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Gene Ontology Annotations
Gene Ontology AnnotationsBiological Process Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | atrioventricular valve morphogenesis | | ISO | RGD:1312806 | 1624291 | UniProtKB:Q9WV93 | RGD | MGI:MGI:3783952 PMID:17303760 | cardiac epithelial to mesenchymal transition | | ISO | RGD:1312806 | 1624291 | UniProtKB:Q9WV93 | RGD | MGI:MGI:3783952 PMID:17303760 | cardiac ventricle morphogenesis | | ISO | RGD:1312806 | 1624291 | MGI:MGI:3783952|PMID:17303760 | RGD | MGI:MGI:3783952 PMID:17303760 | endocardial cushion morphogenesis | | ISO | RGD:1312806 | 1624291 | UniProtKB:Q9WV93 | RGD | MGI:MGI:3783952 PMID:17303760 | epithelial to mesenchymal transition involved in endocardial cushion formation | | ISO | RGD:1312806 | 1624291 | MGI:MGI:1341800 | RGD | MGI:MGI:3783952 PMID:17303760 | mesenchymal cell development | | ISO | RGD:1312806 | 1624291 | UniProtKB:Q9WV93 | RGD | MGI:MGI:3783952 PMID:17303760 | negative regulation of androgen receptor activity | | ISO | RGD:1312805 | 1624291 | PMID:21454491 | RGD | PMID:21454491 | negative regulation of androgen receptor signaling pathway | | ISO | RGD:1312805 | 1624291 | PMID:21454491 | RGD | PMID:21454491 | negative regulation of gene expression | | ISO | RGD:1312806 | 1624291 | MGI:MGI:5427763|PMID:22615585 | RGD | MGI:MGI:5427763 PMID:22615585 | negative regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1312806 | 1624291 | MGI:MGI:5285519|PMID:21259317 | RGD | MGI:MGI:5285519 PMID:21259317 | negative regulation of transcription, DNA-dependent | | ISO | RGD:1312806 | 1624291 | MGI:MGI:3603871|PMID:16199874 | RGD | MGI:MGI:3603871 PMID:16199874 | negative regulation of transcription, DNA-dependent | | ISO | RGD:1312805 | 1624291 | PMID:21454491 | RGD | PMID:21454491 | negative regulation of transcription, DNA-dependent | | ISO | RGD:1312805 | 1624291 | PMID:15485867 | RGD | PMID:15485867 | negative regulation of transcription, DNA-dependent | | ISO | RGD:1312806 | 1624291 | MGI:MGI:4365702|PMID:19631204 | RGD | MGI:MGI:4365702 PMID:19631204 | Notch signaling pathway | | ISO | RGD:1312805 | 1624291 | PMID:10964718 | RGD | PMID:10964718 | outflow tract morphogenesis | | ISO | RGD:1312806 | 1624291 | UniProtKB:Q9WV93 | RGD | MGI:MGI:3783952 PMID:17303760 | positive regulation of neuron differentiation | | ISO | RGD:1312806 | 1624291 | MGI:MGI:4365702|PMID:19631204 | RGD | MGI:MGI:4365702 PMID:19631204 | positive regulation of neuron differentiation | | ISO | RGD:1312806 | 1624291 | MGI:MGI:5285519|PMID:21259317 | RGD | MGI:MGI:5285519 PMID:21259317 | positive regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1312805 | 1624291 | PMID:21290414 | RGD | PMID:21290414 | positive regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1312806 | 1624291 | MGI:MGI:5285519|PMID:21259317 | RGD | MGI:MGI:5285519 PMID:21259317 | positive regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1312806 | 1624291 | UniProtKB:Q9WV93 | RGD | MGI:MGI:3783952 PMID:17303760 | pulmonary valve morphogenesis | | ISO | RGD:1312806 | 1624291 | UniProtKB:Q9WV93 | RGD | MGI:MGI:3783952 PMID:17303760 | regulation of transcription from RNA polymerase II promoter | | ISO | RGD:1312806 | 1624291 | MGI:MGI:3603871|PMID:16199874 | RGD | MGI:MGI:3603871 PMID:16199874 | regulation of transcription, DNA-dependent | | IEA | UniProtKB-KW:KW-0805 | 1600115 | GO_REF:0000038 | UniProtKB | GO_REF:0000038 | skeletal muscle cell differentiation | | ISO | RGD:1312806 | 1624291 | MGI:MGI:5300631|PMID:22147266 | RGD | MGI:MGI:5300631 PMID:22147266 | transcription, DNA-dependent | | IEA | UniProtKB-KW:KW-0804 | 1600115 | GO_REF:0000038 | UniProtKB | GO_REF:0000038 | ventricular septum morphogenesis | | ISO | RGD:1312806 | 1624291 | UniProtKB:Q9WV93 | RGD | MGI:MGI:3783952 PMID:17303760 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Pathway Annotations
Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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References - curated| 1. |
Fischer A and Gessler M, Nucleic Acids Res. 2007;35(14):4583-96. Epub 2007 Jun 22. |
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GOA data from the GO Consortium |
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MGD data from the GO Consortium |
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RGD automated import pipeline for gene-chemical interactions |
RGD Disease Portals| Heyl has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Heyl (Rattus norvegicus) |
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| HEYL (Homo sapiens) |
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| Heyl (Mus musculus) |
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Position Markers| D4Mit11 |
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| RH137535 |
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| RH143142 |
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| RH143336 |
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| BG378118 |
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| BE100438 |
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| D4Mit11 |
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QTLs in Region (RGSC Genome Assembly v3.4)| The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
Nucleotide Sequences| Nucleotide RefSeqs | NM_001107977 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AABR06039771 | (Get FASTA) | Search GEO for Microarray Profiles |
| AAHX01039565 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC114512 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH473968 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_001107977 | ||||||||||||||||||||
| RefSeq Status: | PROVISIONAL | ||||||||||||||||||||
| Type: | CODING | ||||||||||||||||||||
| Protein Acc Id: | NP_001101447 | ||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_001101447 | (Get FASTA) |
| GenBank Protein | EDL80374 | (Get FASTA) |
Strain Sequence Variants
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSRNOG00000015318 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Protein | ENSRNOP00000020928 | ENTREZGENE, UniProtKB/TrEMBL |
| Ensembl Transcript | ENSRNOT00000020929 | ENTREZGENE, UniProtKB/TrEMBL |
| Entrez Gene | 313575 | ENTREZGENE |
| Gene3D-CATH | HLH_DNA_bd | UniProtKB/TrEMBL |
| HomoloGene Group ID | 8494 | ENTREZGENE |
| InterPro | HLH_DNA-bd | UniProtKB/TrEMBL |
| Orange | UniProtKB/TrEMBL | |
| Orange_subgroup | UniProtKB/TrEMBL | |
| IPI | IPI00209608 | UniProtKB/TrEMBL |
| KEGG Report | rno:313575 | ENTREZGENE, UniProtKB/TrEMBL |
| Pfam | Hairy_orange | UniProtKB/TrEMBL |
| HLH | UniProtKB/TrEMBL | |
| PROSITE | HLH | UniProtKB/TrEMBL |
| ORANGE | UniProtKB/TrEMBL | |
| SMART | HLH | UniProtKB/TrEMBL |
| ORANGE | UniProtKB/TrEMBL | |
| Superfamily-SCOP | HLH_basic | UniProtKB/TrEMBL |
| UniGene | Rn.22252 | ENTREZGENE |
| UniProt | D3ZIH3_RAT | UniProtKB/TrEMBL |
Nomenclature History| Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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| 2008-04-30 | Heyl | hairy/enhancer-of-split related with YRPW motif-like | Heyl_predicted | hairy/enhancer-of-split related with YRPW motif-like (predicted) | 'predicted' is removed | 24709 | APPROVED |
| 2005-01-12 | Heyl_predicted | hairy/enhancer-of-split related with YRPW motif-like (predicted) | Symbol and Name status set to approved | 1724 | APPROVED |
| More on Heyl | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1305022 |
| Created: | 2005-01-12 |
| Species: | Rattus norvegicus |
| Last Modified: | 2013-04-16 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




