Dohh (deoxyhypusine hydroxylase) - Rat Genome Database

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Gene: Dohh (deoxyhypusine hydroxylase) Rattus norvegicus
Analyze
Symbol: Dohh
Name: deoxyhypusine hydroxylase
RGD ID: 1304783
Description: Predicted to enable deoxyhypusine monooxygenase activity and iron ion binding activity. Orthologous to human DOHH (deoxyhypusine hydroxylase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4,4'-sulfonyldiphenol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: deoxyhypusine dioxygenase; deoxyhypusine hydroxylase/monooxygenase; deoxyhypusine monooxygenase; LOC314644; RGD1304783; similar to RIKEN cDNA 1110033C18
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,972,202 - 8,977,025 (-)NCBIGRCr8
mRatBN7.278,321,466 - 8,326,305 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,321,466 - 8,326,289 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,207,123 - 11,211,953 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,082,610 - 13,087,440 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,950,258 - 10,955,089 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,191,127 - 11,195,971 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,191,131 - 11,195,866 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,358,019 - 11,362,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,806,005 - 9,810,744 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,806,004 - 9,810,744 (-)NCBI
Celera76,510,531 - 6,515,270 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:16371467   PMID:16533814   PMID:17213197   PMID:19706422   PMID:24832488   PMID:25865244   PMID:30053369  


Genomics

Comparative Map Data
Dohh
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr878,972,202 - 8,977,025 (-)NCBIGRCr8
mRatBN7.278,321,466 - 8,326,305 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl78,321,466 - 8,326,289 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx711,207,123 - 11,211,953 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0713,082,610 - 13,087,440 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0710,950,258 - 10,955,089 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0711,191,127 - 11,195,971 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl711,191,131 - 11,195,866 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0711,358,019 - 11,362,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.479,806,005 - 9,810,744 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.179,806,004 - 9,810,744 (-)NCBI
Celera76,510,531 - 6,515,270 (-)NCBICelera
Cytogenetic Map7q11NCBI
DOHH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,490,824 - 3,500,674 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,490,821 - 3,500,674 (-)EnsemblGRCh38hg38GRCh38
GRCh37193,490,822 - 3,500,672 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36193,441,822 - 3,451,621 (-)NCBINCBI36Build 36hg18NCBI36
Celera193,427,630 - 3,437,748 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef193,256,753 - 3,266,895 (-)NCBIHuRef
CHM1_1193,490,467 - 3,500,586 (-)NCBICHM1_1
T2T-CHM13v2.0193,468,995 - 3,478,845 (-)NCBIT2T-CHM13v2.0
Dohh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391081,220,268 - 81,224,186 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1081,220,262 - 81,224,186 (+)EnsemblGRCm39 Ensembl
GRCm381081,384,434 - 81,388,352 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,384,466 - 81,391,560 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl1081,384,428 - 81,388,352 (+)EnsemblGRCm38mm10GRCm38
MGSCv371080,847,173 - 80,851,097 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361080,787,640 - 80,791,481 (+)NCBIMGSCv36mm8
Celera1082,405,461 - 82,409,385 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1039.72NCBI
Dohh
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554955,076,705 - 5,079,798 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554955,073,794 - 5,080,298 (+)NCBIChiLan1.0ChiLan1.0
DOHH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2207,889,743 - 7,904,833 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1197,121,358 - 7,136,433 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0192,517,866 - 2,527,786 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1193,467,563 - 3,478,128 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl193,468,094 - 3,474,038 (-)Ensemblpanpan1.1panPan2
DOHH
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12055,896,919 - 55,906,326 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2055,897,382 - 55,906,357 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2055,621,579 - 55,630,779 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02056,556,150 - 56,565,298 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2056,553,980 - 56,565,072 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12055,611,838 - 55,621,208 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02056,095,360 - 56,104,503 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02056,294,230 - 56,303,377 (-)NCBIUU_Cfam_GSD_1.0
Dohh
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118215,849,726 - 215,856,299 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365881,974,092 - 1,985,320 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365881,978,487 - 1,985,056 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DOHH
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl275,164,787 - 75,173,439 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1275,164,536 - 75,173,443 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2275,730,711 - 75,739,634 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DOHH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.163,256,088 - 3,272,082 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl63,256,087 - 3,265,460 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660815,220,128 - 5,236,427 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dohh
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248285,875,797 - 5,884,360 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248285,876,034 - 5,882,342 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dohh
21 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:83
Count of miRNA genes:70
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000005640
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat

Markers in Region
RH137503  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.278,321,482 - 8,321,683 (+)MAPPERmRatBN7.2
Rnor_6.0711,191,144 - 11,191,344NCBIRnor6.0
Rnor_5.0711,358,036 - 11,358,236UniSTSRnor5.0
RGSC_v3.479,806,022 - 9,806,222UniSTSRGSC3.4
Celera76,510,548 - 6,510,748UniSTS
Cytogenetic Map7q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 36 57 41 19 41 8 11 74 35 41 11 8
Low 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000005640   ⟹   ENSRNOP00000005640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,321,466 - 8,326,260 (-)Ensembl
Rnor_6.0 Ensembl711,191,131 - 11,195,866 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000104214   ⟹   ENSRNOP00000095710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,322,408 - 8,326,289 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112038   ⟹   ENSRNOP00000093565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl78,321,466 - 8,326,287 (-)Ensembl
RefSeq Acc Id: NM_001025006   ⟹   NP_001020177
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr878,972,202 - 8,977,025 (-)NCBI
mRatBN7.278,321,466 - 8,326,289 (-)NCBI
Rnor_6.0711,191,127 - 11,195,866 (-)NCBI
Rnor_5.0711,358,019 - 11,362,858 (-)NCBI
RGSC_v3.479,806,005 - 9,810,744 (-)RGD
Celera76,510,531 - 6,515,270 (-)RGD
Sequence:
RefSeq Acc Id: NP_001020177   ⟸   NM_001025006
- UniProtKB: Q5PPJ4 (UniProtKB/Swiss-Prot),   A0A8L2Q272 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005640   ⟸   ENSRNOT00000005640
RefSeq Acc Id: ENSRNOP00000093565   ⟸   ENSRNOT00000112038
RefSeq Acc Id: ENSRNOP00000095710   ⟸   ENSRNOT00000104214

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PPJ4-F1-model_v2 AlphaFold Q5PPJ4 1-302 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694973
Promoter ID:EPDNEW_R5497
Type:initiation region
Name:Dohh_1
Description:deoxyhypusine hydroxylase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0711,195,887 - 11,195,947EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304783 AgrOrtholog
BioCyc Gene G2FUF-35025 BioCyc
BioCyc Pathway PWY-5905 [hypusine biosynthesis] BioCyc
BioCyc Pathway Image PWY-5905 BioCyc
Ensembl Genes ENSRNOG00000004259 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055032747 UniProtKB/Swiss-Prot
  ENSRNOG00060032309 UniProtKB/Swiss-Prot
  ENSRNOG00065021680 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005640.7 UniProtKB/TrEMBL
  ENSRNOT00000104214.1 UniProtKB/TrEMBL
  ENSRNOT00000112038 ENTREZGENE
  ENSRNOT00000112038.1 UniProtKB/Swiss-Prot
  ENSRNOT00055056623 UniProtKB/Swiss-Prot
  ENSRNOT00060056007 UniProtKB/Swiss-Prot
  ENSRNOT00065036893 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7314221 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Deoxyhypusine_hydroxylase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBS_lyase_HEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105594 IMAGE-MGC_LOAD
NCBI Gene 314644 ENTREZGENE
PANTHER DEOXYHYPUSINE HYDROXYLASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PBS LYASE HEAT-LIKE PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam HEAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HEAT_PBS UniProtKB/TrEMBL
PhenoGen Dohh PhenoGen
RatGTEx ENSRNOG00000004259 RatGTEx
  ENSRNOG00055032747 RatGTEx
  ENSRNOG00060032309 RatGTEx
  ENSRNOG00065021680 RatGTEx
SMART EZ_HEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ANT1_RAT UniProtKB/TrEMBL
  A0A8L2Q272 ENTREZGENE, UniProtKB/TrEMBL
  DOHH_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-01 Dohh  deoxyhypusine hydroxylase  Dohh  deoxyhypusine hydroxylase/monooxygenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Dohh  deoxyhypusine hydroxylase/monooxygenase  RGD1304783  similar to RIKEN cDNA 1110033C18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1304783  similar to RIKEN cDNA 1110033C18  RGD1304783_predicted  similar to RIKEN cDNA 1110033C18 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1304783_predicted  similar to RIKEN cDNA 1110033C18 (predicted)  LOC314644_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC314644_predicted  similar to RIKEN cDNA 1110033C18 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL