Gene: Tmem147 (transmembrane protein 147)
Rattus norvegicus
Symbol:
Tmem147
Name:
transmembrane protein 147
Description:
FOUND IN endoplasmic reticulum membrane (inferred); integral to membrane (inferred); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC292792_predicted; MGC125231; RGD1304706; rgd1304706; RGD1304706_predicted; seven transmembrane domain protein; similar to seven transmembrane domain protein; similar to seven transmembrane domain protein (predicted); transmembrane protein 147
Latest Assembly:
RGSC Genome Assembly v3.4
Position:
Map Chr Position Strand Source Rat Cytogenetic Map 1 q21 NCBI RGSC Genome Assembly v5.0 1 90,332,924 - 90,334,744 - NCBI RGSC Genome Assembly v3.4 1 85,771,683 - 85,773,503 - NCBI Rat Celera Assembly 1 80,348,600 - 80,350,420 - NCBI Genome Assembly 3.1 1 85,849,790 - 85,851,609 - NCBI
Model
Gene-Chemical Interaction Annotations
17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of TMEM147 mRNA CTD PMID:17351261 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1312308 6480464 Tetrachlorodibenzodioxin results in decreased expression of TMEM147 mRNA CTD PMID:19465110 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1312308 6480464 Tetrachlorodibenzodioxin affects the expression of TMEM147 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of TMEM147 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of TMEM147 mRNA CTD PMID:22298810 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of TMEM147 mRNA] CTD PMID:21215274 2,4,6-trinitrotoluene affects expression EXP 6480464 Trinitrotoluene affects the expression of TMEM147 mRNA CTD PMID:21346803 2,4-dinitrotoluene affects expression EXP 6480464 2,4-dinitrotoluene affects the expression of TMEM147 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2,6-dinitrotoluene affects the expression of TMEM147 mRNA CTD PMID:21346803 benzo[a]pyrene multiple interactions ISO RGD:1312308 6480464 [Benzo(a)pyrene co-treated with XPA gene mutant form co-treated with TRP53 gene mutant form] results in decreased expression of TMEM147 mRNA CTD PMID:21715664 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of TMEM147 mRNA CTD PMID:21839799 C60 fullerene decreases expression EXP 6480464 fullerene C60 results in decreased expression of TMEM147 mRNA CTD PMID:19167457 clofibrate multiple interactions ISO RGD:1312308 6480464 PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of TMEM147 mRNA] CTD PMID:17585979 copper(2+) sulfate decreases expression ISO RGD:1607077 6480464 Copper Sulfate results in decreased expression of TMEM147 mRNA CTD PMID:19549813 cyclosporin A increases expression ISO RGD:1607077 6480464 Cyclosporine results in increased expression of TMEM147 mRNA CTD PMID:20106945 hydrogen peroxide affects expression ISO RGD:1607077 6480464 Hydrogen Peroxide affects the expression of TMEM147 mRNA CTD PMID:20044591 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of TMEM147 mRNA CTD PMID:18164116 paracetamol affects expression ISO RGD:1312308 6480464 Acetaminophen affects the expression of TMEM147 mRNA CTD PMID:17562736 paracetamol multiple interactions ISO RGD:1312308 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of TMEM147 mRNA; more ... CTD PMID:17585979 pirinixic acid increases expression ISO RGD:1312308 6480464 pirinixic acid results in increased expression of TMEM147 mRNA CTD PMID:20813756 PMID:15302862 pirinixic acid increases expression ISO RGD:1312308 6480464 pirinixic acid results in increased expression of TMEM147 mRNA CTD PMID:15302862 PMID:20813756
Gene Ontology Annotations
Cellular Component endoplasmic reticulum membrane IEA UniProtKB-SubCell:SL-0097 1600115 GO_REF:0000039 UniProtKB GO_REF:0000039 integral to membrane IEA UniProtKB-KW:KW-0812 1600115 GO_REF:0000037 UniProtKB GO_REF:0000037
631495 Bp96 Blood pressure QTL 96 4.52 Blood pressure systolic 1 22842898 102532417 Rat 634314 Niddm44 Non-insulin dependent diabetes mellitus QTL 44 Glucose level 1 43872827 204280278 Rat 631512 Scl6 Serum cholesterol level QTL 6 9.6 Lipid level cholesterol 1 71659707 90282193 Rat 631688 Hcas2 Hepatocarcinoma susceptibility QTL 2 3 .0001 Liver tumor susceptibility nodule number 1 6253946 116153262 Rat 738022 Anxrr13 Anxiety related response QTL 13 4.6 .00039 Anxiety response open field inner locomotion 1 83945235 128945235 Rat 1300121 Hrtrt1 Heart rate QTL 1 3.7 Heart rate salt-loaded 1 64744882 116153262 Rat 1549903 Bp267 Blood pressure QTL 267 Blood pressure systolic, nighttime 1 77541583 106445306 Rat 1582234 Gluco18 Glucose level QTL 18 3.4 .0003 Glucose level uptake 1 79749065 124749065 Rat 1578654 Bss10 Bone structure and strength QTL 10 4 Bone structure femoral neck cortical area 1 43872710 162735928 Rat 1578649 Bmd8 Bone mineral density QTL 8 4.9 Bone mineral density femoral neck trabecular vBMD 1 43872710 88872710 Rat 1578780 Cm52 Cardiac mass QTL 52 3.3 .0001 Cardiac mass 1 81342810 225814178 Rat 1358359 Sradr1 Stress Responsive Adrenal Weight QTL 1 4.74 Hypothalamic-pituitary-adrenal axis adrenal gland weight 1 28716493 124749065 Rat 2298545 Neuinf8 Neuroinflammation QTL 8 2.9 Neuroinflammation 1 55083934 154002647 Rat 2302059 Pia36 Pristane induced arthritis QTL 36 3.8 .001 Joint/bone inflammation pristane induced 1 41645883 86645883 Rat 2300164 Bmd44 Bone mineral density QTL 44 5.4 .0001 Bone mineral density 1 56601368 101601368 Rat 2300324 Fetw1 Fetal weight QTL 1 12.1 .005 Fetal weight 1 55540384 100540384 Rat 2313402 Anxrr24 Anxiety related response QTL 24 Anxiety response domestication 1 43426139 146971983 Rat 2313094 Bss58 Bone structure and strength QTL 58 3.7 .0001 Bone strength 1 37646940 119780561 Rat 2313078 Bss54 Bone structure and strength QTL 54 3.5 .0001 Bone structure 1 37646940 119780561 Rat 2313051 Bss57 Bone structure and strength QTL 57 3.7 .0001 Bone strength 1 37646940 119780561 Rat 2313072 Bss53 Bone structure and strength QTL 53 4.3 .0001 Bone structure 1 37646940 119780561 Rat 2313059 Bss55 Bone structure and strength QTL 55 3.2 .0001 Bone structure 1 37646940 119780561 Rat 2313098 Bmd70 Bone mineral density QTL 70 3.6 .0001 Bone mineral density 1 37646940 119780561 Rat 2313099 Bss56 Bone structure and strength QTL 56 2.4 .0001 Bone structure 1 37646940 119780561 Rat 2313083 Bmd74 Bone mineral density QTL 74 4 .0001 Bone mineral density 1 81947770 119780561 Rat 4889494 Scort2 Serum corticosterone level QTL 2 4.2 Hormone level corticosterone 1 80851478 125851478 Rat 6903308 Scl36 Serum cholesterol QTL 36 2 .0125 Lipid level cholesterol level 1 53013200 90306478 Rat 631519 Pia11 Pristane induced arthritis QTL 11 5.3 Joint/bone inflammation arthritis severity 1 83489176 186472032 Rat
Gene Ontology Annotations
