Meak7 (MTOR associated protein, eak-7 homolog) - Rat Genome Database

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Gene: Meak7 (MTOR associated protein, eak-7 homolog) Rattus norvegicus
Analyze
Symbol: Meak7
Name: MTOR associated protein, eak-7 homolog
RGD ID: 1308461
Description: Predicted to be involved in several processes, including TOR signaling; positive regulation of protein localization to lysosome; and response to insulin. Predicted to act upstream of or within negative regulation of cellular response to oxidative stress. Predicted to be located in cytosol; lysosomal membrane; and nuclear lumen. Orthologous to human MEAK7 (MTOR associated protein, eak-7 homolog); INTERACTS WITH atrazine; bisphenol A; methoxychlor.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC307901; MTOR-associated protein MEAK7; RGD1308461; similar to RIKEN cDNA 4632415K11; TBC/LysM-associated domain containing 1; TLD domain-containing protein 1; Tldc1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,722,528 - 64,745,443 (-)NCBIGRCr8
mRatBN7.21947,813,899 - 47,836,830 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,811,416 - 47,841,278 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1954,608,244 - 54,630,309 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,288,974 - 55,311,038 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,501,966 - 57,523,940 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,408,700 - 52,430,198 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,408,917 - 52,424,318 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01963,149,967 - 63,174,142 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,959,688 - 50,055,661 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11949,950,948 - 50,065,567 (-)NCBI
Celera1947,071,440 - 47,094,134 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (IEA,ISO)
lysosomal membrane  (ISO)
membrane  (ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17897319   PMID:24223779   PMID:26668325   PMID:29750193   PMID:38190869  


Genomics

Comparative Map Data
Meak7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81964,722,528 - 64,745,443 (-)NCBIGRCr8
mRatBN7.21947,813,899 - 47,836,830 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1947,811,416 - 47,841,278 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1954,608,244 - 54,630,309 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01955,288,974 - 55,311,038 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01957,501,966 - 57,523,940 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01952,408,700 - 52,430,198 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1952,408,917 - 52,424,318 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01963,149,967 - 63,174,142 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41949,959,688 - 50,055,661 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11949,950,948 - 50,065,567 (-)NCBI
Celera1947,071,440 - 47,094,134 (-)NCBICelera
Cytogenetic Map19q12NCBI
MEAK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381684,476,355 - 84,504,659 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1684,476,355 - 84,554,033 (-)EnsemblGRCh38hg38GRCh38
GRCh371684,509,961 - 84,538,265 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361683,068,608 - 83,095,794 (-)NCBINCBI36Build 36hg18NCBI36
Celera1668,812,050 - 68,840,421 (-)NCBICelera
Cytogenetic Map16q24.1NCBI
HuRef1670,262,699 - 70,291,067 (-)NCBIHuRef
CHM1_11685,921,538 - 85,949,838 (-)NCBICHM1_1
T2T-CHM13v2.01690,542,752 - 90,570,998 (-)NCBIT2T-CHM13v2.0
Meak7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398120,486,802 - 120,505,173 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8120,486,815 - 120,505,155 (-)EnsemblGRCm39 Ensembl
GRCm388119,760,063 - 119,778,439 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8119,760,076 - 119,778,416 (-)EnsemblGRCm38mm10GRCm38
MGSCv378122,284,487 - 122,302,316 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368122,646,564 - 122,664,393 (-)NCBIMGSCv36mm8
Celera8123,976,804 - 123,994,606 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map868.32NCBI
Meak7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955541101,275 - 115,079 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495554199,319 - 114,122 (-)NCBIChiLan1.0ChiLan1.0
MEAK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21894,223,152 - 94,249,697 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan116100,135,189 - 100,166,944 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01665,141,319 - 65,167,898 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11684,482,997 - 84,509,530 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1684,482,997 - 84,509,530 (-)Ensemblpanpan1.1panPan2
MEAK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1567,958,596 - 67,976,945 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl567,962,242 - 67,975,264 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha567,973,302 - 67,991,776 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0568,192,142 - 68,210,560 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl568,192,336 - 68,210,560 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1568,205,086 - 68,221,906 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0568,041,325 - 68,059,794 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0568,456,742 - 68,475,145 (+)NCBIUU_Cfam_GSD_1.0
Meak7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934927,733,273 - 27,748,562 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366413,490,531 - 3,498,615 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEAK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl64,204,080 - 4,228,567 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.164,169,840 - 4,226,798 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.264,628,177 - 4,650,999 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEAK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1569,873,518 - 69,903,097 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660475,851,277 - 5,880,664 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Meak7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247461,451,466 - 1,477,669 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247461,449,741 - 1,469,116 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Meak7
44 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:71
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000021743
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194434021455283277Rat

Markers in Region
RH144624  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21947,811,135 - 47,811,301 (+)MAPPERmRatBN7.2
Rnor_6.01952,404,375 - 52,404,540NCBIRnor6.0
Rnor_5.01963,149,822 - 63,149,987UniSTSRnor5.0
Celera1947,068,673 - 47,068,838UniSTS
RH 3.4 Map19649.3UniSTS
Cytogenetic Map19q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 6 1 3 1 54 32 27 9
Low 43 51 40 16 40 8 11 20 3 14 2 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000021743   ⟹   ENSRNOP00000021743
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1947,811,416 - 47,841,278 (-)Ensembl
Rnor_6.0 Ensembl1952,408,917 - 52,424,318 (-)Ensembl
RefSeq Acc Id: NM_001400970   ⟹   NP_001387899
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,722,528 - 64,744,592 (-)NCBI
mRatBN7.21947,813,899 - 47,835,969 (-)NCBI
RefSeq Acc Id: XM_039098199   ⟹   XP_038954127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,722,532 - 64,745,435 (-)NCBI
mRatBN7.21947,813,899 - 47,836,825 (-)NCBI
RefSeq Acc Id: XM_039098200   ⟹   XP_038954128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,722,532 - 64,745,443 (-)NCBI
mRatBN7.21947,813,899 - 47,836,830 (-)NCBI
RefSeq Acc Id: XM_039098202   ⟹   XP_038954130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,722,532 - 64,735,811 (-)NCBI
mRatBN7.21947,813,899 - 47,826,054 (-)NCBI
RefSeq Acc Id: XR_005496987
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,722,532 - 64,745,435 (-)NCBI
mRatBN7.21947,813,899 - 47,836,825 (-)NCBI
RefSeq Acc Id: XR_005496988
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81964,722,532 - 64,745,443 (-)NCBI
mRatBN7.21947,813,899 - 47,836,830 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001387899 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954127 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954128 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954130 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92683 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021743
  ENSRNOP00000021743.8
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000021743   ⟸   ENSRNOT00000021743
RefSeq Acc Id: XP_038954128   ⟸   XM_039098200
- Peptide Label: isoform X1
- UniProtKB: D4A255 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954127   ⟸   XM_039098199
- Peptide Label: isoform X1
- UniProtKB: D4A255 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038954130   ⟸   XM_039098202
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001387899   ⟸   NM_001400970
Protein Domains
TLDc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A255-F1-model_v2 AlphaFold D4A255 1-453 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308461 AgrOrtholog
BioCyc Gene G2FUF-5503 BioCyc
Ensembl Genes ENSRNOG00000016224 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021743.8 UniProtKB/TrEMBL
InterPro TLDc UniProtKB/TrEMBL
NCBI Gene 307901 ENTREZGENE
PANTHER MTOR-ASSOCIATED PROTEIN MEAK7 UniProtKB/TrEMBL
  NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED UniProtKB/TrEMBL
Pfam TLD UniProtKB/TrEMBL
PhenoGen Meak7 PhenoGen
PROSITE TLDC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016224 RatGTEx
SMART TLDc UniProtKB/TrEMBL
UniProt D4A255 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-17 Meak7  MTOR associated protein, eak-7 homolog  Tldc1  TBC/LysM-associated domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-03-20 Tldc1  TBC/LysM-associated domain containing 1  RGD1308461  similar to RIKEN cDNA 4632415K11  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1308461  similar to RIKEN cDNA 4632415K11   RGD1308461_predicted  similar to RIKEN cDNA 4632415K11 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1308461_predicted  similar to RIKEN cDNA 4632415K11 (predicted)  LOC307901_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC307901_predicted  similar to RIKEN cDNA 4632415K11 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL