Lrrc58 (leucine rich repeat containing 58)

Gene: Lrrc58 (leucine rich repeat containing 58) Rattus norvegicus

Analyze

Symbol:

Lrrc58

Name:

leucine rich repeat containing 58

RGD ID:

1307440

Description:

Predicted to be involved in signal transduction. Orthologous to human LRRC58 (leucine rich repeat containing 58); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

leucine-rich repeat-containing protein 58; LOC303919; RGD1307440; similar to RIKEN cDNA C330018J07 gene

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LRRC58 (leucine rich repeat containing 58)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, PhylomeDB, Treefam
Mus musculus (house mouse):	Lrrc58 (leucine rich repeat containing 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Lrrc58 (leucine rich repeat containing 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LRRC58 (leucine rich repeat containing 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LRRC58 (leucine rich repeat containing 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lrrc58 (leucine rich repeat containing 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LRRC58 (leucine rich repeat containing 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LRRC58 (leucine rich repeat containing 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lrrc58 (leucine rich repeat containing 58)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	ANAPC7 (anaphase promoting complex subunit 7)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Lrrc58 (leucine rich repeat containing 58)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	LRRC58 (leucine rich repeat containing 58)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lrrc58b (leucine rich repeat containing 58b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	lrrc58a (leucine rich repeat containing 58a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	Y42G9A.3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG32687	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	lrrc58	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	76,355,987 - 76,368,309 (-)	NCBI		GRCr8
mRatBN7.2	11	62,850,507 - 62,862,829 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	62,847,562 - 62,862,829 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	71,662,995 - 71,675,321 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	64,325,211 - 64,337,533 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	63,375,244 - 63,387,580 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	65,747,235 - 65,759,558 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	65,747,036 - 65,759,581 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	68,841,233 - 68,853,498 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	64,635,216 - 64,646,888 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	64,703,933 - 64,704,423 (-)	NCBI
Celera	11	62,348,644 - 62,360,967 (-)	NCBI		Celera
Cytogenetic Map	11	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

acrolein (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper atom (EXP)

copper(0) (EXP)

crotonaldehyde (ISO)

dibenzo[a,l]pyrene (ISO)

ethanol (ISO)

folic acid (ISO)

geldanamycin (ISO)

gentamycin (EXP)

isoprenaline (ISO)

MeIQx (ISO)

miconazole (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

propiconazole (ISO)

rac-lactic acid (ISO)

sunitinib (ISO)

temozolomide (ISO)

thioacetamide (EXP)

trichostatin A (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

signal transduction (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548

Genomics

Comparative Map Data

Lrrc58
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	11	76,355,987 - 76,368,309 (-)	NCBI		GRCr8
mRatBN7.2	11	62,850,507 - 62,862,829 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	11	62,847,562 - 62,862,829 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	11	71,662,995 - 71,675,321 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	11	64,325,211 - 64,337,533 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	11	63,375,244 - 63,387,580 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	11	65,747,235 - 65,759,558 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	11	65,747,036 - 65,759,581 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	11	68,841,233 - 68,853,498 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	11	64,635,216 - 64,646,888 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	11	64,703,933 - 64,704,423 (-)	NCBI
Celera	11	62,348,644 - 62,360,967 (-)	NCBI		Celera
Cytogenetic Map	11	q21	NCBI

LRRC58
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	120,324,509 - 120,349,354 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	120,324,509 - 120,349,354 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	120,043,356 - 120,068,201 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	121,526,266 - 121,550,876 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	3	118,452,974 - 118,477,585 (-)	NCBI		Celera
Cytogenetic Map	3	q13.33	NCBI
HuRef	3	117,419,401 - 117,444,024 (-)	NCBI		HuRef
CHM1_1	3	120,007,169 - 120,031,803 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	123,044,047 - 123,068,908 (-)	NCBI		T2T-CHM13v2.0

Lrrc58
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	16	37,688,762 - 37,709,219 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	16	37,688,751 - 37,709,220 (+)	Ensembl		GRCm39 Ensembl
GRCm38	16	37,868,400 - 37,888,857 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	16	37,868,389 - 37,888,858 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	16	37,868,486 - 37,888,943 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	16	37,787,628 - 37,801,693 (+)	NCBI		MGSCv36	mm8
Celera	16	38,283,717 - 38,295,526 (+)	NCBI		Celera
Cytogenetic Map	16	B3	NCBI
cM Map	16	26.49	NCBI

Lrrc58
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955427	19,896,034 - 19,911,233 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955427	19,896,034 - 19,911,233 (-)	NCBI	ChiLan1.0	ChiLan1.0

LRRC58
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	118,300,627 - 118,325,099 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	118,305,289 - 118,329,660 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	117,451,035 - 117,470,085 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	124,357,398 - 124,399,452 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	124,363,716 - 124,399,452 (-)	Ensembl	panpan1.1		panPan2

LRRC58
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	33	23,841,249 - 23,861,675 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	33	23,847,086 - 23,862,146 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	33	23,871,217 - 23,891,596 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	33	24,081,600 - 24,101,985 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	33	24,081,649 - 24,102,503 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	33	23,882,593 - 23,902,964 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	33	23,923,410 - 23,943,761 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	33	24,486,998 - 24,507,383 (-)	NCBI		UU_Cfam_GSD_1.0

Lrrc58
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	130,420,326 - 130,442,418 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936536	7,083,941 - 7,102,125 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936536	7,083,584 - 7,101,704 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRRC58
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	139,927,781 - 139,948,702 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	139,927,708 - 139,951,263 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	149,281,673 - 149,297,073 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRRC58
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	60,462,872 - 60,481,802 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	60,463,037 - 60,480,690 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	105,822,794 - 105,847,046 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrrc58
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624731	27,900,833 - 27,918,751 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Lrrc58
94 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	104
Count of miRNA genes:	84
Interacting mature miRNAs:	94
Transcripts:	ENSRNOT00000034334
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300147	Bp187	Blood pressure QTL 187	3.67		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	11	1	69446234	Rat
1558659	Tescar1	Testicular tumor resistance QTL 1	3.9		testis integrity trait (VT:0010572)	percentage of study population developing testis tumors during a period of time (CMO:0001261)	11	1041931	66113562	Rat
724554	Iddm17	Insulin dependent diabetes mellitus QTL 17		0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	18976208	86241447	Rat
10058952	Gmadr6	Adrenal mass QTL 6	2.29	0.0072	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	22959403	67959403	Rat
8694376	Bw156	Body weight QTL 156	2.25	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
9590313	Scort20	Serum corticosterone level QTL 20	6.51	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	11	23280456	68280456	Rat
9589032	Epfw10	Epididymal fat weight QTL 10	9.29	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	11	23280456	68280456	Rat
8694424	Bw162	Body weight QTL 162	3.8	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	11	23280456	68280456	Rat
724563	Uae10	Urinary albumin excretion QTL 10	6		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	11	27672410	82846715	Rat
1300110	Stl7	Serum triglyceride level QTL 7	4.64		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	11	29528418	82566702	Rat
2298551	Neuinf10	Neuroinflammation QTL 10	3.7		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	11	31239134	78851519	Rat
70180	BpQTLcluster10	Blood pressure QTL cluster 10	3.19		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	11	34918041	79918041	Rat
1300135	Rf19	Renal function QTL 19	3.38		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	11	40946188	82566702	Rat
2312566	Glom20	Glomerulus QTL 20	3.6	0.001	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	11	44285759	82566702	Rat
1581565	Pur10	Proteinuria QTL 10		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
1581572	Uae35	Urinary albumin excretion QTL 35		0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	11	44803318	82846466	Rat
4889859	Pur28	Proteinuria QTL 28	19.5	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	11	45459323	75190161	Rat
724561	Plsm4	Polydactyly-luxate syndrome (PLS) morphotypes QTL 4		0.0003	forelimb integrity trait (VT:0010562)	front foot phalanges count (CMO:0001947)	11	54457534	86241447	Rat
4889521	Gluco62	Glucose level QTL 62	2.82	0.001	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	11	55136729	82993457	Rat
7411658	Foco27	Food consumption QTL 27	16.2	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	11	56351424	86241447	Rat
631506	Bp104	Blood pressure QTL 104	2.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	11	59802794	82566545	Rat
70208	Niddm22	Non-insulin dependent diabetes mellitus QTL 22	3.61		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	11	59802794	82566553	Rat
10058954	Gmadr7	Adrenal mass QTL 7	2.49	0.0049	adrenal gland mass (VT:0010420)	both adrenal glands wet weight to body weight ratio (CMO:0002411)	11	60346590	86241447	Rat

Markers in Region

BE116020

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	62,845,118 - 62,845,304 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	65,741,847 - 65,742,032	NCBI	Rnor6.0
Rnor_5.0	11	68,835,849 - 68,836,034	UniSTS	Rnor5.0
RGSC_v3.4	11	64,629,421 - 64,629,606	UniSTS	RGSC3.4
Celera	11	62,343,256 - 62,343,441	UniSTS
RH 3.4 Map	11	495.8	UniSTS
Cytogenetic Map	11	q21	UniSTS

RH142472

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	11	62,856,724 - 62,856,850 (+)	MAPPER	mRatBN7.2
Rnor_6.0	11	65,753,453 - 65,753,578	NCBI	Rnor6.0
Rnor_5.0	11	68,847,394 - 68,847,519	UniSTS	Rnor5.0
RGSC_v3.4	11	64,640,890 - 64,641,015	UniSTS	RGSC3.4
Celera	11	62,354,862 - 62,354,987	UniSTS
RH 3.4 Map	11	499.1	UniSTS
Cytogenetic Map	11	q21	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	41	51	35	19	35	8	10	74	35	40	11	8
Low	1	2	6	6		6		1			1
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001195558	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAHX01069619	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC106292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB547021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB805034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK845572	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000011	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000034334 ⟹ ENSRNOP00000037105

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	11	62,847,562 - 62,862,829 (-)	Ensembl
Rnor_6.0 Ensembl	11	65,747,036 - 65,759,581 (-)	Ensembl

RefSeq Acc Id:

NM_001195558 ⟹ NP_001182487

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	11	76,355,987 - 76,368,309 (-)	NCBI
mRatBN7.2	11	62,850,507 - 62,862,829 (-)	NCBI
Rnor_6.0	11	65,747,235 - 65,759,558 (-)	NCBI
Rnor_5.0	11	68,841,233 - 68,853,498 (-)	NCBI
Celera	11	62,348,644 - 62,360,967 (-)	NCBI

Sequence:

show sequence

TCGCTTCAGGTTCCGGGGCGCGCCGCCTCGGCTAGCGGCCTGGGGTCCGGCGGGATGGAGGAGG
CCGCGCTCGGGGAGGCCGAACTCAACTGGTCCCGCCTCAGCGTGTCGGCCGAGGCGCTGGAGTC
GGAGCTGGAGGCGCGCGCGGAGGAGCGGCGCGGCTCACGGGAGGCGCTGCTGCGGCTGCTGCTG
CCGTATAACCGTCTGACGTCGCTGCCACGGGCGCTGGGCAGCGGCTTCCCACACCTCCAGCTCC
TGGACGTGAGCGGCAACGCGCTCACGGCGCTGGGACCCGAGCTGCTGACGCTGAGCGGCCTGCG
CACGCTGCTGGCCAGGAACAACCGGCTCGGCGGCCCGGGCTCGCTGCCCAAGGGCCTGGGCCAG
TCGCCGCTCTGCCGCAGCCTCCAGGTACTCAACCTCAGCGGCAACTGCTTCCAGGAGCTGCCGG
CCTCGCTGCTGGAGCTGCGCGCGCTTCAGACCCTCAGCCTGGGAGGCAACCAGCTGCAGAGCAT
CCCCGCCGAGATCGAGAACTTGCAGAGTTTAGAATGTTTATACCTTGGAGGAAACTTCATTAAA
GAAATCCCACCAGAATTAGCAAATCTGCCTTCTCTGAATTACTTGGTGTTGTGTGACAACAAGA
TCCAAAGTGTGCCTCCTCAGCTCTCACAGCTGCATTCGCTTCGATCCCTCAGTCTACACAATAA
CTTGCTGACGTACCTGCCTCGAGAGATCCTCAATCTTATTCACCTGGAAGAGTTGAGTTTACGA
GGAAACCCATTGGTGGTCCGTTTTGTTAGAGATTTAACGTATGACCCTCCAACTCTTCTGGAAT
TAGCTGCAAGGACCATTAAGATCCGAAGTATTTCTTACACTCCCTATGATCTTCCTGGGAATCT
TCTTAGATACTTGGGCTCTGCCAGCAATTGTCCAAACCCAAAGTGCGGTGGAGTCTATTTTGAC
TGTTGTGTCAGACAGATTAAGTTTGTGGACTTCTGTGGGAAGTACCGCCTCCCCCTCATGCACT
ATCTGTGTTCTCCAGAGTGCTCCTCCCCCTGCAGCTCTGCCTCACACAGCTCCACATCCCAGAG
TGAGTCTGACTCAGAAGATGAGGCCAGTGTGGCCGCACACAGAATGCAGAAAGTTCTTCTTGGT
TGA

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Protein Sequences


Protein RefSeqs	NP_001182487	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000037105
	ENSRNOP00000037105.5

RefSeq Acc Id:

NP_001182487 ⟸ NM_001195558

- UniProtKB:

D3ZWP8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEEAALGEAELNWSRLSVSAEALESELEARAEERRGSREALLRLLLPYNRLTSLPRALGSGFPH
LQLLDVSGNALTALGPELLTLSGLRTLLARNNRLGGPGSLPKGLGQSPLCRSLQVLNLSGNCFQ
ELPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELANLPSLNYLVLC
DNKIQSVPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPT
LLELAARTIKIRSISYTPYDLPGNLLRYLGSASNCPNPKCGGVYFDCCVRQIKFVDFCGKYRLP
LMHYLCSPECSSPCSSASHSSTSQSESDSEDEASVAAHRMQKVLLG

hide sequence

RefSeq Acc Id:

ENSRNOP00000037105 ⟸ ENSRNOT00000034334

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZWP8-F1-model_v2	AlphaFold	D3ZWP8	1-366	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698171

Promoter ID:

EPDNEW_R8696

Type:

initiation region

Name:

Lrrc58_1

Description:

leucine rich repeat containing 58

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	11	65,759,574 - 65,759,634	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307440	AgrOrtholog
BioCyc Gene	G2FUF-21261	BioCyc
Ensembl Genes	ENSRNOG00000027151	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000034334	ENTREZGENE
	ENSRNOT00000034334.6	UniProtKB/TrEMBL
Gene3D-CATH	3.80.10.10	UniProtKB/TrEMBL
InterPro	L_dom-like	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_4	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
KEGG Report	rno:303919	UniProtKB/TrEMBL
NCBI Gene	303919	ENTREZGENE
PANTHER	LEUCINE-RICH REPEAT-CONTAINING	UniProtKB/TrEMBL
	LEUCINE-RICH REPEAT-CONTAINING PROTEIN 58	UniProtKB/TrEMBL
Pfam	LRR_1	UniProtKB/TrEMBL
	LRR_4	UniProtKB/TrEMBL
	LRR_8	UniProtKB/TrEMBL
PhenoGen	Lrrc58	PhenoGen
PROSITE	LRR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000027151	RatGTEx
SMART	LRR_TYP	UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/TrEMBL
UniProt	D3ZWP8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Lrrc58	leucine rich repeat containing 58	Lrrc58_predicted	leucine rich repeat containing 58 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Lrrc58_predicted	leucine rich repeat containing 58 (predicted)	RGD1307440_predicted	similar to RIKEN cDNA C330018J07 gene (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1307440_predicted	similar to RIKEN cDNA C330018J07 gene (predicted)	LOC303919_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC303919_predicted	similar to RIKEN cDNA C330018J07 gene (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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