Gene: Ift27 (intraflagellar transport 27 homolog (Chlamydomonas))
Rattus norvegicus
Symbol:
Ift27
Name:
intraflagellar transport 27 homolog (Chlamydomonas)
Description:
ENCODES a protein that exhibits GTP binding (inferred); INVOLVED IN small GTPase mediated signal transduction (inferred); INTERACTS WITH 17alpha-ethynylestradiol; C60 fullerene; 2,3,7,8-tetrachlorodibenzodioxine (ortholog)
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
intraflagellar transport 27 homolog; LOC300062; RAB, member of RAS oncogene family-like 4; RAB, member of RAS oncogene family-like 4 (predicted); Rabl4; Rabl4_predicted
Orthologs:
Homo sapiens : IFT27
(intraflagellar transport 27 homolog (Chlamydomonas))
HGNC
Ift27
(intraflagellar transport 27)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 7 q34 NCBI RGSC Genome Assembly v5.0 7 119,384,971 - 119,401,297 - NCBI RGSC Genome Assembly v3.4 7 116,080,404 - 116,096,150 - NCBI Rat Celera Assembly 7 106,078,487 - 106,094,278 - NCBI Genome Assembly 3.1 7 116,114,639 - 116,148,320 - NCBI
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol multiple interactions ISO RGD:1318629 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IFT27 mRNA CTD PMID:17942748 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of IFT27 mRNA CTD PMID:17557909 17alpha-ethynylestradiol increases expression ISO RGD:1318629 6480464 Ethinyl Estradiol results in increased expression of IFT27 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1318628 6480464 Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IFT27 mRNA] CTD PMID:11007951 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1318629 6480464 Tetrachlorodibenzodioxin results in decreased expression of IFT27 mRNA CTD PMID:15034205 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1318629 6480464 AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IFT27 mRNA] CTD PMID:15034205 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1318629 6480464 Tetrachlorodibenzodioxin affects the expression of IFT27 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1318628 6480464 Tetrachlorodibenzodioxin results in decreased expression of IFT27 mRNA CTD PMID:11007951 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1318629 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of IFT27 mRNA CTD PMID:17942748 2-methylcholine affects expression ISO RGD:1318628 6480464 beta-methylcholine affects the expression of IFT27 mRNA CTD PMID:21179406 acetylsalicylic acid increases expression ISO RGD:1318628 6480464 Aspirin results in increased expression of IFT27 mRNA CTD PMID:11906190 benzo[a]pyrene multiple interactions ISO RGD:1318629 6480464 AHR protein inhibits the reaction [Benzo(a)pyrene results in decreased expression of IFT27 mRNA] CTD PMID:15034205 benzo[a]pyrene decreases expression ISO RGD:1318629 6480464 Benzo(a)pyrene results in decreased expression of IFT27 mRNA CTD PMID:15034205 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of IFT27 mRNA CTD PMID:19167457 cobalt dichloride decreases expression ISO RGD:1318628 6480464 cobaltous chloride results in decreased expression of IFT27 mRNA CTD PMID:19376846 cycloheximide multiple interactions ISO RGD:1318628 6480464 Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IFT27 mRNA] CTD PMID:11007951 cyclosporin A increases expression ISO RGD:1318628 6480464 Cyclosporine results in increased expression of IFT27 mRNA CTD PMID:20106945 hydrogen peroxide affects expression ISO RGD:1318628 6480464 Hydrogen Peroxide affects the expression of IFT27 mRNA CTD PMID:21179406 nickel atom affects expression ISO RGD:1318628 6480464 Nickel affects the expression of IFT27 mRNA CTD PMID:14575637 nickel atom multiple interactions ISO RGD:1318628 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of IFT27 mRNA] CTD PMID:14575637 paracetamol affects expression ISO RGD:1318629 6480464 Acetaminophen affects the expression of IFT27 mRNA CTD PMID:17562736 trichostatin A multiple interactions ISO RGD:1318628 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of IFT27 mRNA] CTD PMID:14575637 valproic acid increases expression ISO RGD:1318629 6480464 Valproic Acid results in increased expression of IFT27 mRNA CTD PMID:21427059
Gene Ontology Annotations
Biological Process small GTPase mediated signal transduction IEA InterPro:IPR001806 1600115 GO_REF:0000002 InterPro GO_REF:0000002
634336 Anxrr17 Anxiety related response QTL 17 3.66 Anxiety response 7 1786555 121975577 Rat 61357 Bp38 Blood pressure QTL 38 1.6 .052 Blood pressure 7 44698822 125481104 Rat 1300179 Kidm5 Kidney mass QTL 5 3.51 Kidney mass salt-loaded 7 47145687 124315164 Rat 631504 Cm27 Cardiac mass QTL 27 3.45 Cardiac mass left ventricle 7 47865637 125399168 Rat 70173 Niddm19 Non-insulin dependent diabetes mellitus QTL 19 4.33 .00005 Glucose level postprandial 7 68162496 143002779 Rat 2316947 Rf58 Renal function QTL 58 7 Renal function 7 72552109 120746007 Rat 2316952 Pur22 Proteinuria QTL 22 5.2 Renal function urine protein level 7 72552109 120746007 Rat 2316955 Stl24 Serum triglyceride level QTL 24 7.1 Lipid level serum triglyceride level 7 72552109 120746007 Rat 631540 Bw9 Body weight QTL 9 4.5 Body weight 7 74244786 123665486 Rat 1357338 Stl17 Serum triglyceride level QTL 17 3.23 Lipid level triglyceride 7 74244916 119494569 Rat 2293644 Bmd29 Bone mineral density QTL 29 5.4 .0001 Bone mineral density 7 74658964 120536775 Rat 2293685 Bmd21 Bone mineral density QTL 21 4.2 .0003 Bone mineral density 7 74658964 120536775 Rat 2293696 Bmd32 Bone mineral density QTL 32 5.1 .0001 Bone mineral density 7 74658964 120536775 Rat 634331 Pia17 Pristane induced arthritis QTL 17 4.7 Joint/bone inflammation pristane induced 7 78497123 137838800 Rat 1331746 Kidm9 Kidney mass QTL 9 3.934 Kidney mass right kidney mass 7 85089895 119050197 Rat 1331728 Bp214 Blood pressure QTL 214 2.825 Blood pressure mean arterial 7 85089895 130953311 Rat 1331768 Kidm10 Kidney mass QTL 10 4.62096 Kidney mass left kidney mass 7 85089895 140651095 Rat 631529 Tls2 T-lymphoma susceptibility QTL 2 13.1 .001 T-lymphoma susceptibility propylnitrosourea induced 7 85090032 137838850 Rat 2317052 Aia17 Adjuvant induced arthritis QTL 17 2.13 Joint/bone inflammation adjuvant induced 7 87525274 132525274 Rat 1358891 Bp265 Blood pressure QTL 265 2.21 Blood pressure post renin-angiotensin system block 7 88583730 142441286 Rat 1358914 Bp266 Blood pressure QTL 266 Blood pressure post sympathetic nervous system block 7 88583730 142441286 Rat 71114 Niddm14 Non-insulin dependent diabetes mellitus QTL 14 4.5 Glucose level plasma glucose homeostasis 7 90478161 135478161 Rat 2298475 Eau6 Experimental allergic uveoretinitis QTL 6 .0029 Uvea inflammation 7 90478161 135478161 Rat 1357336 Gluco6 Glucose level QTL 6 3.4 Glucose level plasma glucose 7 91775447 119050197 Rat 1558655 Swd4 Spike wave discharge measurement QTL 4 3.68 .0002 Spike wave discharge measurement grading 7 93320292 138320292 Rat 61428 Scl3 Serum cholesterol level QTL 3 3.2 Lipid level cholesterol 7 95054656 132141292 Rat 2299163 Iddm34 Insulin dependent diabetes mellitus QTL 34 2.71 Glucose level insulin-dependent 7 96517746 137757704 Rat 631687 Hcas1 Hepatocarcinoma susceptibility QTL 1 3.9 .001 Liver tumor susceptibility nodule volume fraction 7 96649133 137404381 Rat 1549899 Stresp8 Stress response QTL 8 4.37 .0008 Stress response defensive burying - shocks 7 97285400 142285400 Rat 2293703 Bss48 Bone structure and strength QTL 48 16.05 .0001 Bone structure 7 98036672 143002779 Rat 2300184 Bmd53 Bone mineral density QTL 53 5.4 .0001 Bone mineral density 7 98036672 143002779 Rat 2313102 Bmd79 Bone mineral density QTL 79 2.3 .0001 Bone mineral density 7 100273558 123635849 Rat 731176 Glom5 Glomerulus QTL 5 2.5 .0035 Renal histology 7 103894800 143002779 Rat 1331731 Bp216 Blood pressure QTL 216 2.851 Blood pressure mean arterial 7 108021523 141116504 Rat 70159 Bp61 Blood pressure QTL 61 .0001 Blood pressure systolic 7 108875615 123635849 Rat 731174 Uae23 Urinary albumin excretion QTL 23 2.4 .0042 Renal function urine albumin level 7 112114092 143002779 Rat
Gene Ontology Annotations
