Trim31 (tripartite motif-containing 31) - Rat Genome Database

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Gene: Trim31 (tripartite motif-containing 31) Rattus norvegicus
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Symbol: Trim31
Name: tripartite motif-containing 31
RGD ID: 1308607
Description: Predicted to enable transcription coactivator activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including antiviral innate immune response; negative regulation of NLRP3 inflammasome complex assembly; and protein polyubiquitination. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Orthologous to human TRIM31 (tripartite motif containing 31); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; cadmium dichloride.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: E3 ubiquitin-protein ligase TRIM31; LOC294208; Trim31l; tripartite motif protein 31; tripartite motif protein 31-like
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8201,658,386 - 1,671,711 (-)NCBIGRCr8
mRatBN7.2201,653,165 - 1,666,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl201,653,165 - 1,666,494 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx201,706,020 - 1,719,826 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0201,709,513 - 1,723,321 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0201,650,953 - 1,663,946 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0202,146,245 - 2,159,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,146,257 - 2,159,631 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0204,183,577 - 4,196,772 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4201,745,437 - 1,758,194 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1201,746,131 - 1,757,962 (-)NCBI
Celera202,361,720 - 2,375,040 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
mitochondrion  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15060004   PMID:18248090   PMID:23077300  


Genomics

Comparative Map Data
Trim31
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8201,658,386 - 1,671,711 (-)NCBIGRCr8
mRatBN7.2201,653,165 - 1,666,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl201,653,165 - 1,666,494 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx201,706,020 - 1,719,826 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0201,709,513 - 1,723,321 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0201,650,953 - 1,663,946 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0202,146,245 - 2,159,875 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,146,257 - 2,159,631 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0204,183,577 - 4,196,772 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4201,745,437 - 1,758,194 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1201,746,131 - 1,757,962 (-)NCBI
Celera202,361,720 - 2,375,040 (-)NCBICelera
Cytogenetic Map20p12NCBI
TRIM31
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,102,897 - 30,113,090 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,102,897 - 30,113,090 (-)EnsemblGRCh38hg38GRCh38
GRCh37630,070,674 - 30,080,867 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,178,653 - 30,188,846 (-)NCBINCBI36Build 36hg18NCBI36
Build 34630,178,654 - 30,188,833NCBI
Celera631,668,926 - 31,679,124 (-)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef629,868,836 - 29,879,034 (-)NCBIHuRef
CHM1_1630,072,756 - 30,082,946 (-)NCBICHM1_1
T2T-CHM13v2.0629,967,171 - 29,977,357 (-)NCBIT2T-CHM13v2.0
Trim31
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391737,209,022 - 37,221,109 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1737,209,010 - 37,221,106 (+)EnsemblGRCm39 Ensembl
GRCm381736,898,130 - 36,910,217 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1736,898,118 - 36,910,214 (+)EnsemblGRCm38mm10GRCm38
MGSCv371737,035,075 - 37,047,162 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361736,506,183 - 36,518,270 (+)NCBIMGSCv36mm8
Celera1740,317,255 - 40,329,416 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1719.16NCBI
TRIM31
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2544,693,821 - 44,720,839 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1640,656,853 - 40,683,843 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0629,880,668 - 29,890,905 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1630,550,802 - 30,560,993 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl630,550,802 - 30,560,977 (-)Ensemblpanpan1.1panPan2
Trim31
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494632,646,388 - 32,657,283 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936723934,808 - 945,279 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TRIM31
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1722,665,150 - 22,681,616 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2724,946,635 - 24,960,048 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Trim31
229 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:208
Count of miRNA genes:152
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000061558
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2013624629Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat

Markers in Region
D20Rat1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2201,658,903 - 1,659,140 (+)MAPPERmRatBN7.2
Rnor_6.0202,151,984 - 2,152,218NCBIRnor6.0
Rnor_5.0204,189,287 - 4,189,521UniSTSRnor5.0
Celera202,367,455 - 2,367,687UniSTS
RH 3.4 Map2011.4UniSTS
RH 3.4 Map2011.4RGD
RH 2.0 Map200.0RGD
SHRSP x BN Map200.04RGD
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3
Low 8 41 25 19 25 8 8 11 21 11 11 8
Below cutoff 15 10 10 10 3 4 8 12

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000061558   ⟹   ENSRNOP00000058275
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl201,653,165 - 1,666,494 (-)Ensembl
Rnor_6.0 Ensembl202,146,257 - 2,159,631 (-)Ensembl
RefSeq Acc Id: NM_001106376   ⟹   NP_001099846
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8201,658,386 - 1,671,711 (-)NCBI
mRatBN7.2201,653,165 - 1,666,494 (-)NCBI
Rnor_6.0202,146,245 - 2,159,631 (-)NCBI
Rnor_5.0204,183,577 - 4,196,772 (-)NCBI
RGSC_v3.4201,745,437 - 1,758,194 (-)RGD
Celera202,361,720 - 2,375,040 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099846 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL84606 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058275
  ENSRNOP00000058275.3
Reference Protein Sequences
RefSeq Acc Id: NP_001099846   ⟸   NM_001106376
- UniProtKB: D3ZN56 (UniProtKB/TrEMBL),   A6KR83 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000058275   ⟸   ENSRNOT00000061558
Protein Domains
B box-type   B30.2/SPRY   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZN56-F1-model_v2 AlphaFold D3ZN56 1-507 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701275
Promoter ID:EPDNEW_R11799
Type:initiation region
Name:Trim31_1
Description:tripartite motif-containing 31
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0202,159,643 - 2,159,703EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308607 AgrOrtholog
BioCyc Gene G2FUF-4974 BioCyc
Ensembl Genes ENSRNOG00000021518 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061558 ENTREZGENE
  ENSRNOT00000061558.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
  Classic Zinc Finger UniProtKB/TrEMBL
InterPro B30.2/SPRY_sf UniProtKB/TrEMBL
  B302 UniProtKB/TrEMBL
  Butyrophylin UniProtKB/TrEMBL
  ConA-like_dom UniProtKB/TrEMBL
  PRY UniProtKB/TrEMBL
  SPRY_rcpt UniProtKB/TrEMBL
  Znf_B-box UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
  Znf_RING_CS UniProtKB/TrEMBL
KEGG Report rno:294208 UniProtKB/TrEMBL
NCBI Gene 294208 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE TRIM UniProtKB/TrEMBL
  E3 UBIQUITIN-PROTEIN LIGASE TRIM31 UniProtKB/TrEMBL
Pfam SPRY UniProtKB/TrEMBL
  zf-B_box UniProtKB/TrEMBL
  zf-C3HC4_4 UniProtKB/TrEMBL
PhenoGen Trim31 PhenoGen
PRINTS BUTYPHLNCDUF UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/TrEMBL
  ZF_BBOX UniProtKB/TrEMBL
  ZF_RING_1 UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021518 RatGTEx
SMART BBOX UniProtKB/TrEMBL
  PRY UniProtKB/TrEMBL
  RING UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
Superfamily-SCOP B-box zinc-binding domain UniProtKB/TrEMBL
  ConA_like_lec_gl UniProtKB/TrEMBL
  RING/U-box UniProtKB/TrEMBL
UniProt A6KR83 ENTREZGENE, UniProtKB/TrEMBL
  D3ZN56 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-31 Trim31  tripartite motif-containing 31  Trim31_predicted  tripartite motif protein 31 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Trim31_predicted  tripartite motif protein 31 (predicted)    tripartite motif-containing 31 (predicted)  Name updated 1299863 APPROVED
2005-01-12 Trim31_predicted  tripartite motif-containing 31 (predicted)      Symbol and Name status set to approved 70820 APPROVED