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Gene-Chemical Interaction AnnotationsGene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1318214 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of NKX2-2 mRNA | CTD | PMID:16922920 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1318213 | 6480464 | [Tretinoin co-treated with EGF protein] results in increased expression of NKX2-2 mRNA | CTD | PMID:17196394 | all-trans-retinoic acid | multiple interactions | ISO | RGD:1318214 | 6480464 | [Tretinoin co-treated with SHH protein] results in increased expression of NKX2-2 protein | CTD | PMID:15996115 | carmustine | decreases expression | ISO | RGD:1318213 | 6480464 | Carmustine results in decreased expression of NKX2-2 mRNA | CTD | PMID:15980968 | cocaine | decreases expression | EXP | | 6480464 | Cocaine results in decreased expression of NKX2-2 mRNA | CTD | PMID:17898221 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology AnnotationsMolecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Maturity onset diabetes of the young |
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Maturity onset diabetes of the young |
References - curated| 1. |
Delisle JC, etal., BMC Res Notes. 2009 Jan 9;2:3. |
| 2. |
Fancy SP, etal., Mol Cell Neurosci 2004 Nov;27(3):247-54. |
| 3. |
GOA data from the GO Consortium |
| 4. |
Kawasaki H, etal., J Hepatobiliary Pancreat Surg. 2008;15(3):310-7. Epub 2008 Jun 6. |
| 5. |
Labombarda F, etal., Glia. 2008 Dec 2. |
| 6. |
MGD data from the GO Consortium |
| 7. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 8. |
RGD automated import pipeline for gene-chemical interactions |
| 9. |
RGD comprehensive gene curation |
| 10. |
Umezawa K, etal., Biomed Pharmacother. 2003 Oct;57(8):341-50. |
| 11. |
Watanabe M, etal., Glia. 2004 May;46(3):311-22. |
References - uncuratedRGD Disease Portals| Nkx2-2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Nkx2-2 (Rattus norvegicus) |
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| NKX2-2 (Homo sapiens) |
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| Nkx2-2 (Mus musculus) |
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Position Markers| D3Ztm2 |
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| UniSTS:238165 |
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| Nkx2-2 |
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| Nkx2-2 |
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| Nkx2-2 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. |  | Full Report | | CSV | | TAB | | Printer | | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001191904 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06026764 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01025624 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | XM_001056116 | ||||||||||
| RefSeq Status: | |||||||||||
| Type: | CODING | ||||||||||
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| RefSeq Acc Id: | XM_345446 | ||||||||||
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| Type: | CODING | ||||||||||
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| RefSeq Acc Id: | NM_001191904 | ||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||
| Type: | CODING | ||||||||||
| Protein Acc Id: | NP_001178833 | ||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001178833 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000012728 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000017364 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000017364 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 366214 | ENTREZGENE |
| Gene3D-CATH | Homeodomain-rel | UniProtKB/TrEMBL |
| HomoloGene Group ID | 1879 | ENTREZGENE |
| InterPro | Homeobox | UniProtKB/TrEMBL |
| Homeobox_CS | UniProtKB/TrEMBL | |
| Homeobox_region | UniProtKB/TrEMBL | |
| Homeodomain-like | UniProtKB/TrEMBL | |
| IPI | IPI00192110 | UniProtKB/TrEMBL |
| KEGG Report | rno:366214 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | Homeobox | UniProtKB/TrEMBL |
| PRINTS | HOMEOBOX | UniProtKB/TrEMBL |
| PROSITE | HOMEOBOX_1 | UniProtKB/TrEMBL |
| HOMEOBOX_2 | UniProtKB/TrEMBL | |
| SMART | HOX | UniProtKB/TrEMBL |
| Superfamily-SCOP | Homeodomain_like | UniProtKB/TrEMBL |
| UniGene | Rn.32651 | ENTREZGENE |
| UniProt | D3ZDQ2_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-09-26 | Nkx2-2 | NK2 homeobox 2 | Nkx2-2 | NK2 transcription factor related, locus 2 (Drosophila) | Nomenclature updated to reflect human and mouse nomenclature | 10779 | APPROVED |
| 2008-04-30 | Nkx2-2 | NK2 transcription factor related, locus 2 (Drosophila) | Nkx2-2_predicted | NK2 transcription factor related, locus 2 (Drosophila) (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2005-01-12 | Nkx2-2_predicted | NK2 transcription factor related, locus 2 (Drosophila) (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Nkx2-2 | |
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Entrez Gene |
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Ensembl Gene |
| Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1308443 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.