Pofut2 (protein O-fucosyltransferase 2)

Gene: Pofut2 (protein O-fucosyltransferase 2) Rattus norvegicus

Analyze

Symbol:

Pofut2

Name:

protein O-fucosyltransferase 2

RGD ID:

1307334

Description:

Predicted to enable peptide-O-fucosyltransferase activity. Predicted to be involved in positive regulation of protein folding; protein O-linked fucosylation; and regulation of secretion. Predicted to act upstream of or within several processes, including fucosylation; mesoderm formation; and regulation of epithelial to mesenchymal transition. Predicted to be located in Golgi apparatus. Orthologous to human POFUT2 (protein O-fucosyltransferase 2); PARTICIPATES IN O-linked glycan biosynthetic pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GDP-fucose protein O-fucosyltransferase 2; LOC309686

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	POFUT2 (protein O-fucosyltransferase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Pofut2 (protein O-fucosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Pofut2 (protein O-fucosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	POFUT2 (protein O-fucosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	POFUT2 (protein O-fucosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Pofut2 (protein O-fucosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	POFUT2 (protein O-fucosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	POFUT2 (protein O-fucosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Pofut2 (protein O-fucosyltransferase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	POFUT2 (protein O-fucosyltransferase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Pofut2 (protein O-fucosyltransferase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	pofut2 (protein O-fucosyltransferase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	pad-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	O-fut2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	pofut2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	11,366,636 - 11,378,252 (-)	NCBI		GRCr8
mRatBN7.2	20	11,367,073 - 11,377,788 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	11,367,096 - 11,377,743 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	12,063,353 - 12,074,197 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	11,424,338 - 11,435,182 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	11,896,070 - 11,906,914 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	12,117,811 - 12,128,747 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	12,117,811 - 12,128,747 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	14,281,734 - 14,293,273 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	11,763,519 - 11,774,234 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	11,763,761 - 11,774,702 (-)	NCBI
Celera	20	12,869,042 - 12,879,695 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Axenfeld-Rieger syndrome type 3 (ISO)

cataract 9 multiple types (ISO)

developmental and epileptic encephalopathy 30 (ISO)

genetic disease (ISO)

homocystinuria (ISO)

Neurodevelopmental Disorders (ISO)

primary ciliary dyskinesia (ISO)

progressive myoclonus epilepsy (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-tribromophenol (ISO)

2,4-dinitrotoluene (EXP)

2-methylcholine (ISO)

3-chloropropane-1,2-diol (EXP)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

all-trans-retinoic acid (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

butanal (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cobalt dichloride (ISO)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

fenthion (ISO)

fenvalerate (EXP)

hydrogen cyanide (ISO)

indometacin (ISO)

ivermectin (ISO)

ketamine (EXP)

methyl methanesulfonate (ISO)

phenobarbital (ISO)

potassium cyanide (ISO)

SB 431542 (ISO)

temozolomide (ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

titanium dioxide (ISO)

toluene (EXP)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

fucose metabolic process (IEA)

fucosylation (ISO)

mesoderm formation (ISO)

positive regulation of protein folding (ISO)

protein O-linked fucosylation (ISO)

regulation of epithelial to mesenchymal transition (ISO)

regulation of gene expression (ISO)

regulation of secretion (ISO)

Cellular Component

endoplasmic reticulum (IEA)

Golgi apparatus (ISO)

Molecular Function

fucosyltransferase activity (ISO)

peptide-O-fucosyltransferase activity (IBA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

O-linked glycan biosynthetic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:15233996	PMID:17395589	PMID:20637190	PMID:22588082	PMID:25544610

Genomics

Comparative Map Data

Pofut2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	11,366,636 - 11,378,252 (-)	NCBI		GRCr8
mRatBN7.2	20	11,367,073 - 11,377,788 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	11,367,096 - 11,377,743 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	12,063,353 - 12,074,197 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	11,424,338 - 11,435,182 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	11,896,070 - 11,906,914 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	12,117,811 - 12,128,747 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	12,117,811 - 12,128,747 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	14,281,734 - 14,293,273 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	11,763,519 - 11,774,234 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	11,763,761 - 11,774,702 (-)	NCBI
Celera	20	12,869,042 - 12,879,695 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

POFUT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	45,263,935 - 45,287,895 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	45,263,928 - 45,287,898 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	46,683,850 - 46,707,810 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	45,508,271 - 45,532,239 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	21	45,508,271 - 45,532,235	NCBI
Celera	21	31,791,392 - 31,815,364 (-)	NCBI		Celera
Cytogenetic Map	21	q22.3	NCBI
HuRef	21	32,055,824 - 32,079,809 (-)	NCBI		HuRef
CHM1_1	21	46,244,614 - 46,268,649 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	21	43,627,968 - 43,651,850 (-)	NCBI		T2T-CHM13v2.0

Pofut2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	77,095,056 - 77,105,420 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	77,095,052 - 77,105,409 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	77,259,081 - 77,269,586 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	77,259,218 - 77,269,575 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	76,722,045 - 76,732,331 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	76,703,016 - 76,713,302 (+)	NCBI		MGSCv36	mm8
Celera	10	78,303,122 - 78,313,408 (+)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	39.72	NCBI

Pofut2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	41,972,717 - 41,984,095 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	41,972,833 - 41,984,095 (-)	NCBI	ChiLan1.0	ChiLan1.0

POFUT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	41,325,621 - 41,347,850 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	36,195,733 - 36,217,956 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	31,572,645 - 31,594,027 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	44,855,437 - 44,876,862 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	44,855,437 - 44,876,862 (-)	Ensembl	panpan1.1		panPan2

POFUT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	38,813,252 - 38,821,656 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	38,813,255 - 38,818,734 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	38,011,321 - 38,020,838 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	38,419,017 - 38,428,528 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	38,419,017 - 38,428,746 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	38,281,541 - 38,291,629 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	38,243,013 - 38,252,458 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	38,756,782 - 38,766,883 (-)	NCBI		UU_Cfam_GSD_1.0

Pofut2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	38,093,845 - 38,106,139 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936778	1,023,992 - 1,039,135 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936778	1,024,066 - 1,036,365 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POFUT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	13	207,801,101 - 207,818,138 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	217,902,861 - 217,919,990 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POFUT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	88,949,293 - 88,973,007 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666054	17,131,714 - 17,154,705 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pofut2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	30,644,681 - 30,658,909 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	30,648,423 - 30,658,862 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Pofut2
91 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	110
Count of miRNA genes:	89
Interacting mature miRNAs:	99
Transcripts:	ENSRNOT00000001644
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24159021	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	14101050	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	4606607	17617956	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	4606607	17617956	Rat
70154	Insul2	Insulin level QTL 2	3.75		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	6691706	17489458	Rat
1581577	Pur15	Proteinuria QTL 15	4.38	0.0002	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	20	8042410	17617956	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8042410	29322208	Rat
631265	Iresp1	Immunoglobin response QTL1	8.3		blood anti-double stranded DNA antibody amount (VT:0004762)	serum anti-DNA antibody level (CMO:0001533)	20	9039719	13461775	Rat

Markers in Region

RH129685

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	11,376,119 - 11,376,297 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	12,126,858 - 12,127,035	NCBI	Rnor6.0
Rnor_5.0	20	14,290,781 - 14,290,958	UniSTS	Rnor5.0
RGSC_v3.4	20	11,772,566 - 11,772,743	UniSTS	RGSC3.4
Celera	20	12,878,089 - 12,878,266	UniSTS
Cytogenetic Map	20	p12	UniSTS

RH134530

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	11,367,173 - 11,367,572 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	12,117,912 - 12,118,310	NCBI	Rnor6.0
Rnor_5.0	20	14,281,835 - 14,282,233	UniSTS	Rnor5.0
RGSC_v3.4	20	11,763,620 - 11,764,018	UniSTS	RGSC3.4
Celera	20	12,869,143 - 12,869,541	UniSTS
RH 3.4 Map	20	151.8	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	47	31	19	31	4	7	74	35	41	11	4
Low			10	10		10	4	4					4
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107621	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279157	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005497256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005497257	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AA965207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BQ190934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CV103570	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CV117486	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DY565624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000001644 ⟹ ENSRNOP00000001644

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	11,367,096 - 11,377,743 (-)	Ensembl
Rnor_6.0 Ensembl	20	12,117,811 - 12,128,747 (-)	Ensembl

RefSeq Acc Id:

NM_001107621 ⟹ NP_001101091

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	11,366,636 - 11,377,351 (-)	NCBI
mRatBN7.2	20	11,367,073 - 11,377,788 (-)	NCBI
Rnor_6.0	20	12,117,811 - 12,128,747 (-)	NCBI
Rnor_5.0	20	14,281,734 - 14,293,273 (-)	NCBI
RGSC_v3.4	20	11,763,519 - 11,774,234 (-)	RGD
Celera	20	12,869,042 - 12,879,695 (-)	RGD

Sequence:

show sequence

TCCGCCGGGCAGACAGGCGCGCTTCCGGAGCGGGGCGCGGCAGCCGGAAGTGCGTGGCCGCCGG
GGCCATGGCGGCGCTCAGCGTCGTCTGTCTGCTGCTGGCAGCAGCATCCTGGCGGCCGGTCTCG
GCTTCAGGAGAAGAATTCTGGCCTGGCCAGTCGGCGGCGGACATCCTGTCGGGGGCGGCATCCC
GCAGACGGTACCTTCTGTATGATGTCAACCCCCCGGAAGGCTTTAATCTCCGCAGGGATGTCTA
TATCCGGGTGGCATCCTTGCTAAAGACGCTGCTGAAGACAGAGGAGTGGGTGCTTGTCCTGCCC
CCATGGGGCCGCCTCTACCACTGGCAAAGCCCTGATATCCATCAGGTCCGGATTCCCTGGTCTG
AGTTTTTTGACCTCCCGAGTCTCAATAAAAACATCCCCGTTATAGAGTACGAGCAGTTCATTGC
AGAGTCCGGCGGGCCCTTTATTGACCAGGTGTACGTCCTGCAAGGCTACGCCGAGGGCTGGAAG
GAGGGCACCTGGGAGGAGAAGGTGGACGAGCGGCCCTGCATAGACCCTCTGCTGTACTCACAGG
ACAAGCATGAGTATTTCAGAGGCTGGTTTTGGGGCTACGAAGAAACACGGGGTCTGAATGTCTC
CTGCCTGTCCGTCCAGGGGTCGGCTTCTGTCATCGCGCCTGTACTCTTAAAAAACACATCTGCT
CGGTCTGTGATGCTGGACCGAGCTGAAAACCTGCTTCATGACCACTATGGAGGCAGAGAGTACT
GGGACACCCGGCGCAGCATGGTGTTTGCAAAGCACTTGCGGGCCGTGGGAGACGAATTCAGGAG
CCAGCACCTCAACTCCACGGATGCCGCCGATAAGATGGTCCTGGAGGAAGACTGGACCAGGATG
AAGGTCAAACTGGGCTCAGCGCTAGGCGGCCCCTACCTTGGCGTCCACCTGAGAAGGAAGGACT
TCATCTGGGGCCACAGGGAGGATGTGCCCAGCCTAGAAGGTGCCGTGAAGAAGATCCGCAGCCT
CATGAAGACTCACCAGCTGGACAAGGTGTTCGTGGCCACAGATGCCATCAGGAAGGAACAGGAA
GAACTGAGGAAGCTGCTGCCGGAAATGGTGAGGTTTGAGCCCACGTGGGAGGAGCTGGAACTGT
ACAAGGACGGAGGCGTCGCCATCATCGACCAGTGGATCTGCGCTCATGCCAGGTTTTTTATTGG
TACCTCCGTTTCCACGTTTTCCTTTCGGATTCATGAAGAGAGAGAGATCCTGGGGTTGGACCCC
AAGACGACATACAACCGGTTCTGTGGAGACCAGGAGAAAGCGTGCGAGCAGCCCACGCACTGGA
AGATTGCGTACTGAGGGCCACCTATCCACCACCAGTCACTCGGTCACAGGGTCCCCGAGGAGGC
TCCCACTTGGGTAACAACACATCTGAAGCCCGTGTTCCCTTGTGTCCATGGGCTGACATCTACC
TGTGTCTAGGCTCTGCCACCTTCAGGATTCACAAATGTGTCTTCTCTCAGTACCTGAGAACCCA
TGTCCCCATCACAGATGTCACATGCGTGCAAGTCCAGAAATGGGAGAACATTTGTCAGCTCCGG
CACAAGCCTTTCAACCGCCTTCCTGAGCAAGTTGAGAATGGCCAGTGTGTGGCAACCCGTACAG
GCGTGGATGCGGGCTCCTGAGGTGTTGGGGTGACTGACTTCTGAGATCACTTCACACATGGCCA
GTGTGAGCAGACACCAGGTTTTGCCTCAGCCTCCACCTGTATGGAGGTTCCTTCTGAGTGAACG
ACTCAGGCACTGCTGTCATCTGAGTGCTGGGAACCTTAGGACAGCCCTTGAGCCTTGCCATAGA
CTCTCTCACCTCACGTGGATTCCCCAGACTCGTTGCACACTGCTGAGAAATAGAATGGAGAGGG
AACAGAAGTGGCCTTCAAAAGGCCACATCTGAGACATGCCCCTGCTTTATGAAACCCTTTCCTA
GGCCTCACGCTGCACCATGGGAGGCAGAGTCAGCACAGCCTTGGCCAGGGCATCCCCAGGTCCT
TGACCTGGTGCTTACCAGTACACCCCTCCCCCCAGTGCTGTGCACTGAGCACCCCTGCCCCCTC
AGCTACTGCCCAGGTCTCCATCCCAAGCACCAAGGTAGTCCCTGAGCACAGACTCAGCCAACCA
AGTAGAATCACGTATTTATTTTCCATTTGTACATCCAAGAGTATGAATAAAATACTTTTTCAAG
AAAGCTGCAATCCTAGAAA

hide sequence

RefSeq Acc Id:

XM_063279157 ⟹ XP_063135227

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	11,366,636 - 11,378,252 (-)	NCBI

RefSeq Acc Id:

XR_005497256

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	11,366,636 - 11,378,252 (-)	NCBI
mRatBN7.2	20	11,367,077 - 11,377,783 (-)	NCBI

RefSeq Acc Id:

XR_005497257

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	11,367,484 - 11,378,252 (-)	NCBI
mRatBN7.2	20	11,367,077 - 11,377,783 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101091	(Get FASTA)	NCBI Sequence Viewer
	XP_063135227	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL97112	(Get FASTA)	NCBI Sequence Viewer
	EDL97113	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001644
	ENSRNOP00000001644.5

RefSeq Acc Id:	NP_001101091 ⟸ NM_001107621
- Peptide Label:	precursor
- UniProtKB:	D3ZUN5 (UniProtKB/TrEMBL), A6JK96 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAALSVVCLLLAAASWRPVSASGEEFWPGQSAADILSGAASRRRYLLYDVNPPEGFNLRRDVYI RVASLLKTLLKTEEWVLVLPPWGRLYHWQSPDIHQVRIPWSEFFDLPSLNKNIPVIEYEQFIAE SGGPFIDQVYVLQGYAEGWKEGTWEEKVDERPCIDPLLYSQDKHEYFRGWFWGYEETRGLNVSC LSVQGSASVIAPVLLKNTSARSVMLDRAENLLHDHYGGREYWDTRRSMVFAKHLRAVGDEFRSQ HLNSTDAADKMVLEEDWTRMKVKLGSALGGPYLGVHLRRKDFIWGHREDVPSLEGAVKKIRSLM KTHQLDKVFVATDAIRKEQEELRKLLPEMVRFEPTWEELELYKDGGVAIIDQWICAHARFFIGT SVSTFSFRIHEEREILGLDPKTTYNRFCGDQEKACEQPTHWKIAY hide sequence

RefSeq Acc Id:

ENSRNOP00000001644 ⟸ ENSRNOT00000001644

RefSeq Acc Id:	XP_063135227 ⟸ XM_063279157
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZUN5-F1-model_v2	AlphaFold	D3ZUN5	1-429	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701508

Promoter ID:

EPDNEW_R12032

Type:

multiple initiation site

Name:

Pofut2_1

Description:

protein O-fucosyltransferase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	12,128,699 - 12,128,759	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307334	AgrOrtholog
BioCyc Gene	G2FUF-4227	BioCyc
Ensembl Genes	ENSRNOG00000001228	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001644	ENTREZGENE
	ENSRNOT00000001644.6	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.11340	UniProtKB/TrEMBL
	3.40.50.11350	UniProtKB/TrEMBL
InterPro	GDP-Fuc_prot_O-FucTrfase	UniProtKB/TrEMBL
	OFUT2-like	UniProtKB/TrEMBL
KEGG Report	rno:309686	UniProtKB/TrEMBL
NCBI Gene	309686	ENTREZGENE
PANTHER	GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2	UniProtKB/TrEMBL
	PTHR13398	UniProtKB/TrEMBL
Pfam	O-FucT	UniProtKB/TrEMBL
PhenoGen	Pofut2	PhenoGen
RatGTEx	ENSRNOG00000001228	RatGTEx
UniProt	A6JK96	ENTREZGENE, UniProtKB/TrEMBL
	D3ZUN5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Pofut2	protein O-fucosyltransferase 2	Pofut2_predicted	protein O-fucosyltransferase 2 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Pofut2_predicted	protein O-fucosyltransferase 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)