Rrp15 (ribosomal RNA processing 15 homolog) - Rat Genome Database

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Gene: Rrp15 (ribosomal RNA processing 15 homolog) Rattus norvegicus
Analyze
Symbol: Rrp15
Name: ribosomal RNA processing 15 homolog
RGD ID: 1306106
Description: Predicted to be involved in maturation of 5.8S rRNA and maturation of LSU-rRNA. Predicted to be part of preribosome, large subunit precursor. Orthologous to human RRP15 (ribosomal RNA processing 15 homolog); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC360895; MGC105708; RGD1306106; ribosomal RNA processing 15 homolog (S. cerevisiae); ribosomal RNA-processing protein 15; RRP15-like protein; similar to RIKEN cDNA 2810430M08
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813100,807,729 - 100,830,812 (-)NCBIGRCr8
mRatBN7.21398,276,276 - 98,299,357 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1398,276,134 - 98,299,370 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13100,793,786 - 100,816,887 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013102,180,954 - 102,204,035 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01399,376,101 - 99,399,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013105,155,824 - 105,178,907 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13105,155,441 - 105,179,095 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013109,807,397 - 109,830,711 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413102,833,812 - 102,856,894 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113103,022,855 - 103,045,937 (-)NCBI
Celera1397,784,470 - 97,807,553 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:15769876  


Genomics

Comparative Map Data
Rrp15
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813100,807,729 - 100,830,812 (-)NCBIGRCr8
mRatBN7.21398,276,276 - 98,299,357 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1398,276,134 - 98,299,370 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13100,793,786 - 100,816,887 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013102,180,954 - 102,204,035 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01399,376,101 - 99,399,202 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013105,155,824 - 105,178,907 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13105,155,441 - 105,179,095 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013109,807,397 - 109,830,711 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413102,833,812 - 102,856,894 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113103,022,855 - 103,045,937 (-)NCBI
Celera1397,784,470 - 97,807,553 (-)NCBICelera
Cytogenetic Map13q26NCBI
RRP15
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381218,285,293 - 218,337,983 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1218,285,293 - 218,337,983 (+)EnsemblGRCh38hg38GRCh38
GRCh371218,458,635 - 218,511,325 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361216,525,252 - 216,577,948 (+)NCBINCBI36Build 36hg18NCBI36
Celera1191,675,091 - 191,727,786 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1189,126,828 - 189,179,495 (+)NCBIHuRef
CHM1_11219,730,946 - 219,783,677 (+)NCBICHM1_1
T2T-CHM13v2.01217,520,058 - 217,572,747 (+)NCBIT2T-CHM13v2.0
Rrp15
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,453,283 - 186,481,555 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1186,453,175 - 186,481,555 (-)EnsemblGRCm39 Ensembl
GRCm381186,721,086 - 186,749,358 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,720,978 - 186,749,358 (-)EnsemblGRCm38mm10GRCm38
MGSCv371188,544,965 - 188,573,237 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361188,421,880 - 188,452,712 (-)NCBIMGSCv36mm8
Celera1193,664,585 - 193,683,559 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map189.95NCBI
Rrp15
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955406262,346 - 296,439 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955406260,447 - 295,842 (-)NCBIChiLan1.0ChiLan1.0
RRP15
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2131,074,833 - 31,121,954 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1131,037,398 - 31,083,991 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01193,846,921 - 193,900,077 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11198,698,849 - 198,745,011 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1198,698,850 - 198,745,011 (+)Ensemblpanpan1.1panPan2
RRP15
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13813,377,518 - 13,416,809 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3813,377,571 - 13,421,810 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3813,419,617 - 13,459,111 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03813,411,023 - 13,450,593 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.13813,420,320 - 13,466,150 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03813,766,942 - 13,812,671 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03814,075,819 - 14,121,556 (+)NCBIUU_Cfam_GSD_1.0
Rrp15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934458,391,000 - 58,446,398 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936628408,911 - 456,425 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936628408,854 - 456,464 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RRP15
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl108,253,822 - 8,303,860 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1108,253,798 - 8,296,143 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21010,300,927 - 10,339,246 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RRP15
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12511,273,756 - 11,318,280 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2511,274,241 - 11,318,290 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605511,685,342 - 11,729,923 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rrp15
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248352,314,499 - 2,349,259 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248352,314,341 - 2,355,741 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rrp15
183 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:47
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000003359
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
RH130884  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21398,276,305 - 98,276,522 (+)MAPPERmRatBN7.2
Rnor_6.013105,155,854 - 105,156,070NCBIRnor6.0
Rnor_5.013109,807,427 - 109,807,643UniSTSRnor5.0
RGSC_v3.413102,833,842 - 102,834,058UniSTSRGSC3.4
Celera1397,784,500 - 97,784,716UniSTS
RH 3.4 Map13670.0UniSTS
Cytogenetic Map13q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 27 27 24 7 24 3 66 25 33 10
Low 16 30 17 12 17 8 8 8 10 8 1 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000003359   ⟹   ENSRNOP00000003359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1398,276,134 - 98,299,370 (-)Ensembl
Rnor_6.0 Ensembl13105,155,441 - 105,179,095 (-)Ensembl
RefSeq Acc Id: NM_001009702   ⟹   NP_001009702
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr813100,807,729 - 100,830,812 (-)NCBI
mRatBN7.21398,276,276 - 98,299,357 (-)NCBI
Rnor_6.013105,155,824 - 105,178,907 (-)NCBI
Rnor_5.013109,807,397 - 109,830,711 (-)NCBI
RGSC_v3.413102,833,812 - 102,856,894 (-)RGD
Celera1397,784,470 - 97,807,553 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001009702 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87649 (Get FASTA)   NCBI Sequence Viewer  
  EDL94933 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000003359
  ENSRNOP00000003359.4
  ENSRNOP00055017196
  ENSRNOP00060009507
  ENSRNOP00065023069
GenBank Protein Q5M947 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001009702   ⟸   NM_001009702
- UniProtKB: Q5M947 (UniProtKB/Swiss-Prot),   A6JGS7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003359   ⟸   ENSRNOT00000003359

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M947-F1-model_v2 AlphaFold Q5M947 1-280 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699098
Promoter ID:EPDNEW_R9623
Type:multiple initiation site
Name:Rrp15_1
Description:ribosomal RNA processing 15 homolog
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013105,178,922 - 105,178,982EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1306106 AgrOrtholog
BioCyc Gene G2FUF-16956 BioCyc
Ensembl Genes ENSRNOG00000002450 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055012467 UniProtKB/Swiss-Prot
  ENSRNOG00060007613 UniProtKB/Swiss-Prot
  ENSRNOG00065017426 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003359 ENTREZGENE
  ENSRNOT00000003359.7 UniProtKB/Swiss-Prot
  ENSRNOT00055021259 UniProtKB/Swiss-Prot
  ENSRNOT00060012547 UniProtKB/Swiss-Prot
  ENSRNOT00065029107 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7310706 IMAGE-MGC_LOAD
InterPro Rrp15 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360895 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105708 IMAGE-MGC_LOAD
NCBI Gene 360895 ENTREZGENE
PANTHER PTHR13245 UniProtKB/Swiss-Prot
  RRP15-LIKE PROTEIN UniProtKB/Swiss-Prot
  RRP15-LIKE PROTEIN UniProtKB/TrEMBL
  RRP15-LIKE PROTEIN UniProtKB/TrEMBL
Pfam Rrp15p UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rrp15 PhenoGen
RatGTEx ENSRNOG00000002450 RatGTEx
  ENSRNOG00055012467 RatGTEx
  ENSRNOG00060007613 RatGTEx
  ENSRNOG00065017426 RatGTEx
UniProt A6JGS7 ENTREZGENE, UniProtKB/TrEMBL
  Q5M947 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-30 Rrp15  ribosomal RNA processing 15 homolog  Rrp15  ribosomal RNA processing 15 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Rrp15  ribosomal RNA processing 15 homolog (S. cerevisiae)  RGD1306106  similar to RIKEN cDNA 2810430M08  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1306106  similar to RIKEN cDNA 2810430M08  RGD1306106_predicted  similar to RIKEN cDNA 2810430M08 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1306106_predicted  similar to RIKEN cDNA 2810430M08 (predicted)  LOC360895_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC360895_predicted  similar to RIKEN cDNA 2810430M08 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL