Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ARHGEF40 mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | increases expression | ISO | Arhgef40 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of ARHGEF40 mRNA | CTD | PMID:22206623 | 1,2-dimethylhydrazine | multiple interactions | ISO | Arhgef40 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of ARHGEF40 mRNA | CTD | PMID:22206623 | 17alpha-ethynylestradiol | decreases expression | EXP | | 6480464 | Ethinyl Estradiol results in decreased expression of ARHGEF40 mRNA | CTD | PMID:17557909 | 17beta-estradiol | multiple interactions | ISO | ARHGEF40 (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in increased expression of ARHGEF40 mRNA | CTD | PMID:30165855 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of ARHGEF40 mRNA | CTD | PMID:32145629 | 3,3',4,4',5-pentachlorobiphenyl | increases expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | 3 more ... | CTD | PMID:19692669 | 4,4'-sulfonyldiphenol | increases methylation | ISO | Arhgef40 (Mus musculus) | 6480464 | bisphenol S results in increased methylation of ARHGEF40 exon | CTD | PMID:33297965 | 4,4'-sulfonyldiphenol | affects methylation | ISO | Arhgef40 (Mus musculus) | 6480464 | bisphenol S affects the methylation of ARHGEF40 gene | CTD | PMID:31683443 | acrylamide | decreases expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of ARHGEF40 mRNA | CTD | PMID:32763439 | aflatoxin B1 | decreases methylation | ISO | ARHGEF40 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of ARHGEF40 gene | CTD | PMID:27153756 | all-trans-retinoic acid | increases expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of ARHGEF40 mRNA | CTD | PMID:23724009 and PMID:23830798 | antirheumatic drug | increases expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of ARHGEF40 mRNA | CTD | PMID:24449571 | benzo[a]pyrene | multiple interactions | ISO | Arhgef40 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ARHGEF40 mRNA | CTD | PMID:27858113 | benzo[b]fluoranthene | multiple interactions | ISO | Arhgef40 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ARHGEF40 mRNA | CTD | PMID:27858113 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of ARHGEF40 mRNA | CTD | PMID:25181051 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of ARHGEF40 mRNA | CTD | PMID:30816183 more ... | butanal | decreases expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of ARHGEF40 mRNA | CTD | PMID:26079696 | cadmium atom | multiple interactions | ISO | Arhgef40 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of ARHGEF40 mRNA | CTD | PMID:37325564 | cadmium dichloride | multiple interactions | ISO | Arhgef40 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of ARHGEF40 mRNA | CTD | PMID:37325564 | caffeine | affects phosphorylation | ISO | ARHGEF40 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of ARHGEF40 protein | CTD | PMID:35688186 | chlorpyrifos | increases expression | ISO | Arhgef40 (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of ARHGEF40 mRNA | CTD | PMID:37019170 | chrysene | multiple interactions | ISO | Arhgef40 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ARHGEF40 mRNA | CTD | PMID:27858113 | cisplatin | decreases expression | EXP | | 6480464 | Cisplatin results in decreased expression of ARHGEF40 mRNA | CTD | PMID:22023808 | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of ARHGEF40 mRNA | CTD | PMID:24386269 | copper atom | increases expression | EXP | | 6480464 | Copper results in increased expression of ARHGEF40 mRNA | CTD | PMID:30556269 | copper(0) | increases expression | EXP | | 6480464 | Copper results in increased expression of ARHGEF40 mRNA | CTD | PMID:30556269 | copper(II) sulfate | decreases expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of ARHGEF40 mRNA | CTD | PMID:19549813 | cyclosporin A | decreases expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of ARHGEF40 mRNA | CTD | PMID:20106945 more ... | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of ARHGEF40 mRNA | CTD | PMID:25152437 | dorsomorphin | multiple interactions | ISO | ARHGEF40 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | ethanol | increases expression | ISO | Arhgef40 (Mus musculus) | 6480464 | Ethanol results in increased expression of ARHGEF40 mRNA | CTD | PMID:30319688 | folic acid | multiple interactions | ISO | Arhgef40 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of ARHGEF40 mRNA | CTD | PMID:22206623 | FR900359 | affects phosphorylation | ISO | ARHGEF40 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of ARHGEF40 protein | CTD | PMID:37730182 | furan | decreases expression | EXP | | 6480464 | furan results in decreased expression of ARHGEF40 mRNA | CTD | PMID:25539665 | ozone | multiple interactions | ISO | ARHGEF40 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of ARHGEF40 mRNA | CTD | PMID:35430440 | p-chloromercuribenzoic acid | increases expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in increased expression of ARHGEF40 mRNA | CTD | PMID:26272509 | p-chloromercuribenzoic acid | multiple interactions | ISO | ARHGEF40 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ARHGEF40 mRNA | CTD | PMID:27188386 | pirinixic acid | multiple interactions | ISO | ARHGEF40 (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ARHGEF40 mRNA | CTD | PMID:19710929 | SB 431542 | multiple interactions | ISO | ARHGEF40 (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | sodium arsenite | decreases expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of ARHGEF40 mRNA | CTD | PMID:34032870 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of ARHGEF40 mRNA | CTD | PMID:19281266 | sunitinib | decreases expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of ARHGEF40 mRNA | CTD | PMID:31533062 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of ARHGEF40 mRNA] | CTD | PMID:31150632 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of ARHGEF40 mRNA | CTD | PMID:31150632 | tetraphene | multiple interactions | ISO | Arhgef40 (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ARHGEF40 mRNA | CTD | PMID:27858113 | thioacetamide | decreases expression | EXP | | 6480464 | Thioacetamide results in decreased expression of ARHGEF40 mRNA | CTD | PMID:23411599 | triptonide | decreases expression | ISO | Arhgef40 (Mus musculus) | 6480464 | triptonide results in decreased expression of ARHGEF40 mRNA | CTD | PMID:33045310 | tris(2-butoxyethyl) phosphate | affects expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of ARHGEF40 mRNA | CTD | PMID:29024780 | urethane | decreases expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | Urethane results in decreased expression of ARHGEF40 mRNA | CTD | PMID:28818685 | valproic acid | affects expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of ARHGEF40 mRNA | CTD | PMID:25979313 | valproic acid | decreases expression | ISO | ARHGEF40 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of ARHGEF40 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | ARHGEF40 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of ARHGEF40 mRNA | CTD | PMID:27188386 | |