Predicted to enable chromatin binding activity; histone binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to act upstream of or within spermatogenesis. Predicted to be located in nucleoplasm. Predicted to be part of PRC1 complex and heterochromatin. Predicted to be active in nucleus. Orthologous to human PHC2 (polyhomeotic homolog 2); PARTICIPATES IN histone modification pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.
[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PHC2 mRNA and Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PHC2 gene]
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHC2 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHC2 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHC2 mRNA
[NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHC2 mRNA
[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PHC2 mRNA