Meltf (melanotransferrin) - Rat Genome Database

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Gene: Meltf (melanotransferrin) Rattus norvegicus
Analyze
Symbol: Meltf
Name: melanotransferrin
RGD ID: 1308155
Description: Predicted to enable iron ion binding activity. Predicted to be involved in several processes, including negative regulation of substrate adhesion-dependent cell spreading; positive regulation of extracellular matrix disassembly; and positive regulation of plasminogen activation. Predicted to be located in cell surface. Predicted to be active in endosome; extracellular space; and plasma membrane. Orthologous to human MELTF (melanotransferrin); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; copper atom.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5; LOC288038; Magea1; melanoma antigen, family A, 1; Mfi2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,389,420 - 82,411,270 (-)NCBIGRCr8
mRatBN7.21168,884,446 - 68,906,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,884,446 - 68,906,300 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,721,502 - 77,743,348 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,378,082 - 70,399,924 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01169,410,595 - 69,432,442 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01172,135,311 - 72,158,106 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1172,135,668 - 72,157,522 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,210,907 - 75,232,739 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,706,384 - 70,728,239 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,763,761 - 70,789,919 (-)NCBI
Celera1168,306,411 - 68,328,215 (-)NCBICelera
Cytogenetic Map11q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7556058   PMID:15469901   PMID:16291590   PMID:16713448   PMID:19056867   PMID:19199708   PMID:20458337   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Meltf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81182,389,420 - 82,411,270 (-)NCBIGRCr8
mRatBN7.21168,884,446 - 68,906,300 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1168,884,446 - 68,906,300 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1177,721,502 - 77,743,348 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01170,378,082 - 70,399,924 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01169,410,595 - 69,432,442 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01172,135,311 - 72,158,106 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1172,135,668 - 72,157,522 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01175,210,907 - 75,232,739 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41170,706,384 - 70,728,239 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11170,763,761 - 70,789,919 (-)NCBI
Celera1168,306,411 - 68,328,215 (-)NCBICelera
Cytogenetic Map11q22NCBI
MELTF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383197,001,740 - 197,029,817 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3196,980,590 - 197,029,835 (-)EnsemblGRCh38hg38GRCh38
GRCh373196,728,611 - 196,756,688 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363198,214,553 - 198,241,083 (-)NCBINCBI36Build 36hg18NCBI36
Build 343198,234,134 - 198,244,952NCBI
Celera3195,315,485 - 195,343,561 (-)NCBICelera
Cytogenetic Map3q29NCBI
HuRef3194,028,926 - 194,056,861 (-)NCBIHuRef
CHM1_13196,699,891 - 196,727,973 (-)NCBICHM1_1
T2T-CHM13v2.03199,727,923 - 199,756,006 (-)NCBIT2T-CHM13v2.0
Meltf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391631,697,449 - 31,717,838 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1631,697,628 - 31,717,838 (+)EnsemblGRCm39 Ensembl
GRCm381631,878,629 - 31,899,020 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1631,878,810 - 31,899,020 (+)EnsemblGRCm38mm10GRCm38
MGSCv371631,878,896 - 31,899,106 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361631,798,557 - 31,818,767 (+)NCBIMGSCv36mm8
Celera1632,372,678 - 32,392,986 (+)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1622.4NCBI
Meltf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542013,035,309 - 13,055,548 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542013,036,767 - 13,055,477 (-)NCBIChiLan1.0ChiLan1.0
MELTF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22194,871,162 - 194,899,434 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13194,877,388 - 194,904,154 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03194,345,474 - 194,373,690 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13204,283,094 - 204,310,867 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3204,262,182 - 204,310,710 (-)Ensemblpanpan1.1panPan2
MELTF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13329,985,007 - 30,006,437 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3329,985,206 - 30,003,742 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3330,009,799 - 30,029,326 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03330,234,505 - 30,254,139 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3330,234,535 - 30,254,104 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13330,028,940 - 30,048,487 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03330,065,764 - 30,085,678 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03330,687,031 - 30,706,694 (-)NCBIUU_Cfam_GSD_1.0
Meltf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602143,060,677 - 143,084,817 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936833853,007 - 875,547 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936833853,925 - 875,069 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MELTF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13133,094,863 - 133,122,065 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113133,094,869 - 133,122,092 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213142,726,198 - 142,753,704 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MELTF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11590,225,699 - 90,254,893 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1590,225,780 - 90,255,263 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604164,002,116 - 64,030,310 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Meltf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473061,971,877 - 61,988,902 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473061,967,868 - 61,990,576 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Meltf
107 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:269
Count of miRNA genes:163
Interacting mature miRNAs:204
Transcripts:ENSRNOT00000002373
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)112952841882566702Rat
2298551Neuinf10Neuroinflammation QTL 103.7nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)113123913478851519Rat
70180BpQTLcluster10Blood pressure QTL cluster 103.19arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)113491804179918041Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)114094618882566702Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)114428575982566702Rat
1581565Pur10Proteinuria QTL 100.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
1581572Uae35Urinary albumin excretion QTL 350.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)114480331882846466Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)114545932375190161Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)115445753486241447Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)115513672982993457Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)115635142486241447Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)115980279482566545Rat
70208Niddm22Non-insulin dependent diabetes mellitus QTL 223.61blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)115980279482566553Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)116034659086241447Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)116611332182169223Rat
634339Niddm50Non-insulin dependent diabetes mellitus QTL 503.32blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)116642214886241447Rat
1354593Stl12Serum triglyceride level QTL 123.36blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)116642214886241447Rat

Markers in Region
BQ190983  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21168,885,411 - 68,885,603 (+)MAPPERmRatBN7.2
Rnor_6.01172,136,634 - 72,136,825NCBIRnor6.0
Rnor_5.01175,211,873 - 75,212,064UniSTSRnor5.0
RGSC_v3.41170,707,350 - 70,707,541UniSTSRGSC3.4
Celera1168,307,377 - 68,307,568UniSTS
RH 3.4 Map11405.2UniSTS
Cytogenetic Map11q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 9
Low 1 42 19 21 8
Below cutoff 2 32 40 24 19 24 5 6 30 16 11 3 5

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000002373   ⟹   ENSRNOP00000002373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,884,446 - 68,906,300 (-)Ensembl
Rnor_6.0 Ensembl1172,135,668 - 72,157,522 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116374   ⟹   ENSRNOP00000093219
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1168,884,446 - 68,901,990 (-)Ensembl
RefSeq Acc Id: NM_001105872   ⟹   NP_001099342
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81182,389,420 - 82,411,270 (-)NCBI
mRatBN7.21168,884,446 - 68,906,300 (-)NCBI
Rnor_6.01172,135,668 - 72,157,522 (-)NCBI
Rnor_5.01175,210,907 - 75,232,739 (-)NCBI
RGSC_v3.41170,706,384 - 70,728,239 (-)RGD
Celera1168,306,411 - 68,328,215 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099342 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM11456 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000002373
  ENSRNOP00000002373.5
  ENSRNOP00000093219.1
Reference Protein Sequences
RefSeq Acc Id: NP_001099342   ⟸   NM_001105872
- Peptide Label: precursor
- UniProtKB: D4ADK7 (UniProtKB/TrEMBL),   A6IRV3 (UniProtKB/TrEMBL),   A0A8I6AJB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000002373   ⟸   ENSRNOT00000002373
RefSeq Acc Id: ENSRNOP00000093219   ⟸   ENSRNOT00000116374
Protein Domains
Transferrin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4ADK7-F1-model_v2 AlphaFold D4ADK7 1-738 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308155 AgrOrtholog
BioCyc Gene G2FUF-21067 BioCyc
Ensembl Genes ENSRNOG00000001739 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002373 ENTREZGENE
  ENSRNOT00000002373.6 UniProtKB/TrEMBL
  ENSRNOT00000116374.1 UniProtKB/TrEMBL
Gene3D-CATH Periplasmic binding protein-like II UniProtKB/TrEMBL
InterPro Peptidase_S60 UniProtKB/TrEMBL
  Transferrin UniProtKB/TrEMBL
  Transferrin_Fe_BS UniProtKB/TrEMBL
KEGG Report rno:288038 UniProtKB/TrEMBL
NCBI Gene 288038 ENTREZGENE
PANTHER PTHR11485:SF21 UniProtKB/TrEMBL
  TRANSFERRIN UniProtKB/TrEMBL
Pfam Transferrin UniProtKB/TrEMBL
PhenoGen Meltf PhenoGen
PIRSF Transferrin UniProtKB/TrEMBL
PRINTS TRANSFERRIN UniProtKB/TrEMBL
PROSITE TRANSFERRIN_LIKE_1 UniProtKB/TrEMBL
  TRANSFERRIN_LIKE_2 UniProtKB/TrEMBL
  TRANSFERRIN_LIKE_3 UniProtKB/TrEMBL
  TRANSFERRIN_LIKE_4 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001739 RatGTEx
SMART TR_FER UniProtKB/TrEMBL
Superfamily-SCOP Periplasmic binding protein-like II UniProtKB/TrEMBL
UniProt A0A8I6AJB3 ENTREZGENE, UniProtKB/TrEMBL
  A6IRV3 ENTREZGENE, UniProtKB/TrEMBL
  D4ADK7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Meltf  melanotransferrin  Mfi2  antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mfi2  antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5   Mfi2_predicted  antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mfi2_predicted  antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 (predicted)      Symbol and Name status set to approved 70820 APPROVED