Stk32b (serine/threonine kinase 32B) - Rat Genome Database

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Gene: Stk32b (serine/threonine kinase 32B) Rattus norvegicus
Analyze
Symbol: Stk32b
Name: serine/threonine kinase 32B
RGD ID: 1306173
Description: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Orthologous to human STK32B (serine/threonine kinase 32B); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC305431; serine/threonine-protein kinase 32B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81477,300,675 - 77,562,721 (+)NCBIGRCr8
mRatBN7.21473,077,944 - 73,337,976 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1473,078,061 - 73,336,458 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1477,532,529 - 77,786,668 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01478,773,385 - 79,027,521 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01475,213,974 - 75,465,059 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01477,837,073 - 78,098,731 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1477,829,400 - 78,097,919 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01477,813,472 - 78,072,506 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41478,375,197 - 78,885,879 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11478,441,739 - 78,886,159 (+)NCBI
Celera1472,040,534 - 72,291,397 (+)NCBICelera
Cytogenetic Map14q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Stk32b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81477,300,675 - 77,562,721 (+)NCBIGRCr8
mRatBN7.21473,077,944 - 73,337,976 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1473,078,061 - 73,336,458 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1477,532,529 - 77,786,668 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01478,773,385 - 79,027,521 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01475,213,974 - 75,465,059 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01477,837,073 - 78,098,731 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1477,829,400 - 78,097,919 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01477,813,472 - 78,072,506 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41478,375,197 - 78,885,879 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11478,441,739 - 78,886,159 (+)NCBI
Celera1472,040,534 - 72,291,397 (+)NCBICelera
Cytogenetic Map14q21NCBI
STK32B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3845,019,386 - 5,500,989 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl45,051,480 - 5,500,994 (+)EnsemblGRCh38hg38GRCh38
GRCh3745,053,207 - 5,502,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3645,104,428 - 5,553,626 (+)NCBINCBI36Build 36hg18NCBI36
Build 3445,171,598 - 5,620,797NCBI
Celera44,950,734 - 5,400,385 (+)NCBICelera
Cytogenetic Map4p16.2NCBI
HuRef44,990,003 - 5,438,540 (+)NCBIHuRef
CHM1_145,051,522 - 5,500,683 (+)NCBICHM1_1
T2T-CHM13v2.044,989,033 - 5,470,430 (+)NCBIT2T-CHM13v2.0
Stk32b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39537,604,169 - 37,874,503 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl537,604,169 - 37,874,515 (-)EnsemblGRCm39 Ensembl
GRCm38537,446,825 - 37,717,153 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl537,446,825 - 37,717,171 (-)EnsemblGRCm38mm10GRCm38
MGSCv37537,838,064 - 38,108,392 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36537,735,074 - 38,005,312 (-)NCBIMGSCv36mm8
Celera534,897,642 - 35,165,478 (-)NCBICelera
Cytogenetic Map5B3NCBI
cM Map520.18NCBI
Stk32b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555144,468,653 - 4,719,083 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555144,467,504 - 4,719,026 (-)NCBIChiLan1.0ChiLan1.0
LOC100987783
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v235,317,025 - 5,764,561 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan145,239,771 - 5,697,581 (+)NCBINHGRI_mPanPan1
PanPan1.145,129,317 - 5,573,868 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl45,129,204 - 5,571,970 (+)Ensemblpanpan1.1panPan2
STK32B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1370,384,486 - 70,769,806 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl370,384,486 - 70,768,259 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,935,143 - 73,320,010 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0371,143,662 - 71,530,011 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,143,660 - 71,530,006 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1370,414,692 - 70,807,284 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0370,575,135 - 70,961,598 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0370,959,886 - 71,345,435 (+)NCBIUU_Cfam_GSD_1.0
Stk32b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528563,832,442 - 64,111,878 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647717,533,935 - 17,812,468 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647717,534,264 - 17,813,224 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STK32B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl85,056,817 - 5,418,329 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.185,056,816 - 5,418,326 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
STK32B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12741,225,325 - 41,638,650 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2741,225,583 - 41,641,077 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604788,018,376 - 88,433,452 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stk32b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475521,992,404 - 22,295,510 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475521,992,406 - 22,294,961 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Stk32b
1904 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:503
Count of miRNA genes:235
Interacting mature miRNAs:291
Transcripts:ENSRNOT00000052006
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
2313048Bss84Bone structure and strength QTL 843.10.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143766971982669719Rat
2313084Bss83Bone structure and strength QTL 832.90.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143766971982669719Rat
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat
738037Hcas6Hepatocarcinoma susceptibility QTL 62.93liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)143905723783368335Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
70153Bp59Blood pressure QTL 593.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)146875779683368335Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 45 17 5
Low 26 16 14 7 14 29 18 33 5
Below cutoff 1 15 22 12 11 12 7 10 3 6 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000052006   ⟹   ENSRNOP00000045999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1477,829,400 - 78,097,584 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081198   ⟹   ENSRNOP00000070055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1473,078,061 - 73,336,458 (+)Ensembl
Rnor_6.0 Ensembl1477,922,045 - 78,097,919 (+)Ensembl
RefSeq Acc Id: NM_001107224   ⟹   NP_001100694
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81477,302,755 - 77,562,721 (+)NCBI
mRatBN7.21473,077,996 - 73,337,976 (+)NCBI
Rnor_6.01477,837,073 - 78,097,584 (+)NCBI
Rnor_5.01477,813,472 - 78,072,506 (+)NCBI
RGSC_v3.41478,375,197 - 78,885,879 (+)RGD
Celera1472,040,534 - 72,291,397 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017599197   ⟹   XP_017454686
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81477,379,331 - 77,562,721 (+)NCBI
mRatBN7.21473,154,564 - 73,336,128 (+)NCBI
Rnor_6.01477,919,262 - 78,098,731 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039091947   ⟹   XP_038947875
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81477,300,675 - 77,525,710 (+)NCBI
mRatBN7.21473,077,944 - 73,304,053 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001100694 (Get FASTA)   NCBI Sequence Viewer  
  XP_017454686 (Get FASTA)   NCBI Sequence Viewer  
  XP_038947875 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM00023 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070055
  ENSRNOP00000070055.2
Reference Protein Sequences
RefSeq Acc Id: NP_001100694   ⟸   NM_001107224
- UniProtKB: F1M3G9 (UniProtKB/TrEMBL),   A0A0G2JWX7 (UniProtKB/TrEMBL),   A6IJV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017454686   ⟸   XM_017599197
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JWX7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070055   ⟸   ENSRNOT00000081198
RefSeq Acc Id: ENSRNOP00000045999   ⟸   ENSRNOT00000052006
RefSeq Acc Id: XP_038947875   ⟸   XM_039091947
- Peptide Label: isoform X2
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M3G9-F1-model_v2 AlphaFold F1M3G9 1-414 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306173 AgrOrtholog
BioCyc Gene G2FUF-15364 BioCyc
Ensembl Genes ENSRNOG00000031397 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000081198 ENTREZGENE
  ENSRNOT00000081198.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:305431 UniProtKB/TrEMBL
NCBI Gene 305431 ENTREZGENE
PANTHER G PROTEIN-COUPLED RECEPTOR KINASE/RIBOSOMAL PROTEIN S6 KINASE UniProtKB/TrEMBL
  SERINE/THREONINE KINASE 32A UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Stk32b PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000031397 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2JWX7 ENTREZGENE, UniProtKB/TrEMBL
  A6IJV9 ENTREZGENE, UniProtKB/TrEMBL
  F1M3G9 ENTREZGENE
UniProt Secondary F1M3G9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Stk32b  serine/threonine kinase 32B   Stk32b_predicted  serine/threonine kinase 32B (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Stk32b_predicted  serine/threonine kinase 32B (predicted)      Symbol and Name status set to approved 70820 APPROVED