Sec61a2 (SEC61 translocon subunit alpha 2) - Rat Genome Database

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Gene: Sec61a2 (SEC61 translocon subunit alpha 2) Rattus norvegicus
Analyze
Symbol: Sec61a2
Name: SEC61 translocon subunit alpha 2
RGD ID: 1305948
Description: Predicted to enable protein transmembrane transporter activity; ribosome binding activity; and signal sequence binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and post-translational protein targeting to membrane, translocation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of Sec61 translocon complex. Orthologous to human SEC61A2 (SEC61 translocon subunit alpha 2); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; phagocytosis pathway; INTERACTS WITH 2,6-dinitrotoluene; bisphenol A; difenoconazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361273; Sec61 alpha 2 subunit; Sec61 alpha 2 subunit (S. cerevisiae); Sec61 translocon alpha 2 subunit; Sec61, alpha subunit 2; Sec61, alpha subunit 2 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81777,316,901 - 77,354,978 (+)NCBIGRCr8
mRatBN7.21772,407,574 - 72,445,630 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1772,407,671 - 72,434,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1775,913,660 - 75,940,192 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01779,735,106 - 79,761,650 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01773,785,375 - 73,811,910 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01776,358,947 - 76,385,860 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1776,358,944 - 76,385,103 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01778,015,619 - 78,041,935 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41783,467,290 - 83,495,417 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11783,477,994 - 83,506,232 (+)NCBI
Celera1771,858,801 - 71,884,088 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:8889548   PMID:16705175  


Genomics

Comparative Map Data
Sec61a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81777,316,901 - 77,354,978 (+)NCBIGRCr8
mRatBN7.21772,407,574 - 72,445,630 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1772,407,671 - 72,434,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1775,913,660 - 75,940,192 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01779,735,106 - 79,761,650 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01773,785,375 - 73,811,910 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01776,358,947 - 76,385,860 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1776,358,944 - 76,385,103 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01778,015,619 - 78,041,935 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41783,467,290 - 83,495,417 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11783,477,994 - 83,506,232 (+)NCBI
Celera1771,858,801 - 71,884,088 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
SEC61A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381012,129,641 - 12,169,958 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1012,129,637 - 12,169,961 (+)EnsemblGRCh38hg38GRCh38
GRCh371012,171,640 - 12,211,957 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361012,211,704 - 12,246,832 (+)NCBINCBI36Build 36hg18NCBI36
Build 341012,211,703 - 12,246,832NCBI
Celera1012,101,504 - 12,141,488 (+)NCBICelera
Cytogenetic Map10p14NCBI
HuRef1012,088,501 - 12,128,497 (+)NCBIHuRef
CHM1_11012,171,610 - 12,211,952 (+)NCBICHM1_1
T2T-CHM13v2.01012,140,919 - 12,181,232 (+)NCBIT2T-CHM13v2.0
Sec61a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3925,875,788 - 5,900,199 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl25,875,798 - 5,900,243 (-)EnsemblGRCm39 Ensembl
GRCm3825,870,977 - 5,895,432 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl25,870,987 - 5,895,432 (-)EnsemblGRCm38mm10GRCm38
MGSCv3725,792,033 - 5,816,399 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3625,788,259 - 5,812,625 (-)NCBIMGSCv36mm8
Celera25,822,085 - 5,848,609 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map23.62NCBI
Sec61a2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955462166,423 - 189,585 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955462166,423 - 189,592 (+)NCBIChiLan1.0ChiLan1.0
SEC61A2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2824,658,895 - 24,697,771 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11024,664,227 - 24,703,107 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01012,136,907 - 12,175,765 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11012,102,536 - 12,161,092 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1012,102,536 - 12,161,092 (+)Ensemblpanpan1.1panPan2
SEC61A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1224,267,260 - 24,292,466 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl224,267,271 - 24,349,736 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha221,291,407 - 21,317,572 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0224,637,671 - 24,663,859 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl224,635,382 - 24,663,850 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1221,765,047 - 21,791,189 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0222,607,417 - 22,633,605 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0223,322,632 - 23,348,852 (-)NCBIUU_Cfam_GSD_1.0
Sec61a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934427,006,482 - 27,039,560 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364843,168,803 - 3,204,736 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364843,171,444 - 3,204,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SEC61A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1059,773,852 - 59,817,010 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11059,790,073 - 59,817,039 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21065,576,995 - 65,603,953 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SEC61A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1912,176,814 - 12,216,343 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl912,176,894 - 12,215,422 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605117,680,636 - 17,723,064 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sec61a2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248054,873,506 - 4,901,907 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248054,873,523 - 4,901,907 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sec61a2
266 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:79
Count of miRNA genes:64
Interacting mature miRNAs:75
Transcripts:ENSRNOT00000039621
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176364000973951021Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)177100332581153923Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)177177462182479847Rat

Markers in Region
D17Rat62  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21772,420,094 - 72,420,215 (+)MAPPERmRatBN7.2
Rnor_6.01776,371,428 - 76,371,548NCBIRnor6.0
Rnor_5.01778,028,077 - 78,028,197UniSTSRnor5.0
RGSC_v3.41783,479,938 - 83,480,058UniSTSRGSC3.4
RGSC_v3.41783,479,937 - 83,480,058RGDRGSC3.4
RGSC_v3.11783,490,771 - 83,490,891RGD
Celera1771,871,260 - 71,871,380UniSTS
RH 3.4 Map17719.6RGD
RH 3.4 Map17719.6UniSTS
RH 2.0 Map17615.4RGD
SHRSP x BN Map1742.3499RGD
FHH x ACI Map1757.6RGD
Cytogenetic Map17q12.3UniSTS
RH130992  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21772,406,213 - 72,406,396 (+)MAPPERmRatBN7.2
Rnor_6.01776,357,547 - 76,357,729NCBIRnor6.0
Rnor_5.01778,014,245 - 78,014,427UniSTSRnor5.0
RGSC_v3.41783,465,799 - 83,465,981UniSTSRGSC3.4
Celera1771,857,310 - 71,857,492UniSTS
RH 3.4 Map17719.9UniSTS
Cytogenetic Map17q12.3UniSTS
RH133786  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21772,434,252 - 72,434,453 (+)MAPPERmRatBN7.2
Rnor_6.01776,385,586 - 76,385,786NCBIRnor6.0
Rnor_5.01778,042,010 - 78,042,210UniSTSRnor5.0
RGSC_v3.41783,495,496 - 83,495,696UniSTSRGSC3.4
Celera1771,884,167 - 71,884,367UniSTS
RH 3.4 Map17719.5UniSTS
Cytogenetic Map17q12.3UniSTS
RH133879  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21772,433,884 - 72,434,102 (+)MAPPERmRatBN7.2
Rnor_6.01776,385,218 - 76,385,435NCBIRnor6.0
Rnor_5.01778,041,642 - 78,041,859UniSTSRnor5.0
RGSC_v3.41783,495,128 - 83,495,345UniSTSRGSC3.4
Celera1771,883,799 - 71,884,016UniSTS
RH 3.4 Map17717.6UniSTS
Cytogenetic Map17q12.3UniSTS
RH138877  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21772,418,787 - 72,418,939 (+)MAPPERmRatBN7.2
Rnor_6.01776,370,121 - 76,370,272NCBIRnor6.0
Rnor_5.01778,026,770 - 78,026,921UniSTSRnor5.0
RGSC_v3.41783,478,631 - 83,478,782UniSTSRGSC3.4
Celera1771,869,953 - 71,870,104UniSTS
RH 3.4 Map17717.6UniSTS
Cytogenetic Map17q12.3UniSTS
BF390786  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21772,429,443 - 72,429,599 (+)MAPPERmRatBN7.2
Rnor_6.01776,380,777 - 76,380,932NCBIRnor6.0
Rnor_5.01778,037,319 - 78,037,474UniSTSRnor5.0
RGSC_v3.41783,490,354 - 83,490,509UniSTSRGSC3.4
Celera1771,879,299 - 71,879,454UniSTS
RH 3.4 Map17717.2UniSTS
Cytogenetic Map17q12.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 39 28 12 18 12 8 11 74 35 41 11 8
Low 4 29 29 1 29
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000039621   ⟹   ENSRNOP00000036212
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1772,407,671 - 72,434,494 (+)Ensembl
Rnor_6.0 Ensembl1776,359,022 - 76,384,994 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092448
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1772,407,671 - 72,425,643 (+)Ensembl
Rnor_6.0 Ensembl1776,358,944 - 76,374,284 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092481   ⟹   ENSRNOP00000075773
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1772,407,713 - 72,434,161 (+)Ensembl
Rnor_6.0 Ensembl1776,359,042 - 76,385,103 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097004   ⟹   ENSRNOP00000091806
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1772,408,016 - 72,434,088 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000107273   ⟹   ENSRNOP00000088152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1772,407,671 - 72,434,479 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119882   ⟹   ENSRNOP00000097707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1772,408,016 - 72,434,088 (+)Ensembl
RefSeq Acc Id: NM_001170343   ⟹   NP_001163814
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81777,317,054 - 77,343,521 (+)NCBI
mRatBN7.21772,407,704 - 72,434,174 (+)NCBI
Rnor_6.01776,359,038 - 76,385,507 (+)NCBI
Rnor_5.01778,015,619 - 78,041,935 (+)NCBI
RGSC_v3.41783,467,290 - 83,495,417 (+)RGD
Celera1771,858,801 - 71,884,088 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254257   ⟹   XP_006254319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81777,316,915 - 77,343,874 (+)NCBI
mRatBN7.21772,407,574 - 72,434,155 (+)NCBI
Rnor_6.01776,358,947 - 76,385,860 (+)NCBI
Rnor_5.01778,015,619 - 78,041,935 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039095932   ⟹   XP_038951860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81777,316,901 - 77,354,978 (+)NCBI
mRatBN7.21772,407,575 - 72,445,630 (+)NCBI
RefSeq Acc Id: XM_039095933   ⟹   XP_038951861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81777,318,855 - 77,343,874 (+)NCBI
mRatBN7.21772,409,502 - 72,434,178 (+)NCBI
RefSeq Acc Id: XM_063276637   ⟹   XP_063132707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81777,316,915 - 77,337,824 (+)NCBI
RefSeq Acc Id: XR_005495306
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81777,316,901 - 77,354,978 (+)NCBI
mRatBN7.21772,407,575 - 72,445,630 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001163814   ⟸   NM_001170343
- UniProtKB: A0A8I6AA70 (UniProtKB/TrEMBL),   A0A8I6GFI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254319   ⟸   XM_006254257
- Peptide Label: isoform X3
- UniProtKB: A0A8I6GFI1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075773   ⟸   ENSRNOT00000092481
RefSeq Acc Id: ENSRNOP00000036212   ⟸   ENSRNOT00000039621
RefSeq Acc Id: XP_038951860   ⟸   XM_039095932
- Peptide Label: isoform X1
- UniProtKB: D3ZEH3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038951861   ⟸   XM_039095933
- Peptide Label: isoform X2
- UniProtKB: A0A8L2Q9G3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000088152   ⟸   ENSRNOT00000107273
RefSeq Acc Id: ENSRNOP00000091806   ⟸   ENSRNOT00000097004
RefSeq Acc Id: ENSRNOP00000097707   ⟸   ENSRNOT00000119882
RefSeq Acc Id: XP_063132707   ⟸   XM_063276637
- Peptide Label: isoform X4
- UniProtKB: A0A0U1RRQ7 (UniProtKB/TrEMBL)
Protein Domains
Translocon Sec61/SecY plug

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZEH3-F1-model_v2 AlphaFold D3ZEH3 1-476 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700570
Promoter ID:EPDNEW_R11092
Type:initiation region
Name:Sec61a2_1
Description:Sec61 translocon alpha 2 subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01776,359,009 - 76,359,069EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305948 AgrOrtholog
BioCyc Gene G2FUF-8707 BioCyc
Ensembl Genes ENSRNOG00000013743 UniProtKB/TrEMBL
  ENSRNOG00000023278 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018454.6 UniProtKB/TrEMBL
  ENSRNOT00000039621.8 UniProtKB/TrEMBL
  ENSRNOT00000092448.2 UniProtKB/TrEMBL
  ENSRNOT00000092481.2 UniProtKB/TrEMBL
  ENSRNOT00000097004.1 UniProtKB/TrEMBL
  ENSRNOT00000100854.1 UniProtKB/TrEMBL
  ENSRNOT00000107273 ENTREZGENE
  ENSRNOT00000107273.1 UniProtKB/TrEMBL
  ENSRNOT00000119882.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.3370.10 UniProtKB/TrEMBL
InterPro SecY UniProtKB/TrEMBL
  SecY_CS UniProtKB/TrEMBL
  SecY_su_dom UniProtKB/TrEMBL
  Translocon_Sec61/SecY_plug_dom UniProtKB/TrEMBL
KEGG Report rno:361273 UniProtKB/TrEMBL
NCBI Gene 361273 ENTREZGENE
PANTHER PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1 UniProtKB/TrEMBL
  PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 2 UniProtKB/TrEMBL
  SecY UniProtKB/TrEMBL
Pfam Plug_translocon UniProtKB/TrEMBL
  SecY UniProtKB/TrEMBL
PhenoGen Sec61a2 PhenoGen
PIRSF SecY UniProtKB/TrEMBL
PRINTS SECYTRNLCASE UniProtKB/TrEMBL
PROSITE SECY_1 UniProtKB/TrEMBL
  SECY_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013743 RatGTEx
  ENSRNOG00000023278 RatGTEx
Superfamily-SCOP SecY UniProtKB/TrEMBL
UniProt A0A0U1RRQ7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUP9_RAT UniProtKB/TrEMBL
  A0A8I6AA70 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEC5_RAT UniProtKB/TrEMBL
  A0A8I6ATH2_RAT UniProtKB/TrEMBL
  A0A8I6GFI1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q9G3 ENTREZGENE, UniProtKB/TrEMBL
  D3ZEH3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-06 Sec61a2  SEC61 translocon subunit alpha 2  Sec61a2  Sec61 translocon alpha 2 subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-11 Sec61a2  Sec61 translocon alpha 2 subunit  Sec61a2  Sec61 alpha 2 subunit (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-12-15 Sec61a2  Sec61 alpha 2 subunit (S. cerevisiae)  Sec61a2  Sec61, alpha subunit 2 (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Sec61a2  Sec61, alpha subunit 2 (S. cerevisiae)   Sec61a2_predicted  Sec61, alpha subunit 2 (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sec61a2_predicted  Sec61, alpha subunit 2 (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED