Osgin2 (oxidative stress induced growth inhibitor family member 2) - Rat Genome Database

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Gene: Osgin2 (oxidative stress induced growth inhibitor family member 2) Rattus norvegicus
Analyze
Symbol: Osgin2
Name: oxidative stress induced growth inhibitor family member 2
RGD ID: 1306323
Description: Predicted to enable growth factor activity. Predicted to be involved in negative regulation of cell growth. Orthologous to human OSGIN2 (oxidative stress induced growth inhibitor family member 2); INTERACTS WITH bisphenol A; Cuprizon; furan.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC313085; oxidative stress-induced growth inhibitor 2; RGD1306323; similar to Protein C8orf1 (hT41)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8534,297,417 - 34,316,353 (-)NCBIGRCr8
mRatBN7.2529,500,406 - 29,519,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl529,500,408 - 29,520,831 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx531,656,853 - 31,675,705 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0533,249,519 - 33,268,371 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0533,209,699 - 33,228,549 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0529,663,131 - 29,683,634 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl529,663,685 - 29,682,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0534,341,646 - 34,361,956 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4530,582,447 - 30,601,332 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1530,582,407 - 30,601,836 (-)NCBI
Celera528,705,683 - 28,726,264 (-)NCBICelera
Cytogenetic Map5q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Osgin2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8534,297,417 - 34,316,353 (-)NCBIGRCr8
mRatBN7.2529,500,406 - 29,519,340 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl529,500,408 - 29,520,831 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx531,656,853 - 31,675,705 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0533,249,519 - 33,268,371 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0533,209,699 - 33,228,549 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0529,663,131 - 29,683,634 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl529,663,685 - 29,682,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0534,341,646 - 34,361,956 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4530,582,447 - 30,601,332 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1530,582,407 - 30,601,836 (-)NCBI
Celera528,705,683 - 28,726,264 (-)NCBICelera
Cytogenetic Map5q13NCBI
OSGIN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38889,901,868 - 89,927,888 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl889,901,849 - 89,927,888 (+)EnsemblGRCh38hg38GRCh38
GRCh37890,914,096 - 90,940,116 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36890,983,269 - 91,009,271 (+)NCBINCBI36Build 36hg18NCBI36
Build 34890,983,268 - 91,009,271NCBI
Celera887,108,907 - 87,134,906 (+)NCBICelera
Cytogenetic Map8q21.3NCBI
HuRef886,124,270 - 86,150,270 (+)NCBIHuRef
CHM1_1890,955,027 - 90,981,021 (+)NCBICHM1_1
T2T-CHM13v2.0891,025,051 - 91,051,069 (+)NCBIT2T-CHM13v2.0
Osgin2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39415,996,354 - 16,015,266 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl415,997,121 - 16,013,888 (-)EnsemblGRCm39 Ensembl
GRCm38415,996,354 - 16,015,258 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl415,997,121 - 16,013,888 (-)EnsemblGRCm38mm10GRCm38
MGSCv37415,924,268 - 15,941,024 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36415,924,268 - 15,941,024 (-)NCBIMGSCv36mm8
Celera415,800,419 - 15,817,277 (-)NCBICelera
Cytogenetic Map4A2NCBI
cM Map46.66NCBI
Osgin2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554176,816,346 - 6,833,810 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554176,816,348 - 6,833,257 (+)NCBIChiLan1.0ChiLan1.0
OSGIN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v27107,297,549 - 107,322,521 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1882,837,201 - 82,862,192 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0886,590,912 - 86,616,817 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1888,543,550 - 88,569,609 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl888,543,550 - 88,569,069 (+)Ensemblpanpan1.1panPan2
OSGIN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12935,386,817 - 35,405,133 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2935,390,259 - 35,404,269 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2935,534,147 - 35,557,301 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02935,579,176 - 35,602,495 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2935,578,475 - 35,602,018 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12935,570,328 - 35,593,670 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02935,591,068 - 35,614,314 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02936,024,837 - 36,048,581 (+)NCBIUU_Cfam_GSD_1.0
Osgin2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530344,030,169 - 44,055,294 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365443,737,412 - 3,761,555 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365443,737,417 - 3,762,536 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OSGIN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl446,886,968 - 46,912,255 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1446,886,961 - 46,912,941 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2451,350,644 - 51,376,596 (-)NCBISscrofa10.2Sscrofa10.2susScr3
OSGIN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1884,986,109 - 85,011,312 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl884,987,441 - 85,013,933 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603955,868,175 - 55,893,307 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Osgin2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247442,070,775 - 2,091,549 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Osgin2
187 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:28
Interacting mature miRNAs:30
Transcripts:ENSRNOT00000012394
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
1600358Mamtr5Mammary tumor resistance QTL 5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)51887394763873947Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
8552954Pigfal14Plasma insulin-like growth factor 1 level QTL 149blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)52122674466226744Rat
1549901Neudeg2Neurodegradation QTL 240nervous system integrity trait (VT:0010566)mononuclear cell count (CMO:0002119)52483871044045280Rat
1578767Stresp17Stress response QTL 174.30.01blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)52795544072955440Rat
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
6903292Stl28Serum triglyceride level QTL 282.60.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)52851548973515489Rat
6903306Scl35Serum cholesterol QTL 352.60.0073blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)52851548973515489Rat

Markers in Region
BM386272  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2529,501,167 - 29,501,376 (+)MAPPERmRatBN7.2
Rnor_6.0529,663,893 - 29,664,101NCBIRnor6.0
Rnor_5.0534,342,408 - 34,342,616UniSTSRnor5.0
RGSC_v3.4530,583,209 - 30,583,417UniSTSRGSC3.4
Celera528,706,445 - 28,706,653UniSTS
RH 3.4 Map5160.82UniSTS
Cytogenetic Map5q13UniSTS
RH144151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2529,520,463 - 29,520,698 (+)MAPPERmRatBN7.2
Rnor_6.0529,683,189 - 29,683,423NCBIRnor6.0
Rnor_5.0534,361,702 - 34,361,936UniSTSRnor5.0
RGSC_v3.4530,602,503 - 30,602,737UniSTSRGSC3.4
Celera528,725,819 - 28,726,053UniSTS
RH 3.4 Map5159.31UniSTS
Cytogenetic Map5q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 24 14 15 14 6 6 73 2 21 11 6
Low 3 41 33 27 4 27 2 5 1 33 20 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012394   ⟹   ENSRNOP00000012394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl529,500,408 - 29,519,306 (-)Ensembl
Rnor_6.0 Ensembl529,663,685 - 29,682,005 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095460   ⟹   ENSRNOP00000092835
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl529,500,412 - 29,519,364 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109378   ⟹   ENSRNOP00000097694
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl529,500,408 - 29,520,831 (-)Ensembl
RefSeq Acc Id: NM_001399569   ⟹   NP_001386498
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8534,297,417 - 34,316,317 (-)NCBI
mRatBN7.2529,500,406 - 29,519,306 (-)NCBI
RefSeq Acc Id: XM_006237919   ⟹   XP_006237981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8534,297,417 - 34,316,311 (-)NCBI
mRatBN7.2529,500,406 - 29,519,325 (-)NCBI
Rnor_6.0529,663,131 - 29,682,059 (-)NCBI
Rnor_5.0534,341,646 - 34,361,956 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039110948   ⟹   XP_038966876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8534,297,417 - 34,305,398 (-)NCBI
mRatBN7.2529,500,406 - 29,508,387 (-)NCBI
RefSeq Acc Id: XM_039110950   ⟹   XP_038966878
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8534,299,182 - 34,316,353 (-)NCBI
mRatBN7.2529,502,170 - 29,519,339 (-)NCBI
RefSeq Acc Id: XM_063287579   ⟹   XP_063143649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8534,297,417 - 34,308,810 (-)NCBI
RefSeq Acc Id: XM_063287580   ⟹   XP_063143650
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8534,297,417 - 34,302,094 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_006237981   ⟸   XM_006237919
- Peptide Label: isoform X1
- UniProtKB: A6IIB2 (UniProtKB/TrEMBL),   A0A8I6ASB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000012394   ⟸   ENSRNOT00000012394
RefSeq Acc Id: XP_038966876   ⟸   XM_039110948
- Peptide Label: isoform X3
- UniProtKB: A6IIB3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038966878   ⟸   XM_039110950
- Peptide Label: isoform X5
RefSeq Acc Id: ENSRNOP00000092835   ⟸   ENSRNOT00000095460
RefSeq Acc Id: ENSRNOP00000097694   ⟸   ENSRNOT00000109378
RefSeq Acc Id: NP_001386498   ⟸   NM_001399569
- UniProtKB: D3ZB49 (UniProtKB/TrEMBL),   A6IIB1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063143649   ⟸   XM_063287579
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063143650   ⟸   XM_063287580
- Peptide Label: isoform X4
- UniProtKB: A0A8I6GKD4 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZB49-F1-model_v2 AlphaFold D3ZB49 1-550 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693587
Promoter ID:EPDNEW_R4106
Type:multiple initiation site
Name:Osgin2_1
Description:oxidative stress induced growth inhibitor family member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0529,682,057 - 29,682,117EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306323 AgrOrtholog
BioCyc Gene G2FUF-41860 BioCyc
Ensembl Genes ENSRNOG00000009358 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012394 ENTREZGENE
  ENSRNOT00000012394.7 UniProtKB/TrEMBL
  ENSRNOT00000095460.1 UniProtKB/TrEMBL
  ENSRNOT00000109378.1 UniProtKB/TrEMBL
Gene3D-CATH 3.50.50.60 UniProtKB/TrEMBL
InterPro FAD/NAD-bd_sf UniProtKB/TrEMBL
  OKL38_fam UniProtKB/TrEMBL
KEGG Report rno:313085 UniProtKB/TrEMBL
NCBI Gene 313085 ENTREZGENE
PANTHER PTHR15192 UniProtKB/TrEMBL
  PTHR15192:SF4 UniProtKB/TrEMBL
PhenoGen Osgin2 PhenoGen
RatGTEx ENSRNOG00000009358 RatGTEx
Superfamily-SCOP Nucleotide-binding domain UniProtKB/TrEMBL
  SSF51905 UniProtKB/TrEMBL
UniProt A0A8I6ASB1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKD4 ENTREZGENE, UniProtKB/TrEMBL
  A6IIB1 ENTREZGENE, UniProtKB/TrEMBL
  A6IIB2 ENTREZGENE, UniProtKB/TrEMBL
  A6IIB3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZB49 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Osgin2  oxidative stress induced growth inhibitor family member 2  RGD1306323_predicted  similar to Protein C8orf1 (hT41) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 RGD1306323_predicted  similar to Protein C8orf1 (hT41) (predicted)  LOC313085_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC313085_predicted  similar to Protein C8orf1 (hT41) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL