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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | ISO | RGD:1318490 | 6480464 | Ethinyl Estradiol affects the expression of ALDH7A1 mRNA | CTD | PMID:17555576 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of ALDH7A1 mRNA | CTD | PMID:17557909 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of ALDH7A1 mRNA | CTD | PMID:18796159 | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2,4-dinitrotoluene affects the expression of ALDH7A1 mRNA | CTD | PMID:21346803 | 2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 2,6-dinitrotoluene affects the expression of ALDH7A1 mRNA | CTD | PMID:21346803 | 4,4'-diaminodiphenylmethane | increases expression | ISO | RGD:1318490 | 6480464 | 4,4'-diaminodiphenylmethane results in increased expression of ALDH7A1 mRNA | CTD | PMID:18648102 | 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one | increases expression | ISO | RGD:1318489 | 6480464 | 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of ALDH7A1 mRNA | CTD | PMID:19038236 | 4-hydroxynon-2-enal | increases metabolic processing | ISO | RGD:1318489 | 6480464 | ALDH7A1 protein results in increased metabolism of 4-hydroxy-2-nonenal | CTD | PMID:21338592 | 4-hydroxynon-2-enal | decreases response to substance | ISO | RGD:1318489 | 6480464 | ALDH7A1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal | CTD | PMID:21338592 | acetaldehyde | multiple interactions | ISO | RGD:1318490 | 6480464 | [CGA protein results in increased abundance of Acetaldehyde] which results in increased expression of ALDH7A1 mRNA | CTD | PMID:22285649 | all-trans-retinoic acid | decreases expression | ISO | RGD:1318489 | 6480464 | Tretinoin results in decreased expression of ALDH7A1 mRNA | CTD | PMID:21934132 | allysine | increases oxidation | ISO | RGD:1318489 | 6480464 | ALDH7A1 protein results in increased oxidation of allysine | CTD | PMID:21185811 | allysine | affects binding | ISO | RGD:1318489 | 6480464 | allysine binds to ALDH7A1 protein | CTD | PMID:21185811 | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of ALDH7A1 mRNA | CTD | PMID:16483693 | biochanin A | decreases expression | ISO | RGD:1318489 | 6480464 | biochanin A results in decreased expression of ALDH7A1 mRNA | CTD | PMID:12111696 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of ALDH7A1 mRNA | CTD | PMID:20691718 | choline | multiple interactions | ISO | RGD:1318490 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ALDH7A1 gene | CTD | PMID:20938992 | clofibrate | decreases expression | ISO | RGD:1318490 | 6480464 | Clofibrate results in decreased expression of ALDH7A1 mRNA | CTD | PMID:17585979 | clofibric acid | increases expression | ISO | RGD:1318490 | 6480464 | Clofibric Acid results in increased expression of ALDH7A1 mRNA | CTD | PMID:17998271 | cobalt dichloride | decreases expression | ISO | RGD:1318489 | 6480464 | cobaltous chloride results in decreased expression of ALDH7A1 mRNA | CTD | PMID:19376846 | copper atom | multiple interactions | ISO | RGD:1318489 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of ALDH7A1 mRNA | CTD | PMID:20971185 | copper(0) | multiple interactions | ISO | RGD:1318489 | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of ALDH7A1 mRNA | CTD | PMID:20971185 | copper(2+) sulfate | decreases expression | ISO | RGD:1318489 | 6480464 | Copper Sulfate results in decreased expression of ALDH7A1 mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | RGD:1318489 | 6480464 | Cyclosporine results in decreased expression of ALDH7A1 mRNA | CTD | PMID:20106945 | cyclosporin A | decreases expression | ISO | RGD:1318489 | 6480464 | Cyclosporine results in decreased expression of ALDH7A1 mRNA | CTD | PMID:20106945 PMID:21632981 | dibutyl phthalate | decreases expression | EXP | | 6480464 | Dibutyl Phthalate results in decreased expression of ALDH7A1 mRNA | CTD | PMID:21266533 | doxorubicin | affects response to substance | ISO | RGD:1318489 | 6480464 | ALDH7A1 protein affects the susceptibility to Doxorubicin | CTD | PMID:16217747 | flurbiprofen | decreases expression | ISO | RGD:1318490 | 6480464 | Flurbiprofen results in decreased expression of ALDH7A1 mRNA | CTD | PMID:16949054 | folic acid | multiple interactions | ISO | RGD:1318490 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ALDH7A1 gene | CTD | PMID:20938992 | hydrogen peroxide | decreases response to substance | ISO | RGD:1318489 | 6480464 | ALDH7A1 protein results in decreased susceptibility to Hydrogen Peroxide | CTD | PMID:21338592 | L-methionine | multiple interactions | ISO | RGD:1318490 | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of ALDH7A1 gene | CTD | PMID:20938992 | lead diacetate | increases expression | ISO | RGD:1318490 | 6480464 | lead acetate results in increased expression of ALDH7A1 mRNA | CTD | PMID:21829687 | paracetamol | affects expression | ISO | RGD:1318490 | 6480464 | Acetaminophen affects the expression of ALDH7A1 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of ALDH7A1 protein | CTD | PMID:16538041 | perfluorooctanoic acid | decreases expression | ISO | RGD:1318489 | 6480464 | perfluorooctanoic acid results in decreased expression of ALDH7A1 protein | CTD | PMID:22609092 | phlorizin | decreases expression | ISO | RGD:1318490 | 6480464 | Phlorhizin results in decreased expression of ALDH7A1 mRNA | CTD | PMID:22538082 | pirinixic acid | multiple interactions | ISO | RGD:1318489 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of ALDH7A1 mRNA | CTD | PMID:19710929 | tamoxifen | affects expression | ISO | RGD:1318490 | 6480464 | Tamoxifen affects the expression of ALDH7A1 mRNA | CTD | PMID:17555576 | tert-butyl hydroperoxide | decreases expression | ISO | RGD:1318489 | 6480464 | tert-Butylhydroperoxide results in decreased expression of ALDH7A1 mRNA | CTD | PMID:15336504 | testosterone | decreases expression | ISO | RGD:1318490 | 6480464 | Testosterone results in decreased expression of ALDH7A1 mRNA | CTD | PMID:20403060 | troglitazone | increases expression | ISO | RGD:1318490 | 6480464 | troglitazone results in increased expression of ALDH7A1 protein | CTD | PMID:18495193 | vancomycin | increases expression | ISO | RGD:1318490 | 6480464 | Vancomycin results in increased expression of ALDH7A1 mRNA | CTD | PMID:18930951 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations
Disease Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Arginine and proline metabolism |
| Ascorbate and aldarate metabolism | |
| beta-Alanine metabolism | |
| Fatty acid metabolism | |
| Glycerolipid metabolism | |
| Glycine, serine and threonine metabolism | |
| Glycolysis / Gluconeogenesis | |
| Histidine metabolism | |
| Lysine biosynthesis | |
| Lysine degradation | |
| Metabolic pathways | |
| Propanoate metabolism | |
| Pyruvate metabolism | |
| Tryptophan metabolism | |
| Valine, leucine and isoleucine degradation | |
References - curated| 1. |
GOA data from the GO Consortium |
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MGD data from the GO Consortium |
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Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
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RGD automated data pipeline |
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RGD automated import pipeline for gene-chemical interactions |
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RGD Automated Pipelines |
References - uncurated
RGD Disease Portals| Aldh7a1 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Aldh7a1 (Rattus norvegicus) |
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| ALDH7A1 (Homo sapiens) |
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| Aldh7a1 (Mus musculus) |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001271105 | (Get FASTA) | Search GEO for Microarray Profiles |
| XM_001059375 | (Get FASTA) | Search GEO for Microarray Profiles | |
| XM_214535 | (Get FASTA) | Search GEO for Microarray Profiles | |
| GenBank Nucleotide | AABR06095321 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01095281 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473971 | (Get FASTA) | Search GEO for Microarray Profiles | |
| S75019 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | XM_001059375 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | XP_001059375 | ||||||||||
| Position: |
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| RefSeq Acc Id: | XM_214535 | |||||||||||||||
| RefSeq Status: | ||||||||||||||||
| Type: | CODING | |||||||||||||||
| Protein Acc Id: | XP_214535 | |||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001258034 | (Get FASTA) |
| XP_001059375 | (Get FASTA) | |
| XP_214535 | (Get FASTA) | |
| GenBank Protein | AAB31967 | (Get FASTA) |
| EDM14488 | (Get FASTA) | |
| EDM14489 | (Get FASTA) | |
| EDM14490 | (Get FASTA) | |
| EDM14491 | (Get FASTA) | |
| EDM14492 | (Get FASTA) | |
| EDM14493 | (Get FASTA) | |
| Q64057 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000014645 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Protein | ENSRNOP00000020325 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Ensembl Transcript | ENSRNOT00000020325 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Entrez Gene | 291450 | ENTREZGENE |
| Gene3D-CATH | Aldehyde_dehydrogenase_C | UniProtKB/Swiss-Prot |
| Aldehyde_dehydrogenase_N | UniProtKB/Swiss-Prot | |
| Germonline | ENSRNOG00000014645 | UniProtKB/Swiss-Prot |
| HomoloGene Group ID | 913 | ENTREZGENE |
| InterPro | Ald_DH/histidinol_DH | UniProtKB/Swiss-Prot |
| Ald_DH_C | UniProtKB/Swiss-Prot | |
| Ald_DH_CS | UniProtKB/Swiss-Prot | |
| Ald_DH_N | UniProtKB/Swiss-Prot | |
| Aldehyde_DH | UniProtKB/Swiss-Prot | |
| IPI | IPI00208917 | UniProtKB/Swiss-Prot |
| KEGG Report | rno:291450 | ENTREZGENE, UniProtKB/Swiss-Prot |
| Pfam | Aldedh | UniProtKB/Swiss-Prot |
| PROSITE | ALDEHYDE_DEHYDR_CYS; FALSE_NEG | UniProtKB/Swiss-Prot |
| ALDEHYDE_DEHYDR_GLU | UniProtKB/Swiss-Prot | |
| Superfamily-SCOP | Aldehyde_DH/Histidinol_DH | UniProtKB/Swiss-Prot |
| UniGene | Rn.7330 | ENTREZGENE |
| UniProt | AL7A1_RAT | UniProtKB/Swiss-Prot |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-09-26 | Aldh7a1 | aldehyde dehydrogenase 7 family, member A1 | Aldh7a1 | aldehyde dehydrogenase family 7, member A1 | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2005-12-06 | Aldh7a1 | aldehyde dehydrogenase family 7, member A1 | Aldh7a1_predicted | aldehyde dehydrogenase family 7, member A1 (predicted) | Symbol and Name updated | 14393 | APPROVED |
| 2005-01-12 | Aldh7a1_predicted | aldehyde dehydrogenase family 7, member A1 (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Aldh7a1 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1308614 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




