Gene: Slc30a8 (solute carrier family 30 (zinc transporter), member 8)
Rattus norvegicus
Symbol:
Slc30a8
Name:
solute carrier family 30 (zinc transporter), member 8
Description:
ENCODES a protein that exhibits protein homodimerization activity (ortholog); zinc ion transmembrane transporter activity (ortholog); INVOLVED IN cellular zinc ion homeostasis; insulin secretion; positive regulation of insulin secretion; ASSOCIATED WITH Diabetes Mellitus, Type 2 (ortholog); FOUND IN cytoplasmic vesicle; cytoplasmic membrane-bounded vesicle (ortholog); plasma membrane (ortholog); INTERACTS WITH D-glucose; glucose; potassium chloride
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC299903; Slc30a8_predicted; solute carrier family 30 (zinc transporter), member 8; solute carrier family 30 (zinc transporter), member 8 (predicted); solute carrier family 30 member 8; zinc transporter 8; ZnT-8
Orthologs:
Homo sapiens : SLC30A8
(solute carrier family 30 (zinc transporter), member 8)
HGNC
Slc30a8
(solute carrier family 30 (zinc transporter), member 8)
MGI
Allele / Splice:
Slc30a8em1Mcwi
Slc30a8em2Mcwi
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 7 q31 NCBI RGSC Genome Assembly v5.0 7 92,476,024 - 92,508,810 + NCBI RGSC Genome Assembly v3.4 7 88,583,770 - 88,617,145 + NCBI Rat Celera Assembly 7 80,455,350 - 80,488,134 + NCBI Genome Assembly 3.1 7 88,604,575 - 88,639,923 + NCBI
Model
Disease Annotations
Gene-Chemical Interaction Annotations
4,4'-diaminodiphenylmethane decreases expression ISO RGD:1317969 6480464 4,4'-diaminodiphenylmethane results in decreased expression of SLC30A8 mRNA CTD PMID:18648102 benzo[a]pyrene decreases expression ISO RGD:1317968 6480464 Benzo(a)pyrene results in decreased expression of SLC30A8 mRNA CTD PMID:22316170 D-glucose multiple interactions EXP 6480464 SLC30A8 protein affects the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:19479076 D-glucose multiple interactions EXP 6480464 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Glucose results in decreased expression of SLC30A8 mRNA] CTD PMID:23056475 D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of SLC30A8 mRNA CTD PMID:23056475 D-glucose decreases expression EXP 6480464 Glucose results in decreased expression of SLC30A8 CTD PMID:19492079 D-glucose multiple interactions EXP 6480464 [Glucose co-treated with dihydroxyethyldithiocarbamate] results in decreased expression of SLC30A8 CTD PMID:19492079 D-glucose multiple interactions ISO RGD:1317968 6480464 SLC30A8 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:16984975 D-glucose multiple interactions ISO RGD:1317969 6480464 SLC30A8 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:19450229 glucose multiple interactions EXP 6480464 SLC30A8 protein affects the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:19479076 glucose multiple interactions EXP 6480464 N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Glucose results in decreased expression of SLC30A8 mRNA] CTD PMID:23056475 glucose decreases expression EXP 6480464 Glucose results in decreased expression of SLC30A8 mRNA CTD PMID:23056475 glucose decreases expression EXP 6480464 Glucose results in decreased expression of SLC30A8 CTD PMID:19492079 glucose multiple interactions EXP 6480464 [Glucose co-treated with dihydroxyethyldithiocarbamate] results in decreased expression of SLC30A8 CTD PMID:19492079 glucose multiple interactions ISO RGD:1317968 6480464 SLC30A8 protein promotes the reaction [Glucose results in increased secretion of INS protein] CTD PMID:16984975 glucose multiple interactions ISO RGD:1317969 6480464 SLC30A8 gene mutant form inhibits the reaction [Glucose results in increased secretion of INS1 protein] CTD PMID:19450229 paracetamol affects expression ISO RGD:1317969 6480464 Acetaminophen affects the expression of SLC30A8 mRNA CTD PMID:17562736 potassium chloride multiple interactions EXP 6480464 SLC30A8 protein affects the reaction [Potassium Chloride results in increased secretion of INS1 protein] CTD PMID:19479076 zinc atom increases abundance ISO RGD:1317968 6480464 SLC30A8 protein results in increased abundance of Zinc CTD PMID:16984975 zinc atom affects uptake EXP 6480464 SLC30A8 protein affects the uptake of Zinc CTD PMID:19479076 zinc atom affects localization ISO RGD:1317968 6480464 SLC30A8 protein affects the localization of Zinc CTD PMID:15331542 zinc atom increases uptake ISO RGD:1317968 6480464 SLC30A8 protein results in increased uptake of Zinc CTD PMID:16984975 zinc atom increases transport ISO RGD:1317968 6480464 SLC30A8 protein results in increased transport of Zinc CTD PMID:18326752 zinc(0) increases abundance ISO RGD:1317968 6480464 SLC30A8 protein results in increased abundance of Zinc CTD PMID:16984975 zinc(0) increases transport ISO RGD:1317968 6480464 SLC30A8 protein results in increased transport of Zinc CTD PMID:18326752 zinc(0) increases uptake ISO RGD:1317968 6480464 SLC30A8 protein results in increased uptake of Zinc CTD PMID:16984975 zinc(0) affects localization ISO RGD:1317968 6480464 SLC30A8 protein affects the localization of Zinc CTD PMID:15331542 zinc(0) affects uptake EXP 6480464 SLC30A8 protein affects the uptake of Zinc CTD PMID:19479076
634336 Anxrr17 Anxiety related response QTL 17 3.66 Anxiety response 7 1786555 121975577 Rat 1643004 Pain2 Pain QTL 2 1 Pain 7 10973606 103612887 Rat 1300127 Srn1 Serum renin concentration QTL 1 3.49 Renin concentration salt-loaded 7 28488298 89945095 Rat 1300132 Bp182 Blood pressure QTL 182 3.87 Blood pressure salt-loaded time series calculation 7 32004504 89945095 Rat 61357 Bp38 Blood pressure QTL 38 1.6 .052 Blood pressure 7 44698822 125481104 Rat 634326 Hc3 Hypercalciuria QTL 3 2.1 Renal function calcium excretion 7 47007003 92007003 Rat 1358361 Sradr5 Stress Responsive Adrenal Weight QTL 5 5.55 Hypothalamic-pituitary-adrenal axis adrenal gland weight 7 47145687 114883369 Rat 1300179 Kidm5 Kidney mass QTL 5 3.51 Kidney mass salt-loaded 7 47145687 124315164 Rat 1300149 Cm6 Cardiac mass QTL 6 4.09 Cardiac mass salt-loaded left ventricle 7 47145774 107950815 Rat 631504 Cm27 Cardiac mass QTL 27 3.45 Cardiac mass left ventricle 7 47865637 125399168 Rat 738030 Anxrr8 Anxiety related response QTL 8 4.1 Anxiety response open field inner locomotion 7 50941627 95941627 Rat 2293667 Bss42 Bone structure and strength QTL 42 7.25 .0001 Bone structure 7 52159077 97159077 Rat 2293678 Bss24 Bone structure and strength QTL 24 6.71 .0001 Bone structure 7 52159077 97159077 Rat 2293707 Bss32 Bone structure and strength QTL 32 7.64 .0001 Bone structure 7 52159077 97159077 Rat 2300178 Bmd54 Bone mineral density QTL 54 5.3 .0001 Bone mineral density 7 52159077 97159077 Rat 1300151 Bp181 Blood pressure QTL 181 3.36 Blood pressure salt-loaded diastolic 7 57326196 109727159 Rat 2317035 Aia16 Adjuvant induced arthritis QTL 16 2.71 Joint/bone inflammation adjuvant induced 7 65025373 110025373 Rat 1576303 Ept7 Estrogen-induced pituitary tumorigenesis QTL 7 3.7 Gland mass pituitary 7 66201980 107428439 Rat 1559283 Emca4 Estrogen-induced mammary cancer QTL 4 3.7 Mammary tumor susceptibility estradiol-induced 7 66201980 107428439 Rat 70173 Niddm19 Non-insulin dependent diabetes mellitus QTL 19 4.33 .00005 Glucose level postprandial 7 68162496 143002779 Rat 2316947 Rf58 Renal function QTL 58 7.8 Renal function structural damage of the kidney 7 72552109 120746007 Rat 2316952 Pur22 Proteinuria QTL 22 5.2 Renal function urine protein level 7 72552109 120746007 Rat 2316955 Stl24 Serum triglyceride level QTL 24 7.1 Lipid level serum triglyceride level 7 72552109 120746007 Rat 631540 Bw9 Body weight QTL 9 4.5 Body weight 7 74244786 123665486 Rat 1357338 Stl17 Serum triglyceride level QTL 17 3.23 Lipid level triglyceride 7 74244916 119494569 Rat 2293644 Bmd29 Bone mineral density QTL 29 5.4 .0001 Bone mineral density 7 74658964 120536775 Rat 2293685 Bmd21 Bone mineral density QTL 21 4.2 .0003 Bone mineral density 7 74658964 120536775 Rat 2293696 Bmd32 Bone mineral density QTL 32 5.1 .0001 Bone mineral density 7 74658964 120536775 Rat 634331 Pia17 Pristane induced arthritis QTL 17 4.7 Joint/bone inflammation arthritis severity 7 78497123 137838800 Rat 724537 Niddm52 Non-insulin dependent diabetes mellitus QTL 52 .02 Glucose level 7 85089895 98955278 Rat 1641908 Teswt1 Testicular weight QTL 1 3.28 Testicular weight 7 85089895 100273797 Rat 1331746 Kidm9 Kidney mass QTL 9 3.934 Kidney mass right kidney mass 7 85089895 119050197 Rat 1331728 Bp214 Blood pressure QTL 214 2.825 Blood pressure mean arterial 7 85089895 130953311 Rat 1331768 Kidm10 Kidney mass QTL 10 4.62096 Kidney mass left kidney mass 7 85089895 140651095 Rat 631529 Tls2 T-lymphoma susceptibility QTL 2 13.1 .001 T-lymphoma susceptibility propylnitrosourea induced 7 85090032 137838850 Rat 2317052 Aia17 Adjuvant induced arthritis QTL 17 2.13 Joint/bone inflammation adjuvant induced 7 87525274 132525274 Rat 634322 Bw12 Body weight QTL 12 8.6 Body weight 7 88132195 115934193 Rat 1358891 Bp265 Blood pressure QTL 265 2.21 Blood pressure post renin-angiotensin system block 7 88583730 142441286 Rat 1358914 Bp266 Blood pressure QTL 266 Blood pressure post sympathetic nervous system block 7 88583730 142441286 Rat
Gene-Chemical Interaction Annotations
