Gene: Lurap1l (leucine rich adaptor protein 1-like)
Rattus norvegicus
Symbol:
Lurap1l
Name:
leucine rich adaptor protein 1-like
Description:
INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 3',5'-cyclic AMP
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
hypothetical protein LOC362535; leucine rich adaptor protein 1-like; LOC362535_predicted; MGC109234; RGD1308059; RGD1308059_predicted; similar to DNA segment, Chr 4, Brigham & Womens Genetics 0951 expressed; similar to DNA segment, Chr 4, Brigham & Womens Genetics 0951 expressed (predicted); uncharacterized protein C9orf150 homolog
Orthologs:
Homo sapiens : LURAP1L
(leucine rich adaptor protein 1-like)
HGNC
Lurap1l
(leucine rich adaptor protein 1-like)
MGI
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 5 q31 NCBI RGSC Genome Assembly v5.0 5 102,512,705 - 102,558,784 + NCBI RGSC Genome Assembly v3.4 5 99,599,574 - 99,647,041 + NCBI Rat Celera Assembly 5 93,934,901 - 93,982,041 + NCBI Genome Assembly 3.1 5 99,604,799 - 99,652,266 + NCBI
Model
Gene-Chemical Interaction Annotations
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactions EXP 6480464 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [FSHB protein affects the expression of RGD1308059 mRNA]; more ... CTD PMID:19414516 17beta-estradiol increases expression ISO RGD:1317610 6480464 Estradiol results in increased expression of LURAP1L mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1317610 6480464 Tetrachlorodibenzodioxin results in increased expression of LURAP1L mRNA CTD PMID:20106945 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of RGD1308059 mRNA; more ... CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1317611 6480464 Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to D4BWG0951E promoter]; more ... CTD PMID:19654925 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1317611 6480464 Tetrachlorodibenzodioxin results in decreased expression of D4BWG0951E mRNA; more ... CTD PMID:19770486 3',5'-cyclic AMP multiple interactions EXP 6480464 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane affects the reaction [Cyclic AMP affects the expression of RGD1308059 mRNA]; more ... CTD PMID:19414516 benzo[a]pyrene multiple interactions ISO RGD:1317611 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of D4BWG0951E mRNA CTD PMID:21715664 benzo[a]pyrene increases expression ISO RGD:1317610 6480464 Benzo(a)pyrene results in increased expression of LURAP1L mRNA CTD PMID:20106945 more ... benzo[a]pyrene increases expression ISO RGD:1317610 6480464 Benzo(a)pyrene results in increased expression of LURAP1L mRNA CTD PMID:20106945 PMID:22316170 benzo[a]pyrene increases expression ISO RGD:1317610 6480464 Benzo(a)pyrene results in increased expression of LURAP1L mRNA CTD PMID:20106945 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1317611 6480464 Diethylhexyl Phthalate results in decreased expression of D4BWG0951E mRNA; more ... CTD PMID:19850644 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1317611 6480464 PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of D4BWG0951E mRNA]; more ... CTD PMID:19850644 copper atom multiple interactions ISO RGD:1317610 6480464 [NSC 689534 binds to Copper] which results in increased expression of LURAP1L mRNA CTD PMID:20971185 copper(0) multiple interactions ISO RGD:1317610 6480464 [NSC 689534 binds to Copper] which results in increased expression of LURAP1L mRNA CTD PMID:20971185 copper(2+) sulfate increases expression ISO RGD:1317610 6480464 Copper Sulfate results in increased expression of LURAP1L mRNA CTD PMID:19549813 crocidolite asbestos increases expression ISO RGD:1317610 6480464 Asbestos, Crocidolite results in increased expression of LURAP1L mRNA CTD PMID:18687144 cyclosporin A increases expression ISO RGD:1317610 6480464 Cyclosporine results in increased expression of LURAP1L mRNA CTD PMID:20106945 cyclosporin A increases expression ISO RGD:1317610 6480464 Cyclosporine results in increased expression of LURAP1L mRNA CTD PMID:19159671 PMID:20106945 diuron decreases expression EXP 6480464 Diuron results in decreased expression of RGD1308059 mRNA; more ... CTD PMID:21551480 mono(2-ethylhexyl) phthalate increases expression EXP 6480464 mono-(2-ethylhexyl)phthalate results in increased expression of RGD1308059 mRNA; more ... CTD PMID:16809437 paracetamol affects expression ISO RGD:1317611 6480464 Acetaminophen affects the expression of D4BWG0951E mRNA; more ... CTD PMID:17562736
Gene-Chemical Interaction Annotations
References - curated
References - uncurated
Genomics
Comparative Map Data
Lurap1l (Rattus norvegicus) Map Chr Position Strand Source Rat Cytogenetic Map 5 q31 NCBI RGSC Genome Assembly v5.0 5 102,512,705 - 102,558,784 + NCBI RGSC Genome Assembly v3.4 5 99,599,574 - 99,647,041 + NCBI Rat Celera Assembly 5 93,934,901 - 93,982,041 + NCBI Genome Assembly 3.1 5 99,604,799 - 99,652,266 + NCBI
LURAP1L (Homo sapiens) Map Chr Position Strand Source Human Alternate Assembly CHM1_1 9 12,768,865 - 12,817,014 + NCBI Human Genome Assembly HuRef 9 12,739,601 - 12,787,743 + NCBI Human Genome Assembly GRCh37 9 12,775,012 - 12,823,059 + NCBI Human Celera Assembly 9 12,707,578 - 12,755,676 + NCBI Human Genome Assembly Build 36 9 12,765,012 - 12,813,059 + NCBI Human Cytogenetic Map 9 p23 NCBI Human Genome Assembly 9 12,765,011 - 12,813,058 NCBI
Lurap1l (Mus musculus) Map Chr Position Strand Source Mouse Genome Assembly GRCm38 4 80,910,686 - 80,954,301 + NCBI Mouse cM Map 4 37.91 NCBI Mouse Celera Assembly 4 79,465,779 - 79,509,552 + NCBI Mouse Genome Assembly Build 37 4 80,556,590 - 80,600,205 + NCBI Mouse Genome Assembly Build 36.1 4 80,556,590 - 80,600,205 + NCBI Mouse Cytogenetic Map 4 C3 NCBI
Position Markers
AV077978
Map Chr Position Strand Source Rat Cytogenetic Map 5 q31 UniSTS RGSC Genome Assembly v5.0 5 102,558,656 - 102,558,736 UniSTS RGSC Genome Assembly v3.4 5 99,646,913 - 99,646,993 UniSTS Rat Celera Assembly 5 93,981,913 - 93,981,993 UniSTS
D4Bwg0951e
Map Chr Position Strand Source Rat Cytogenetic Map 5 q31 UniSTS RGSC Genome Assembly v5.0 5 102,558,654 - 102,558,781 UniSTS RGSC Genome Assembly v3.4 5 99,646,911 - 99,647,038 UniSTS Rat Celera Assembly 5 93,981,911 - 93,982,038 UniSTS
AV175137
Map Chr Position Strand Source Rat Cytogenetic Map 5 q31 UniSTS RGSC Genome Assembly v5.0 5 102,558,656 - 102,558,784 UniSTS RGSC Genome Assembly v3.4 5 99,646,913 - 99,647,041 UniSTS Rat Celera Assembly 5 93,981,913 - 93,982,041 UniSTS
QTLs in Region (RGSC Genome Assembly v3.4)
70212 Niddm25 Non-insulin dependent diabetes mellitus QTL 25 3.54 Glucose level fasting 5 1 138272129 Rat 634305 Mamtr1 Mammary tumor resistance QTL 1 .0001 Mammary tumor resistance 7,12-dimethylbenzanthracene induced 5 12880403 119333229 Rat 2316959 Gluco59 Glucose level QTL 59 4.7 Glucose level postprandial 5 17517235 119332868 Rat 1578766 Tcas11 Tongue tumor susceptibility QTL 11 4.12 Tongue tumor susceptibility tongue tumor number 5 17517235 168005953 Rat 2290448 Scl54 Serum cholesterol level QTL 54 2.93 Lipid level cholesterol level 5 32701659 138272129 Rat 1331782 Rf36 Renal function QTL 36 3.296 Renal function renal blood flow 5 35390492 101506667 Rat 1576317 Eutr2 Estrogen induced uterine response QTL 2 .01 Uterine inflammation estrogen-induced 5 35911094 109163425 Rat 1641912 Alcrsp18 Alcohol response QTL 18 Alcohol response loss of righting reflex 5 36386126 148460381 Rat 1549845 Scl44 Serum cholesterol level QTL 44 6 Lipid level serum cholesterol, post dietary 5 41498818 155121024 Rat 1331801 Rf33 Renal function QTL 33 4.149 Renal function renal vascular resistance 5 45499364 135916908 Rat 1576312 Emca8 Estrogen-induced mammary cancer QTL 8 4.1 Mammary tumor susceptibility estradiol-induced 5 52434178 148460381 Rat 2303574 Gluco42 Glucose level QTL 42 2 Glucose level fasting 5 57040762 102040762 Rat 61359 Eaex Experimental allergic encephalomyelitis QTL x 3 Brain/spinal cord inflammation onset of disease 5 57974567 102974567 Rat 70189 Mcs5 Mammary carcinoma susceptibility QTL 5 10.51 Mammary tumor susceptibility 5 58063971 139156771 Rat 1358895 Bp254 Blood pressure QTL 254 3.6 .0003 Blood pressure mean arterial 5 61080077 134872385 Rat 61426 Scl2 Serum cholesterol level QTL 2 7.3 .001 Lipid level cholesterol 5 62098646 149757440 Rat 2316957 Pur21 Proteinuria QTL 21 6.2 Renal function urine protein level 5 62098775 119332868 Rat 61386 Bp49 Blood pressure QTL 49 16.6 Blood pressure 5 62555131 103059258 Rat 61393 Bp7 Blood pressure QTL 7 4.5 .0001 Blood pressure salt-loaded systolic 5 62555131 168174140 Rat 2306971 Anxrr21 Anxiety related response QTL 21 9.47 Anxiety response 5 68843563 130756605 Rat 2290005 Mcs24 Mammary carcinoma susceptibility QTL 24 Mammary tumor susceptibility 5 70181758 115181758 Rat 61380 Edpm5 Estrogen-dependent pituitary mass QTL 5 4.5 .92 Gland mass pituitary 5 71814715 109163425 Rat 1357396 Bw44 Body weight QTL 44 4.19 Body weight 5 71814715 109163425 Rat 1357402 Bw46 Body weight QTL 46 4.47 Body weight body mass index 5 71814715 109163425 Rat 2312671 Scl64 Serum cholesterol level QTL 64 .001 Lipid level serum cholesterol 5 71814715 109163425 Rat 2302381 Bw84 Body weight QTL 84 4.47 Body weight BMI 5 71814715 109163425 Rat 1354598 Srn6 Serum renin concentration QTL 6 3.8 Renin concentration serum 5 71971592 157597184 Rat 1298070 Scl18 Serum cholesterol level QTL 18 3.7 Lipid level LDL cholesterol 5 84392127 129392127 Rat 1598846 Bp293 Blood pressure QTL 293 3.9 Blood pressure systolic 5 84392127 129392127 Rat 1598859 Cm66 Cardiac mass QTL 66 2 Cardiac mass 5 84392127 129392127 Rat 1302790 Scl20 Serum cholesterol QTL 20 6.4 .0001 Lipid level cholesterol level 5 86116638 172913795 Rat 1300122 Wbc1 White blood cell count QTL 1 2.75 White blood cell count salt-loaded 5 89261341 147065912 Rat 1298086 Bp156 Blood pressure QTL 156 Blood pressure salt-loaded systolic 5 90916908 135916908 Rat 6903316 Bw113 Body weight QTL 113 2 .0103 Body weight 5 93245548 138245548 Rat 1358909 Kidm25 Kidney mass QTL 25 1.87 Kidney mass 5 94084025 134872385 Rat 1358889 Bp261 Blood pressure QTL 261 2.86 Blood pressure mean arterial 5 94084025 134872385 Rat 631527 Tls1 T-lymphoma susceptibility QTL 1 3.5 .001 T-lymphoma susceptibility propylnitrosourea induced 5 94515803 139515803 Rat 61452 Ciaa5 CIA Autoantibody QTL 5 3.5 Anti-type II collagen autoantibody titer 5 99080786 149757440 Rat 
Gene-Chemical Interaction Annotations
