Zfp414 (zinc finger protein 414) - Rat Genome Database

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Gene: Zfp414 (zinc finger protein 414) Rattus norvegicus
Analyze
Symbol: Zfp414 (Ensembl: Pram1)
Name: zinc finger protein 414 (Ensembl:PML-RARA regulated adaptor molecule 1)
RGD ID: 1308123
Description: Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in nucleus. Orthologous to human ZNF414 (zinc finger protein 414); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC299647; MGC105571; RGD1308123; similar to hypothetical protein MGC15716; Znf414
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8715,122,408 - 15,125,115 (+)NCBIGRCr8
mRatBN7.2714,420,232 - 14,422,939 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl714,420,165 - 14,438,166 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx717,428,898 - 17,431,594 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0719,293,945 - 19,296,640 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0717,174,488 - 17,177,183 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0718,497,795 - 18,500,492 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,497,807 - 18,500,417 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0718,675,379 - 18,678,092 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4716,131,618 - 16,134,227 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1716,131,617 - 16,134,226 (+)NCBI
Celera713,318,965 - 13,321,574 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
nucleus  (IEA)
plasma membrane  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Comparative Map Data
Zfp414
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8715,122,408 - 15,125,115 (+)NCBIGRCr8
mRatBN7.2714,420,232 - 14,422,939 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl714,420,165 - 14,438,166 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx717,428,898 - 17,431,594 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0719,293,945 - 19,296,640 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0717,174,488 - 17,177,183 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0718,497,795 - 18,500,492 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl718,497,807 - 18,500,417 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0718,675,379 - 18,678,092 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4716,131,618 - 16,134,227 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1716,131,617 - 16,134,226 (+)NCBI
Celera713,318,965 - 13,321,574 (+)NCBICelera
Cytogenetic Map7q13NCBI
ZNF414
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38198,509,678 - 8,514,167 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl198,509,678 - 8,514,167 (-)EnsemblGRCh38hg38GRCh38
GRCh37198,574,562 - 8,579,051 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36198,482,219 - 8,485,032 (-)NCBINCBI36Build 36hg18NCBI36
Celera198,433,126 - 8,436,712 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef198,230,896 - 8,234,482 (-)NCBIHuRef
CHM1_1198,574,528 - 8,578,114 (-)NCBICHM1_1
T2T-CHM13v2.0198,497,262 - 8,501,751 (-)NCBIT2T-CHM13v2.0
Zfp414
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391733,848,066 - 33,850,690 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1733,848,064 - 33,850,753 (+)EnsemblGRCm39 Ensembl
GRCm381733,629,092 - 33,631,716 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,629,090 - 33,631,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv371733,766,047 - 33,768,656 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,235,790 - 33,238,399 (+)NCBIMGSCv36mm8
Celera1736,384,469 - 36,387,081 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
Znf414
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955563920,935 - 923,304 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955563920,801 - 923,423 (+)NCBIChiLan1.0ChiLan1.0
ZNF414
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22013,178,415 - 13,182,439 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11912,295,073 - 12,300,020 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,797,356 - 7,801,278 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,641,552 - 8,648,950 (-)NCBIpanpan1.1PanPan1.1panPan2
ZNF414
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,047,820 - 53,050,840 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,035,396 - 53,051,458 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,847,002 - 52,851,778 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02053,574,027 - 53,578,803 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,569,464 - 53,578,770 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,775,825 - 52,780,592 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,222,165 - 53,226,911 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02053,453,322 - 53,458,100 (-)NCBIUU_Cfam_GSD_1.0
Znf414
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118212,536,317 - 212,539,831 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365885,295,855 - 5,298,850 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365885,294,957 - 5,298,856 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRAM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl270,796,822 - 70,802,237 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1270,795,864 - 70,802,968 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ZNF414
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,861,058 - 7,864,913 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607412,396,498 - 12,400,064 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf414
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248281,260,509 - 1,264,841 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248281,261,430 - 1,264,696 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp414
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:133
Count of miRNA genes:114
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000011094
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat

Markers in Region
RH141291  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2714,422,505 - 14,422,803 (+)MAPPERmRatBN7.2
Rnor_6.0718,500,059 - 18,500,356NCBIRnor6.0
Rnor_5.0718,677,659 - 18,677,956UniSTSRnor5.0
RGSC_v3.4716,133,866 - 16,134,163UniSTSRGSC3.4
Celera713,321,213 - 13,321,510UniSTS
RH 3.4 Map769.5UniSTS
Cytogenetic Map7q12UniSTS
MARC_24085-24086:1037392210:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2714,421,578 - 14,422,330 (+)MAPPERmRatBN7.2
Rnor_6.0718,499,132 - 18,499,883NCBIRnor6.0
Rnor_5.0718,676,732 - 18,677,483UniSTSRnor5.0
RGSC_v3.4716,132,939 - 16,133,690UniSTSRGSC3.4
Celera713,320,286 - 13,321,037UniSTS
Cytogenetic Map7q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 43 31 14 31 1 66 28 41 10
Low 9 14 10 5 10 8 10 8 7 1 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000011094   ⟹   ENSRNOP00000011094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl714,420,244 - 14,422,864 (+)Ensembl
Rnor_6.0 Ensembl718,497,807 - 18,500,417 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000060002   ⟹   ENSRNOP00000056752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl714,420,165 - 14,438,166 (+)Ensembl
RefSeq Acc Id: NM_001009664   ⟹   NP_001009664
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,122,420 - 15,125,115 (+)NCBI
mRatBN7.2714,420,244 - 14,422,939 (+)NCBI
Rnor_6.0718,497,811 - 18,500,420 (+)NCBI
Rnor_5.0718,675,379 - 18,678,092 (+)NCBI
RGSC_v3.4716,131,618 - 16,134,227 (+)RGD
Celera713,318,965 - 13,321,574 (+)RGD
Sequence:
RefSeq Acc Id: NM_001393832   ⟹   NP_001380761
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,122,420 - 15,125,115 (+)NCBI
mRatBN7.2714,420,244 - 14,422,939 (+)NCBI
RefSeq Acc Id: XM_006241117   ⟹   XP_006241179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,122,425 - 15,125,043 (+)NCBI
mRatBN7.2714,420,249 - 14,422,939 (+)NCBI
Rnor_6.0718,497,795 - 18,500,492 (+)NCBI
Rnor_5.0718,675,379 - 18,678,092 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006241119   ⟹   XP_006241181
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,122,408 - 15,125,043 (+)NCBI
mRatBN7.2714,420,232 - 14,422,939 (+)NCBI
Rnor_6.0718,497,795 - 18,500,492 (+)NCBI
Rnor_5.0718,675,379 - 18,678,092 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063263190   ⟹   XP_063119260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,122,425 - 15,125,043 (+)NCBI
RefSeq Acc Id: XM_063263191   ⟹   XP_063119261
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8715,122,408 - 15,125,043 (+)NCBI
RefSeq Acc Id: NP_001009664   ⟸   NM_001009664
- Peptide Label: isoform 2
- UniProtKB: Q5PPH4 (UniProtKB/Swiss-Prot),   A6KQG8 (UniProtKB/TrEMBL),   A0A8L2UIH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241179   ⟸   XM_006241117
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UIH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241181   ⟸   XM_006241119
- Peptide Label: isoform X2
- UniProtKB: A6KQG7 (UniProtKB/TrEMBL),   A0A8L2UIH2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011094   ⟸   ENSRNOT00000011094
RefSeq Acc Id: ENSRNOP00000056752   ⟸   ENSRNOT00000060002
RefSeq Acc Id: NP_001380761   ⟸   NM_001393832
- Peptide Label: isoform 1
- UniProtKB: A0A8L2UIH2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063119261   ⟸   XM_063263191
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063119260   ⟸   XM_063263190
- Peptide Label: isoform X3
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PPH4-F1-model_v2 AlphaFold Q5PPH4 1-299 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695081
Promoter ID:EPDNEW_R5606
Type:multiple initiation site
Name:Zfp414_1
Description:zinc finger protein 414
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0718,497,797 - 18,497,857EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308123 AgrOrtholog
BioCyc Gene G2FUF-34715 BioCyc
Ensembl Genes ENSRNOG00000008378 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011094.7 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7310348 IMAGE-MGC_LOAD
InterPro ZN414 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf-C2H2_ribbon UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:299647 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105571 IMAGE-MGC_LOAD
NCBI Gene 299647 ENTREZGENE
PANTHER PTHR21695 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 414 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam zf-C2H2_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zfp414 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008378 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2UIH2 ENTREZGENE, UniProtKB/TrEMBL
  A6KQG7 ENTREZGENE, UniProtKB/TrEMBL
  A6KQG8 ENTREZGENE, UniProtKB/TrEMBL
  Q5PPH4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-26 Zfp414  zinc finger protein 414  RGD1308123  similar to hypothetical protein MGC15716  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1308123  similar to hypothetical protein MGC15716  RGD1308123_predicted  similar to hypothetical protein MGC15716 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308123_predicted  similar to hypothetical protein MGC15716 (predicted)  LOC299647_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC299647_predicted  similar to hypothetical protein MGC15716 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL