Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PCNX1 mRNA | CTD | PMID:24763279 | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PCNX1 mRNA] | CTD | PMID:31150632 | 1,2-dimethylhydrazine | increases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of PCNX1 mRNA | CTD | PMID:22206623 | 1-naphthyl isothiocyanate | decreases expression | EXP | | 6480464 | 1-Naphthylisothiocyanate results in decreased expression of PCNX1 mRNA | CTD | PMID:30723492 | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of PCNX1 mRNA | CTD | PMID:29097150 | 17alpha-ethynylestradiol | multiple interactions | ISO | Pcnx1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PCNX1 mRNA | CTD | PMID:17942748 | 17alpha-ethynylestradiol | increases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Ethinyl Estradiol results in increased expression of PCNX1 mRNA | CTD | PMID:17942748 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PCNX1 mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PCNX1 mRNA | CTD | PMID:18796159 more ... | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Pcnx1 (Mus musculus) | 6480464 | [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PCNX1 mRNA | CTD | PMID:17942748 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of PCNX1 mRNA | CTD | PMID:28973697 | aflatoxin B1 | increases methylation | ISO | PCNX1 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of PCNX1 intron | CTD | PMID:30157460 | all-trans-retinoic acid | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Tretinoin results in increased expression of PCNX1 mRNA | CTD | PMID:33167477 | aristolochic acid A | decreases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PCNX1 mRNA | CTD | PMID:33212167 | arsane | affects methylation | ISO | PCNX1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PCNX1 gene | CTD | PMID:25304211 | arsenic atom | affects methylation | ISO | PCNX1 (Homo sapiens) | 6480464 | Arsenic affects the methylation of PCNX1 gene | CTD | PMID:25304211 | arsenite(3-) | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PCNX1 mRNA] | CTD | PMID:32406909 | atrazine | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Atrazine results in increased expression of PCNX1 mRNA | CTD | PMID:22378314 | benzo[a]pyrene | affects methylation | ISO | PCNX1 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PCNX1 intron | CTD | PMID:30157460 | benzo[a]pyrene | multiple interactions | ISO | Pcnx1 (Mus musculus) | 6480464 | AHR protein affects the reaction [Benzo(a)pyrene affects the expression of PCNX1 mRNA] | CTD | PMID:22228805 | benzo[a]pyrene | increases mutagenesis | ISO | PCNX1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased mutagenesis of PCNX1 gene | CTD | PMID:25435355 | benzo[a]pyrene | increases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PCNX1 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | decreases methylation | ISO | PCNX1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of PCNX1 3' UTR and Benzo(a)pyrene results in decreased methylation of PCNX1 promoter | CTD | PMID:27901495 | Benzo[ghi]perylene | increases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | 1 and 12-benzoperylene results in increased expression of PCNX1 mRNA | CTD | PMID:26377693 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PCNX1 mRNA | CTD | PMID:25181051 and PMID:32145629 | bisphenol A | increases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PCNX1 mRNA | CTD | PMID:26063408 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PCNX1 gene | CTD | PMID:28505145 | bisphenol A | affects methylation | ISO | PCNX1 (Homo sapiens) | 6480464 | bisphenol A affects the methylation of PCNX1 gene | CTD | PMID:31601247 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PCNX1 mRNA | CTD | PMID:30816183 and PMID:32528016 | caffeine | affects phosphorylation | ISO | PCNX1 (Homo sapiens) | 6480464 | Caffeine affects the phosphorylation of PCNX1 protein | CTD | PMID:35688186 | carbon nanotube | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | CGP 52608 | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PCNX1 gene] | CTD | PMID:28238834 | chromium(6+) | affects expression | ISO | Pcnx1 (Mus musculus) | 6480464 | chromium hexavalent ion affects the expression of PCNX1 mRNA | CTD | PMID:28472532 | crocidolite asbestos | decreases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in decreased expression of PCNX1 mRNA | CTD | PMID:29523930 | crocidolite asbestos | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of PCNX1 mRNA | CTD | PMID:29279043 | dorsomorphin | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCNX1 mRNA | CTD | PMID:27188386 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of PCNX1 mRNA | CTD | PMID:29391264 | epoxiconazole | affects expression | ISO | Pcnx1 (Mus musculus) | 6480464 | epoxiconazole affects the expression of PCNX1 mRNA | CTD | PMID:35436446 | ethanol | increases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Ethanol results in increased expression of PCNX1 mRNA | CTD | PMID:30319688 | ethanol | affects splicing | ISO | Pcnx1 (Mus musculus) | 6480464 | Ethanol affects the splicing of PCNX1 mRNA | CTD | PMID:30319688 | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of PCNX1 mRNA | CTD | PMID:24136188 | formaldehyde | decreases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of PCNX1 mRNA | CTD | PMID:20655997 | FR900359 | increases phosphorylation | ISO | PCNX1 (Homo sapiens) | 6480464 | FR900359 results in increased phosphorylation of PCNX1 protein | CTD | PMID:37730182 | glafenine | decreases expression | EXP | | 6480464 | Glafenine results in decreased expression of PCNX1 mRNA | CTD | PMID:24136188 | methidathion | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | methidathion results in decreased expression of PCNX1 mRNA | CTD | PMID:34813904 | methyl methanesulfonate | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of PCNX1 mRNA | CTD | PMID:23649840 | methylmercury chloride | decreases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PCNX1 mRNA | CTD | PMID:28001369 | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of PCNX1 gene | CTD | PMID:33148267 | nefazodone | decreases expression | EXP | | 6480464 | nefazodone results in decreased expression of PCNX1 mRNA | CTD | PMID:24136188 | nickel atom | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Nickel results in increased expression of PCNX1 mRNA | CTD | PMID:24768652 and PMID:25583101 | nimesulide | decreases expression | EXP | | 6480464 | nimesulide results in decreased expression of PCNX1 mRNA | CTD | PMID:24136188 | ozone | multiple interactions | ISO | Pcnx1 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of PCNX1 mRNA and [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of PCNX1 mRNA | CTD | PMID:34911549 | ozone | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of PCNX1 mRNA | CTD | PMID:35430440 | paracetamol | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PCNX1 mRNA | CTD | PMID:22230336 | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in decreased methylation of PCNX1 gene | CTD | PMID:33148267 | SB 431542 | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCNX1 mRNA | CTD | PMID:27188386 | silver atom | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Silver results in decreased expression of PCNX1 mRNA | CTD | PMID:27131904 | silver(0) | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Silver results in decreased expression of PCNX1 mRNA | CTD | PMID:27131904 | tetrachloromethane | decreases expression | EXP | | 6480464 | Carbon Tetrachloride results in decreased expression of PCNX1 mRNA | CTD | PMID:31150632 | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PCNX1 mRNA] | CTD | PMID:31150632 | thimerosal | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Thimerosal results in increased expression of PCNX1 mRNA | CTD | PMID:27188386 | titanium dioxide | affects expression | ISO | Pcnx1 (Mus musculus) | 6480464 | titanium dioxide affects the expression of PCNX1 mRNA | CTD | PMID:17656681 | trichostatin A | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | trichostatin A results in increased expression of PCNX1 mRNA | CTD | PMID:24935251 | tungsten | decreases expression | ISO | Pcnx1 (Mus musculus) | 6480464 | Tungsten results in decreased expression of PCNX1 mRNA | CTD | PMID:30912803 | valproic acid | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PCNX1 mRNA | CTD | PMID:19101580 | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of PCNX1 mRNA | CTD | PMID:29427782 | valproic acid | multiple interactions | ISO | PCNX1 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCNX1 mRNA | CTD | PMID:27188386 | valproic acid | affects expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of PCNX1 mRNA | CTD | PMID:23179753 | valproic acid | decreases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PCNX1 mRNA | CTD | PMID:24383497 more ... | vincristine | increases expression | ISO | PCNX1 (Homo sapiens) | 6480464 | Vincristine results in increased expression of PCNX1 mRNA | CTD | PMID:23649840 | |