Lrrtm3 (leucine rich repeat transmembrane neuronal 3)

Gene: Lrrtm3 (leucine rich repeat transmembrane neuronal 3) Rattus norvegicus

Analyze

Symbol:

Lrrtm3

Name:

leucine rich repeat transmembrane neuronal 3

RGD ID:

1304866

Description:

Predicted to be involved in regulation of presynapse assembly. Predicted to act upstream of or within positive regulation of amyloid-beta formation and positive regulation of synapse assembly. Predicted to be active in several cellular components, including extracellular space; glutamatergic synapse; and postsynaptic density membrane. Orthologous to human LRRTM3 (leucine rich repeat transmembrane neuronal 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

leucine-rich repeat transmembrane neuronal protein 3; LOC294380

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	24,514,304 - 24,688,322 (+)	NCBI		GRCr8
mRatBN7.2	20	24,515,627 - 24,689,669 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	24,515,627 - 24,689,669 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	25,232,288 - 25,407,794 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	24,585,290 - 24,760,796 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	25,149,771 - 25,326,595 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	25,990,304 - 26,163,656 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	25,990,304 - 26,163,656 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	28,060,837 - 28,233,801 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	26,343,897 - 26,518,838 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	26,530,218 - 26,532,637 (-)	NCBI
Celera	20	25,840,823 - 26,013,166 (+)	NCBI		Celera
Cytogenetic Map	20	p11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

arrhythmogenic right ventricular dysplasia 13 (ISO)

autism spectrum disorder (ISO)

Autosomal Dominant Intellectual Developmental Disorder 70 (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

chlorpyrifos (ISO)

crocidolite asbestos (ISO)

dichloroacetic acid (ISO)

ethanol (ISO)

lipopolysaccharide (ISO)

maneb (ISO)

methapyrilene (ISO)

mono(2-ethylhexyl) phthalate (ISO)

paraquat (ISO)

PCB138 (ISO)

phenobarbital (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

trichloroethene (EXP)

triclosan (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of amyloid-beta formation (ISO)

positive regulation of synapse assembly (ISO)

regulation of presynapse assembly (ISO)

Cellular Component

extracellular matrix (IBA)

extracellular space (IBA)

glutamatergic synapse (ISO)

postsynaptic density membrane (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:17098871	PMID:24613359	PMID:26776509

Genomics

Comparative Map Data

Lrrtm3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	24,514,304 - 24,688,322 (+)	NCBI		GRCr8
mRatBN7.2	20	24,515,627 - 24,689,669 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	24,515,627 - 24,689,669 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	25,232,288 - 25,407,794 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	24,585,290 - 24,760,796 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	25,149,771 - 25,326,595 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	25,990,304 - 26,163,656 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	25,990,304 - 26,163,656 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	28,060,837 - 28,233,801 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	26,343,897 - 26,518,838 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	26,530,218 - 26,532,637 (-)	NCBI
Celera	20	25,840,823 - 26,013,166 (+)	NCBI		Celera
Cytogenetic Map	20	p11	NCBI

LRRTM3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	66,926,036 - 67,101,551 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	66,926,036 - 67,101,551 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	68,685,794 - 68,861,309 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	68,355,798 - 68,530,873 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	68,355,818 - 68,529,072	NCBI
Celera	10	61,961,031 - 62,136,119 (+)	NCBI		Celera
Cytogenetic Map	10	q21.3	NCBI
HuRef	10	62,684,879 - 62,859,970 (+)	NCBI		HuRef
CHM1_1	10	68,967,601 - 69,142,679 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	67,789,258 - 67,964,743 (+)	NCBI		T2T-CHM13v2.0

Lrrtm3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	63,764,276 - 63,926,034 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	63,764,251 - 63,926,056 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	63,928,497 - 64,090,255 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	63,928,472 - 64,090,277 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	63,391,245 - 63,553,003 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	63,323,854 - 63,485,612 (-)	NCBI		MGSCv36	mm8
Celera	10	65,025,713 - 65,187,599 (-)	NCBI		Celera
Cytogenetic Map	10	B4	NCBI
cM Map	10	32.57	NCBI

Lrrtm3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955425	19,480,907 - 19,654,804 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955425	19,480,944 - 19,657,178 (+)	NCBI	ChiLan1.0	ChiLan1.0

LRRTM3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	79,081,050 - 79,273,026 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	79,086,355 - 79,278,350 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	63,407,003 - 63,594,210 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	65,721,854 - 65,895,122 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	65,722,425 - 65,893,608 (+)	Ensembl	panpan1.1		panPan2

LRRTM3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	18,320,720 - 18,485,863 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	18,321,084 - 18,481,131 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	18,449,353 - 18,611,927 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	18,591,439 - 18,754,088 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	18,591,459 - 18,754,738 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	18,476,844 - 18,638,825 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	18,693,637 - 18,855,992 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	19,039,648 - 19,202,050 (+)	NCBI		UU_Cfam_GSD_1.0

Lrrtm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	62,534,045 - 62,694,508 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936925	330,399 - 493,632 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936925	330,424 - 492,052 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LRRTM3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	70,172,746 - 70,180,777 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	70,172,460 - 70,352,073 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	76,064,496 - 76,242,177 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LRRTM3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	64,260,513 - 64,435,277 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666048	25,071,912 - 25,246,681 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Lrrtm3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	1,348,129 - 1,496,259 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	1,348,448 - 1,499,649 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Lrrtm3
1445 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	190
Count of miRNA genes:	116
Interacting mature miRNAs:	153
Transcripts:	ENSRNOT00000033980
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8042410	29322208	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	17617832	47606836	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17697550	54435887	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	19190721	54435887	Rat

Markers in Region

AU049904

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	24,556,622 - 24,556,810 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	26,031,411 - 26,031,598	NCBI	Rnor6.0
Rnor_5.0	20	28,101,556 - 28,101,743	UniSTS	Rnor5.0
RGSC_v3.4	20	26,477,670 - 26,477,857	UniSTS	RGSC3.4
Celera	20	25,881,098 - 25,881,285	UniSTS
Cytogenetic Map	20	p11-q11	UniSTS
Cytogenetic Map	20	p11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium									40
Low	1	12	15	4	8	4	8	8	28	8	26	9	8
Below cutoff	2	19	12	7	10	7		2	6	27	14	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001106387	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000033980 ⟹ ENSRNOP00000036369

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	24,515,627 - 24,689,669 (+)	Ensembl
Rnor_6.0 Ensembl	20	25,990,304 - 26,163,656 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000081254 ⟹ ENSRNOP00000069618

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	25,990,656 - 25,996,550 (+)	Ensembl

RefSeq Acc Id:

NM_001106387 ⟹ NP_001099857

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	24,514,304 - 24,688,322 (+)	NCBI
mRatBN7.2	20	24,515,627 - 24,689,669 (+)	NCBI
Rnor_6.0	20	25,990,304 - 26,163,656 (+)	NCBI
Rnor_5.0	20	28,060,837 - 28,233,801 (+)	NCBI
RGSC_v3.4	20	26,343,897 - 26,518,838 (-)	RGD
Celera	20	25,840,823 - 26,013,166 (+)	RGD

Sequence:

show sequence

CAGAATGACAGTCTGCTGGAGTGAGCTGAGCGTGTGCGCGGAACCGGGCTCTCTTGCCTTCTGG
GCTCCAACGCAGCTCCGTGGCTGAACTGGGTGCTCACCACCACGGGACCGCCGGGCTATGGAAT
ACAGATGTGGCAGCACAGGTAGCCCCACGTTGCCTAGAGGAATACATCATGGGTTTTGAGAAGA
AATTATAGGAGCCAGTTTTTTTTTTAACACACACACACACACACACACACACACACACACACAC
ACACACTGTAAAGATGCAAAGACGTAATATCCATGAAGATCCTATTACCTAGGAAGACTCGGAT
GTTTTGCTGTGAATGCGGTGTTGGGATTTATTTGTTCTTGGAGTGTTCTGCATGGCTGATAAAG
AATAATGTTCCAAAATCGGTCCATCTCCCAAGGGGTCCAATTTTTCTTCCTGGGTGTCAGCGAG
CCCTGACTCACTACACTGCAGCTGACAGGGGCTGTCATGCAGGCGGCCCCTAAGCCAAAGCAAA
AGACCTAAGGACGACCTTTGAACAATACAAAGGATGGGTTTCAATGTAATTAGGCTACTGCGCG
GATCAGCTGTAGCGGTGGTCCTAGCCCCCACTGTCTTACTGACTATGCTTTCTTCTGCTGAAAG
AGGATGCCCTAAGGGTTGTAGGTGCGAAGGCAAAATGGTCTACTGTGAGTCTCAGAAACTGCAG
GAGATACCCTCAAGTATATCAGCCGGATGCTTGGGTTTATCCCTTCGCTACAACAGCCTCCAAA
AACTTAAGTATAATCAATTTAAAGGGCTCAACCAGCTCACCTGGCTCTACCTTGACCATAACCA
TATCAGCAATATCGACGAGAATGCTTTCAATGGGATACGCAGACTCAAAGAGTTGATTCTGAGT
TCCAACAGAATCTCCTATTTCCTTAACAACACCTTCAGACCTGTGACCAATCTACGGAACTTGG
ATCTGTCCTATAATCAGCTCCATTCTCTGGGATCTGAACAGTTCCGGGGCTTGAGGAAGCTGCT
CAGTTTACACCTCCGCTCCAACTCACTGAGAACCATCCCGGTGCGGATTTTCCAAGACTGTCGC
AACCTGGAACTTCTGGACCTGGGCTATAACAGGATCCGAAGTTTAGCCAGGAATGTCTTTGCTG
GCATGATCAGACTCAAAGAGCTTCACCTGGAGCACAATCAATTTTCCAAGCTCAACCTGGCCCT
TTTCCCAAGGTTGGTGAGCCTTCAGAACTTGTACATGCAGTGGAATAAAATCAGTGTCATAGGA
CAAACCATGTCCTGGACTTGGAGCTCCTTACAGAGACTTGACCTGTCGGGTAATGAGATCGAAG
CCTTCAGTGGACCCAGTGTCTTCCAGTGTGTCCCCAATCTGCAACGCCTCAACCTGGATTCCAA
CAAGCTCACATTTATTGGTCAAGAGATTCTGGATTCTTGGATCTCTCTCAATGACATCAGCCTT
GCTGGGAATATATGGGAATGCAGCAGGAATATCTGCTCCCTGGTGAACTGGCTGAAAAGTTTTA
AAGGTCTGAGAGAGAATACAATTCTCTGCGCCAGTCCCAAAGAGCTGCAGGGGGTTAACGTGAT
CGATGCAGTGAAGAACTACAGCATCTGTGGCAAGAGCACTACCACAGAGAGGTTTGACCTGGCC
AGGGCCCTCCCCAAACCCACGTTTAAGCCCAAGCTCCCCAGGCCTAAGCACGAGAGCAAGCCTC
CGCTGCCCCCCACGGTGGGAGCTAGCGAGCCCAGCCCAGAGACAGATGTGGACACGGAGCACAT
CTCCTTCCATAAGATCATCGCGGGCAGCGTGGCCCTTTTCCTGTCGGTGCTGGTCATCCTCTTG
GTTATGTACGTGTCCTGGAAGCGGTACCCCGCCAGCATGAAGCAGCTGCAGCAGCGCTCCCTCA
TGCGAAGGCACCGGAAGAAGAAACGGCAATCGCTCAAGCAAATGACTCCAGGCACCCAGGAATT
TTATGTAGATTATAAACCCACCAACACGGAGACCAGCGAGATGCTGCTGAACGGAACCGGACCC
TGCACCTATAGCAAATCAGGCTCCAGGGAATGTGAGATACCTTTATCAATGAATGTGTCAACTT
TTCTGGCATACGACCAGCCCACAATAAGTTACTGTGGGGTCCATCATGAACTCCTCTCCCATAA
GACCTTTGAAACGAATGCACAGGAAGACACGATGGAAAGCCACCTAGAGACTGAGCTGGACTTG
AGCACAATCACGTCAGCTGGCCGCATCGGCGACCATAAACCACAGCTGGCCTGACCCAGCTGGC
CTGACCCAGCTGAACGGTAGCCCAGGCTTGCCACCCAACTATAACCTCAACTACAGAAAGAGGA
GACTCTGTTCATTGCAATTCTCGAATACAAAACAAAAACAAAACTCCCCTGTTCAAATAAACAA
AATTTTAAGATTGGTTCATGAAATAAAAGAGGACATGAATTGTTTCAAGTCTACACTTTGTAAC
TAGCTAAGTTGTGCAGTATTTTTTTGACTTTAACAGAGAACGACCCTGAAAAAAAATCATTTTT
TTTCTCCAAAACTCATCCTACCTACATGTAAAAATTGTACAGCGCTAATGTATTTTTCATATTA
TAAAGTTTCAATTCTAGGAACAACTGGTATGTACAGTACTGTAATTTAATTGATGCTTTACTTT
ACACCTTTCAGTTTCTAAAATTTTAAATTAACCAACATTATTTTCTTGTGTTCTTGAGAGTTAC
TTGGTTTTGTGGGGGCTGTTTTGTTACTGCATTTGTGCCCAGAAACCTTGACTCTGAAATCTGT
GCTGTGCAAACAACGCACGATTTTTATCATTACCACGCTTACTGCATAGAATTTTATCTACTTG
TTCCAGAAATAATACATTAACCAAAAGAAGGTTTTAATTGTTCAGACGTGTAAGATGTTCTTCA
ATTACATAGACAGGTCTTTCTTATAAACGGAAAAAAATCAGATTTTTTTTAACAGTTCTTCTAA
GACTCAACTGTTGCCTTGAATTACAGCCTAGTTTTTAAGCAGTGAAATGTAATGATAAAGAGGG
ATATTTTAACAAAATATTTCCGAATGAATGACTCATTATTTCATCCTTTTGAATAACCATTGTT
AAGGGTAGGGGAAAGCATGGACCAAACATCACTGGAAACAAAGGTTGTAACCATAGCAACAGAC
TTCTTCTATACACTTCAAAGGTGCAGCTAACATGACAAAGAAAAACCCCTGTTACATCTCCTCC
TCGTTGTCAGGCCAAGGTGGGAGGATATGGCATAATTGTACAGTAGCAATTTTTTCTCTTAATT
AACTCAAAGTGGTTTATCTAAAAATAACCACAAGTCAGTTCAAACTGCCTGGTTCTTAAGGCAA
GTTTTCATTTGGAAGGCGAAACTATATTTGGGAACATCTTGTAAGAAAAATACAGATTTTTTTT
CTTTACTGTGTGCCACACCTAAGAAAGAACTTTATACATCTGGTTCTTTGAGGATAGATGTGCT
GGAGTAGAGAAAAGTCACTGCAGAATAGACCATACCATTGTTCGTGTTGTTGTTCATTTGGGAG
TTTAACTACAAGTTATCTAAAACAATAACCAAGAGCTGTTGGCCCTCAATCTAACTTACATATT
GGTTATTCGATTGTGTTTTAAACTGAATTCAAATCAGATAAAGAAAACCTGTTCTTTTCTCCAG
CTAAAATGACAACTTGTTTCTGTCGTCTAGCTGACAGGTTATTATTGGAAATATCAAGTTTGTT
CATGGTAATCACACATTCCCTTTTTGTTTTTGCTTTGTTTGTTTTTAAAGAATATTTAGAT

hide sequence

Protein Sequences


Protein RefSeqs	NP_001099857	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D3ZAL8	(Get FASTA)	NCBI Sequence Viewer
	EDL97348	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000036369
	ENSRNOP00000036369.2
	ENSRNOP00055013171
	ENSRNOP00060003339
	ENSRNOP00065031443

RefSeq Acc Id:	NP_001099857 ⟸ NM_001106387
- Peptide Label:	precursor
- UniProtKB:	D3ZAL8 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MGFNVIRLLRGSAVAVVLAPTVLLTMLSSAERGCPKGCRCEGKMVYCESQKLQEIPSSISAGCL GLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISYFLNNT FRPVTNLRNLDLSYNQLHSLGSEQFRGLRKLLSLHLRSNSLRTIPVRIFQDCRNLELLDLGYNR IRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLVSLQNLYMQWNKISVIGQTMSWTWSSLQ RLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIGQEILDSWISLNDISLAGNIWECSRNI CSLVNWLKSFKGLRENTILCASPKELQGVNVIDAVKNYSICGKSTTTERFDLARALPKPTFKPK LPRPKHESKPPLPPTVGASEPSPETDVDTEHISFHKIIAGSVALFLSVLVILLVMYVSWKRYPA SMKQLQQRSLMRRHRKKKRQSLKQMTPGTQEFYVDYKPTNTETSEMLLNGTGPCTYSKSGSREC EIPLSMNVSTFLAYDQPTISYCGVHHELLSHKTFETNAQEDTMESHLETELDLSTITSAGRIGD HKPQLA hide sequence

RefSeq Acc Id:

ENSRNOP00000036369 ⟸ ENSRNOT00000033980

RefSeq Acc Id:

ENSRNOP00000069618 ⟸ ENSRNOT00000081254

Protein Domains

LRRCT LRRNT

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZAL8-F1-model_v2	AlphaFold	D3ZAL8	1-582	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1304866	AgrOrtholog
BioCyc Gene	G2FUF-3828	BioCyc
Ensembl Genes	ENSRNOG00000026466	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055009685	UniProtKB/Swiss-Prot
	ENSRNOG00060002885	UniProtKB/Swiss-Prot
	ENSRNOG00065022710	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000033980	ENTREZGENE
	ENSRNOT00000033980.3	UniProtKB/Swiss-Prot
	ENSRNOT00055016373	UniProtKB/Swiss-Prot
	ENSRNOT00060004668	UniProtKB/Swiss-Prot
	ENSRNOT00065038769	UniProtKB/Swiss-Prot
Gene3D-CATH	3.80.10.10	UniProtKB/Swiss-Prot
InterPro	Leu-rich_rpt	UniProtKB/Swiss-Prot
	Leu-rich_rpt_typical-subtyp	UniProtKB/Swiss-Prot
	LRR_dom_sf	UniProtKB/Swiss-Prot
	LRRNT	UniProtKB/Swiss-Prot
KEGG Report	rno:294380	UniProtKB/Swiss-Prot
NCBI Gene	294380	ENTREZGENE
PANTHER	LEUCINE-RICH REPEAT TRANSMEMBRANE NEURONAL PROTEIN 3	UniProtKB/Swiss-Prot
	SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN	UniProtKB/Swiss-Prot
Pfam	LRR_8	UniProtKB/Swiss-Prot
PhenoGen	Lrrtm3	PhenoGen
PROSITE	LRR	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000026466	RatGTEx
	ENSRNOG00055009685	RatGTEx
	ENSRNOG00060002885	RatGTEx
	ENSRNOG00065022710	RatGTEx
SMART	LRR_SD22	UniProtKB/Swiss-Prot
	LRR_TYP	UniProtKB/Swiss-Prot
	LRRNT	UniProtKB/Swiss-Prot
Superfamily-SCOP	L domain-like	UniProtKB/Swiss-Prot
UniProt	D3ZAL8	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Lrrtm3	leucine rich repeat transmembrane neuronal 3	Lrrtm3_predicted	leucine rich repeat transmembrane neuronal 3 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Lrrtm3_predicted	leucine rich repeat transmembrane neuronal 3 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

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