Cts7l2 (cathepsin 7 like 2) - Rat Genome Database

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Gene: Cts7l2 (cathepsin 7 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cts7l2 (Ensembl: RGD1308751)
Name: cathepsin 7 like 2 (Ensembl:similar to Cathepsin L precursor (Major excreted protein) (MEP))
RGD ID: 1308751
Description: Predicted to enable cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Predicted to be involved in immune response; positive regulation of apoptotic signaling pathway; and proteolysis involved in protein catabolic process. Predicted to be active in extracellular space and lysosome; INTERACTS WITH C60 fullerene; Cuprizon; manganese(II) chloride.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cathepsin L1; LOC290981; procathepsin L; RGD1308751; similar to Cathepsin L precursor (Major excreted protein) (MEP)
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,909,208 - 3,912,241 (+)NCBIGRCr8
mRatBN7.2173,903,602 - 3,907,088 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,903,602 - 3,906,568 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0174,270,207 - 4,273,173 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl174,256,299 - 4,273,170 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0176,498,230 - 6,501,196 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4179,590,989 - 9,593,955 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1179,589,871 - 9,593,955 (+)NCBI
Celera174,032,621 - 4,035,587 (+)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Cts7l2
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:96
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000061391
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system hemolymphoid system reproductive system
High
Medium
Low
Below cutoff 2 12 4 5

Sequence


RefSeq Acc Id: ENSRNOT00000061391   ⟹   ENSRNOP00000058108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl174,270,207 - 4,273,170 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000061398   ⟹   ENSRNOP00000058115
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl174,256,311 - 4,259,381 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083451   ⟹   ENSRNOP00000070135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl174,256,299 - 4,273,170 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090013   ⟹   ENSRNOP00000074913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl173,903,602 - 3,906,568 (+)Ensembl
Rnor_6.0 Ensembl174,256,311 - 4,273,170 (+)Ensembl
RefSeq Acc Id: XM_225137   ⟹   XP_225137
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,909,208 - 3,912,241 (+)NCBI
mRatBN7.2173,903,602 - 3,907,088 (+)NCBI
Rnor_6.0174,270,207 - 4,273,173 (+)NCBI
Rnor_5.0176,498,230 - 6,501,196 (+)NCBI
RGSC_v3.4179,590,989 - 9,593,955 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs XP_225137 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93863 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000074913
  ENSRNOP00000074913.1
RefSeq Acc Id: XP_225137   ⟸   XM_225137
- UniProtKB: D3ZKC3 (UniProtKB/TrEMBL),   A6KAF5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074913   ⟸   ENSRNOT00000090013
RefSeq Acc Id: ENSRNOP00000058115   ⟸   ENSRNOT00000061398
RefSeq Acc Id: ENSRNOP00000058108   ⟸   ENSRNOT00000061391
RefSeq Acc Id: ENSRNOP00000070135   ⟸   ENSRNOT00000083451
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JX50-F1-model_v2 AlphaFold A0A0G2JX50 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308751 AgrOrtholog
BioCyc Gene G2FUF-10469 BioCyc
Ensembl Genes ENSRNOG00000039954 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090013.2 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro Papain_like_cys_pep_sf UniProtKB/TrEMBL
  Pept_asp_AS UniProtKB/TrEMBL
  Pept_cys_AS UniProtKB/TrEMBL
  Pept_his_AS UniProtKB/TrEMBL
  Peptidase_C1A UniProtKB/TrEMBL
  Peptidase_C1A_C UniProtKB/TrEMBL
  Peptidase_C1A_papain-like UniProtKB/TrEMBL
  Prot_inhib_I29 UniProtKB/TrEMBL
KEGG Report rno:290981 UniProtKB/TrEMBL
NCBI Gene 290981 ENTREZGENE
PANTHER CATHEPSIN L-LIKE 3-RELATED UniProtKB/TrEMBL
  CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/TrEMBL
Pfam Inhibitor_I29 UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/TrEMBL
PhenoGen Cts7l2 PhenoGen
PRINTS PAPAIN UniProtKB/TrEMBL
PROSITE THIOL_PROTEASE_ASN UniProtKB/TrEMBL
  THIOL_PROTEASE_CYS UniProtKB/TrEMBL
  THIOL_PROTEASE_HIS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039954 RatGTEx
SMART Inhibitor_I29 UniProtKB/TrEMBL
  Pept_C1 UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A6KAF5 ENTREZGENE, UniProtKB/TrEMBL
  D3ZKC3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Cts7l2  cathepsin 7 like 2  RGD1308751  similar to Cathepsin L precursor (Major excreted protein) (MEP)  Symbol and Name Changed 1299863 APPROVED
2008-04-30 RGD1308751  similar to Cathepsin L precursor (Major excreted protein) (MEP)   RGD1308751_predicted  similar to Cathepsin L precursor (Major excreted protein) (MEP) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1308751_predicted  similar to Cathepsin L precursor (Major excreted protein) (MEP) (predicted)  LOC290981_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC290981_predicted  similar to Cathepsin L precursor (Major excreted protein) (MEP) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL