Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-alpha-phellandrene | decreases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | alpha phellandrene results in decreased expression of TFAP4 mRNA | CTD | PMID:25075043 | 17beta-estradiol | decreases expression | ISO | Tfap4 (Mus musculus) | 6480464 | Estradiol results in decreased expression of TFAP4 mRNA | CTD | PMID:25210133 | 17beta-estradiol | increases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | Estradiol results in increased expression of TFAP4 mRNA | CTD | PMID:31614463 and PMID:36828454 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of TFAP4 mRNA | CTD | PMID:21215274 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of TFAP4 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Tfap4 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TFAP4 mRNA | CTD | PMID:21570461 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of TFAP4 mRNA | CTD | PMID:30047161 | afimoxifene | multiple interactions | ISO | TFAP4 (Homo sapiens) | 6480464 | afimoxifene inhibits the reaction [Estrogens results in increased expression of TFAP4 mRNA] | CTD | PMID:21233418 | all-trans-retinoic acid | decreases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of TFAP4 mRNA | CTD | PMID:23724009 and PMID:33167477 | alpha-phellandrene | decreases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | alpha phellandrene results in decreased expression of TFAP4 mRNA | CTD | PMID:25075043 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of TFAP4 mRNA | CTD | PMID:30047161 | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of TFAP4 mRNA | CTD | PMID:30779732 | Aroclor 1254 | increases expression | ISO | Tfap4 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in increased expression of TFAP4 mRNA | CTD | PMID:23650126 | atrazine | increases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | Atrazine results in increased expression of TFAP4 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | increases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of TFAP4 mRNA | CTD | PMID:22316170 | benzo[a]pyrene | affects methylation | ISO | TFAP4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of TFAP4 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases methylation | ISO | TFAP4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of TFAP4 3' UTR | CTD | PMID:27901495 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TFAP4 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of TFAP4 mRNA | CTD | PMID:33670352 and PMID:36828454 | bisphenol A | affects methylation | ISO | Tfap4 (Mus musculus) | 6480464 | bisphenol A affects the methylation of TFAP4 promoter | CTD | PMID:27334623 | caffeine | affects phosphorylation | ISO | TFAP4 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of TFAP4 protein | CTD | PMID:35688186 | calcitriol | decreases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of TFAP4 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | TFAP4 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of TFAP4 mRNA | CTD | PMID:21592394 | chlorpyrifos | decreases expression | ISO | Tfap4 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of TFAP4 mRNA | CTD | PMID:37019170 | choline | multiple interactions | ISO | Tfap4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TFAP4 gene | CTD | PMID:20938992 | cocaine | increases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | Cocaine results in increased expression of TFAP4 mRNA | CTD | PMID:12629581 | coumarin | increases phosphorylation | ISO | TFAP4 (Homo sapiens) | 6480464 | coumarin results in increased phosphorylation of TFAP4 protein | CTD | PMID:35688186 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of TFAP4 mRNA | CTD | PMID:27523638 | deoxynivalenol | decreases phosphorylation | ISO | Tfap4 (Mus musculus) | 6480464 | deoxynivalenol results in decreased phosphorylation of TFAP4 protein | CTD | PMID:23352502 | dexamethasone | decreases expression | ISO | Tfap4 (Mus musculus) | 6480464 | Dexamethasone results in decreased expression of TFAP4 mRNA | CTD | PMID:15944155 | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of TFAP4 mRNA | CTD | PMID:29391264 | folic acid | multiple interactions | ISO | Tfap4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TFAP4 gene | CTD | PMID:20938992 | FR900359 | increases phosphorylation | ISO | TFAP4 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of TFAP4 protein | CTD | PMID:37730182 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of TFAP4 mRNA | CTD | PMID:26194646 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of TFAP4 mRNA | CTD | PMID:33387578 | L-methionine | multiple interactions | ISO | Tfap4 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of TFAP4 gene | CTD | PMID:20938992 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of TFAP4 mRNA | CTD | PMID:30047161 | paracetamol | decreases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of TFAP4 mRNA | CTD | PMID:22230336 | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of TFAP4 mRNA | CTD | PMID:33387578 | PCB138 | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:23829299 | potassium chromate | increases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of TFAP4 mRNA | CTD | PMID:22714537 | propiconazole | decreases expression | ISO | Tfap4 (Mus musculus) | 6480464 | propiconazole results in decreased expression of TFAP4 mRNA | CTD | PMID:21278054 | resveratrol | decreases expression | ISO | Tfap4 (Mus musculus) | 6480464 | resveratrol results in decreased expression of TFAP4 protein | CTD | PMID:25505154 | resveratrol | multiple interactions | ISO | TFAP4 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of TFAP4 mRNA | CTD | PMID:23557933 | silicon dioxide | decreases expression | ISO | Tfap4 (Mus musculus) | 6480464 | Silicon Dioxide results in decreased expression of TFAP4 mRNA | CTD | PMID:19073995 | sodium arsenite | decreases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of TFAP4 mRNA | CTD | PMID:12679051 | sodium arsenite | increases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of TFAP4 mRNA | CTD | PMID:17879257 and PMID:34032870 | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of TFAP4 mRNA | CTD | PMID:30047161 | sunitinib | increases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of TFAP4 mRNA | CTD | PMID:31533062 | Tanshinone I | decreases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | tanshinone results in decreased expression of TFAP4 mRNA | CTD | PMID:15849732 | temozolomide | increases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | Temozolomide results in increased expression of TFAP4 mRNA | CTD | PMID:31758290 | testosterone | decreases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of TFAP4 mRNA | CTD | PMID:21592394 | testosterone | multiple interactions | ISO | TFAP4 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of TFAP4 mRNA | CTD | PMID:21592394 | tetrachloroethene | increases expression | ISO | Tfap4 (Mus musculus) | 6480464 | Tetrachloroethylene results in increased expression of TFAP4 mRNA | CTD | PMID:28973375 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of TFAP4 mRNA | CTD | PMID:34492290 | trichostatin A | affects expression | ISO | TFAP4 (Homo sapiens) | 6480464 | trichostatin A affects the expression of TFAP4 mRNA | CTD | PMID:28542535 | troglitazone | decreases expression | ISO | Tfap4 (Mus musculus) | 6480464 | troglitazone results in decreased expression of TFAP4 mRNA | CTD | PMID:28973697 | urethane | decreases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | Urethane results in decreased expression of TFAP4 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | Tfap4 (Mus musculus) | 6480464 | Valproic Acid affects the expression of TFAP4 mRNA | CTD | PMID:17963808 | valproic acid | increases methylation | ISO | TFAP4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of TFAP4 gene | CTD | PMID:29154799 | zearalenone | increases expression | ISO | TFAP4 (Homo sapiens) | 6480464 | Zearalenone results in increased expression of TFAP4 mRNA | CTD | PMID:36828454 | |