,264 - 26,435,311 (+)	NCBI
RGSC_v3.4	12	22,474,002 - 22,544,784 (+)	RGD
Celera	12	23,082,103 - 23,152,967 (+)	RGD

Sequence:

show sequence

CCGGCGAGGCCTCTGGCGACGGTTGAGCGGCAAGATGAGTGTCTTCTCGCGCCTCAGGAACGGA
ATCCCACCGTCGCGAGACGACTGCCAGTCTCCCTATGAGCGATTAAGTCAACGCATGTTGGACA
TTTCTGGGGACCGAGGTGTGCTGAAAGATATCATCCGCGAGGGCGCTGGCGATCCTGTGACACC
TGACGCTTCTGTGCTGGTGAAATACTCTGGATACCTGGAGCACATGGATAAGCCTTTCGACTCC
AATTGCTTTAGGAAAACCCCTCGGCTGATGAAACTTGGAGAAGATATTACACTCTGGGGCATGG
AGCTGGGCCTTCTAAGCATGCGCAGAGGGGAACTGGCCAGGTTCCTGTTCAAGCCAACCTATGC
TTATGGTACCCTGGGGTGCCCGCCCCTCATCCCTCCAAATGCCACTGTCCTGTTTGAGATCGAG
CTGATTGACTTCCTGGACTCTGCCGAGTCGGACAAGTTTTGTGCACTCTCAGCTGAGCAGCAAG
AACAGTTTCCACTCCAGAAAGTCCTCAAGGTAGCGGCAACCGAGAGGGAGTTTGGCAACTACCT
TTTCCGCCAGAATCGCTTCTGTGATGCCAAAGTGAGATACAAGCGGGCCTTGTTGCTGCTCCAT
CGACGCTTGGCCATCTGTGAGGAGCAGCACTTGGTAGAACCTGCTGAGCTCCTAGTCCTCCTTA
ACCTTTCATTTGTGTACCTGAAGCTAGACCGCCCTGCTATGGCCCTGCGCTATGGGGAGCAGGC
TCTGCTCATTGACAAAAGGAACGCCAAAGCCCTCTTCAGGTGTGGACAGGCTTGCCTCCTCCTG
ACCGAGTATGAGCAGGCTCGGGACTTTCTAGTGAGAGCTCAGAAGGAGCAGCCCTGTAACCATG
ACATCAATAATGAGCTGAAGAAGCTGTCCAGCCACTACAGGGACTATGTGGACAGAGAGAGAGA
GATGTGTCACCGGATGTTTGCTCCCTGTGGAAGCGGCTCTTCAGTGGGAGGAAACTGAAGGGTT
TCAGCTACTGCAAACACAACTGGACTCCTCCTTCGAACTGTGGCTGGGGATGGATGGAGCTCCT
AGTGCAGACTGCTCCAGCCACCCCTGGAAGACAGCGACGCCCTGCCAGACTGTTTCTCCAGGTT
CATACACAGTAGCAAAGGGTAGTCCCTGACAGCAGAAACCGCTCAGACAAGTAGGTTTTGTATG
TGTGTCAGTTCTCCGCTTACCTCCCAGCCTCACCCCCACCTCCTTTCCAAATGCTGATGTCAGT
GGGCCAGTACAGATAGAAATGCCTTTGTATATTCTGTTGGGTTTTTTGAAGAGAATTATGTTAC
AATTGTTTTTGTTGTAAATAAAACACATTCTTGTCCTAGCA

hide sequence

RefSeq Acc Id:

XM_006249131 ⟹ XP_006249193

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,956,208 - 27,026,913 (+)	NCBI
mRatBN7.2	12	21,319,645 - 21,390,313 (+)	NCBI
Rnor_6.0	12	24,367,308 - 24,438,088 (+)	NCBI
Rnor_5.0	12	26,363,264 - 26,435,311 (+)	NCBI

Sequence:

show sequence

AGGGGGGTCTGGGAGCCTGGGAGCACGAGCTGGGGAGCACCAGGAGCACGGCCATGGGTGGTAG
CACCCGAGGCCGGGGAGCCCTGGAAGGGGACGACGTCCTAGGCCAGTCTCCCTATGAGCGATTA
AGTCAACGCATGTTGGACATTTCTGGGGACCGAGGTGTGCTGAAAGATATCATCCGCGAGGGCG
CTGGCGATCCTGTGACACCTGACGCTTCTGTGCTGGTGAAATACTCTGGATACCTGGAGCACAT
GGATAAGCCTTTCGACTCCAATTGCTTTAGGAAAACCCCTCGGCTGATGAAACTTGGAGAAGAT
ATTACACTCTGGGGCATGGAGCTGGGCCTTCTAAGCATGCGCAGAGGGGAACTGGCCAGGTTCC
TGTTCAAGCCAACCTATGCTTATGGTACCCTGGGGTGCCCGCCCCTCATCCCTCCAAATGCCAC
TGTCCTGTTTGAGATCGAGCTGATTGACTTCCTGGACTCTGCCGAGTCGGACAAGTTTTGTGCA
CTCTCAGCTGAGCAGCAAGAACAGTTTCCACTCCAGAAAGTCCTCAAGGTAGCGGCAACCGAGA
GGGAGTTTGGCAACTACCTTTTCCGCCAGAATCGCTTCTGTGATGCCAAAGTGAGATACAAGCG
GGCCTTGTTGCTGCTCCATCGACGCTTGGCCATCTGTGAGGAGCAGCACTTGGTAGAACCTGCT
GAGCTCCTAGTCCTCCTTAACCTTTCATTTGTGTACCTGAAGCTAGACCGCCCTGCTATGGCCC
TGCGCTATGGGGAGCAGGCTCTGCTCATTGACAAAAGGAACGCCAAAGCCCTCTTCAGGTGTGG
ACAGGCTTGCCTCCTCCTGACCGAGTATGAGCAGGCTCGGGACTTTCTAGTGAGAGCTCAGAAG
GAGCAGCCCTGTAACCATGACATCAATAATGAGCTGAAGAAGCTGTCCAGCCACTACAGGGACT
ATGTGGACAGAGAGAGAGAGATGTGTCACCGGATGTTTGCTCCCTGTGGAAGCGGCTCTTCAGT
GGGAGGAAACTGAAGGGTTTCAGCTACTGCAAACACAACTGGACTCCTCCTTCGAACTGTGGCT
GGGGATGGATGGAGCTCCTAGTGCAGACTGCTCCAGCCACCCCTGGAAGACAGCGACGCCCTGC
CAGACTGTTTCTCCAGGTTCATACACAGTAGCAAAGGGTAGTCCCTGACAGCAGAAACCGCTCA
GACAAGTAGGTTTTGTATGTGTGTCAGTTCTCCGCTTACCTCCCAGCCTCACCCCCACCTCCTT
TCCAAATGCTGATGTCAGTGGGCCAGTACAGATAGAAATGCCTTTGTATATTCTGTTGGGTTTT
TTGAAGAGAATTATGTTACAATTGTTTTTGTTGTAAATAAAACACATTCTTGTCCTAGCAGTAT
GCAGTACAATTCATTGTGTGAATTGTGCTCAACTCCTGAAGTCTATGGCCTGGCAGAGGGAACC
ATTTGCAGAGAGCAGCAAGAGTGGGAA

hide sequence

RefSeq Acc Id:

XM_008769130 ⟹ XP_008767352

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,954,816 - 26,974,896 (+)	NCBI
mRatBN7.2	12	21,318,251 - 21,340,953 (+)	NCBI
Rnor_6.0	12	24,365,941 - 24,380,793 (+)	NCBI

Sequence:

show sequence

TCAGTCCCTTGCCTTCTGCCAGACTAGGCCCTCCAATCCAGACAGTCACGGTCCTGGTTCATAT
CCTCCTACCAGCTGCCTGCCCCCCGCGTGGTGCCTGACTTCCGGGAGTCGTTTTNNCCGGCGAG
GCCTCTGGCGACGGTTGAGCGGCAAGATGAGTGTCTTCTCGCGCCTCAGGAACGGAATCCCACC
GTCGCGAGACGACTGCCAGTCTCCCTATGAGCGATTAAGTCAACGCATGTTGGACATTTCTGGG
GACCGAGGTGTGCTGAAAGATATCATCCGCGAGGGCGCTGGCGATCCTGTGACACCTGACGCTT
CTGTGCTGGTGAAATACTCTGGATACCTGGAGCACATGGATAAGCCTTTCGACTCCAATTGCTT
TAGGAAAACCCCTCGGCTGATGAAACTTGGAGAAGATATTACACTCTGGGGCATGGAGCTGGGC
CTTCTAAGCATGCGCAGAGGGGAACTGGCCAGGTTCCTGTTCAAGCCAACCTATGCTTATGGTA
CCCTGGGGTGCCCGCCCCTCATCCCTCCAAATGCCACTGTCCTGTTTGAGATCGAGCTGATTGA
CTTCCTGGACTCTGCCGAGTCGGACAAGTTTTGTGCACTCTCAGCTGAGCAGCAAGAACAGTTT
CCACTCCAGAAAGTCCTCAAGGTAGCGGCAACCGAGAGGGAGTTTGGCAACTACCTTTTCCGCC
AGAATCGCTTCTGTGATGCCAAAGTGAGATACAAGCGGGCCTTGTTGCTGCTCCATCGACGCTT
GGCCATCTGTGAGGAGCAGCACTTGGTAGAACCTGCTGAGCTCCTAGTCCTCCTTAACCTTTCA
TTTGTGTACCTGAAGCTAGACCGCCCTGCTATGGCCCTGCGCTATGGGGAGCAGGCTCTGCTCA
TTGACAAAAGGAACGCCAAAGCCCTCTTCAGGTGTGGACAGGCTTGCCTCCTCCTGACCGAGTA
TGAGCAGGCTCGGGACTTTCTAGTGAGAGCTCAGAAGGAGCAGCCCTGTAACCATGACATCAAT
AATGAGCTGAAGAAGCTGTCCAGCCACTACAGGGACTATGTGGACAGAGAGAGAGAGATGTGTC
ACCGGATGTTTGCTCCCTGTGGAAGCGGCTCTTCAGTGGGAGGAAACTGAAGAAACGGCTTGAG
AGGAGGGGTCATGAAAGGCCCATTCATCCATGCGCTCTAGCAGGTTCTGAAGTGCTGCTGTCTG
CTTGGCAGATGCCCACTATTAGTGCCTTTGCAGGCATGACTTTTTGATCCCATCCTCTGAGTCT
TCCAGGGGAACTTCTGAACTAAGCTGCAACCAGAAGACCTCTTGTGATTTGGCTCTTGTCACAT
TCAGTAGAGATATAAGACATCTGTTTCCCAGATCCTCTGTGTGTAAGGATCTGCGTGGCTGCAT
GTGTTCTCTCTCTCTCTCTCTCTCTCTCTCTC

hide sequence

RefSeq Acc Id:

XM_017598299 ⟹ XP_017453788

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,954,817 - 27,026,913 (+)	NCBI
mRatBN7.2	12	21,318,252 - 21,390,345 (+)	NCBI
Rnor_6.0	12	24,365,941 - 24,438,087 (+)	NCBI

Sequence:

show sequence

TCAGTCCCTTGCCTTCTGCCAGACTAGGCCCTCCAATCCAGACAGTCACGGTCCTGGTTCATAT
CCTCCTACCAGCTGCCTGCCCCCCGCGTGGTGCCTGACTTCCGGGAGTCGTTTTNNCCGGCGAG
GCCTCTGGCGACGGTTGAGCGGCAAGATGAGTGTCTTCTCGCGCCTCAGGAACGGAATCCCACC
GTCGCGAGACGACTGCCAGTCTCCCTATGAGCGATTAAGTCAACGCATGTTGGACATTTCTGGG
GACCGAGGTGTGCTGAAAGATATCATCCGCGAGGGCGCTGGCGATCCTGTGACACCTGACGCTT
CTGTGCTGGTGAAATACTCTGGATACCTGGAGCACATGGATAAGCCTTTCGACTCCAATTGCTT
TAGGAAAACCCCTCGGCTGATGAAACTTGGAGAAGATATTACACTCTGGGGCATGGAGCTGGGC
CTTCTAAGCATGCGCAGAGGGGAACTGGCCAGGTTCCTGTTCAAGCCAACCTATGCTTATGGTA
CCCTGGGGTGCCCGCCCCTCATCCCTCCAAATGCCACTGTCCTGTTTGAGATCGAGCTGATTGA
CTTCCTGGACTCTGCCGAGTCGGACAAGTTTTGTGCACTCTCAGCTGAGCAGCAAGAACAGTTT
CCACTCCAGAAAGTCCTCAAGGTAGCGGCAACCGAGAGGGAGTTTGGCAACTACCTTTTCCGCC
AGAATCGCTTCTGTGATGCCAAAGTGAGATACAAGCGGGCCTTGTTGCTGCTCCATCGACGCTT
GGCCATCTGTGAGGAGCAGCACTTGGTAGAACCTGCTGAGCTCCTAGTCCTCCTTAACCTTTCA
TTTGTGTACCTGAAGCTAGACCGCCCTGCTATGGCCCTGCGCTATGGGGAGCAGGCTCTGCTCA
TTGACAAAAGGAACGCCAAAGCCCTCTTCAGGTGTGGACAGGCTTGCCTCCTCCTGACCGAGTA
TGAGCAGGCTCGGGACTTTCTAGTGAGAGCTCAGAAGGAGCAGCCCTGTAACCATGACATCAAT
AATGAGCTGAAGAAGCTGTCCAGCCACTACAGGGACTATGTGGACAGAGAGAGAGAGATGTGTC
ACCGGATGTTTGCTCCCTGTGGAAGCGGCTCTTCAGTGGGAGGAAACTGAAGGGTTTCAGCTAC
TGCAAACACAACTGGACTCCTCCTTCGAACTGTGGCTGGGGATGGATGGAGCTCCTAGTGCAGA
CTGCTCCAGCCACCCCTGGAAGACAGCGACGCCCTGCCAGACTGTTTCTCCAGGTTCATACACA
GTAGCAAAGGGTAGTCCCTGACAGCAGAAACCGCTCAGACAAGTAGGTTTTGTATGTGTGTCAG
TTCTCCGCTTACCTCCCAGCCTCACCCCCACCTCCTTTCCAAATGCTGATGTCAGTGGGCCAGT
ACAGATAGAAATGCCTTTGTATATTCTGTTGGGTTTTTTGAAGAGAATTATGTTACAATTGTTT
TTGTTGTAAATAAAACACATTCTTGTCCTAGCAGTATGCAGTACAATTCATTGTGTGAATTGTG
CTCAACTCCTGAAGTCTATGGCCTGGCAGAGGGAACCATTTGCAGAGAGCAGCAAGAGTGGGA

hide sequence

RefSeq Acc Id:

XM_063271155 ⟹ XP_063127225

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,947,443 - 27,026,913 (+)	NCBI

RefSeq Acc Id:

XM_063271157 ⟹ XP_063127227

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	26,956,236 - 26,974,896 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001099392	(Get FASTA)	NCBI Sequence Viewer
	XP_006249193	(Get FASTA)	NCBI Sequence Viewer
	XP_008767352	(Get FASTA)	NCBI Sequence Viewer
	XP_017453788	(Get FASTA)	NCBI Sequence Viewer
	XP_063127225	(Get FASTA)	NCBI Sequence Viewer
	XP_063127227	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D3ZQF4	(Get FASTA)	NCBI Sequence Viewer
	EDM13376	(Get FASTA)	NCBI Sequence Viewer
	EDM13377	(Get FASTA)	NCBI Sequence Viewer
	EDM13378	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001971
	ENSRNOP00000001971.2
	ENSRNOP00000083089
	ENSRNOP00000083089.1
	ENSRNOP00000086905.1
	ENSRNOP00055000376
	ENSRNOP00060014780
	ENSRNOP00065001062

RefSeq Acc Id:

NP_001099392 ⟸ NM_001105922

- UniProtKB:

D3ZQF4 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MSVFSRLRNGIPPSRDDCQSPYERLSQRMLDISGDRGVLKDIIREGAGDPVTPDASVLVKYSGY
LEHMDKPFDSNCFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPTYAYGTLGCPPLIP
PNATVLFEIELIDFLDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCDAKV
RYKRALLLLHRRLAICEEQHLVEPAELLVLLNLSFVYLKLDRPAMALRYGEQALLIDKRNAKAL
FRCGQACLLLTEYEQARDFLVRAQKEQPCNHDINNELKKLSSHYRDYVDREREMCHRMFAPCGS
GSSVGGN

hide sequence

RefSeq Acc Id:	XP_006249193 ⟸ XM_006249131
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I5ZW77 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGGSTRGRGALEGDDVLGQSPYERLSQRMLDISGDRGVLKDIIREGAGDPVTPDASVLVKYSGY LEHMDKPFDSNCFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPTYAYGTLGCPPLIP PNATVLFEIELIDFLDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCDAKV RYKRALLLLHRRLAICEEQHLVEPAELLVLLNLSFVYLKLDRPAMALRYGEQALLIDKRNAKAL FRCGQACLLLTEYEQARDFLVRAQKEQPCNHDINNELKKLSSHYRDYVDREREMCHRMFAPCGS GSSVGGN hide sequence

RefSeq Acc Id:	XP_008767352 ⟸ XM_008769130
- Peptide Label:	isoform X2
- UniProtKB:	D3ZQF4 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MSVFSRLRNGIPPSRDDCQSPYERLSQRMLDISGDRGVLKDIIREGAGDPVTPDASVLVKYSGY LEHMDKPFDSNCFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPTYAYGTLGCPPLIP PNATVLFEIELIDFLDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCDAKV RYKRALLLLHRRLAICEEQHLVEPAELLVLLNLSFVYLKLDRPAMALRYGEQALLIDKRNAKAL FRCGQACLLLTEYEQARDFLVRAQKEQPCNHDINNELKKLSSHYRDYVDREREMCHRMFAPCGS GSSVGGN hide sequence

RefSeq Acc Id:	XP_017453788 ⟸ XM_017598299
- Peptide Label:	isoform X2
- UniProtKB:	D3ZQF4 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MSVFSRLRNGIPPSRDDCQSPYERLSQRMLDISGDRGVLKDIIREGAGDPVTPDASVLVKYSGY LEHMDKPFDSNCFRKTPRLMKLGEDITLWGMELGLLSMRRGELARFLFKPTYAYGTLGCPPLIP PNATVLFEIELIDFLDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCDAKV RYKRALLLLHRRLAICEEQHLVEPAELLVLLNLSFVYLKLDRPAMALRYGEQALLIDKRNAKAL FRCGQACLLLTEYEQARDFLVRAQKEQPCNHDINNELKKLSSHYRDYVDREREMCHRMFAPCGS GSSVGGN hide sequence

RefSeq Acc Id:

ENSRNOP00000001971 ⟸ ENSRNOT00000001971

RefSeq Acc Id:

ENSRNOP00000086905 ⟸ ENSRNOT00000094090

RefSeq Acc Id:

ENSRNOP00000083089 ⟸ ENSRNOT00000098264

RefSeq Acc Id:	XP_063127225 ⟸ XM_063271155
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063127227 ⟸ XM_063271157
- Peptide Label:	isoform X3
- UniProtKB:	A0A8I5ZW77 (UniProtKB/TrEMBL)

Protein Domains

PPIase FKBP-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZQF4-F1-model_v2	AlphaFold	D3ZQF4	1-327	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698555

Promoter ID:

EPDNEW_R9080

Type:

multiple initiation site

Name:

Fkbp6_1

Description:

FK506 binding protein 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	24,367,204 - 24,367,264	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308926	AgrOrtholog
BioCyc Gene	G2FUF-19615	BioCyc
Ensembl Genes	ENSRNOG00000001451	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055000299	UniProtKB/Swiss-Prot
	ENSRNOG00060011211	UniProtKB/Swiss-Prot
	ENSRNOG00065001161	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000001971	ENTREZGENE
	ENSRNOT00000001971.5	UniProtKB/Swiss-Prot
	ENSRNOT00000094090.1	UniProtKB/TrEMBL
	ENSRNOT00000098264.1	UniProtKB/TrEMBL
	ENSRNOT00055000513	UniProtKB/Swiss-Prot
	ENSRNOT00060018950	UniProtKB/Swiss-Prot
	ENSRNOT00065001529	UniProtKB/Swiss-Prot
Gene3D-CATH	1.25.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.10.50.40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	FKBP6/shu	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PPIase_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PPIase_FKBP_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR-like_helical_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR_repeat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:288597	UniProtKB/Swiss-Prot
NCBI Gene	288597	ENTREZGENE
PANTHER	INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR46674	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	FKBP_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Fkbp6	PhenoGen
PROSITE	FKBP_PPIASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TPR_REGION	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000001451	RatGTEx
	ENSRNOG00055000299	RatGTEx
	ENSRNOG00060011211	RatGTEx
	ENSRNOG00065001161	RatGTEx
SMART	TPR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	FKBP-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF48452	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I5ZW77	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6A6Z3_RAT	UniProtKB/TrEMBL
	D3ZQF4	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-10-12	Fkbp6	FKBP prolyl isomerase family member 6	Fkbp6	FKBP prolyl isomerase 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2018-11-09	Fkbp6	FKBP prolyl isomerase 6	Fkbp6	FK506 binding protein 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-10-22	Fkbp6	FK506 binding protein 6	Fkbp6	FK506 binding protein 6, 36kDa	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Fkbp6	FK506 binding protein 6, 36kDa	Fkbp6	FK506 binding protein 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Fkbp6	FK506 binding protein 6	Fkbp6_predicted	FK506 binding protein 6 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Fkbp6_predicted	FK506 binding protein 6 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM