Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17beta-estradiol | decreases expression | ISO | Pi16 (Mus musculus) | 6480464 | Estradiol results in decreased expression of PI16 mRNA | CTD | PMID:19484750 | 2,2',5,5'-tetrachlorobiphenyl | increases expression | ISO | PI16 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:36804509 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of PI16 mRNA | CTD | PMID:34747641 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | Pi16 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of PI16 mRNA | CTD | PMID:20188158 | 3,4-methylenedioxymethamphetamine | decreases methylation | ISO | Pi16 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased methylation of PI16 promoter | CTD | PMID:26251327 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Pi16 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of PI16 mRNA | CTD | PMID:26251327 | 3,7-dihydropurine-6-thione | increases expression | EXP | | 6480464 | Mercaptopurine results in increased expression of PI16 mRNA | CTD | PMID:23358152 | 4,4'-sulfonyldiphenol | increases expression | ISO | Pi16 (Mus musculus) | 6480464 | bisphenol S results in increased expression of PI16 mRNA | CTD | PMID:30951980 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Pi16 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of PI16 mRNA | CTD | PMID:28973697 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of PI16 mRNA | CTD | PMID:24780913 | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of PI16 mRNA | CTD | PMID:31881176 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of PI16 mRNA | CTD | PMID:28959563 | aldehydo-D-glucose | multiple interactions | ISO | Pi16 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of PI16 mRNA | CTD | PMID:37567420 | amphetamine | increases expression | EXP | | 6480464 | Amphetamine results in increased expression of PI16 mRNA | CTD | PMID:30779732 | benzo[a]pyrene | decreases expression | ISO | Pi16 (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of PI16 mRNA | CTD | PMID:22610609 | benzo[a]pyrene | increases expression | ISO | Pi16 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PI16 mRNA | CTD | PMID:32417428 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PI16 promoter | CTD | PMID:23359474 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PI16 promoter | CTD | PMID:23359474 | bisphenol A | increases expression | ISO | Pi16 (Mus musculus) | 6480464 | bisphenol A results in increased expression of PI16 mRNA | CTD | PMID:32156529 | bisphenol A | multiple interactions | ISO | PI16 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of PI16 gene | CTD | PMID:31601247 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PI16 mRNA | CTD | PMID:25181051 | buta-1,3-diene | decreases expression | ISO | Pi16 (Mus musculus) | 6480464 | 1 and 3-butadiene results in decreased expression of PI16 mRNA | CTD | PMID:29038090 | cantharidin | decreases expression | ISO | Pi16 (Mus musculus) | 6480464 | Cantharidin results in decreased expression of PI16 mRNA | CTD | PMID:36907384 | carbon nanotube | decreases expression | ISO | Pi16 (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | carbon nanotube | increases expression | ISO | Pi16 (Mus musculus) | 6480464 | Nanotubes and Carbon results in increased expression of PI16 mRNA | CTD | PMID:25620056 | cerium trichloride | decreases expression | ISO | Pi16 (Mus musculus) | 6480464 | cerous chloride results in decreased expression of PI16 mRNA | CTD | PMID:23573234 | CGP 52608 | multiple interactions | ISO | PI16 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PI16 gene] | CTD | PMID:28238834 | chromium atom | multiple interactions | ISO | Pi16 (Mus musculus) | 6480464 | LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of PI16 mRNA] | CTD | PMID:16940432 | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of PI16 mRNA | CTD | PMID:30556269 | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of PI16 mRNA | CTD | PMID:30556269 | D-glucose | multiple interactions | ISO | Pi16 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of PI16 mRNA | CTD | PMID:37567420 | dexamethasone | decreases expression | ISO | Pi16 (Mus musculus) | 6480464 | Dexamethasone results in decreased expression of PI16 mRNA | CTD | PMID:22733784 | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of PI16 promoter | CTD | PMID:23359474 | dioxygen | multiple interactions | EXP | | 6480464 | [Oxygen deficiency co-treated with Blood Glucose deficiency co-treated with Particulate Matter] results in decreased expression of PI16 mRNA | CTD | PMID:33729688 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of PI16 mRNA | CTD | PMID:25152437 | doxorubicin | decreases expression | ISO | PI16 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PI16 mRNA | CTD | PMID:29803840 | fructose | multiple interactions | ISO | Pi16 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of PI16 mRNA | CTD | PMID:37567420 | fulvestrant | multiple interactions | ISO | PI16 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of PI16 gene | CTD | PMID:31601247 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of PI16 mRNA | CTD | PMID:27387713 | genistein | decreases expression | ISO | Pi16 (Mus musculus) | 6480464 | Genistein results in decreased expression of PI16 mRNA | CTD | PMID:32186404 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of PI16 mRNA | CTD | PMID:22061828 and PMID:33387578 | glucose | multiple interactions | ISO | Pi16 (Mus musculus) | 6480464 | [lard co-treated with Cholesterol and Dietary co-treated with Dietary Sucrose co-treated with Fructose co-treated with Glucose] results in increased expression of PI16 mRNA | CTD | PMID:37567420 | lead diacetate | multiple interactions | ISO | Pi16 (Mus musculus) | 6480464 | [lead acetate results in increased abundance of Lead] which results in increased methylation of PI16 5' UTR more ... | CTD | PMID:33445541 | lead(0) | multiple interactions | ISO | Pi16 (Mus musculus) | 6480464 | [lead acetate results in increased abundance of Lead] which results in increased methylation of PI16 5' UTR more ... | CTD | PMID:33445541 | lipopolysaccharide | multiple interactions | ISO | PI16 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | mercaptopurine | increases expression | EXP | | 6480464 | Mercaptopurine results in increased expression of PI16 mRNA | CTD | PMID:23358152 | monosodium L-glutamate | decreases expression | ISO | Pi16 (Mus musculus) | 6480464 | Sodium Glutamate results in decreased expression of PI16 mRNA | CTD | PMID:22078008 | nicotinic acid | multiple interactions | ISO | Pi16 (Mus musculus) | 6480464 | LEPR gene mutant form promotes the reaction [[Niacin binds to Chromium] which results in increased expression of PI16 mRNA] | CTD | PMID:16940432 | paracetamol | decreases expression | ISO | PI16 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of PI16 mRNA | CTD | PMID:22230336 | pirinixic acid | increases expression | ISO | Pi16 (Mus musculus) | 6480464 | pirinixic acid results in increased expression of PI16 mRNA | CTD | PMID:20813756 | propanal | increases expression | ISO | PI16 (Homo sapiens) | 6480464 | propionaldehyde results in increased expression of PI16 mRNA | CTD | PMID:26079696 | purine-6-thiol | increases expression | EXP | | 6480464 | Mercaptopurine results in increased expression of PI16 mRNA | CTD | PMID:23358152 | S-(1,2-dichlorovinyl)-L-cysteine | decreases expression | ISO | PI16 (Homo sapiens) | 6480464 | S-(1 and 2-dichlorovinyl)cysteine results in decreased expression of PI16 mRNA | CTD | PMID:35811015 | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | PI16 (Homo sapiens) | 6480464 | [S-(1 more ... | CTD | PMID:35811015 | silicon dioxide | decreases expression | ISO | PI16 (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of PI16 mRNA | CTD | PMID:23806026 | sodium arsenite | increases expression | ISO | Pi16 (Mus musculus) | 6480464 | sodium arsenite results in increased expression of PI16 mRNA | CTD | PMID:37682722 | Soman | increases expression | EXP | | 6480464 | Soman results in increased expression of PI16 mRNA | CTD | PMID:19281266 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PI16 mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | ISO | Pi16 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of PI16 mRNA | CTD | PMID:23557971 | troglitazone | increases expression | ISO | Pi16 (Mus musculus) | 6480464 | troglitazone results in increased expression of PI16 mRNA | CTD | PMID:28973697 | trovafloxacin | decreases expression | ISO | Pi16 (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of PI16 mRNA | CTD | PMID:35537566 | |