Mettl4 (methyltransferase 4, N6-adenosine) - Rat Genome Database

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Gene: Mettl4 (methyltransferase 4, N6-adenosine) Rattus norvegicus
Analyze
Symbol: Mettl4
Name: methyltransferase 4, N6-adenosine
RGD ID: 1306451
Description: Predicted to enable RNA methyltransferase activity and site-specific DNA-methyltransferase (adenine-specific) activity. Predicted to be involved in negative regulation of gene expression, epigenetic; nucleic acid metabolic process; and regulation of nucleobase-containing compound metabolic process. Predicted to be located in mitochondrial matrix. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in cytosol and nucleus. Orthologous to human METTL4 (methyltransferase 4, N6-adenosine); INTERACTS WITH amphetamine; bisphenol A; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC316731; methyltransferase like 4; methyltransferase-like protein 4; N(6)-adenine-specific methyltransferase METTL4; RGD1306451; similar to hypothetical protein FLJ23017
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89118,887,740 - 118,967,433 (+)NCBIGRCr8
mRatBN7.29111,440,976 - 111,523,871 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9111,441,027 - 111,464,749 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9119,844,679 - 119,866,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09124,973,930 - 124,995,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09123,310,491 - 123,332,377 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09119,871,519 - 119,953,248 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9119,873,170 - 119,897,268 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09119,324,922 - 119,373,475 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49110,736,288 - 110,766,258 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19110,945,767 - 110,975,115 (+)NCBI
Celera9108,569,553 - 108,589,384 (+)NCBICelera
Cytogenetic Map9q38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:30982744   PMID:31913360   PMID:33992834  


Genomics

Comparative Map Data
Mettl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89118,887,740 - 118,967,433 (+)NCBIGRCr8
mRatBN7.29111,440,976 - 111,523,871 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9111,441,027 - 111,464,749 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9119,844,679 - 119,866,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09124,973,930 - 124,995,816 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09123,310,491 - 123,332,377 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09119,871,519 - 119,953,248 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9119,873,170 - 119,897,268 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09119,324,922 - 119,373,475 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49110,736,288 - 110,766,258 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19110,945,767 - 110,975,115 (+)NCBI
Celera9108,569,553 - 108,589,384 (+)NCBICelera
Cytogenetic Map9q38NCBI
METTL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38182,537,530 - 2,571,505 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl182,537,525 - 2,571,509 (-)EnsemblGRCh38hg38GRCh38
GRCh37182,537,529 - 2,571,504 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36182,527,524 - 2,561,489 (-)NCBINCBI36Build 36hg18NCBI36
Build 34182,527,529 - 2,561,470NCBI
Celera182,412,830 - 2,446,793 (-)NCBICelera
Cytogenetic Map18p11.32NCBI
HuRef182,499,255 - 2,532,978 (-)NCBIHuRef
CHM1_1182,536,901 - 2,570,862 (-)NCBICHM1_1
T2T-CHM13v2.0182,693,282 - 2,727,252 (-)NCBIT2T-CHM13v2.0
Mettl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391795,030,018 - 95,057,579 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1795,030,018 - 95,057,447 (-)EnsemblGRCm39 Ensembl
GRCm381794,722,590 - 94,750,214 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1794,722,590 - 94,750,019 (-)EnsemblGRCm38mm10GRCm38
MGSCv371795,126,420 - 95,149,232 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361795,031,189 - 95,054,001 (-)NCBIMGSCv36mm8
Celera1799,126,838 - 99,149,657 (-)NCBICelera
Cytogenetic Map17E5NCBI
cM Map1761.17NCBI
Mettl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554027,732,627 - 7,763,038 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554027,733,220 - 7,762,756 (+)NCBIChiLan1.0ChiLan1.0
METTL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21735,874,434 - 35,908,314 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11821,567,026 - 21,600,906 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01811,711,502 - 11,745,222 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11814,018,279 - 14,051,974 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1814,018,279 - 14,051,974 (+)Ensemblpanpan1.1panPan2
METTL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1769,229,717 - 69,268,223 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl769,191,223 - 69,267,683 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha768,665,874 - 68,723,331 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0769,272,450 - 69,330,069 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl769,291,648 - 69,329,591 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1768,955,089 - 69,012,718 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0768,975,650 - 69,032,839 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0769,272,402 - 69,330,056 (-)NCBIUU_Cfam_GSD_1.0
Mettl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494465,601,744 - 65,630,845 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366721,910,851 - 1,941,520 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366721,911,109 - 1,940,897 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METTL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6104,055,814 - 104,078,381 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16104,055,813 - 104,384,416 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
METTL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11861,767,806 - 61,834,994 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1861,799,324 - 61,834,973 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605036,653,215 - 36,694,906 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mettl4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477012,905,100 - 12,938,189 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477012,905,138 - 12,937,859 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mettl4
457 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:245
Count of miRNA genes:150
Interacting mature miRNAs:171
Transcripts:ENSRNOT00000037587
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat

Markers in Region
RH142477  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29111,452,853 - 111,453,144 (+)MAPPERmRatBN7.2
Rnor_6.09119,883,389 - 119,883,678NCBIRnor6.0
Rnor_5.09119,336,803 - 119,337,092UniSTSRnor5.0
RGSC_v3.49110,746,136 - 110,746,425UniSTSRGSC3.4
Celera9108,579,401 - 108,579,690UniSTS
RH 3.4 Map9867.0UniSTS
Cytogenetic Map9q38UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 6 7 3
Low 3 43 51 41 12 41 8 11 74 35 38 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000037587   ⟹   ENSRNOP00000029385
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9111,442,631 - 111,464,749 (+)Ensembl
Rnor_6.0 Ensembl9119,873,170 - 119,897,268 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115048   ⟹   ENSRNOP00000092806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9111,441,027 - 111,464,749 (+)Ensembl
RefSeq Acc Id: NM_001191814   ⟹   NP_001178743
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89118,889,613 - 118,911,473 (+)NCBI
mRatBN7.29111,443,005 - 111,464,867 (+)NCBI
Rnor_6.09119,873,541 - 119,896,104 (+)NCBI
Rnor_5.09119,324,922 - 119,373,475 (+)NCBI
Celera9108,569,553 - 108,589,384 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006245658   ⟹   XP_006245720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89118,887,740 - 118,924,629 (+)NCBI
mRatBN7.29111,440,984 - 111,464,867 (+)NCBI
Rnor_6.09119,871,521 - 119,896,104 (+)NCBI
Rnor_5.09119,324,922 - 119,373,475 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083791   ⟹   XP_038939719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89118,890,021 - 118,924,629 (+)NCBI
mRatBN7.29111,443,417 - 111,464,867 (+)NCBI
RefSeq Acc Id: XM_039083792   ⟹   XP_038939720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89118,887,741 - 118,924,629 (+)NCBI
mRatBN7.29111,440,984 - 111,464,867 (+)NCBI
RefSeq Acc Id: XM_063267334   ⟹   XP_063123404
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89118,887,740 - 118,935,006 (+)NCBI
RefSeq Acc Id: XM_063267335   ⟹   XP_063123405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89118,887,740 - 118,967,433 (+)NCBI
RefSeq Acc Id: XM_063267336   ⟹   XP_063123406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89118,887,740 - 118,910,829 (+)NCBI
RefSeq Acc Id: XM_063267337   ⟹   XP_063123407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89118,887,740 - 118,901,970 (+)NCBI
RefSeq Acc Id: XR_010054608
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89118,887,740 - 118,967,433 (+)NCBI
RefSeq Acc Id: XR_010054609
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89118,887,740 - 118,910,750 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001178743   ⟸   NM_001191814
- UniProtKB: A0A8I6AHA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006245720   ⟸   XM_006245658
- Peptide Label: isoform X1
- UniProtKB: D3ZD59 (UniProtKB/TrEMBL),   A0A8I6AHA3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029385   ⟸   ENSRNOT00000037587
RefSeq Acc Id: XP_038939720   ⟸   XM_039083792
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038939719   ⟸   XM_039083791
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000092806   ⟸   ENSRNOT00000115048
RefSeq Acc Id: XP_063123405   ⟸   XM_063267335
- Peptide Label: isoform X1
- UniProtKB: D3ZD59 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123404   ⟸   XM_063267334
- Peptide Label: isoform X1
- UniProtKB: D3ZD59 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123406   ⟸   XM_063267336
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063123407   ⟸   XM_063267337
- Peptide Label: isoform X3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZD59-F1-model_v2 AlphaFold D3ZD59 1-471 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306451 AgrOrtholog
BioCyc Gene G2FUF-26324 BioCyc
Ensembl Genes ENSRNOG00000026280 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000037587.6 UniProtKB/TrEMBL
  ENSRNOT00000115048.1 UniProtKB/TrEMBL
InterPro DNA_methylase_N6_adenine_CS UniProtKB/TrEMBL
  MT-A70 UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
NCBI Gene 316731 ENTREZGENE
PANTHER N(6)-ADENINE-SPECIFIC METHYLTRANSFERASE METTL4 UniProtKB/TrEMBL
  N6-ADENOSINE-METHYLTRANSFERASE UniProtKB/TrEMBL
Pfam MT-A70 UniProtKB/TrEMBL
PhenoGen Mettl4 PhenoGen
PROSITE MT_A70 UniProtKB/TrEMBL
  N6_MTASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000026280 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A8I6AHA3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZD59 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-17 Mettl4  methyltransferase 4, N6-adenosine  Mettl4  methyltransferase like 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Mettl4  methyltransferase like 4  RGD1306451_predicted  similar to hypothetical protein FLJ23017 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1306451_predicted  similar to hypothetical protein FLJ23017 (predicted)  LOC316731_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC316731_predicted  similar to hypothetical protein FLJ23017 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL