Nat3 (N-acetyltransferase 3) - Rat Genome Database

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Pathways
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Gene: Nat3 (N-acetyltransferase 3) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Nat3
Name: N-acetyltransferase 3
RGD ID: 1307575
Description: Predicted to enable arylamine N-acetyltransferase activity. Predicted to be involved in L-alpha-amino acid transmembrane transport. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to human NAT1 (N-acetyltransferase 1) and NAT2 (N-acetyltransferase 2); PARTICIPATES IN caffeine metabolic pathway; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: arylamine N-acetyltransferase 3; LOC290681
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81626,916,288 - 26,942,642 (-)NCBIGRCr8
mRatBN7.21622,149,605 - 22,175,962 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1622,150,431 - 22,151,303 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1625,518,068 - 25,518,940 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01628,962,189 - 28,963,061 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01624,883,440 - 24,884,312 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01623,901,656 - 23,912,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1623,903,012 - 23,903,884 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01623,786,042 - 23,794,225 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41623,785,757 - 23,786,629 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11623,785,754 - 23,786,627 (-)NCBI
Celera1622,291,045 - 22,291,917 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17567587   PMID:18799802  


Genomics

Variants

.
Variants in Nat3
187 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:72
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000043305
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 1 1 1 1 1 1 1 2 1
Below cutoff 1 10 17 6 9 6 1 1 19 14 18 7 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006253021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY253757 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY253758 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY253759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ099526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ099527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ099528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ099529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ099530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ099531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ099532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ099533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ099534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ099535 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ099536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ099537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB919720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HB961334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HC977129 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD018744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000043305   ⟹   ENSRNOP00000048448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1622,150,431 - 22,151,303 (-)Ensembl
Rnor_6.0 Ensembl1623,903,012 - 23,903,884 (-)Ensembl
RefSeq Acc Id: NM_001013052   ⟹   NP_001013070
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81626,916,288 - 26,942,642 (-)NCBI
mRatBN7.21622,149,605 - 22,175,962 (-)NCBI
Rnor_6.01623,903,012 - 23,903,884 (-)NCBI
Rnor_5.01623,786,042 - 23,794,225 (-)NCBI
RGSC_v3.41623,785,757 - 23,786,629 (-)RGD
Celera1622,291,045 - 22,291,917 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_001013070   ⟸   NM_001013052
- UniProtKB: G3V9I5 (UniProtKB/TrEMBL),   A6KFK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000048448   ⟸   ENSRNOT00000043305

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V9I5-F1-model_v2 AlphaFold G3V9I5 1-290 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307575 AgrOrtholog
BioCyc Gene G2FUF-11678 BioCyc
Ensembl Genes ENSRNOG00000029977 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000043305 ENTREZGENE
  ENSRNOT00000043305.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2140.20 UniProtKB/TrEMBL
InterPro N-AcTrfase UniProtKB/TrEMBL
  Papain_like_cys_pep_sf UniProtKB/TrEMBL
KEGG Report rno:290681 UniProtKB/TrEMBL
NCBI Gene 290681 ENTREZGENE
PANTHER Acetyltransf2 UniProtKB/TrEMBL
  ARYLAMINE N-ACETYLTRANSFERASE 3 UniProtKB/TrEMBL
Pfam Acetyltransf_2 UniProtKB/TrEMBL
PhenoGen Nat3 PhenoGen
PRINTS ANATRNSFRASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000029977 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A6KFK4 ENTREZGENE, UniProtKB/TrEMBL
  G3V9I5 ENTREZGENE, UniProtKB/TrEMBL
  Q4F8Y7_RAT UniProtKB/TrEMBL
  Q80SX3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-11-15 Nat3  N-acetyltransferase 3  Nat3_predicted  N-acetyltransferase 3 (predicted)  Gene promoted to "normal gene" status; symbol and name updated 1299863 APPROVED
2005-01-12 Nat3_predicted  N-acetyltransferase 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED