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Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | activation of MAPK activity | | ISO | RGD:1317843 | 1624291 | MGI:MGI:3521833 | RGD | MGI:MGI:3513737 PMID:15569927 | activation of MAPK activity | | IEA | Ensembl:ENSMUSP00000020381 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | activation of MAPK activity | | ISO | RGD:1317843 | 1624291 | MGI:MGI:3580390 | RGD | MGI:MGI:3580203 PMID:15870281 | activation of MAPK activity | | ISO | RGD:1317843 | 1624291 | MGI:MGI:3768912|MGI:MGI:3689997 | RGD | MGI:MGI:3772963 PMID:18184727 | anterior/posterior axis specification, embryo | | ISO | RGD:1317843 | 1624291 | MGI:MGI:3580390 | RGD | MGI:MGI:3580203 PMID:15870281 | anterior/posterior axis specification, embryo | | IEA | Ensembl:ENSMUSP00000020381 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | fibroblast growth factor receptor signaling pathway | | ISO | RGD:1317843 | 1624291 | MGI:MGI:95518 | RGD | MGI:MGI:3580203 PMID:15870281 | fibroblast growth factor receptor signaling pathway | | ISO | RGD:1317842 | 1624291 | UniProtKB:P16092 | RGD | PMID:9660748 | fibroblast growth factor receptor signaling pathway | | IEA | Ensembl:ENSMUSP00000020381 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | fibroblast growth factor receptor signaling pathway | | ISO | RGD:1317843 | 1624291 | MGI:MGI:95516 | RGD | MGI:MGI:3767898 PMID:17868091 | fibroblast growth factor receptor signaling pathway | | ISO | RGD:1317843 | 1624291 | UniProtKB:Q9UC54|MGI:MGI:98354|MGI:MGI:95805 | RGD | MGI:MGI:2154590 PMID:11585837 | forebrain development | | ISO | RGD:1317843 | 1624291 | MGI:MGI:3521833 | RGD | MGI:MGI:3608243 PMID:16239343 | forebrain development | | IEA | Ensembl:ENSMUSP00000020381 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | gastrulation with mouth forming second | | ISO | RGD:1317843 | 1624291 | MGI:MGI:3580390 | RGD | MGI:MGI:3580203 PMID:15870281 | gastrulation with mouth forming second | | IEA | Ensembl:ENSMUSP00000020381 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | neuroblast proliferation | | ISO | RGD:1317843 | 1624291 | MGI:MGI:3521833 | RGD | MGI:MGI:3608243 PMID:16239343 | neuroblast proliferation | | IEA | Ensembl:ENSMUSP00000020381 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | optic placode formation involved in camera-type eye formation | | ISO | RGD:1317843 | 1624291 | MGI:MGI:3521833 | RGD | MGI:MGI:3513737 PMID:15569927 | optic placode formation involved in camera-type eye formation | | IEA | Ensembl:ENSMUSP00000020381 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | organ induction | | ISO | RGD:1317843 | 1624291 | MGI:MGI:3521833 | RGD | MGI:MGI:3513737 PMID:15569927 | organ induction | | IEA | Ensembl:ENSMUSP00000020381 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis | | ISO | RGD:1317843 | 1624291 | MGI:MGI:3768912|MGI:MGI:3689997 | RGD | MGI:MGI:3772963 PMID:18184727 | prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis | | IEA | Ensembl:ENSMUSP00000020381 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | regulation of epithelial cell proliferation | | ISO | RGD:1317843 | 1624291 | MGI:MGI:3768912|MGI:MGI:3689997 | RGD | MGI:MGI:3772963 PMID:18184727 | regulation of epithelial cell proliferation | | IEA | Ensembl:ENSMUSP00000020381 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | transmembrane receptor protein tyrosine kinase signaling pathway | | ISO | RGD:1317843 | 1624291 | MGI:MGI:892146|PMID:9182757 | RGD | MGI:MGI:892146 PMID:9182757 | ventricular septum development | | ISO | RGD:1317843 | 1624291 | MGI:MGI:3768912|MGI:MGI:2654594 | RGD | MGI:MGI:3767898 PMID:17868091 | ventricular septum development | | IEA | Ensembl:ENSMUSP00000020381 | 1600115 | GO_REF:0000019 | ENSEMBL | GO_REF:0000019 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Neurotrophin signaling pathway |
| Pathway Interaction Database | FGF signaling pathway (PID:200220) |
| Neurotrophic factor-mediated Trk receptor signaling (PID:200150) | |
| SHP2 signaling (PID:200083) | |
| Signaling events regulated by Ret tyrosine kinase (PID:200070) | |
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Neurotrophin signaling pathway |
| Pathway Interaction Database | FGF signaling pathway (PID:200220) |
| Neurotrophic factor-mediated Trk receptor signaling (PID:200150) | |
| SHP2 signaling (PID:200083) | |
| Signaling events regulated by Ret tyrosine kinase (PID:200070) | |
References - curated| 1. |
GOA data from the GO Consortium |
| 2. |
MGD data from the GO Consortium |
| 3. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 4. |
Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 5. |
RGD automated import pipeline for gene-chemical interactions |
References - uncurated
RGD Disease Portals| Frs2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Frs2 (Rattus norvegicus) |
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| FRS2 (Homo sapiens) |
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| Frs2 (Mus musculus) |
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Position Markers| AA996518 |
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| RH134714 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001108097 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06049811 | (Get FASTA) | Search GEO for Microarray Profiles |
| AABR06049812 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01049434 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AAHX01049435 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CB581691 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473960 | (Get FASTA) | Search GEO for Microarray Profiles | |
| FQ232449 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001108097 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001101567 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001101567 | (Get FASTA) |
| GenBank Protein | EDM16632 | (Get FASTA) |
| EDM16633 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000005642 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000007472 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000007472 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 314850 | ENTREZGENE |
| Gene3D-CATH | PH_type | UniProtKB/TrEMBL |
| HomoloGene Group ID | 4846 | ENTREZGENE |
| InterPro | Insln_rcpt_S1 | UniProtKB/TrEMBL |
| PH_type | UniProtKB/TrEMBL | |
| IPI | IPI00212552 | UniProtKB/TrEMBL |
| KEGG Report | rno:314850 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | IRS | UniProtKB/TrEMBL |
| PROSITE | IRS_PTB | UniProtKB/TrEMBL |
| SMART | PTBI | UniProtKB/TrEMBL |
| UniGene | Rn.22182 | ENTREZGENE |
| UniProt | D4A244_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
|---|---|---|---|---|---|---|---|
| 2008-04-30 | Frs2 | fibroblast growth factor receptor substrate 2 | Frs2_predicted | fibroblast growth factor receptor substrate 2 (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2005-01-12 | Frs2_predicted | fibroblast growth factor receptor substrate 2 (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Frs2 | |
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Entrez Gene |
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Ensembl Gene |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1308201 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




