Fcsk (fucose kinase) - Rat Genome Database

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Gene: Fcsk (fucose kinase) Rattus norvegicus
Analyze
Symbol: Fcsk
Name: fucose kinase
RGD ID: 1307000
Description: Predicted to enable fucokinase activity. Involved in response to dopamine. Orthologous to human FCSK (fucose kinase); PARTICIPATES IN fructose and mannose metabolic pathway; fructosuria pathway; hereditary fructose intolerance syndrome pathway; INTERACTS WITH 2,6-dinitrotoluene; acrylamide; amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fucokinase; Fuk; L-fucose kinase; LOC307848
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81955,743,746 - 55,783,873 (-)NCBIGRCr8
mRatBN7.21938,849,130 - 38,874,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1938,854,762 - 38,874,418 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1945,659,229 - 45,678,857 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,312,597 - 46,332,215 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01948,623,549 - 48,643,224 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,338,146 - 43,357,826 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,338,166 - 43,357,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01954,149,422 - 54,190,885 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41940,803,644 - 40,823,587 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11940,808,531 - 40,863,816 (-)NCBI
Celera1938,247,827 - 38,267,268 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Dopamine stimulated L-fucose incorporation into brain proteins is related to an increase in fucokinase activity. Jork R, etal., Biomed Biochim Acta. 1984;43(3):261-70.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14686921   PMID:30503518  


Genomics

Comparative Map Data
Fcsk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81955,743,746 - 55,783,873 (-)NCBIGRCr8
mRatBN7.21938,849,130 - 38,874,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1938,854,762 - 38,874,418 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1945,659,229 - 45,678,857 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01946,312,597 - 46,332,215 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01948,623,549 - 48,643,224 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01943,338,146 - 43,357,826 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1943,338,166 - 43,357,822 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01954,149,422 - 54,190,885 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41940,803,644 - 40,823,587 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11940,808,531 - 40,863,816 (-)NCBI
Celera1938,247,827 - 38,267,268 (-)NCBICelera
Cytogenetic Map19q12NCBI
FCSK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381670,454,595 - 70,480,274 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1670,454,595 - 70,480,274 (+)EnsemblGRCh38hg38GRCh38
GRCh371670,488,498 - 70,514,177 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361669,045,999 - 69,071,678 (+)NCBINCBI36Build 36hg18NCBI36
Build 341669,045,998 - 69,071,677NCBI
Celera1655,014,116 - 55,039,795 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1656,320,614 - 56,346,293 (+)NCBIHuRef
CHM1_11671,895,869 - 71,921,551 (+)NCBICHM1_1
T2T-CHM13v2.01676,265,623 - 76,291,305 (+)NCBIT2T-CHM13v2.0
Fcsk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398111,609,088 - 111,629,120 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8111,609,088 - 111,629,120 (-)EnsemblGRCm39 Ensembl
GRCm388110,882,456 - 110,902,488 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8110,882,456 - 110,902,488 (-)EnsemblGRCm38mm10GRCm38
MGSCv378113,406,363 - 113,426,359 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368113,769,140 - 113,789,136 (-)NCBIMGSCv36mm8
Celera8115,106,085 - 115,126,168 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map857.79NCBI
Fcsk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554843,263,795 - 3,278,078 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554843,259,165 - 3,278,621 (+)NCBIChiLan1.0ChiLan1.0
FCSK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21883,682,691 - 83,709,163 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11689,612,075 - 89,637,908 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01654,534,064 - 54,559,894 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11670,294,061 - 70,318,493 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1670,294,061 - 70,318,493 (+)Ensemblpanpan1.1panPan2
FCSK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1576,442,597 - 76,463,165 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl576,443,411 - 76,462,771 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha576,403,883 - 76,424,449 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0576,879,027 - 76,899,580 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl576,879,210 - 76,951,921 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1576,705,672 - 76,721,573 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0576,524,033 - 76,544,592 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0577,016,091 - 77,036,654 (+)NCBIUU_Cfam_GSD_1.0
Fcsk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934936,452,464 - 36,472,476 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647523,116,646 - 23,136,604 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647523,116,638 - 23,136,635 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FCSK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl613,471,833 - 13,506,419 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1613,471,771 - 13,492,581 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FCSK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1553,606,693 - 53,634,749 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl553,615,958 - 53,637,550 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604716,402,617 - 16,430,934 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fcsk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474612,694,660 - 12,714,574 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474612,695,007 - 12,715,173 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fcsk
168 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193383821455283146Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193383821455283146Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 4 6 2 1 2 14 18 30 7
Low 1 39 51 39 18 39 8 11 60 17 11 4 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000084739   ⟹   ENSRNOP00000069893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1938,854,762 - 38,874,418 (-)Ensembl
Rnor_6.0 Ensembl1943,338,171 - 43,357,822 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091720   ⟹   ENSRNOP00000069496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1938,854,762 - 38,874,418 (-)Ensembl
Rnor_6.0 Ensembl1943,338,166 - 43,357,505 (+)Ensembl
RefSeq Acc Id: NM_001395146   ⟹   NP_001382075
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81955,764,133 - 55,783,788 (-)NCBI
mRatBN7.21938,854,762 - 38,874,416 (-)NCBI
RefSeq Acc Id: XM_039097766   ⟹   XP_038953694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81955,743,746 - 55,783,873 (-)NCBI
mRatBN7.21938,849,130 - 38,874,497 (-)NCBI
RefSeq Acc Id: XM_039097768   ⟹   XP_038953696
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81955,764,149 - 55,774,834 (-)NCBI
mRatBN7.21938,854,772 - 38,865,450 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001382075 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953694 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953696 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL92551 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000069496
  ENSRNOP00000069496.1
  ENSRNOP00000069893.2
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000069893   ⟸   ENSRNOT00000084739
RefSeq Acc Id: ENSRNOP00000069496   ⟸   ENSRNOT00000091720
RefSeq Acc Id: XP_038953694   ⟸   XM_039097766
- Peptide Label: isoform X1
- UniProtKB: A6IZ73 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038953696   ⟸   XM_039097768
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001382075   ⟸   NM_001395146
- UniProtKB: A0A0G2JVI4 (UniProtKB/TrEMBL),   A6IZ73 (UniProtKB/TrEMBL)
Protein Domains
GHMP kinase C-terminal   GHMP kinase N-terminal   L-fucokinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JVI4-F1-model_v2 AlphaFold A0A0G2JVI4 1-1090 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701144
Promoter ID:EPDNEW_R11668
Type:single initiation site
Name:Fuk_1
Description:fucokinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01943,338,174 - 43,338,234EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307000 AgrOrtholog
BioCyc Gene G2FUF-5672 BioCyc
BioCyc Pathway PWY-6 [GDP-L-fucose biosynthesis II (from L-fucose)] BioCyc
BioCyc Pathway Image PWY-6 BioCyc
Ensembl Genes ENSRNOG00000059453 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084739.2 UniProtKB/TrEMBL
  ENSRNOT00000091720 ENTREZGENE
  ENSRNOT00000091720.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.230.120 UniProtKB/TrEMBL
InterPro Fucokinase UniProtKB/TrEMBL
  GHMP_kinase UniProtKB/TrEMBL
  GHMP_kinase_C_dom UniProtKB/TrEMBL
  GHMP_kinase_C_sf UniProtKB/TrEMBL
  Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
KEGG Report rno:307848 UniProtKB/TrEMBL
NCBI Gene 307848 ENTREZGENE
PANTHER L-FUCOSE KINASE UniProtKB/TrEMBL
  L-FUCOSE KINASE UniProtKB/TrEMBL
Pfam Fucokinase UniProtKB/TrEMBL
  GHMP_kinases_C UniProtKB/TrEMBL
  GHMP_kinases_N UniProtKB/TrEMBL
PhenoGen Fcsk PhenoGen
PRINTS MEVGALKINASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000059453 RatGTEx
Superfamily-SCOP Ribosomal_S5_D2-typ_fold UniProtKB/TrEMBL
  SSF55060 UniProtKB/TrEMBL
UniProt A0A0G2JVI4 ENTREZGENE, UniProtKB/TrEMBL
  A6IZ73 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDZ7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-10 Fcsk  fucose kinase  Fuk  fucokinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Fuk  fucokinase   Fuk_predicted  fucokinase (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Fuk_predicted  fucokinase (predicted)      Symbol and Name status set to approved 70820 APPROVED